Clinical trials: Occlusion of Artery
Cardiac Event, Coronary Artery Disease
Comparison of Clopidogrel-based Antiplatelet Agent Treatment and Aspirin Plus Low Dose Rivaroxaban Therapy
The study aims to conduct a randomized controlled trial among adults aged 19 years or older who have experienced acute myocardial infarction at least one year prior, or who have other comorbidities such as peripheral arterial…
- Conditions
- Cardiac Event, Coronary Artery Disease, Peripheral Artery Disease, Bleeding
- Trial name
- OACART (NCT07796217)
- Testing
- Aspirin and low-dose rivaroxaban, Clopidogrel with or without aspirin
- Where
- South Korea
- Volunteers
- 2,758 people
- Sponsor
- Seoul National University Bundang Hospital
Coronary, Coronary Artery Disease
CAPRA-EVO: a Randomized Serial PCCT Trial of Early Evolocumab After ACS
The CAPRA-EVO trial is a single-center, randomized, open-label study with blinded endpoint assessment comparing early evolocumab plus standard lipid-lowering therapy versus standard-of-care lipid-lowering therapy in patients with…
- Trial name
- CAPRA-EVO (NCT07612774)
- Testing
- Evolocumab, Serial photon-counting coronary computed tomography angiography, Standard Lipid-Lowering Therapy
- Where
- 2 sites in China
- Volunteers
- 232 people
- Sponsor
- West China Hospital
Erectile Dysfunction, Coronary Artery Disease
Erectile and Ejaculatory Function Following Coronary Revascularization
This observational, cross-sectional study aims to compare erectile and ejaculatory function between men with a history of coronary revascularization and men without known coronary artery disease.
- Conditions
- Erectile Dysfunction, Coronary Artery Disease, Ejaculation Disorders
- Trial name
- NCT07878260
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Coronary Artery Disease, Acute Coronary Syndrome
PAR Regulation of Platelet Function in Diabetic Patients
Thrombin is the most potent activator of platelets, and platelet activation is a hallmark of thrombosis. Coronary artery disease (CAD) is the major cause of mortality and morbidity in the United States and other industrialized…
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Diabetes, Metabolic Syndrome
- Trial name
- NCT00855374
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Peripheral Arterial Disease
Clinical Trial to Evaluate Efficacy and Safety of SID142 in Patients With Chronic Artery Occlusive Disease
Rinexin® Tab (Cilostazol 100mg, Ginkgo biloba leaf extract 80mg) has been widely used as an anti-platelet agent for the treatment of PAD.
- Trial name
- NCT03318276
- Testing
- SID142, Rinexin® Tab
- Where
- South Korea
- Volunteers
- 170 people
- Sponsor
- SK Chemicals Co., Ltd.
Ischemic Heart Disease, Myocardial Ischemia
Adipose Stromal Cells Injection in the Myocardium for Induction of Revascularization
Treatment of ischemic myocardium has been the subject of intense research in recent years and stem cell therapy is one of the great promises.
- Conditions
- Ischemic Heart Disease, Myocardial Ischemia, Coronary Artery Disease
- Trial name
- ADMIRE (NCT04005989)
- Testing
- Stromal Cells Injection
- Sponsor
- Hospital do Coracao
Peripheral Artery Disease, Atherosclerosis
Clinical Use and Safety of the Xtreme Touch (Magic Touch PTA)- Neo Sirolimus Coated PTA Balloon Catheter in the Treatment of Infrainguinal Peripheral Arterial Disease
This study postulates that the application of Sirolimus, an anti-proliferative agent that inhibits neointimal hyperplasia, via Sirolimus coated balloon (SCB) will be safe and will result in better arterial patency in…
- Trial name
- XTOSI (NCT04368091)
- Testing
- Xtreme Touch - Neo sirolimus coated PTA balloon catheter
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Concept Medical Inc.
Acute Myocardial Infarction, Unstable Angina
Therapeutic Use of Contrast Ultrasound in Acute Coronary Artery Disease
Preclinical studies have demonstrated that high mechanical index (MI) impulses from a diagnostic ultrasound (DUS) transducer during an intravenous microbubble infusion (sonothrombolysis) can restore epicardial and microvascular…
- Trial name
- HUBBLE-I (NCT04732091)
- Testing
- Therapeutic ultrasound with 20 usec
- Where
- 2 sites in United States, Brazil
- Volunteers
- 540 people
- Sponsor
- University of Sao Paulo General Hospital
Stroke
Safety and Efficacy of the Penumbra™ System in Acute Middle Cerebral Artery (MCA) Stroke
Stroke prognosis is intimately related to reperfusion. Reperfusion in acute setting can be achieved with different strategies - varying from intravenous rtPA from mechanical thrombectomy.
- Trial name
- NCT01133223
- Testing
- Penumbra™ System, Recombinant tissue plasminogen activator
- Where
- Brazil
- Sponsor
- Hospital de Clinicas de Porto Alegre
Healthy Volunteers
Phase 1, Single Dose Study to Evaluate Safety, Pharmacokinetics, and Pharmacodynamics of MEDI5884
A Phase 1, single dose study with 4 cohorts of ascending doses and an optional Japanese cohort designed to evaluate the safety, pharmacokinetics, and pharmacodynamics of MEDI5884 in healthy volunteers
- Trial name
- NCT03001297
- Testing
- MEDI5884 Dose 1, MEDI5884 Dose 2, MEDI5884 Dose 3
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Coronary Arterial Disease (CAD)
Drug-Coated Coronary Balloons in Different Clinical Scenarios
Coronary stents are the best treatment method ever accepted in the treatment of coronary artery stenoses. Due to some limitations and complications of stent use, the operators tried to find new solutions.
- Trial name
- DCB-DCS (NCT06915597)
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 1,500 people
- Sponsor
- Kutahya Health Sciences University
Coronary Artery Disease (CAD), Obstructive Sleep Apnea (OSA)
Chemoreflex Control of Sympathetic Activity in Patients With Coronary Artery Disease
The investigators hypothesize that chemoreflex response of muscle sympathetic nerve activity (MSNA) during hypoxia and hypercapnia will be increased in coronary artery disease (CAD) patients and that the presence of obstructive…
- Trial name
- NCT02624297
- Testing
- Aerobic exercise training
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Cardiovascular Diseases, Heart Diseases
Effects of Highly Active Anti-Retroviral Therapy on Cardiovascular Health in Infants of HIV-Infected Mothers
This study will determine the impact of highly active antiretroviral therapy (HAART) on the developing cardiovascular system, the evolution of HAART-associated cardiovascular changes over time, and the association between…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, HIV Infections
- Trial name
- CHAART-1 (NCT00253682)
- Where
- 5 sites in United States
- Volunteers
- 167 people
- Sponsor
- University of Miami
Hypercholesterolaemia
Dose Effect of Limicol on (LDL)-Cholesterol Levels
The principal objective of this study is to investigate the dose-effect of the Limicol food supplement on LDL-cholesterol level in moderate hypercholesterolaemia subjects.
- Trial name
- NCT01354340
- Testing
- Limicol
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Lescuyer Laboratory
Coronary Artery Disease, Acute Coronary Syndrome
Personalized Vs. Standard Duration of Dual Antiplatelet Therapy and New-generation Polymer-Free vs- Biodegradable-Polymer DES
New-generation metallic drug-eluting stents represent the standard of care among patients undergoing percutaneous coronary intervention (PCI).
- Conditions
- Coronary Artery Disease, Acute Coronary Syndrome, Chronic Coronary Syndrome, Myocardial Infarction
- Trial name
- PARTHENOPE (NCT04135989)
- Testing
- Percutaneous coronary intervention with implantation of amphilimus-eluting stents for coronary artery disease., Percutaneous coronary intervention with implantation of everolimus-eluting stents for coronary artery disease., Personalized DAPT duration
- Where
- 13 sites in Italy
- Volunteers
- 2,106 people
- Sponsor
- Federico II University
Chronic Limb Threatening Ischemia, Infrapopliteal Arterial Occlusive Disease
Revascularization of Single Vesrus Multiple Infrapopliteal Vessels in Chronic Limb Threatening Ischemia
This interventional prospective study aims to assess the effectiveness of single vessel versus multiple vessel infrapopliteal angioplasty in patients with chronic threatening limb ischemia .
- Trial name
- NCT07068789
- Testing
- balloon angioplasty
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Ischemic Stroke, Acute
Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion
Iron overload has been associated with greater brain injury in ischemia/reperfusion experimental stroke models and ischemic stroke patients, especially in those treated with thrombolytic treatment.
- Trial name
- TANDEM-1 (NCT00777140)
- Testing
- Deferoxamine
- Where
- 4 sites in Spain
- Volunteers
- 62 people
- Sponsor
- Germans Trias i Pujol Hospital
Aortic Aneurysm, Peripheral Arterial Disease
Validation of the Cheetah NICOM by Comparison to TEE During Open Vascular Surgery - Pilot Study
The Cheetah NICOM is a non-invasive cardiac output monitor that has been validated in various clinical contexts but not during the occlusion of major arteries, as takes place in vascular surgery.
- Trial name
- NCT02630550
- Testing
- Cheetah NICOM, Transesophageal echocardiography (TEE)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Coronary Artery Disease
A Trial of Bare Metal Stent - Cobalt Chromium Versus Stent Coating With Sirolimus
The objective of this study is to evaluate the security issues and efficacy of coronary stenting Cobalt Chrome covered with sirolimus-eluting Cobalt Chrome platform in patients with coronary artery lesion.
- Trial name
- INSPIRON (NCT01093391)
- Testing
- DRUG ELUTING STENT, BARE METAL STENT
- Where
- 4 sites in Brazil
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Scitech Produtos Medicos SA
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