Clinical trials: Ocular Diseases
Glaucoma, Retinal Disease
Agreement and Precision Study of the Nidek Mirante
This study is a prospective comparative, randomized, single center study to gather agreement and precision of the Nidek Mirante OCT with SLO and Anterior Segment Imaging capabilities in comparison to the Optovue RTVue XR Avanti…
- Conditions
- Glaucoma, Retinal Disease, Corneal Disease
- Trial name
- NCT04318132
- Testing
- Nidek Mirante, Optovue RTVue XR Avanti, Optos P200DTx
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Behçet's Syndrome, Behçet's Syndrome (BS)
Corticotropin for Behçet's Disease: A Multicenter Randomized Controlled TrialAcronym.
Adrenocorticotropic hormone (ACTH) is a polypeptide hormone secreted by the anterior pituitary gland. It can stimulate adrenal cortical hyperplasia and the secretion of glucocorticoids, thereby exerting anti-inflammatory…
- Trial name
- NCT07833163
- Testing
- Repository Corticotropin Injection (ACTH)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University People's Hospital
Limbal Stem Cell Deficiency
Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of LSCD
The aim of this clinical trial is to investigate the efficacy (by monitoring neovascularization and epithelial defects) of up to four doses of the investigational medicinal product (IMP) LSC2 topically administered on the target…
- Trial name
- NCT03549299
- Testing
- LSC2
- Where
- 5 sites in United States, Germany
- Volunteers
- 16 people
- Sponsor
- RHEACELL GmbH & Co. KG
Dry Eye Disease
Evaluating the Efficacy of Dry Eye (DE) Disease Treatment Using Novel Tear Film Imager (TFI)
Dry Eye disease signs and symptoms are reduced in patients who receive topical steroids and topical hyaluronic acid. AdOM's Tear Film Imager measurements are reproducible and it can diagnose the dry eye disease state in a single…
- Trial name
- NCT04670263
- Testing
- Tear Film Imager
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Adom Advanced Optical Technologies Ltd.
Refractive Disorders
Evaluation of the Effects of Virtual Reality on Preoperative Anxiety in Refractive Surgery
The objective of this study is to determine to what extent the use of a software application prior to refractive surgery involving multisensory immersion (visual and auditory) in a hypnotic and relaxing sound and visual…
- Trial name
- ERVAN (NCT07050498)
- Testing
- Virtual reality, Usual Care Group
- Where
- France
- Volunteers
- 68 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Visual Field Defect, Peripheral
Virtual Reality Visual Field Testing as an Alternative in Childhood Eye Disease
The purpose of this study is to test a new way of measuring the peripheral vision (called a visual field test) using a device which can be worn as goggles rather than being a large instrument the patient must sit at.
- Trial name
- NCT05150197
- Testing
- VisuALL, Humphrey Visual Field
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Glaucoma and Ocular Hypertension
Artificial Intelligence for Staging Glaucoma Severity: A Comparison With an Eye Specialist Using Visual Field Tests
The study titled "Reliability of Artificial Intelligence in Glaucoma Severity Staging Using the Brusini GSS2 System: A Longitudinal Comparative Study against Expert Assessment" aims to evaluate the diagnostic reliability and…
- Trial name
- AI-GSS2 (NCT07820709)
- Testing
- Artificial Intelligence GSS2 Staging
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Salerno
Strabismus, Concomitant Squint
Management of Consecutive Exotropia
Patients with consecutive exotropia will be managed by medial rectus muscle advancement +/- resection or medial rectus muscle advancement +/- lateral rectus recession
- Conditions
- Strabismus, Concomitant Squint, Divergent Strabismus
- Trial name
- NCT04961021
- Testing
- Strabismus surgery
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Minia University
Dry Eye Syndromes
Safety, Efficacy, Tolerability and Pharmacokinetics of AGN-223575 Ophthalmic Suspension in Patients With Dry Eye Disease
This study will evaluate the safety, efficacy, tolerability, and systemic pharmacokinetics of 3 different doses of topical ophthalmic AGN-223575 suspension compared to AGN-223575 vehicle in patients with dry eye disease.
- Trial name
- NCT02435914
- Testing
- AGN-223575 ophthalmic solution, AGN-223575 vehicle ophthalmic solution
- Where
- 28 sites in United States
- Volunteers
- 236 people
- Sponsor
- Allergan
Diabetes Mellitus, Sarcoidosis
Salivary Proteins in Disease and Health
This study will examine saliva samples from healthy volunteers and patients with various diseases to learn more about how disease affects the mouth and salivary glands.
- Conditions
- Diabetes Mellitus, Sarcoidosis, Dental Caries, Sjorgren's Syndrome
- Trial name
- NCT00100204
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dry Eye Disease (DED)
Randomized Single Center Study to Evaluate Tolerability, Symptoms, and Visual Functional Outcomes With the Use of OTC Lubricating Eye Drops in Subjects With Dry Eye Disease
A study to evaluate the effect of over- the- counter (OTC) lubricating eye drops on tolerability, symptoms and visual outcomes in patients with dry eye disease (DED)
- Trial name
- NCT07676084
- Testing
- Preservative Free Polyethylene glycol 400 0.25%, Propylene Glycol (0.6%), Carboxymethylcellulose sodium 0.5%, Glycerin 1.0%, Polysorbate 80 0.5%
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Andover Research Eye Institute
Oral Lichen Planus, Mucous Membrane Pemphigoid
Dexamethasone Solution and Dexamethasone in Mucolox™
Topical steroid therapy is considered the first line of treatment for Oral Inflammatory Ulcerative Diseases with current treatment regimens requiring multiple application or rinses daily.
- Conditions
- Oral Lichen Planus, Mucous Membrane Pemphigoid, Pemphigus Vulgaris, Chronic Graft-versus-host-disease
- Trial name
- NCT04540133
- Testing
- dexamethasone 0.5mg/5ml solution, dexamethasone 0.5mg/5ml solution in Mucolox™
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Macular Degeneration, Age-Related, Diabetic Retinopathy
Visual Enhancement Device in Low Vision Patients
This study will be a prospective, non-randomized study of low-vision individuals diagnosed with either age-related macular degeneration (AMD) or diabetic macular edema with ETDRS visual acuity from 20/60 to 20/400 in both eyes…
- Trial name
- Evergaze (NCT03794752)
- Testing
- Head-Mounted Visual Enhancement Device
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Age-related Macular Degeneration
Prophylactic Ranibizumab for Exudative Age-Related Macular Degeneration
To evaluate Ranibizumab as prophylaxis against the conversion to neovascular Age-Related Macular Degeneration
- Trial name
- PROTECT (NCT02302989)
- Testing
- Ranibizumab 0.5mg
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Leonard Feiner, MD, PhD
Age Related Macular Degeneration
High-Resolution Ultrasound Imaging of the Retina and Choroid for Detection on Age Related Macular Degeneration
The macula is the site of central vision within the retina. The retina is oxygenated by the underlying choroid. These tissues are less than 1 mm thick in total.
- Trial name
- NCT00277784
- Testing
- Ultrasound examination
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Dry Eye
Product Preference With Systane Compared to Artificial Tears on Frequency of Drop Use
The objective of this study was to evaluate the effect of Systane® compared to marketed artificial tears on the frequency of drop use.
- Trial name
- NCT00347984
- Testing
- Systane Lubricant eye drops
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Alcon Research
Cancer
Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer
RATIONALE: Cyproheptadine hydrochloride may prevent weight loss caused by cancer or cancer treatment. It is not yet known whether cyproheptadine is more effective than a placebo in preventing weight loss in young patients…
- Trial name
- NCT01132547
- Testing
- cyproheptadine hydrochloride
- Where
- 14 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of South Florida
Blindness Congenital
Comparison of Balance and Coordination Parameters of Visually Impaired and Healthy Individuals
The aim of this [observational study] is to examine balance in multiple aspects by comparing balance, coordination, and gait parameters between congenitally blind individuals and healthy individuals with multiple scales.
- Trial name
- NCT06687915
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Cataract
Efficacy of Lutein, Zeaxanthine and Trypan Blue to Stain the Anterior Lens Capsule
Effectiveness of lutein, zeaxanthin and trypan blue to stain the anterior lens capsule during cataract phacoemulsification.
- Trial name
- NCT01621789
- Testing
- dye of lutein, zeaxanthin, trypan blue
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Federal University of São Paulo
Deafness, Kidney Diseases
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors
The von Hippel Lindau (VHL) gene has recently been identified as the genetic defect resulting in a syndrome of multiple neoplasias.
- Conditions
- Deafness, Kidney Diseases, Kidney Neoplasms, Neoplasms
- Trial name
- NCT00001668
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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