Clinical trials: Ocular Diseases
Spatial Neglect, Stroke
Virtual Reality for Neglect Diagnostics
Compared to the classical "paper and pencil"-tests, testing patients in our virtual reality setup might have a higher sensitivity and specificity.
- Trial name
- KMS-Neglect (NCT01399073)
- Testing
- virtual reality setup, paper and pencil tests, c-mri
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Keratitis
Use of a Biological Lens of Amniotic Membrane (LV-Visio-AMTRIX) in the Treatment of Treatment-Resistant Keratitis
The purpose of this open, mono center trial is to assess the impact of the use of an amniotic membrane on the healing of a keratitis resistant to medical treatment.
- Trial name
- NCT05250583
- Testing
- LV-Visio-AMTRIX
- Where
- France
- Volunteers
- 5 people
- Sponsor
- TBF Genie Tissulaire
Endophthalmitis
Study of Intraocular Concentrations (Aqueous Humor, Vitreous Humor) of Antibiotics After Local and/or Systemic Administration in Endophthalmitis
Endophthalmitis is an intraocular inflammation due to a serious infection of bacterial, fungal or parasitic origin, involving visual prognosis if it is not treated in time and correctly.
- Trial name
- CINEBIOPHTA (NCT03968341)
- Testing
- Pharmacokinetic and pharmacodynamic study of antibiotics used in severe endophthalmitis from samples taken from treated patients
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Dry Eye
An Observational Study to Assess Optive MEGA-3 (OM3) on Dry Eye Symptoms and Quality of Life of Adult Participants With Mild to Moderate Dry Eye Disease (DED)
Dry Eye Disease (DED) is a condition where the tear film of the eye becomes unstable and along with ocular surface inflammation and damage leads to inadequate tear production and eye lubrication.
- Trial name
- NCT06439394
- Testing
- Optive MEGA-3 (OM3)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- AbbVie
Retinopathy of Prematurity, Preterm Infants
An Observational Study to Collect Data on How Aflibercept (Eylea) Given Using a Paediatric Dosing Device is Used in Preterm Babies With Retinopathy of Prematurity in the United Kingdom (UK)
This is an observational study in which only data from babies with retinopathy of prematurity (ROP) who are being treated with aflibercept (Eylea) in prefilled syringe (PFS) using a paediatric dosing device (PDD) are collected…
- Trial name
- NCT06315556
- Testing
- Aflibercept (Eylea)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Bayer
Retinal Dystrophy, Cone-Rod, Cone Dystrophy
Study of New Mutations in Cone Disorders
High throughput sequencing gives the opportunity to improve the genetic diagnosis for patients suffering from retinal dystrophies and specially from cone disorders.
- Conditions
- Retinal Dystrophy, Cone-Rod, Cone Dystrophy, Cone Rod Dystrophy, Macular Degeneration
- Trial name
- INTROCONE (NCT04658251)
- Testing
- Blood and/or skin biopsy
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Lille
Glaucoma
Effect of Intra-subject Phaco/Trabectome vs. Phaco/Kahook Dual Blade on Intraocular Pressure
To determine the safety and efficacy of Kahook dual blade over Trabectome in lowering intraocular pressure in glaucoma patients. Glaucoma surgery will be performed in conjunction with cataract surgery.
- Trial name
- NCT03894631
- Testing
- KDB/Phacoemulsification, Trabectome/Phacoemulsification
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- State University of New York at Buffalo
Full Spectrum
A Self-controlled Study of the Effect of Partial Spectral Absence of Visible Light on the Pupil
Previous studies have shown that the spectrum of light influences myopia. LED lights with a partially absent light spectrum increase the risk of myopia progression compared to LEDs with a full spectrum, potentially mediated by…
- Trial name
- NCT06501131
- Testing
- full-spectrum light exposure, specific spectrum absence light exposure
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Fuchs, Fuchs Dystrophy
Descemet Endothelial Thickness Comparison Trial II
Descemet Endothelial Thickness Comparison Trial (DETECT) II is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 60 patients with Fuchs endothelial dystrophy to DMEK versus Descemet Stripping…
- Conditions
- Fuchs, Fuchs Dystrophy, Fuchs' Endothelial Dystrophy
- Trial name
- DETECT II (NCT05275972)
- Testing
- Ripasudil
- Where
- 8 sites in United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Retinal Detachment
Clinical Characteristics and Surgical Outcomes of the Fellow Eye in Bilateral Retinal Detachments
To assess the clinical features and the surgical outcomes of RD repair surgery of the fellow eye in bilateral retinal detachments
- Trial name
- NCT06292572
- Testing
- Retinal Detachment Surgery
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Central Hospital, Nancy, France
Cataract
What is the Efficiency When Comparing Active Sentry at Low IOP vs Ozil at High IOP?
The objective is to assess the efficiency of the Active Sentry handpiece at low intraocular pressure (IOP) compared with the Ozil at high IOP.
- Trial name
- NCT05868772
- Testing
- Active Sentry Handpiece, Ozil Handpiece
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cataract and Laser Institute of Southern Oregon
Dysthyroid Orbitopathy
Morphometric Analysis of Orbital Structures in Graves´ Orbitopathy
The purpose of this protocol is to study orbital structures in Graves´ Disease using multidetector computed tomography and color doppler imaging.
- Trial name
- NCT00665795
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo
Age-related Macular Degeneration
Efficacy and Safety of "Treat-and-Extend" Regimen Versus "Pro Re Nata" of Conbercept in Age-related Macular Degeneration
The study will evaluate the efficacy and safety of two different regimens of Conbercept (Treat-and-Extend (T\&E) Regimen vs. Pro Re Nata (PRN)) in patients with wet AMD.
- Trial name
- NCT02802657
- Testing
- Treat-and-Extend regimen, Pro Re Nata, Conbercept
- Where
- 5 sites in China
- Volunteers
- 141 people
- Sponsor
- Xiaodong Sun
Ophthalmopathy
Injection of Ranibizumab Versus Combination of Ranibizumab and Triamcinolone Acetate for (CRVO)
To compare the clinical effectiveness of ranibizumab and combination of ranibizumab and triamcinolone for the treatment of macular oedema secondary to CRVO
- Trial name
- NCT04460001
- Testing
- Ranibizumab, triamcinolone acetate
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Diabetes, Diabetic Retinopathy
Diabetic Retinopathy Functional Evaluation Study: Monitoring Carotenoid Vitamins Treatment Using ERG
To evaluate the differences in retinal function as measured by ERG in diabetics with and without retinopathy 2) the ability of the Chromatic Electroretinogram (chERG) to detect changes in global retinal function following…
- Trial name
- NCT04117022
- Testing
- DVS supplementation
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- ZeaVision, LLC
Dry Eye Syndromes
Pilot Study of TearCare System - Long-Term Extension
The objective of the study is to evaluate the long-term clinical utility, safety, and effectiveness of re-treatment with the TearCare™ System in adult patients with dry eye syndrome who had previously been treated with the…
- Trial name
- NCT03804502
- Testing
- TearCare
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Sight Sciences, Inc.
Myopia, Astigmatism
Photorefractive Keratectomy (PRK) : Comparison of Corneal Haze Between Two Modes of De-epithelialisation (Laser Versus Manual Alcohol)
surgical correction of ametropia. A number of improvements have been introduced to overcome the side effects and complications such as corneal haze, epithelial irregularities induced by wound healing, pain and delayed visual…
- Trial name
- H-TransPKR (NCT05072977)
- Testing
- TransPRK, Alcohol PRK
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Cataract
Patient Satisfaction and Visual Outcomes After Bilateral PanOptix Implantation in Patients With Previous Multifocal Contact Lens
To evaluate spectacle independence and patient satisfaction and visual outcomes after bilateral PanOptix implantation in patients with previous multifocal contact lens experience.
- Trial name
- NCT05518227
- Testing
- The Clareon™ PanOptix™ Trifocal (toric and non-toric models)
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Vivid Laser Center
Parkinson Disease
The Effect of Eye Exercises in Parkinson's Disease
Parkinson's disease is commonly associated with impaired gait, postural instability, reduced physical function, and increased concern about falling, all of which contribute substantially to disability and reduced quality of life.
- Trial name
- NCT07525973
- Testing
- Supervised In-Center Eye Exercises
- Where
- Iran
- Volunteers
- 68 people
- Sponsor
- Pardis Specialized Wellness Institute
Dry Eye
Tear Layer Lipid Thickness in Pterygium Patient Before and After Surgery
The investigators study aims to capture the objective effects of pterygium surgery on tear layer lipid thickness and the tear layer.
- Trial name
- NCT02160769
- Where
- Singapore
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
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