Clinical trials: Ocular Discomfort, active
Dry Eye
Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK
Collecting data using Kera Sol tear usage during the initial two-week post-operative period after Laser-Assisted In Situ Keratomileusis (LASIK) has on the signs and symptoms of surgical temporary ocular discomfort syndrome (STODS)
- Trial name
- NCT07155070
- Testing
- Kera Sol Eye Drops
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Dry Eye, Meibomian Gland Dysfunction
Ocular Surface Health and Tear Film Stability With a Nasal Spray Dry Eye Treatment
The purpose of this study is to examine the impact of nasal spray treatment on Meibomian gland function and ocular surface health in symptomatic dry eye patients with mild to moderate Meibomian gland dysfunction (MGD).
- Trial name
- NCT07606625
- Testing
- Varenicline 0.03Mg/Spray Nasal Soln
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of California, Berkeley
Contact Lens Discomfort, Meibomian Gland Dysfunction
Meibomian Gland Dysfunction Management
The purpose of this study is to compare electronic debridement of the eyelid margin (BlephEx) to manual debridement of the eyelid margin as treatment options for patients intolerant to contact lens wear consequent to Meibomian…
- Trial name
- NCT03652337
- Testing
- BlephEx, Manual debridement
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of the Incarnate Word
Dry Eye Disease (DED), Contact Lens Discomfort (CLD)
Treating Contact Lens Discomfort With Cyclosporine 0.1% Ophthalmic Solution
Of the 140 million contact lens (CL) wearers worldwide, most wear soft contact lenses. Despite major improvements in contact lens care, nearly 20% of wearers stop using lenses, with contact lens discomfort (CLD) being the main…
- Trial name
- NCT07904728
- Testing
- Cyclosporine 0.1% Ophthalmic Solution
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ocular Aesthetics, LLC dba Ocular Clinical Trials
Dry Eye Disease (DED)
An Exploratory Efficacy and Safety Study of DFL24498 Topical Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Disease
This is a Phase 2, randomized, multicenter, double masked, vehicle controlled, parallel group study to evaluate the efficacy and safety of DFL24498 topical ophthalmic solution versus vehicle in participants with dry eye disease.
- Trial name
- NCT07503886
- Testing
- DFL24498, Vehicle
- Where
- 24 sites in United States
- Volunteers
- 417 people
- Sponsor
- Dompé Farmaceutici S.p.A
Cataract, Dry Eye
Evaluation of the Effectiveness of Three Tear Substitute Formulations in Postoperative Discomfort After Cataract Surgery
The primary objective of this study is the assessment of three tear substitute formulations in terms of postoperative discomfort following cataract extraction surgery by means of phacoemulsification and intraocular lens…
- Trial name
- DRY-CAT (NCT07581548)
- Testing
- Sodium Hyaluronate 0.15% and Dexpanthenol 2% drops (Hylopan max), Sodium Hyaluronate 0.15% and Trehalose 3% drops (Thealoz duo), Sodium Hyaluronate 0.2% and Amino acids drops (Helenvision ultra)
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- Democritus University of Thrace
Adverse Drug Effect, Phenylephrine
Clinical Determinants and Adverse Reactions to Tropicamide/Phenylephrine in Hospitalized Patients.
To evaluate the association between clinical determinants and the occurrence of adverse drug reactions in hospitalized patients who received tropicamide/phenylephrine 8 mg/50 mg/mL.
- Conditions
- Adverse Drug Effect, Phenylephrine, Hypertension, Cardiovascular Complication
- Trial name
- RAM-TF-IOCV (NCT07178600)
- Testing
- Ophthalmic administration of tropicamide/phenylephrine 8 mg/50 mg/mL.
- Where
- Mexico
- Volunteers
- 1,000 people
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Corneal Diseases
The Relation Between BSS Solution Temperature and Endothelial Cells and Post Phaco Discomfort
patients underwent phacoemulsification , balanced saline solution used during the operation will be at room temperature in one group and cool 2.7 c in the other group.
- Trial name
- NCT06904560
- Testing
- phacoemulsification
- Volunteers
- 40 people
- Sponsor
- Sohag University
Dry Eye, Contact Lens Discomfort
Contact Lens-Wearing Dry Eye Subjects Who Are Treated With Acoltremon 0.003%
Dry Eye Disease is a multifaceted condition which has symptoms such as eye dryness, burning, and stinging sensation in the eyes. As well as clinical diagnosis such as a decreased ability to create tear film.
- Conditions
- Dry Eye, Contact Lens Discomfort, Eye Drops
- Trial name
- NCT07848373
- Testing
- acoltremon 0.003%
- Volunteers
- 50 people
- Sponsor
- Eye Research Associates, LLC
Dry Eye Disease
Characterization of Subjective Discomfort in Patients With Tear Dysfunction
Characterization of subjective discomfort/pain in patients with ocular surface dysfunction in association with clinical and laboratory parameters, for a better understanding of the underlying pathogenic mechanisms.
- Trial name
- NCT06819631
- Where
- Italy
- Volunteers
- 12,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Epiphora, Dacryostenosis
Does Topical Ophthalmic Proparacaine 0.5% Prior to Probing and Irrigation Decrease Pain?
Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves…
- Conditions
- Epiphora, Dacryostenosis, Dacryocystitis
- Trial name
- NCT05663684
- Testing
- Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Glaucoma, Ocular Surface Disease
Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications
To evaluate glaucoma patients' response to treatment with Xiidra, an FDA-approved drug for ocular surface discomfort, which will be prescribed as standard of care treatment.
- Trial name
- NCT04354545
- Testing
- Xiidra (Lifitegrast ophthalmic solution) 5%
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Dry Eye
Treating Contact Lens Discomfort With Varenicline Solution Nasal Spray 0.03mg
The objective of this study is to evaluate whether twice-daily use of Tyrvaya improves contact lens comfort in contact lens wearers.
- Trial name
- NCT07705893
- Testing
- Tyrvaya
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ocular Aesthetics, LLC dba Ocular Clinical Trials