Clinical trials: Ocd
Obsessive-compulsive Disorder, Ocd
Riluzole Augmentation in Treatment-refractory Obsessive-compulsive Disorder
Obsessive-compulsive disorder (OCD) affects 2-3% of the population and leads to a great deal of suffering. Many patients benefit from established treatments, the mainstay of which are cognitive behavioral therapy and a group of…
- Trial name
- NCT00523718
- Testing
- riluzole
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Yale University
Obsessive-Compulsive Disorder, Microbiota
Microbiome in Obsessive-compulsive Disorder
Background: Humans live in symbiosis with microbes and their implication for health and disease is evident. The importance of microbiome-gut-brain axis in psychiatric disorders is an area of increasing research interest.
- Trial name
- MIO (NCT03638791)
- Testing
- Exposure and response inhibition
- Where
- Sweden
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
OCD
Neuromodulation for a Novel OCD Biomarker and Treatment
Although multiple treatments for OCD exist, slow symptom decrease, high remission, and significant side effects for some OCD patients limit their efficacy.
- Trial name
- NCT05994053
- Testing
- high definition transcranial alternating current stimulation
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Hoarding Disorder, Attentional Impairment
Cognitive Remediation for Neuropsychological Impairment in Compulsive Hoarding
The primary aim of this pilot randomized controlled trial is to examine whether cognitive remediation, compared to a placebo, improves attention and related cognitive functions in patients with compulsive hoarding.
- Trial name
- NCT01451697
- Testing
- Cognitive Remediation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hartford Hospital
Psychiatric Disorder
Low Frequency TMS on DLPFC and OFC in OCD Patients
This study aims to evaluate the therapeutic effect of low frequency rTMS over the right DLPFC, versus right OFC versus Sham group of obsessive-compulsive disorder (OCD) patients.
- Trial name
- NCT03207633
- Testing
- Repetitive trans-magnetic stimulation (rTMS) on DLPFC, Repetitive trans-magnetic stimulation (rTMS) on OFC
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Obsessive Compulsive Disorder
Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-compulsive Disorder Patients
The objective of this trial is to compare in an open trial format the efficacy of association of clomipramine and quetiapine with SSRI after SSRI treatment failed to produce complete remission of obsessive compulsive disorder…
- Trial name
- QCAT (NCT00564564)
- Testing
- Quetiapine, Clomipramine
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- University of Sao Paulo
Obsessive-compulsive Disorder (OCD)
Psilocybin for Treatment of Obsessive Compulsive Disorder
This study will evaluate whether psilocybin, a hallucinogenic drug, improves symptoms of obsessive compulsive disorder (OCD), whether it is safely tolerated as treatment of OCD, and will investigate the mechanisms by which it…
- Trial name
- PSILOCD (NCT03300947)
- Testing
- Psilocybin 100 mcg/kg, Psilocybin 300 mcg/kg, Lorazepam 1 mg
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Arizona
OBSESSIVE COMPULSIVE DISORDER (OCD)
The Efficacy of TBCT Compared to ERP in the Treatment of OCD Patients, by the Assessment of Magnetic Resonance.
This is a sample made up of ninety-six adult individuals of both sexes to be divided into three groups: the experimental group of thirty-two patients with OCD who will be undergone Trial-Based Cognitive Therapy; the gold…
- Trial name
- NCT02656784
- Testing
- Cognitive Therapy, Behavioral Therapy
- Where
- Brazil
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual do PiauÍ
Anxiety, Obsessive Compulsive Disorder
Virtual Reality System to Increase Access to Exposure Therapy for Anxiety and OCD
Cognitive Behavioral Therapy with fear provoking exposures is the most effective therapy for anxiety disorders. Investigators aim to enhance this therapy with the use of virtual reality exposures and to make therapy more…
- Trial name
- NCT02713516
- Testing
- Virtual Reality
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Obsessive-Compulsive Disorder
Neuroinflammation in Patients With OCD
The goal of this study is to examine whether measurements of inflammation from brain scanning and blood tests can predict how much benefit patients with obsessive-compulsive disorder (OCD) will have from treatment with an…
- Trial name
- NCT04786548
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Multimodal Assessment of Cannabinoid Target Engagement in Adults With Obsessive-Compulsive Disorder
The purpose of this research study is to test how a medication called nabilone (Cesamet) affects neurocognitive processes involved in obsessive-compulsive disorder (OCD), including threat response, processing of fear signals, and…
- Trial name
- NCT04880278
- Testing
- Nabilone
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Anxiety Disorders
Transdiagnostic Treatment for Anxiety Disorders in Two Cities of México
This study evaluates the effectiveness of The Unified Transdiagnostic Protocol, a psychological treatment for the intervention of a broad range of anxiety disorders.
- Trial name
- NCT03916315
- Testing
- Transdiagnostic Treatment
- Where
- 2 sites in Mexico
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Baja California
Obsessive-compulsive Disorder
Booster as an Adjunct to Internet-based Cognitive Behavior Therapy (CBT)
In this trial, we test if adding an Internet-based booster program to regular Internet-based cognitive behavior therapy (ICBT) is effective for patients with obsessive-compulsive disorder (OCD).
- Trial name
- NCT01525576
- Testing
- Booster
- Where
- Sweden
- Volunteers
- 98 people
- Sponsor
- Karolinska Institutet
Obsessive Compulsive Disorder, Major Depressive Disorder
ON/OFF Stimulation and Impulsivity in Patients With Deep Brain Stimulators
The investigators propose a test of causality by examining a cohort of patients undergoing deep brain stimulation (DBS) within the ventral striatum.
- Trial name
- NCT01506206
- Where
- 2 sites in United States
- Sponsor
- Massachusetts General Hospital
Hoarding Disorder
Functional and Cognitive Rehabilitation of Hoarding Disorder
Hoarding Disorder (HD) is serious and disabling in Veterans. Present in up to 7% of Veterans and even higher symptom rates in older Veterans; HD contributes to functional impairment and poor quality of life.
- Trial name
- CREST (NCT04697849)
- Testing
- Cognitive Rehabilitation and Exposure/Sorting Therapy, Case Management
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Office of Research and Development
Obsessive-Compulsive Disorder
Neural Correlates of Compulsivity
This study aims to collect data from individuals with obsessive-compulsive disorder (OCD) and healthy controls in order to clarify how learning strategies are employed differently by individuals with compulsive psychopathology…
- Trial name
- NCT05195476
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Columbia University
Anxiety Disorders, Obsessive Compulsive Disorder
Web Based Therapist Training on Cognitive Behavior Therapy for Anxiety Disorders
Anxiety disorders are a major public health concern, having a profound impact on functioning, causing significant disability, loss of productivity and suffering.
- Conditions
- Anxiety Disorders, Obsessive Compulsive Disorder, PTSD
- Trial name
- NCT02089984
- Testing
- Internet Based CBT Training
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Center for Psychological Consultation
Obsessive-Compulsive Disorder, Cognitive Flexiblity
Cognitive Flexibility and Response to TMS Therapy
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option for treatment-resistant obsessive-compulsive disorder.
- Trial name
- CogFlexTMS (NCT06769243)
- Testing
- TMS
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Obsessive-Compulsive Disorder, Pain, Intractable
Psychosocial, Behavioral, and Radiologic Changes Following Radiosurgery for Benign Neurologic Disease
A number of studies from the literature suggest important behavioral, psychosocial, or radiologic changes occur following significant neurologic events or interventions such as stroke, neurosurgery, medications, radiation…
- Conditions
- Obsessive-Compulsive Disorder, Pain, Intractable, Depression
- Trial name
- NCT04688554
- Testing
- fMRI and DTI, Behavioral questionnaires, Disease-Specific Patient-Reported Outcomes
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Vanderbilt University Medical Center
Hoarding Disorder
Testing a Brief Exercise Intervention in Hoarding Disorder
Hoarding disorder (HD) is characterized by difficulty discarding personal possessions due to significant emotional distress when parting with personal items.
- Trial name
- Exercise BDNF (NCT06561659)
- Testing
- Exercise Condition, Relaxation Control Condition
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Hartford Hospital