Clinical trials: Ocular Diseases
Moderate to Severe Vernal Keratoconjunctivitis
A Study to Compare the Effectiveness and Safety of T1695 Versus Ciclosporin in Participants With Moderate to Severe Vernal Keratoconjunctivitis
The aim of the study is to Compare the Effectiveness and Safety of T1695 Versus Ciclosporin in Participants with Moderate to Severe Vernal Keratoconjunctivitis
- Trial name
- NCT07169695
- Testing
- Slit Lamp Examination, Far Best Corrected Visual Acuity (BCVA), T1695
- Where
- 11 sites in India
- Volunteers
- 120 people
- Sponsor
- Laboratoires Thea
Keratoconus, Ectasia
Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia
This prospective, randomized study is being conducted to evaluate the safety and effectiveness of corneal cross-linking (CXL) in patients with keratoconus or post-refractive ectasia (post-LASIK or PRK) utilizing two techniques…
- Trial name
- CXL (NCT03080077)
- Testing
- Ricrolin+, Epi-Off
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Myopia, Refractive Errors
Dual-Action Lenses for Slowing Myopia in Children and Teens: A Randomized, Double-Blind Trial
This is a single-center, randomized, double-blind, controlled study to test whether a new type of eyeglass lens - a "dual-action" lens that combines two technologies (multiple defocus zones and dot diffusion) - can slow the…
- Trial name
- NCT07854457
- Testing
- Dual-Action Myopia-Control Spectacle Lens, Stellest Myopia-Control Spectacle Lens（Highly Aspherical Lenslet Target / HALT Lens）
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Intracranial Pressure Increase
Evaluation of the Effect of Trendelenburg Position Duration on Intracranial Pressure
The Lloyd Davies position is a position used in laparoscopic hysterectomies where the head is lowered 45 degrees and the legs are bent from the knee area.It is a version of the Trendelenburg position.
- Trial name
- NCT06048900
- Testing
- ultrasound guided optic nerve sheath diameter measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Dilek Cetinkaya
Age-Related Macular Degeneration
A Study Of The Safety And Efficacy Of AG-013,958 In Subjects With Subfoveal Choroidal Neovascularization Associated With Age-Related Macular Degeneration
AG-013,958 is being studied to treat patients with Age-Related Macular Degeneration. A total of 144 subjects may be enrolled in the trial.
- Trial name
- NCT00090532
- Testing
- AG-013,958
- Where
- 39 sites in United States, Australia and 2 more
- Volunteers
- 155 people
- Sponsor
- Pfizer
Geographic Atrophy
Long-Term Safety of Lampalizumab Intravitreal (ITV) Injections in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (OMASPECT)
This multicenter open-label extension study is designed to evaluate the safety and tolerability of lampalizumab intravitreal injections in participants with GA secondary to age-related macular degeneration (AMD) who completed 96…
- Trial name
- NCT02745119
- Testing
- Lampalizumab
- Where
- 208 sites in United States, Australia and 17 more
- Volunteers
- 994 people
- Sponsor
- Hoffmann-La Roche
Allergic Conjunctivitis
Efficacy of AC-150 for the Treatment of Allergic Conjunctivitis in the Enviro-CAC™ Model
The purpose of this study is to evaluate the efficacy of AC-150 compared to vehicle and its components in the prevention of the signs and symptoms of allergic conjunctivitis in Enviro-CAC™ Model.
- Trial name
- NCT01134328
- Testing
- AC-150 Combo, AC-150A 0.1%, AC-150B 0.005%
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Aciex Therapeutics, Inc.
Lymphoma, Small Intestine Cancer
S0355 Ixabepilone in Treating Patients With Advanced Solid Tumors or Lymphomas and Liver Dysfunction
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This phase I trial is studying the side effects and best dose of ixabepilone in treating…
- Conditions
- Lymphoma, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00049400
- Testing
- BMS-247550
- Where
- 23 sites in United States
- Volunteers
- 78 people
- Sponsor
- SWOG Cancer Research Network
Glaucoma, Primary Open Angle
Evaluation the Safety and Effectiveness of the GORE GDI in Adult Subjects With Primary Open-angle Glaucoma in Whom Previous Medical and Surgical Treatment Have Failed.
Evaluation the Safety and Effectiveness of the GORE GDI in Adult Subjects With Primary Open-angle Glaucoma in Whom Previous Medical and Surgical Treatment Have Failed.
- Trial name
- NCT07880132
- Testing
- GORE Glaucoma Drainage Implant
- Volunteers
- 70 people
- Sponsor
- Gore Ophthalmic
Solid Tumor, Adult Central Nervous System Germ Cell Tumor
Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor
RATIONALE: Giving high-dose chemotherapy before an autologous stem cell transplant stops the growth of tumor cells by stopping them from dividing or killing them.
- Conditions
- Solid Tumor, Adult Central Nervous System Germ Cell Tumor, Adult Rhabdomyosarcoma, Childhood Central Nervous System Germ Cell Tumor
- Trial name
- NCT00638898
- Testing
- busulfan, melphalan, topotecan hydrochloride
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- City of Hope Medical Center
Myopia
Study of ACUVUE® ADVANCE® PLUS Contact Lenses.
The purpose of this study is to compare ACUVUE® ADVANCE® Plus contact lenses made prior to process qualification (prePQ) against the ACUVUE® ADVANCE® Plus lenses made after the process qualification (postPQ).
- Trial name
- NCT01244893
- Testing
- Acuvue Advance Plus prePQ, Acuvue Advance Plus postPQ
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Glaucoma
Community Based Treatment for (ComBaT) Glaucoma
The purpose of this research is to evaluate if intervention and education can change the behavior of someone's willingness to see an eye care provider to prevent blindness and glaucoma.
- Trial name
- NCT06124521
- Testing
- ComBaT Glaucoma
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Dry Eye, Keratoconjunctivitis Sicca
Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort B
The purpose of this interventional study is to assess safety, patient tolerability, plug retention rate, and preliminary efficacy in improving the symptoms of Dry Eye Disease (DED) of EXP-TC tacrolimus releasing punctal plug.
- Conditions
- Dry Eye, Keratoconjunctivitis Sicca, Ocular Inflammation
- Trial name
- NCT05618730
- Testing
- punctum plug insertion, Eye Drops, Lubricant
- Where
- Mexico
- Volunteers
- 20 people
- Sponsor
- Eximore Ltd.
Glaucoma
Study of Patient Use and Perception of the Travatan Dosing Aid
The primary objective of this study is to determine the opinions of patients who are given the Travatan Compliance Monitoring Dispenser to use to dispense their Travatan glaucoma drops.
- Trial name
- NCT00626067
- Testing
- Fully functional monitoring device, Partially functional monitoring device, Non-functional monitoring device
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Macular Edema, Cystoid Macular Edema
Effectiveness of Periocular Drug Injection in CATaract Surgery
Cystoid macular edema (CME) is a major cause of suboptimal postoperative visual acuity after cataract surgery. Topical steroidal and nonsteroidal anti-inflammatory drugs (NSAIDs) are used to prevent CME.
- Conditions
- Macular Edema, Cystoid Macular Edema, Retinal Disease, Cataract
- Trial name
- EPICAT (NCT05158699)
- Testing
- Bromfenac, Dexamethasone, Triamcinolone Acetonide
- Where
- 10 sites in Austria, Germany and 2 more
- Volunteers
- 628 people
- Sponsor
- Luigi Rondas
Myopia, Soft Contact Lenses
A Clinical Trial Assessing the Efficacy and Safety of ST-1 Silicone Hydrogel Daily Disposable Soft Contact Lenses Compared to Miru 1day UpSide
This study will enroll 63 eligible subjects (126 eligible eyes, complete at least 108 evaluable eyes) in approximately 6 different medical centers in Taiwan, in order to evaluate the efficacy and safety of ST-1 silicone hydrogel…
- Conditions
- Myopia, Soft Contact Lenses, Daily Disposable Soft Contact Lenses
- Trial name
- NCT07345416
- Testing
- ST-1, Miru 1day UpSide
- Where
- 6 sites in Taiwan
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Menicon Co., Ltd.
Glaucoma, Primary Open Angle
Safety and Feasibility of the ELIOS System in POAG Patients
Evaluation of the safety and effectiveness of the ELIOS System procedure to reduce intraocular pressure (IOP) in adult subjects with mild to moderate primary open-angle glaucoma (POAG)
- Trial name
- NCT05999006
- Testing
- ELIOS Procedure
- Where
- 6 sites in United States
- Volunteers
- 22 people
- Sponsor
- Elios Vision, Inc.
Leber's Hereditary Optic Neuropathy (LHON)
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection
Leber's hereditary optic neuropathy (LHON) is a rare mitochondrial genetic disorder characterized by optic nerve atrophy due to the degeneration of retinal ganglion cells, which leads to acute visual loss.
- Trial name
- NCT05555784
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Argo Sante
Anterior Chamber Inflammation, Ocular Pain
A Retrospective Review of DEXTENZA 0.4 mg inseRt Following Corneal Transplant or Cataract Surgery
A Retrospective Review of Pain and Inflammation Resolution Outcomes in Patients Who Received DEXTENZA Intracanalicular Dexamethasone (0.4 mg) Insert Prior to or Following Corneal transplant or Cataract surgery
- Conditions
- Anterior Chamber Inflammation, Ocular Pain, Corneal Edema, Corneal Defect
- Trial name
- NCT04975971
- Testing
- Dextenza 0.4Mg Ophthalmic Insert
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Nicole Fram M.D.
Iris Melanoma, Medium/Large Size Posterior Uveal Melanoma
Radiation Therapy in Preventing Liver Metastases in Patients With Uveal Melanoma Who HaveMonosomy 3 or DecisionDx Class 2 Disease and Are More Likely to Develop Liver Metastases
This clinical trial studies giving radiation therapy to the liver in patients with uveal (eye) melanoma who have a specific chromosome loss (monosomy 3) or are DecisionDx Class 2 and therefore more likely to have their disease…
- Conditions
- Iris Melanoma, Medium/Large Size Posterior Uveal Melanoma, Stage IIA Uveal Melanoma, Stage IIB Uveal Melanoma
- Trial name
- NCT02336763
- Testing
- External Beam Radiation Therapy, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Jonsson Comprehensive Cancer Center
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