Clinical trials: Occlusion Carotid
Carotid Artery Stenosis
Progression Assessment of Carotid Artery Stenosis by Ultrafast Ultrasound Flow Imaging
Rationale: Approximately 15-20% of strokes originates from an atherosclerotic plaque rupture in the carotid artery. To reduce the risk of stroke, patients should be evaluated for possible carotid endarterectomy (CEA), which is…
- Trial name
- CAS-PRO (NCT05270005)
- Testing
- Ultrasound-based flow imaging, Ultrasound-based strain imaging, Conventional duplex
- Where
- 2 sites in Netherlands
- Volunteers
- 85 people
- Sponsor
- Rijnstate Hospital
Moyamoya, Stroke
The Adult Hemorrhagic Moyamoya Surgery Study
The aim of this study is to investigate whether extracranial-intracranial(EC-IC) bypass surgery could prevent rebleeding and improve neurological function in adult moyamoya with hemorrhagic onset.
- Trial name
- AHMSS (NCT02319980)
- Testing
- Extracranial-intracranial bypass surgery
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Huashan Hospital
Moyamoya Disease
Study on the Mechanism of Cognitive Impairment in Patients with Moyamoya Disease
The purpose of this study is to comprehensively evaluate the risk factors for cognitive decline in patients with moyamoya disease, identify imaging target areas associated with cognitive damage in the brain, and explore the…
- Trial name
- NCT06832839
- Testing
- Revascularization
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Plaque, Ischemic Stroke
18F FDG and 68Ga FAPI PET/MR Imaging of Carotid Artery Plaque Vulnerability: A Clinical Study in Carotid Artery Plaque Patients
Carotid atherosclerotic plaque rupture is the main cause of ischemic stroke attacks, and early and precise assessment of plaque vulnerability can prevent ischemic stroke.
- Conditions
- Carotid Artery Plaque, Ischemic Stroke, PET / MR
- Trial name
- NCT07004673
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Hypertension, Carotid Stenosis
Reconstruction of the Carotid Bifurcation in Patients With Arterial Hypertension of 2-3 Degrees
Carotid endarterectomy (CEA) is a well-established procedure for preventing ischemic brain damage. Stenosis of the precerebral vessels are often combined with arterial hypertension.
- Conditions
- Hypertension, Carotid Stenosis, Symptomatic Carotid Artery Stenosis
- Trial name
- NCT05931003
- Testing
- Carotid stenting, Carotid endarterectomy
- Where
- Russia
- Volunteers
- 90 people
- Sponsor
- Samara State Medical University
Carotid Stenosis, Carotid Artery Diseases
Direct Access Carotid Artery Stenting Using the Neuroguard IEP System (PERFORMANCE III)
The PERFORMANCE III study is a prospective, multicenter single-arm, open label study to evaluate the safety and effectiveness of the Neuroguard IEP® Direct System for the treatment of carotid artery stenosis in subjects at…
- Trial name
- NCT05845710
- Testing
- Neuroguard IEP Direct System
- Where
- 32 sites in United States, France
- Volunteers
- 178 people
- Sponsor
- Contego Medical, Inc.
Type 2 Diabetes
Effect of Bydureon on Carotid Atherosclerosis Progression in Type 2 Diabetes Mellitus
Investigators will be determining whether a once weekly injectable medication Bydureon versus placebo is able to reduce the development of atherosclerosis.
- Trial name
- NCT02162550
- Testing
- Bydureon
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Phoenix VA Health Care System
Moyamoya Disease
The Safety and Efficacy of RIC on Adult Moyamoya Disease
There are a series of symptoms such as ischemic stroke、transient ischemic attack 、hemorrhagic stroke、headache 、seizure and so on in moyamoya disease( MMD) patients .Nowadays, revascularization is the only effective way for…
- Trial name
- RIC-AMD (NCT04012268)
- Testing
- RIC, Aspirin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Capital Medical University
Stroke, Acute, Stroke, Ischemic
Carotid Artery Stenting During Endovascular Treatment of Acute Stroke
Rationale: Approximately 20% of the patients with acute ischemic stroke due to an intracranial large vessel occlusion (LVO) has a high-grade stenosis in the ipsilateral cervical carotid artery.
- Conditions
- Stroke, Acute, Stroke, Ischemic, Carotid Stenosis, Carotid Atherosclerosis
- Trial name
- CASES (NCT06511089)
- Testing
- carotid artery stenting during EVT, no carotid artery stenting during EVT
- Where
- Netherlands
- Volunteers
- 600 people
- Sponsor
- University Medical Center Groningen
Carotid Stenosis, Hypoperfusion
Physiological Magnetic Resonance Imaging (MRI) to Improve Carotid Endarterectomy Outcomes
The carotid arteries are blood vessels in the neck that supply blood to the brain. Carotid stenosis disease is defined as a narrowing of these arteries due to the build up of plaque.
- Conditions
- Carotid Stenosis, Hypoperfusion, Transient Ischemic Attack
- Trial name
- NCT01272843
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Sunnybrook Health Sciences Centre
Rheumatoid Arthritis
The Effect of Puerarin Injection on Carotid Intima-Media Thickness in Patients With Rheumatoid Arthritis
The purpose of this study is to access the effect (week 12/week 24) of puerarin injection on carotid intima-media thickness (CIMT) in rheumatoid arthritis (RA) patients despite routine anti-rheumatic treatment.
- Trial name
- NCT02254655
- Testing
- Puerarin injection 400 mg, Control
- Volunteers
- 119 people
- Sponsor
- Chengdu PLA General Hospital
Cervical Plexus Block Comparison
Medial Cervical Block for Carotid Endarterectomy Comparison With Standard Method
The purpose of the study is to compare efficacy, complications and safety of the standard method of Combined (superficial and deep) cervical plexus block (SDCPB) with Ultrasound guided Medial Cervical plexus block technique…
- Trial name
- NCT01608126
- Testing
- cervical block
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Daniel Nalos MD
Carotid Stenosis
Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis
Purpose of this study: Primary: Comparison of cardiovascular mortality and morbidity which includes cardiac and neurological morbidity (TIA and CVA) in the two invasive treatments of asymptomatic carotid artery stenosis…
- Trial name
- NCT00772278
- Testing
- carotid artery stenting, carotid endarterectomy
- Where
- Israel
- Volunteers
- 137 people
- Sponsor
- Carmel Medical Center
Carotid Artery Stenosis (Symptomatic and Asymptomatic)
CEST-PROTECT: Proximal Flow Control With a Balloon Guide Catheter Plus Distal Embolic Protection: a Randomised, Open-label Trial Evaluating Cerebral Protection Techniques
This randomized controlled trial aims to evaluate whether a proximal-distal dual cerebral protection strategy can reduce the occurrence of new cerebral ischemic lesions compared with a single cerebral protection strategy in…
- Trial name
- CEST-PROTECT (NCT07841132)
- Testing
- BGC proximal flow control plus distal filter embolic protection device during carotid artery stenting, Single distal filter embolic protection device during carotid artery stenting
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Moyamoya Disease, Moyamoya Syndrome
Development and Validation of Risk Prediction Models for Stroke and Cognitive Impairment in Moyamoya Disease and Moyamoya Syndrome
This multicenter prospective observational cohort study aims to develop and validate individualized risk prediction models for stroke and cognitive decline in patients with moyamoya disease or moyamoya syndrome by integrating…
- Trial name
- NCT07894107
- Where
- 13 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Beijing Tiantan Hospital
Carotid Artery Stenosis
A Cohort Study Comparing PCSK9 Inhibitor Plus Statin With Statin Monotherapy for Carotid Artery Stenosis
A multicenter cohort study
- Trial name
- TRIP-CAS (NCT07036991)
- Testing
- PCSK9 inhibitor (biweekly injections) + Rosuvastatin/Atorvastatin ± Ezetimibe, Rosuvastatin/Atorvastatin ± Ezetimibe
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Changhai Hospital
Atherosclerosis
Pollutants in the Atherosclerotic Plaque and Cardiovascular Events
Air pollution, microplastics and climate change pose serious public health risks. In recent years, air pollution has been associated with an increased risk of morbidity, all-cause mortality, cardio-respiratory-related mortality…
- Trial name
- APAChE (NCT05900947)
- Testing
- analysis of carotid atherosclerotic plaque
- Where
- Italy
- Volunteers
- 312 people
- Sponsor
- University of Campania Luigi Vanvitelli
Carotid Artery Stenosis
Prospective Trial of IVL for Calcified Carotid Lesions(CREATE Trial)(Extended Follow-Up)
Purpose: To assess the long-term safety and efficacy of the intravascular lithotripsy system for pre-treatment of calcified carotid artery stenosis.
- Trial name
- NCT06936189
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Bluesail Boyuan Medical Technology Co., Ltd.
Arteriosclerosis, Diabetes Mellitus
A High-Resolution Magnetic Resonance Imaging Study to Evaluate the Effect of Rosuvastatin on Carotid Atherosclerotic Plaques
The aim of this study is to assess whether high intensive statin therapy could regress carotid atherosclerotic plaques as determined by High-Resolution Contrast Enhanced Magnetic Resonance imaging (CE-MRI).
- Conditions
- Arteriosclerosis, Diabetes Mellitus, Lipid Disorder
- Trial name
- NCT02305862
- Testing
- Rosuvastatin 5mg, Rosuvastatin 20mg
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Capital Medical University
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
Coated or Chewable Aspirin and a Hybrid Strategy to Mitigate Adverse Effects of Air Pollution in Stable Atherosclerotic Disease
Although both enteric-coated and plain formulations of aspirin are being used commonly, there are no high-quality comparisons between these formulations with respect to clinical efficacy outcomes in patients with atherosclerotic…
- Conditions
- Atherosclerotic Cardiovascular Disease, Coronary Artery Disease, Ischemic Heart Disease, Ischemic Stroke
- Trial name
- COATED-AIR (NCT06541691)
- Testing
- Enteric-coated aspirin, Plain aspirin, Hybrid strategy
- Where
- Iran
- Volunteers
- 3,000 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center