Clinical trials: Ocular Diseases
Diabetic Retinopathy, Diabetic Macular Edema
Anti-VEGF Treatment for Prevention of PDR/DME
Multiple studies have implicated vascular endothelial growth factor VEGF as a major causative factor in human eye diseases characterized by neovascularization including proliferative diabetic retinopathy (PDR) and vascular…
- Trial name
- NCT02634333
- Testing
- Prompt aflibercept, Deferred laser, Deferred aflibercept
- Where
- 85 sites in United States, Canada
- Volunteers
- 399 people
- Sponsor
- Jaeb Center for Health Research
CBD Stone
Re-use of Ambu aScope During Exploration of the Common Bile Duct for Stones in Low-Resource Settings- a Retrospective Study
Various methods confirm stone clearance during surgical exploration of bile duct, but choledochoscopy is considered the most effective. However, choledochoscopes are expensive and often unavailable in low-resource settings.
- Trial name
- NCT07285447
- Testing
- Ambu aScope for visualization of biliary tree during exploration of CBD for stone
- Where
- Nepal
- Volunteers
- 75 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Prostate Disease
In Vivo Dosimetry During Prostate Cancer Radiotherapy
The goal of this clinical research study is to learn if a rectal balloon with attached radiation detectors can be used to help researchers monitor the dose of external beam radiation that is delivered to the prostate during…
- Trial name
- NCT01307852
- Testing
- Plastic Scintillation Detectors
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- M.D. Anderson Cancer Center
Age Related Macular Degeneration
Plaqenil Role in Prevention of Age Related Macular Degeneration
The investigators think that there is a connection between the use of plaquenil and the prevention of Age related macular degeneration (AMD).
- Trial name
- NCT01541449
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Cystic Fibrosis
An Ocular Safety Study of Ivacaftor-Treated Pediatric Patients 11 Years of Age or Younger With Cystic Fibrosis
This study is designed to evaluate the risk of cataracts (lens opacities) and describe the best corrected distance vision (with glasses/contacts for those who wear them) of pediatric patients with Cystic Fibrosis who are 11 years…
- Trial name
- NCT01863238
- Testing
- Ophthalmologic examinations, Ivacaftor Exposed
- Where
- 38 sites in United States
- Volunteers
- 95 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Dry Eye Disease
Ocular Microbiome and Immune System in Dry Eyes
The primary objectives of this study are the characterization of the ocular microbiome as well as of the local immune system in participants with and without dry eye disease.
- Trial name
- NCT04658238
- Testing
- Ocular microbiome, Ocular immune system
- Where
- Switzerland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Bardet-Biedl Syndrome
Characterizing the Genotype and Phenotype in Adults With Bardet-Biedl Syndrome
Bardet-Biedl syndrome (BBS; OMIN #209900) is a rare genetic disorder characterized by six core features: rod-cone dystrophy (retinitis pigmentosa), polydactyly, obesity, genital anomalies, renal anomalies, and learning…
- Trial name
- NCT05400278
- Testing
- No intervention
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- Oslo University Hospital
Blepharospasm
Safety and Efficacy of NABOTA in Treatment of Essential Blepharospasm
The purpose of this study is to evaluate the Efficacy and Safety of NABOTA in treatment of essential blepharospasm
- Trial name
- NCT02947815
- Testing
- Clostridium Botulinum Toxin Type A
- Where
- South Korea
- Volunteers
- 234 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Vernal Keratoconjunctivitis
Topical Tacrolimus in Vernal Keratoconjunctivitis
The main aim of this study is to evaluate the efficacy and safety of topical tacrolimus 0.01% eyedrops in patients with vernal keratoconjunctivitis.
- Trial name
- NCT02456025
- Testing
- Topical tacrolimus
- Where
- Saudi Arabia
- Volunteers
- 20 people
- Sponsor
- The Eye Center and The Eye Foundation for Research in Ophthalmology
Keratitis
Microbiological Keratitis in a Countryside City of Brazil
The purpose of this study is to identify the predisposing factors, epidemiological features and clinical and microbiological diagnosis of infectious keratitis in two public referral centers of ophthalmology in a countryside city…
- Trial name
- NCT00949468
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Sao Jose do Rio Preto Medical School
Refractive Errors
Evaluation of the Agreement Between Automated Program-Operated Phoropter Subjective Refraction and Optometrist-Performed Subjective Refraction
This study aims to evaluate the performance of an automated subjective refraction system that operates a digital phoropter. By comparing its results with those obtained through conventional subjective refraction performed by an…
- Trial name
- NCT07891897
- Testing
- Automated Program-Controlled Subjective Refraction, Optometrist-Performed Subjective Refraction
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Multiple Sclerosis, EDSS 4-7
Efficiency of 4-aminopyridin (Fampyra) on Gait, Vision, Cognition, Fatigue and Micturation in Patients With Multiple Sclerosis
The aim of the study is to assess improvement in visual evoked potential, cognition, fatigue, micturation and walking impairment under 3 months of Fampyra treatment
- Trial name
- NCT01720849
- Testing
- Fampyra
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Vestre Viken Hospital Trust
Glaucoma, Open-Angle
Safety and Effects of Brimonidine Intravitreal Implant in Patients With Glaucomatous Optic Neuropathy
A multicenter, randomized, patient-masked, sham-controlled evaluation of the safety and effects on visual function of brimonidine intravitreal implant in patients with glaucomatous optic neuropathy.
- Trial name
- NCT00693485
- Testing
- 400 ug Brimonidine Implant, 200 ug Brimonidine Implant
- Where
- 2 sites in United States, Israel
- Volunteers
- 70 people
- Sponsor
- Allergan
Dry Eye After LASIK-Laser in Situ Keratomileusis
Ocular Surface Syndrome Post-lasik, Outcomes of Treatment With Platelet Rich Plasma
To evaluate the efficacy of autologous platelet-rich plasma eye drops (E-PRP) for the treatment of chronic ocular surface syndrome (OSS) following laser in situ keratomileusis (LASIK).
- Trial name
- PRP-OSS (NCT03322917)
- Testing
- PRP autologous
- Volunteers
- 80 people
- Sponsor
- Vissum, Instituto Oftalmológico de Alicante
Sedation, Cataract
Comparison of Two Sedation Versus Placebo Techniques During Cataract Surgery Under Local Anesthesia
Check the sedation conditions during topic cataract surgery
- Trial name
- NCT04149340
- Testing
- Cataract surgery
- Where
- Belgium
- Volunteers
- 300 people
- Sponsor
- University of Liege
Open Angle Glaucoma (OAG)
Conventional Non-Penetrating Deep Sclerectomy Versus Modified Subflap Mattress Suture in OAG
The goal of this clinical trial is to learn if modified non-penetrating deep sclerectomy (NPDS) with a sub-flap mattress suture works to treat open-angle glaucoma (OAG).
- Trial name
- NCT07425743
- Testing
- Modified Deep Sclerectomy with Ahmed's sub-flap mattress suture (modified NPDS), Conventional Nonpenetrating Deep Sclerectomy (NPDS)
- Where
- 2 sites in Egypt
- Volunteers
- 26 people
- Sponsor
- Beni-Suef University
Cataract
DEXYCU (Dexamethasone Intraocular Suspension) 9% Retrospective Study 001
Retrospective study to provide clinical outcomes with DEXYCU (dexamethasone intraocular suspension) 9%.
- Trial name
- DEXYCURetro (NCT04290676)
- Testing
- DEXYCU (dexamethasone intraocular suspension) 9%.
- Where
- 22 sites in United States
- Volunteers
- 527 people
- Sponsor
- EyePoint Pharmaceuticals, Inc.
Presbyopia
Study of AGN-190584 Eye Drops to Assess Safety and Efficacy in Participants Aged 40-80 Years With Pseudophakic Presbyopia
Presbyopia is a condition in which the eye exhibits a diminished ability to focus on near objects with increasing age. This study will assess the safety and exploratory efficacy of AGN-190584 is in treating participants with…
- Trial name
- ARIES (NCT05393089)
- Testing
- AGN-190584, Vehicle
- Where
- 32 sites in United States
- Sponsor
- Allergan
Central Serous Chorioretinopathy
Optical Coherence Tomography Angiography (OCT-A) and Central Serous Chorioretinopathy (CSC)
Optical Coherence Tomography Angiography (OCT-A) is a noninvasive imaging technique that allows one to see blood vessels in the retina.
- Trial name
- OPACITY (NCT03950089)
- Testing
- Optical Coherence Tomography Angiography (OCT-A)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Behcet Disease
A Study to Evaluate Efficacy and Safety of Infliximab in Participant With Moderate-to-Severe Refractory Intestinal Behcet's Disease
The purpose of this study is to evaluate the efficacy of infliximab in induction regimen by assessing the mean decrease in Disease Activity Index for intestinal Behcet's disease (DAIBD) score of 20 or more in participants with…
- Trial name
- BEGIN (NCT02505568)
- Testing
- Infliximab
- Where
- 5 sites in South Korea
- Volunteers
- 33 people
- Sponsor
- Janssen Korea, Ltd., Korea
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