Clinical trials: Ocular Diseases
Age-Related Macular Degeneration
Lucentis Utilizing Visudyne (LUV Trial) Combination Therapy in the Treatment of Age-Related Macular Degeneration
The PDT/Lucentis trial will be a Phase IV comparative trial comparing the use of combination therapy with ITV ranibizumab and verteporfin PDT to ITV ranibizumab alone in patients with exudative AMD.
- Trial name
- NCT00423189
- Testing
- Ranibizumab (Lucentis), 0.5mg ranibizumab
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- David M. Brown, M.D.
Ametropia
Ocular Responses to Short and Long-term Lens Wear
The purpose of this study was to determine whether ocular surface sensitivity to pneumatic, mechanical and chemical stimulation would be affected by the use of the combination of a specific silicone hydrogel lens material with…
- Trial name
- NCT00722891
- Testing
- Purevision Lenses with ReNu Multiplus, Purevision Lenses with Optifree RepleniSH
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Refractory Glaucoma
Ahmed Glaucoma Valve Alone, With Amniotic Membrane or With Mitomycin C (MMC) for Treatment of Refractory Glaucoma
This randomized, controlled trial (RCT) compares the efficacy and safety of Ahmed Glaucoma Valve (AGV) implantation alone, with 3 minutes MMC application or with a single layer coverage of amniotic membrane.
- Trial name
- NCT00893490
- Testing
- Ahmed Glaucoma Valve (AGV), Mitomycin C (MMC), amniotic membrane coverage
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Sjögren's Syndrome
Efficacy and Safety of Belimumab in Primary Sjögren's Syndrome
Background and rationale Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by chronic inflammation of salivary and lachrymal glands, frequently accompanied by systemic symptoms.
- Trial name
- NCT01008982
- Testing
- LimphoStat-B
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Udine
Dry Eye Disease
A Dose-Finding Study Comparing InSite Vision, Inc. 101 to Vehicle and DuraSite Alone for Dry Eye Disease
The purpose of this study is to evaluate the safety, tolerability, and efficacy in topical administration of differing dosing regimens of ISV-101 (Bromfenac in DuraSite® ophthalmic solution) compared to Vehicle and DuraSite alone.
- Trial name
- ISV-101 (NCT01478555)
- Testing
- ISV 101
- Sponsor
- Sun Pharmaceutical Industries Limited
Rapid Eye Movement Sleep Behavior Disorder
RBD Longitudinal as Prognostic for PD
Purpose - to validate a combination of biological and clinical markers in the rapid-eye-movement (REM) sleep behavior disorder (RBD) population as indicative of the pre-symptomatic stage of Parkinson's disease (PD).
- Trial name
- RBD6YR (NCT00817726)
- Where
- United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Glaucoma, Ocular Hypertension
A Safety Study of Bimatoprost in Patients With Glaucoma or Ocular Hypertension
This safety study will evaluate bimatoprost 0.01% and 0.03% in patients with glaucoma or ocular hypertension (OHT).
- Trial name
- NCT01830140
- Testing
- Bimatoprost 0.01%, Bimatoprost 0.03%
- Where
- 2 sites in United States
- Volunteers
- 466 people
- Sponsor
- Allergan
Methylmalonic Aciduria and Homocystinuria,Cblc Type, Genetic Disease
EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment
The aim of the research is to investigate the safety and efficacy of EPI-743 treatment in patients with Cbl-C defect and related visual and neurological impairment.
- Conditions
- Methylmalonic Aciduria and Homocystinuria,Cblc Type, Genetic Disease, Retinopathy
- Trial name
- NCT01793090
- Testing
- Epi-743
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Choroidal Melanoma
Safety and Efficacy of Silicone Oil Tamponade for Surgical Attenuation of Radiation Damage in Choroidal Melanoma
A prospective, experimental, case series of 20 patients, with choroidal melanoma, in which pars plana vitrectomy and Silicone oil as vitreous substitute will be used as intraocular shielding for attenuating the deleterious…
- Trial name
- NCT01460810
- Testing
- 1000CsK Silicon Oil Tamponade
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Post Traumatic Stress Disorder, Intensive Care Psychiatric Disorder
Early EMDR Following Covid-19 Critical Illness: A Feasibility Trial
Primary objective is to evaluate the feasibility of delivering an online early Eye Movement Desensitisation Reprocessing (EMDR) Recent Traumatic Events Protocol (R-TEP) to patients who have survived Covid-19 related critical…
- Conditions
- Post Traumatic Stress Disorder, Intensive Care Psychiatric Disorder, Anxiety Disorders, Depression
- Trial name
- Cov-EMERALD (NCT04455360)
- Testing
- Eye Movement Desensitisation and Reprocessing Recent traumatic Event Protocol
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Angle Closure Glaucoma
Comparing Nd:YAG Laser and Sequential Double Frequency YAG-Nd:YAG Laser Iridotomy
No single type of laser or set of laser parameters is appropriate for all type of irides. Pure Nd:YAG laser iridotomy is very effective in the light color irides. It was considered as the gold standard for iridotomy.
- Trial name
- NCT02474238
- Testing
- The sequential technique, The pure Nd:YAG laser technique
- Where
- Thailand
- Volunteers
- 82 people
- Sponsor
- Prince of Songkla University
Wet Macular Degeneration
Non-Persistence/Non-Adherence (NP/NA) in Wet Age-related Macular Degeneration (wAMD) Patients in Germany
In the research study an observation of patients with wet age-related macular degeneration (wet AMD) will be performed. The term observational study indicates that the current course of therapy and the associated circumstances…
- Trial name
- NCT01448538
- Testing
- Anti-VEGF injections
- Where
- Germany
- Volunteers
- 480 people
- Sponsor
- Bayer
Myopia
Clinical Evaluation of a Myopia Control Lens in Slowing Myopia Progression (DAL)
This is a mono-centre, prospective, one-arm, unmask clinical trial to evaluate the effectiveness of test lens in slowing myopia progression with respect to axial length elongation compared to a single vision spectacle lens from…
- Trial name
- NCT05840185
- Testing
- Test myopia control lenses (DAL)
- Where
- Singapore
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Essilor International
Amblyopia
Efficacy of Over-glasses Patch Treatment for Amblyopia in Children : OPTA Study
This is a study to investigate efficacy of over-glasses patch treatment for amblyopic children using visual function improvement and Amblyopia Treatment Index (ATI) changes.
- Trial name
- OPTA (NCT03080285)
- Testing
- over-glasses patch, Conventional patch
- Volunteers
- 107 people
- Sponsor
- Pusan National University Hospital
Cataract, Glaucoma
Comparison of Phaco-Trabeculectomy and MSICS-Trab in Cataract and Glaucoma Patients
The goal of this interventional study is to compare the outcomes of two surgical techniques, Phaco-Trabeculectomy and Manual Small Incision Cataract Surgery (MSICS) with Trabeculectomy, in patients with coexisting cataract and…
- Trial name
- NCT06739343
- Testing
- PHACO-Trabeculectomy, MSICS-Trabeculectomy
- Where
- Nigeria
- Volunteers
- 122 people
- Sponsor
- Emeka John Dingwoke
Posterior Capsule Opacification, Cataract
Posterior Capsule Opacification Development With Two Different Intraocular Lenses
Age-related cataract is the main cause of impaired vision in the elderly population worldwide. The only treatment that can restore functional visual ability is cataract surgery where the opacified crystalline lens is removed by…
- Trial name
- MIPHY (NCT01734343)
- Testing
- HOYA iMics Y-60H, PhysIOL microAY
- Where
- Austria
- Volunteers
- 65 people
- Sponsor
- Medical University of Vienna
Proliferative Vitreoretinopathy
Imaging and Predictive Modelling of Proliferative Vitreoretinopathy.
Patients with retinal detachment are at risk of recurrence and failure of surgery requiring multiple surgeries due to a condition called proliferative vitreoretinopathy (PVR).
- Trial name
- NCT07682025
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Retinal Disease
Peripheral Retina Robotically Aligned OCT Study
Optical coherence tomography (OCT) is a 3D imaging technology that has seen wide adoption within ophthalmology. However, optical access to the retinal periphery remains a challenge for conventional OCT systems.
- Trial name
- PR-RAOCT (NCT06451068)
- Testing
- Peripheral retina robotically aligned optical coherence tomography (OCT) system, Likert Scales
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Dermatochalasis of Upper Eyelid, Blepharoplasty
Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes
The goal of this clinical trial is to determine whether buffering, warming, or addition of hyaluronidase or tranexamic acid to lignocaine during eyelid injection of local anaesthesia reduce injection pain and procedure-related…
- Trial name
- P4LE (NCT07734740)
- Testing
- Sodium Bicarbonate (NaHCO3), Warmed lignocaine, Hyaluronidase Injection
- Where
- 3 sites in Hong Kong
- Volunteers
- 80 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Presbyopia
Evaluate the Efficacy and Safety of CTO0307 in Adults With Presbyopia
This study was to compare the presbyopia correction effect between the treatment group and the control group, evaluated by the proportion of patients who achieved an improvement of 3 lines or more in mesopic binocular DCNVA at…
- Trial name
- NCT07723716
- Testing
- CTO0307 Eye drop
- Where
- South Korea
- Volunteers
- 167 people
- Sponsor
- Taejoon Pharmaceutical Co., Ltd.