Clinical trials: Ocular Diseases
Neuromyelitis Optica Spectrum Disorders (NMOSD)
Modified Zipper Therapy for AQP4-IgG Positive Neuromyelitis Optica Spectrum Disorder
Study Title: A National, Multicenter, Randomized Controlled Trial of the Modified Zipper Therapy in AQP4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder (ELITE Study) Brief Summary: The goal of this clinical trial is to…
- Trial name
- ELITE (NCT07420296)
- Testing
- Eculizumab administration, High-dose corticosteroid pulse therapy, Plasma exchange (PE)
- Where
- China
- Volunteers
- 198 people
- Sponsor
- Tianjin Medical University General Hospital
Psychiatric Disorders (Diagnosis)
Contribution of Virtual Reality Eye Tracking in the Identification of Schizophrenia, Bipolar and Depression
Schizophrenia (SCZ), bipolar disorder (BP), and depression (DEP) are systematically associated with a severe impairment of the overall abilities of patients, which precludes them from functioning adequately in daily life.
- Trial name
- ReViPSY (NCT07057024)
- Testing
- Clinical and eye movements
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Macular Hole
Optical Coherence Tomography in Gas-filled Eyes
The aim of this study is to determine the condition to detect the status of a macular hole by spectral domain optical coherence tomography (SD-OCT) in gas-filled eyes.
- Trial name
- NCT01266746
- Testing
- Vitreous surgery
- Where
- Japan
- Volunteers
- 37 people
- Sponsor
- Kyorin University
Refractive Errors, Ametropia
Clinical Performance of Two Daily Disposable Toric Soft Contact Lenses
The purpose of this study is to compare the clinical performance of PRECISION1™ for Astigmatism (P1fA) contact lenses with 1-DAY ACUVUE MOIST® for ASTIGMATISM (AMfA) contact lenses.
- Conditions
- Refractive Errors, Ametropia, Astigmatism
- Trial name
- NCT04908488
- Testing
- Verofilcon A toric contact lenses, Etafilcon A toric contact lenses
- Where
- 8 sites in United States
- Volunteers
- 115 people
- Sponsor
- Alcon Research
Multiple Sclerosis, Internuclear Ophthalmoplegia
Study and Treatment of Visual Dysfunction and Motor Fatigue in Multiple Sclerosis
Primary fatigue represents a major cause of disability in patients with multiple sclerosis (MS), being reported in about 90% of cases.
- Conditions
- Multiple Sclerosis, Internuclear Ophthalmoplegia, Fatigue
- Trial name
- NCT02391961
- Testing
- Dalfampridine
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- VA Office of Research and Development
Cataract, Astigmatism
Evaluation of the Accuracy & Safety of the LaserArcs Nomogram
Evaluation of the Accuracy and Safety of the LaserArcs Femtosecond Cataract Surgery Arcuate Incision Nomogram in Patients Undergoing Cataract Surgery and Astigmatism Reduction
- Trial name
- NCT05278442
- Testing
- LaserArc
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Research Insight LLC
Sjogren's Syndrome
Hydroxychloroquine Blood Levels in Primary Sjögren Syndrome Patients
Introduction. Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by chronic inflammatory infiltration of the salivary and lacrimal glands causing dry eye and mouth.
- Trial name
- 1ASSJHCQ (NCT04546542)
- Testing
- Parallel Assignment
- Where
- 2 sites in Brazil
- Volunteers
- 74 people
- Sponsor
- University of Sao Paulo General Hospital
Retinal Disease
Hematopoietic Stem Cell Transplantation in Autoimmune-Related Retinopathy(ARRON)
ARRON is a disease believed to be due to immune cells, cells which normally protect the body, but are now attacking the tissue in the retina and/or optic nerve.
- Trial name
- NCT00278486
- Testing
- Hematopoietic stem cell transplantation.
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Richard Burt, MD
Corneal Dystrophies, Hereditary
Descemet Stripping (Automated) Endothelial Keratoplasty (DSEK or DSAEK)
To evaluate the transplantation of a posterior corneal disc for the management of corneal endothelial disorders in Descemet Stripping Endothelial Keratoplasty (DSEK) or Descemet Stripping Automated Endothelial Keratoplasty…
- Trial name
- DSAEK (NCT00543660)
- Testing
- Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Netherlands Institute for Innovative Ocular Surgery
Astigmatism
Non-dispensing Study to Check Prescription Equivalence of Two Daily Disposable Toric Contact Lens Types
The purpose of this study is to determine whether the prescription determined for a new daily disposable toric contact lens will be a good match to a prescription determined for an existing brand of lens.
- Trial name
- NCT01120782
- Testing
- etafilcon A toric contact lens with new wetting agent, etafilcon A toric contact lens
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Esotropia
Conservative Treatment of Esotropia in Children up to 3 Years Old
The objective of this prospective study is the treatment of esotropia by prescribing the full precise optical correction of refractive errors in children up to 3 years old.
- Trial name
- NCT02404324
- Testing
- Prescription of spectacles
- Volunteers
- 150 people
- Sponsor
- National Centre of Ophthalmology named after academician Zarifa Aliyeva
Pterygium
Determinants of Pterygium Occurrence and Recurrence in a Rural African Population
The aim of the study is to find out why pterygium occurs and recurs in a rural African population. Participants will be interviewed on personal and lifestyle information, family history of pterygium, environmental exposure and…
- Trial name
- NCT00713180
- Testing
- Pterygium excision followed by grafting
- Where
- South Africa
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Anguria, Peter, M.D.
Diabetic Macular Edema, Vision Disorders
Effect of Intraoperative Dexamethasone Implant in Taut Posterior Hyaloid Removal in Diabetic Macular Edema
This study is undertaken to determine effect of sustained release dexamethasone implant,Ozurdex in improving outcome of taut posterior hyaloid removal in patients with diabetic macular edema Diabetic macular edema constitute…
- Trial name
- NCT01698788
- Testing
- Dexamethasone Drug delivery system (Ozurdex)
- Where
- India
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Macular Edema, Central Retinal Vein Occlusion
Ranibizumab Intravitreal Injections in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion
The present study provided additional efficacy and safety data for 0.5-mg ranibizumab using as needed (PRN) dosing over 24 months in patients with visual impairment due to macular edema secondary to Central Retinal Vein Occlusion…
- Trial name
- CRYSTAL (NCT01535261)
- Testing
- Ranibizumab 0.5 mg/0.05 ml
- Where
- 78 sites in Australia, Austria and 16 more
- Volunteers
- 357 people
- Sponsor
- Novartis Pharmaceuticals
Opsoclonus-myoclonus Syndrome, Opsoclonus
Effectiveness of Rituximab in Pediatric OMS Patients.
The purpose of this study is to reduce the symptoms of OMS by testing rituximab (Rituxan®), to remove B lymphocytes that make antibodies and trigger brain inflammation.
- Conditions
- Opsoclonus-myoclonus Syndrome, Opsoclonus, Myoclonus, Ataxia
- Trial name
- NCT00244361
- Testing
- rituximab
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Pediatric Neuroinflammation Organization, Inc.
Age Related Macular Degeneration
Evaluation of Wet Age-Related Macular Degeneration (AMD) Genetic Profile Interactions With Ranibizumab Treatment Outcomes
Age Related Macular Degeneration (AMD) is the leading cause of blindness in North America. This condition causes a progressive loss of central vision, the part of your vision that allows you to read, drive and see images in sharp…
- Trial name
- NCT01363570
- Testing
- Ranibizumab
- Where
- 2 sites in Canada
- Volunteers
- 70 people
- Sponsor
- McMaster University
Anterior Segment Diseases
Multimodal Deep Learning Model for Multi-task Diagnosis and Triage Suggestions of Ophthalmic Diseases
Accurate and comprehensive interpretation of anterior segment diseases from slit-lamp and smartphone photographs remains a clinical challenge due to the limited specificity and structure of existing Artificial Intelligence tools.
- Trial name
- NCT07447973
- Testing
- Multimodal Vision-language Model Diagnosis
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Eye Abnormalities, Normal Eyes
The Heidelberg Engineering ANTERION Imaging Agreement Study
This is a prospective clinical study that will be conducted at one clinical site located in the United States to assess image quality of acquired biometry images of the eye
- Trial name
- NCT04068818
- Testing
- ANTERION
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Heidelberg Engineering GmbH
Concussion, Mild
Novel Protection Against Potential Brain, Hearing and Vision Injury During Blast Wave Exposure
The purpose of the study is to monitor changes in brain structure and function between the pre-training and post-training, in a population of tactical team members wearing the Device and compared to a similar population not…
- Trial name
- BLAST (NCT03017924)
- Testing
- Q collar
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Electromyography, Eye-tracking
Multimodal Quantified Analysis of Facial Movements: Comparison Between Pathological and Control Subjects
The facial palsy is a frequent disease with a lot of etiologies. It has variable severities with sometimes heavy functional repercussions and different recovery potentials.
- Conditions
- Electromyography, Eye-tracking, Facial Palsy
- Trial name
- AQ2MF (NCT05581680)
- Testing
- dental impressions, Simultaneous MoCap and EMG acquisition, Eye-tracking acquisition for pathological subjects
- Where
- France
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
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