Clinical trials: Ocular Diseases
Acute Conjunctivitis, Adenoviral Conjunctivitis
Evaluation of a Rapid Screening Test for Detection of Adenovirus in Tears
To compare the efficacy of a recently FDA approved point of care diagnostic test, the RPS Adeno Detector (Rapid Pathogen Screening, Inc.; South Williamsport, PA), against cell culture for detecting adenoviral conjunctivitis
- Trial name
- NCT00266734
- Testing
- RPS Adeno Detector
- Where
- 5 sites in United States, Germany
- Volunteers
- 186 people
- Sponsor
- Rapid Pathogen Screening
Age-related Macular Degeneration
Head Mounted Eye Tracking Aide for Loss of Central Vision (HETALCEV)
A device has been developed that has eye trackers integrated within the Head Mounted Display (HMD) and can remap text and images around the scotoma in real time to prevent information loss from a central scotoma.
- Trial name
- HETALCEV (NCT02829606)
- Testing
- small scotoma using Head Mounted Display No re-mapping, Large scotoma using Head Mounted Display PLUS re-mapping
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Dry Eye
Efficacy and Safety of SJP-0132 Eye Drops in Chinese Patients With Dry Eye Disease
This study will evaluate the safety and efficacy of SJP-0132 in Chinese Patients with Dry Eye. Patients will be randomly assigned to receive either SJP-0132 or placebo.
- Trial name
- NCT06717152
- Testing
- SJP-0132
- Where
- 35 sites in China
- Volunteers
- 427 people
- Sponsor
- Senju Pharmaceutical Science & Technology (Beijing) Co., Ltd.
Pancreatic Cysts
Diagnosis of Pancreatic Cysts: Endoscopic Ultrasound With Fine Needle Aspiration (EUS/FNA), Direct Visualization, and Confocal Laser-induced Endomicroscopy-A Pilot Study
The purpose of this study is to assess the yield of combination modalities in the diagnosis of pancreatic cysts using EUS/FNA, Fiber optics (direct visualization probe), and prototype needle based confocal laser-induced…
- Trial name
- NCT01447238
- Testing
- Direct visualization and needle based confocal laser-induced endomicroscopy miniprobe
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- University of California, Irvine
Central Serous Chorioretinopathy, Irvine-Gass Syndrome
Results of Suprachoroidal Steroids Injections in Two Chorioretinal Diseases
Suprachoroidal injection is a safe way for intraocular drug delivery. It was used to treat various retinal conditions.
- Conditions
- Central Serous Chorioretinopathy, Irvine-Gass Syndrome, Pars Planitis, Cystoid Macular Edema
- Trial name
- NCT05337332
- Testing
- Triamcinolone Acetonide
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Benha University
Keratoconjunctivitis Sicca
TearLab Core Validation Study to Establish Referent Values for Dry Eye Disease
This is a prospective, observational case series to determine the clinical utility of tear osmolarity and other commonly used objective tests to diagnose dry eye disease, as well as to establish referent values for objective…
- Trial name
- CVS (NCT00848198)
- Where
- 10 sites in United States, France and 3 more
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- TearLab Corporation
Corneal Dystrophies, Hereditary
Descemet Membrane Endothelial Keratoplasty (DMEK)
To evaluate isolated Descemet membrane transplantation as a refinement of previous advanced techniques for corneal transplantation, like Descemet Stripping Endothelial Keratoplasty (DSEK)
- Trial name
- DMEK (NCT00521898)
- Testing
- Descemet Membrane Endothelial Keratoplasty (DMEK)
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Netherlands Institute for Innovative Ocular Surgery
Xerophthalmia
Clinical Study for the Evaluation of Safety and Tolerability of NCP112 Eye Drops
The objective is to evaluate the safety, local tolerability, and pharmacokinetics of NCP112 eye drops through single and multiple dose-escalation ocular administrations in healthy adults.
- Trial name
- NCT06263998
- Testing
- NCP112
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Urolithiasis
Single-use Digital Flexible Ureteroscope vs Nondisposable Fiber Optic vs Digital Ureteroscope
The aim of this trial is to compare the safety, efficacy and cost effectiveness of the three types of scopes.
- Trial name
- NCT03220516
- Testing
- single use digital ureteroscope, reusable fiberoptic ureteroscope, reusable digital flexible ureteroscope
- Volunteers
- 450 people
- Sponsor
- Guohua Zeng
Choroidal Neovascularization Secondary to Pathologic Myopia
A Study of the Criteria Establishing the Need for Re-treatment With Ranibizumab Upon Relapse in Patients With Visual Impairment Due to Choroidal Neovascularization Secondary to Pathologic Myopia.
The primary objective of the study was to investigate current criteria driving re-treatment in patients affected by Choroidal Neovascularization (CNV) secondary to Pathologic Myopia (PM) and experiencing a relapse of the disease…
- Trial name
- OLIMPIC (NCT02034006)
- Testing
- Ranibizumab
- Where
- 31 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Novartis Pharmaceuticals
Dry Eye Disease
Safety and Efficacy of an Ophthalmic Solution in Dry Eye Disease
The purpose of this study is to investigate the safety and efficacy of an ophthalmic solution in dry eye disease.
- Trial name
- NCT00758784
- Testing
- bromfenac ophthalmic solution 0.06%
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Bausch & Lomb Incorporated
Open-Angle Glaucoma, Ocular Hypertension
Safety and Efficacy of Brinzolamide/Brimonidine Fixed Combination
The purpose of this study was to compare the safety and intraocular pressure (IOP)-lowering efficacy of a new fixed combination of brinzolamide/brimonidine (Brinz/Brim) to: its individual components (Brinz and Brim), and the…
- Trial name
- NCT00961649
- Testing
- Brinzolamide 1%/brimonidine tartrate 0.2% ophthalmic suspension, Brinzolamide ophthalmic suspension, 1%, Brimonidine tartrate ophthalmic solution, 0.2%
- Volunteers
- 195 people
- Sponsor
- Alcon Research
Dry Eye, Dry Eye Syndrome of Unspecified Lacrimal Gland
Safety and Tolerability of the Ophthalmic Gel PRO-167 Versus Corneregel® on Healthy Subjects.
Title of the study: Phase I clinical trial, to evaluate the safety and tolerability of the ophthalmic gel PRO-167 versus Corneregel®, on the ocular surface of ophthalmological and clinically healthy subjects.
- Trial name
- PRO-167/I (NCT03520348)
- Testing
- PRO-167, Corneregel
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Bacterial Conjunctivitis
Moxifloxacin AF Ophthalmic Solution for Treatment of Bacterial Conjunctivitis
The purpose of this study is to evaluate the safety and efficacy of Moxifloxacin AF Ophthalmic Solution compared to Moxifloxacin AF Vehicle in the treatment of bacterial conjunctivitis in patients one month of age or older.
- Trial name
- NCT00759148
- Testing
- Moxifloxacin Alternative Formulation (AF) Ophthalmic Solution 0.5%, Moxifloxacin AF Vehicle
- Volunteers
- 1,179 people
- Sponsor
- Alcon Research
LCA (Leber Congenital Amaurosis), RP (Retinitis Pigmentosa)
Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01)
The purpose of this study is: To evaluate the safety of up to 3 additional courses of oral QLT091001 administered once daily for 7 days in subjects treated previously with a single 7-day course of QLT091001 in Study RET IRD 01 To…
- Trial name
- NCT01521793
- Testing
- QLT091001
- Where
- 6 sites in United States, Canada and 3 more
- Volunteers
- 27 people
- Sponsor
- QLT Inc.
Primary Congenital Glaucoma
The Genetic Characteristics in South Korean Patients With Primary Congenital Glaucoma
Primary congenital glaucoma, which presents at birth or in infancy, if left untreated, may threaten vision. The incidence of congenital glaucoma varies among different geographic locations and ethnic groups.
- Trial name
- NCT01020721
- Where
- South Korea
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Dry Eye Disease
A Trial to Assess the Safety and Efficacy of Subjects With Dry Eye Disease
A Randomized, Double-Masked, Vehicle-Controlled Parallel Group Clinical Trial to Assess Efficacy and Safety of 0.25% Reproxalap Ophthalmic Solution Compared to Vehicle in Subjects with Dry Eye Disease
- Trial name
- NCT06493604
- Testing
- Reproxalap Ophthalmic Solution (0.25%), Vehicle Ophthalmic Solution
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Glaucoma
This Study Examines Whether Personality Traits Influence the Frequency or Severity of Ocular Adverse Effects Reported by Patients Using Glaucoma Medications. The Findings May Identify Patients at Greater Risk of Intolerance and Support More Personalized Treatment and Counselling.
The goal of this observational study is to learn whether personality traits are related to eye side effects from glaucoma medications in adults who currently use or previously used these medications.
- Trial name
- Adverse Events (NCT07739784)
- Testing
- No Interventions
- Where
- Canada
- Volunteers
- 352 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Exophoria
Cervical Manipulation (OAA Technique) in Exophories
Objetive: to assess the efficacy of the occipito-atlas-axis cervical manipulation technique to correct ocular divergence in subjects with exophoria. Design: quantitative, experimental, longitudinal and prospective study.
- Trial name
- NCT04901533
- Testing
- O-A-A, cranial listening
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Seville
Progressive Keratoconus
Corneal Collagen Cross-linking for Progressive Keratoconus
Prospective, randomized multicenter study to determine the safety and effectiveness of performing cornea collagen cross-linking (CXL) using riboflavin and UVA light in eyes with progressive keratoconus.
- Trial name
- CXL (NCT00647699)
- Testing
- riboflavin ophthalmic solution, UVA Irradiation
- Where
- 10 sites in United States
- Volunteers
- 147 people
- Sponsor
- Glaukos Corporation
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