Clinical trials: Ocular Diseases
- Condition Ocular Diseases
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Cataract
Analysis of Cataract Surgery Induced Dry Eye
This is a retrospective study to determine if rates of osmolarity and dry eye disease symptoms increase following cataract surgery.
- Trial name
- NCT01471561
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- TearLab Corporation
Macular Edema, Macular Degeneration
Study Evaluating Retinal Health Monitoring System Thickness Module
Evaluate the ability and accuracy of the Retinal Health Monitoring System - Retinal Thickness Module (RHMS - RTM).
- Trial name
- NCT04428242
- Testing
- RHMS-RTM, SD-OCT
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kubota Vision Inc.
Myopia
Performance Evaluation of Different Daily Disposable Silicone Hydrogel Contact Lenses
The goal of this study is to compare the performance of two daily disposable silicone hydrogel contact lenses.
- Trial name
- NCT05805059
- Testing
- Control Contact Lens (stenfilcon A), Test Contact Lens (senofilcon A)
- Where
- 4 sites in United States, Canada
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- CooperVision, Inc.
Retinal Detachment
Proof of Concept - Digital Electro-optical Surgical Platform as Replacement for Operational Microscopes
Evaluate the use of Elbit's digital electro-optical systems for generating detailed high quality video imaging during surgery, and thus improving the surgeon's visualization, performance and outcome.
- Trial name
- NCT02715388
- Testing
- GlasScope Surgical Microscope
- Where
- Israel
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Elbit Systems LTD
Obesity, Behavior, Health
Evaluation of Brain Activity Changes After a Behavior Change Weight Loss Intervention
The aim of this study is to compare brain changes in individuals with overweight or obesity enrolled in either the Noom Healthy Weight program or a matched control.
- Conditions
- Obesity, Behavior, Health, Weight Loss
- Trial name
- NCT04522245
- Testing
- Noom Healthy Weight; mobile behavior change program for weight loss., Matched Control
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Noom Inc.
Cataract
Evaluate the Safety and Effectiveness of the enVista® One-Piece Hydrophobic Acrylic Trifocal Intraocular Lens
The objective of the study is to evaluate the safety and effectiveness of the enVista trifocal intraocular lens when implanted in the capsular bag.
- Trial name
- NCT03603600
- Testing
- enVista MX60E, enVista MX60EF
- Where
- 23 sites in United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Evaporative Dry Eye
Impact of Tear Substitute Use on Dry Eye in Gamers.
Clinical, prospective, comparative, controlled, single-blind study, on the signs and symptoms of dry eye before and after 3 days of playing video games with the use of artificial tears (Hyabak) versus no intervention.
- Trial name
- HYAGAME (NCT05536661)
- Testing
- Preservative free hyaluronic acid artificial tear
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Laboratorios Thea, Spain
Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy
Neonatal Neurological Observation With Video AI
NeoNOVA is a multi-site, prospective, single-arm, silent observational study to determine: among (Population) infants admitted to newborn services during their inpatient hospital stay, whether (Intervention) continuous bedside…
- Conditions
- Neonatal Encephalopathy, Hypoxic-Ischemic Encephalopathy, Sedation, Sleep
- Trial name
- NeoNOVA (NCT07628829)
- Testing
- Continuous bedside video monitoring with AI anatomic landmark tracking for neurologic monitoring
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Artemis AI Labs
Dry Eye Syndrome
Phase I Study to Evaluate the Tolerability of Eye Drop DA-6034 in Healthy Volunteers
This is a double-blind, randomized, placebo-controlled, 4-period, cross-over clinical trial. The study is designed to evaluate the safety and local tolerability of DA-6034 upon single and repeated-dose topical application to the…
- Trial name
- NCT01162954
- Testing
- DA-6034
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Refractive Assessment, Refractive Disorders
Algorithm-assisted Subjective Refraction Program Dedicated to Children
Current refraction assessment in children is dependent on the Eye Care Specialist and lacks standardization. Essilor has developed new algorithm assisted subjective refraction software dedicated to children of 6-12 years old and…
- Conditions
- Refractive Assessment, Refractive Disorders, Hyperopia and Myopia, Astigmatism
- Trial name
- NCT07046065
- Testing
- Non-cycloplegic Objective refraction, Non-cycloplegic conventional subjective refraction, Non-cycloplegic subjective refraction (Kids refraction software vA with Vision-R™)
- Where
- Portugal
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Essilor International
Dry Eye Syndromes, Lubricant Allergy
Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects
Phase I clinical study, to evaluate the safety and tolerability of the preservative-free ophthalmic solution PRO-087 versus Xyel Ofteno® and Systane Ultra®, on the ocular surface of ophthalmological and clinically healthy…
- Conditions
- Dry Eye Syndromes, Lubricant Allergy, Tear Disorder
- Trial name
- PRO-087/I (NCT03524157)
- Testing
- PRO-087, Systane Ultra, Xyel Ofteno
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Cataract
Evaluation of the EpiGlare Tester for the Measurement of Glare-Induced Changes in BSCVA in Subjects With and Without Cataracts
The EpiGlare Tester will identify visual disability resulting from the glare experienced by subjects with cataracts in the glare-induced change in best spectacle corrected visual acuity (BSCVA).
- Trial name
- NCT04739397
- Testing
- Glare Testing
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Epico, LLC
Myopia; Astigmatism
Dispensing Evaluation of Investigational Contact Lenses
Non-randomized, single-masked, 2-visit, bilateral wear, single-arm dispensing study to evaluate the visual acuity, rotational performance, lens fit, stability and subjective characteristics of a senofilcon-based JJVCI…
- Trial name
- NCT02625220
- Testing
- Prototype toric lens senofilcon A
- Where
- 12 sites in United States
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Stable Coronary Artery Disease, Healthy Volunteers
A Study to See How RO7763505 Works and How Safe it is When Given to Healthy People and People With Stable Heart Disease
This study will evaluate safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses (SAD) (Part 1a), multiple ascending doses (MAD) (Part 1b), and the food effect (Part 1c) of RO7763505 in…
- Trial name
- NCT07495813
- Testing
- RO7763505
- Where
- Netherlands
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Myopia, Myopia Progression
Myopia Control Spectacle Lens Cessation Study
To quantify myopic progression (cycloplegic spherical equivalent refraction - cSER) following the cessation of use of specific spectacle lenses.
- Conditions
- Myopia, Myopia Progression, Juvenile Myopia
- Trial name
- BIRCH (NCT05893979)
- Testing
- Spectacle Lenses
- Where
- 8 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- SightGlass Vision, Inc.
Diabetic Macular Edema, Branch Retinal Vein Occlusion
EffiCacy, Safety and ToLErability of a Novel Ocular ANtiseptic for Ocular Use (CLEAN)
This is a randomized, double-masked, multicenter, study to evaluate the efficacy, safety, and tolerability of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Conditions
- Diabetic Macular Edema, Branch Retinal Vein Occlusion, Glaucoma/Closed Angle Glaucoma
- Trial name
- CLEAN (NCT05127525)
- Testing
- IRX-101, Control
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Glaucoma
Perimetric Testing With Virtual Reality
Perimetry is an essential component in the diagnosis and monitoring of glaucoma. Since the advent of Standard Automated Perimetry (SAP), one of the clinical standards has been the Humphrey Field Analyzer (HFA, Carl Zeiss AG…
- Trial name
- NCT06549010
- Testing
- Perimetric test
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Envision Health Technologies, Inc.
Presbyopia
A Clinical Trial to Evaluate a Corneal Inlay for the Improvement of Near Vision in Presbyopic Patients
This study will be a prospective, multicenter clinical trial in which a total of 400 subjects will be enrolled. All subjects will be followed over a 36 month time frame with a maximum of 15 clinical sites participating.
- Trial name
- NCT01373580
- Testing
- The Raindrop Near Vision Inlay
- Where
- 11 sites in United States
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- ReVision Optics, Inc.
Cataract
Safety and Efficacy of a Violet Visible Light Blocking Intraocular Lens (IOL)
The purpose of this study is to evaluate the safety and effectiveness of a new investigational modified light transmission monofocal intraocular lens compared to a conventional intraocular lens (IOL).
- Trial name
- NCT00747227
- Testing
- modified light transmission intraocular lens, monofocal acrylic intraocular lens
- Where
- 11 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Abbott Medical Optics
Alzheimer Disease, Progressive Supranuclear Palsy
Evaluating Cerebrospinal Fluid Biomarkers in Alzheimer's, Progressive Supranuclear Palsy Subjects, and Controls
This is an experimental medicine study to evaluate the kinetics of cerebrospinal fluid (CSF) biomarkers in subjects with Alzheimer's disease (AD) or progressive supranuclear palsy (PSP) compared to healthy controls using a heavy…
- Trial name
- NCT01348061
- Where
- 3 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- KineMed