Clinical trials: Ocular Diseases
Diabetes Complications, Diabetic Retinopathy
A Pilot Project to Assess the Impact of Diabetes Education During Ophthalmology Visits
The overarching purpose of this project is to provide diabetes education to the diverse patient population at the Lions Eye Clinic, a resident-run ophthalmology practice at California Pacific Medical Center.
- Trial name
- LionsDMed (NCT02334137)
- Testing
- iPad app, Educator sessions, Retinal photos
- Volunteers
- 36 people
- Sponsor
- California Pacific Medical Center Research Institute
Rhegmatogenous Retinal Detachment With Grade C Proliferative Vitreoretinopathy
Comparison of Visual Outcomes of Pars Plana Vitrectomy With and Without Injection Clexane for Rhegmatogenous Retinal Detachment Proliferative Vitreoretinopathy
This interventional prospective study was conducted in the Department of Ophthalmology at Lahore General Hospital, Lahore. The study included 60 male and female patients aged 18-65 years who had rhegmatogenous retinal detachment…
- Trial name
- NCT07787377
- Testing
- Enoxaparin Sodium, Pars Plana Vitrectomy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Lahore General Hospital
Neovascular Age-Related Macular Degeneration
Study of Brolucizumab in Adult Patients With Suboptimal Anatomically Controlled Neovascular Age-related Macular Degeneration
Neovascular age-related macular degeneration is characterized by the presence of choroidal neovascularization (CNV), which consists of abnormal blood vessels originating from the choroid that can lead to hemorrhage, fluid…
- Trial name
- SWIFT (NCT04264819)
- Testing
- RTH258/Brolucizumab
- Where
- 51 sites in France
- Volunteers
- 295 people
- Sponsor
- Novartis Pharmaceuticals
Keratoconus
Intacs for Keratoconus
To study the effects Intacs intracorneal ring segments(Addition Technology, Inc) insertion in the treatment of keratoconus
- Trial name
- NCT00347230
- Testing
- Intacs intracorneal ring insertion for the treatment of keratoconus
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Dry Eye
Acupoint Therapy Device for Dry Eye
To built a dry eye acupoint therapeutic instrument by stimulating acupoints with low impulse current .And the safety of the dry eye acupoint treatment device will be tested and the initial validation will be verified.
- Trial name
- NCT06720428
- Testing
- dry eye acupoint therapy instrument, Artificial tear
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai 10th People's Hospital
Glaucoma, Ocular Hypertension
Safety Assessment of T4090 Eye Drops in Ocular Hypertensive or Glaucomatous Patients.
The study purpose is to evaluate the safety of T4090.
- Trial name
- NCT05389267
- Testing
- Kinezodianone R hydrochloride
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Laboratoires Thea
Cataract, Aphakia
A Multi Focal Visual Outcome Study Using Different Near Additions
A multi-centre non-randomized clinical investigation to assess multifocal visual outcomes using different near additions, for the treatment of aphakia after cataract removal.
- Trial name
- NCT00960700
- Testing
- Visual Acuity, Contrast sensitivity, Reading Speed
- Where
- 2 sites in Germany, Lithuania
- Volunteers
- 52 people
- Sponsor
- Rayner Intraocular Lenses Limited
Macular Holes, Retina Detachment
Comparison of Vitrectomy Without Internal Limiting Membrane Peeling Versus Inverted ILM Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes
The aim of this study was to determine whether inverted ILM peeling technique could contribute to high reattachment and closure rates after vitrectomy in patients with myopic macular hole retinal detachment (MHRD) in comparison…
- Trial name
- NCT04011007
- Testing
- vitrectomy with or without inverted ILM flap technique
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- University of Alexandria
Myopia
Evaluation of Two Silicone Hydrogel Lenses Over a One Month Period
The purpose of this trial is to compare two different contact lenses during 4 weeks of wear.
- Trial name
- NCT00810511
- Testing
- Lotrafilcon A contact lens, Comfilcon A contact lens
- Volunteers
- 213 people
- Sponsor
- CIBA VISION
Optic Neuritis
Treatment of Optic Neuritis With Erythropoietin: a Randomised, Double-blind, Placebo-controlled Trial
This clinical trial aims at preventing visual dysfunction and optic nerve degeneration associated with autoimmune optic neuritis by systemic i.v. administration of 33.000 IU erythropoietin over 3 days.
- Trial name
- TONE (NCT01962571)
- Testing
- Erythropoietin alfa
- Where
- 11 sites in Germany
- Volunteers
- 108 people
- Sponsor
- University Eye Hospital, Freiburg
Healthy, Muscular Dystrophy
Studies of Patients With Skin Disease, Patients With Neurological Degenerations, and Normal Volunteers
It is proposed that patients with skin disease due to presumed immunologic, genetic or viral-induced abnormalities, patients with neurological degenerations, and normal controls be evaluated with various in vitro studies of…
- Conditions
- Healthy, Muscular Dystrophy, Retinal Degeneration, Skin Diseases
- Trial name
- NCT00001164
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Cataract
Outcomes of 3 Incision-size-dependent Phacoemulsification Systems
The purpose of this study is to compare the outcomes of cataract surgery performed with three incision-size-dependent phacoemulsification systems (1.8, 2.2 and 3.0 mm).
- Trial name
- NCT01429532
- Testing
- phacoemulsification
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sun Yat-sen University
Cataract
Clinical Investigation of the Next Generation Intraocular Lens
An investigational IOL designed to provide improved intermediate and near visual acuity and decreased spectacle wear was evaluated for safety and effectiveness in a six-month study.
- Trial name
- NCT03500198
- Testing
- Investigational Intraocular Lens Device #1: Next Generation TECNIS IOL, Control Monofocal Intraocular Lens: TECNIS Monofocal IOL
- Where
- 10 sites in United States
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Surgical Vision, Inc.
Dry Eye Syndrome
Efficacy of Warm Compress Therapy in Enhancing Tear Film Quality and Reducing Postoperative DES
Dry eye disease (DED) is a multifactorial condition often exacerbated by cataract surgery, leading to discomfort and visual disturbances.
- Trial name
- NCT06914232
- Testing
- Warm Compress, Standard Care
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Superior University
Dry Eye
Prostaglandin Analog Eyelash Serum and Ocular Surface Health: A Prospective Study
This prospective interventional study investigates the effects of a prostaglandin analog-based eyelash serum on ocular surface integrity, tear film stability, and eyelash growth over six weeks.
- Trial name
- EYESERUM (NCT06875687)
- Testing
- Prostaglandin Analog-Based Eyelash Serum
- Where
- Spain
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Seville
Primary Open Angle Glaucoma, Ocular Hypertension
A Study of Efficacy and Safety of PHP-201 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
This is a phase 3 study to confirm the efficacy in reduction of intraocular pressure and safety of PHP-201 ophthalmic solution in patients with primary open-angle glaucoma or ocular hypertension.
- Trial name
- NCT04863365
- Testing
- PHP-201 ophthalmic solution
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- pH Pharma
Primary Open Angle Glaucoma
Effect of Xen Implantation on the Aqueous Humor Proteome
The purpose of this study is to determine how the aqueous humor proteome changes after implantation of a Xen microstent for treatment of glaucoma.
- Trial name
- NCT04141865
- Testing
- Xen, Aqueous shunt
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Price Vision Group
Glaucoma, Healthy
Glaucoma Biomarkers
Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments.
- Trial name
- NCT01677507
- Testing
- Variation in eye pressure response to timolol and latanoprost treatment
- Where
- 3 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cancers, Cardiovascular Diseases
Swedish Mammography Cohort
The Swedish Mammography Cohort began in 1987-1990, when 66,651 women living in two counties in central Sweden completed a mailed questionnaire that included items about their diet, parity, age at first child's birth, history of…
- Conditions
- Cancers, Cardiovascular Diseases, Cataract, Gastrointestinal Diseases
- Trial name
- SMC (NCT01127698)
- Volunteers
- 61,433 people
- Sponsor
- Karolinska Institutet
Myopia
Incidence of Myopia in a Prospective Cohort of Emmetropic Children and Associated Ocular and Environmental Factors
Myopia and high myopia are among the leading causes of visual impairment and blindness worldwide. The total number of people with myopia worldwide was estimated at 2.6 billion in 2020 and could reach 4.8 billion by 2050 unless…
- Trial name
- PREMYOP (NCT07316998)
- Testing
- annual follow-up
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
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