Clinical trials: Ocular Diseases
Thyroid Associated Ophthalmopathies
Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues
Prostaglandin analogues eye drops are common and effective treatment for decreasing Intra-Ocular Pressure (IOP) in Glaucoma patients.
- Trial name
- NCT02155049
- Testing
- bimatoprost 0.03%
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Myopia
The Effect of +3.00ADD on Myopia Progression in Chinese Children
The purpose of this study is to evaluate the effect of +3.00ADD vs single vision spectacle on the progression of myopia in children.
- Trial name
- NCT03242226
- Testing
- two spectacles, single vision spectacles
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Myasthenia Gravis (MG), Myasthenia Gravis, Generalized
AXIS MG Patient Registry
The goal of the AXIS Autoimmune Neurology Registry is to learn about the experiences of adults living with autoimmune neurological disorders, starting with myasthenia gravis (MG), over time.
- Conditions
- Myasthenia Gravis (MG), Myasthenia Gravis, Generalized, Myasthenia Gravis, Ocular, Myasthenia Gravis Crisis
- Trial name
- AXIS (NCT07761026)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Autoimmune Neurology Alliance
Behcet Syndrome
Zinc Supplementation and Behçet's Syndrome
To study the effects of zinc gluconate supplementation on patients with Behçet's syndrome, 50 patients will be randomly allocated to two groups: placebo group or zinc group (one tablet of 30 mg/day elemental zinc) for 12 weeks.
- Trial name
- NCT05098678
- Testing
- Zinc gluconate
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Tabriz University of Medical Sciences
Presbyopia
Volumetric Visual Fields at Different Distances in Presbyopic Patients Using Occupational (PC-133 and PC-200) and General-Purpose Progressive Addition Lenses
This single-center, randomized, double-blind, crossover clinical trial aims to compare the volumetric visual fields provided by two occupational progressive addition lenses (OPLs) optimized for intermediate and near vision in…
- Trial name
- CIVIUS2026PAL (NCT07870785)
- Testing
- OPAL PC 133 assessment, OPAL PC 200 assessment, PAL assessment
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- University of Seville
Diabetic Retinopathy, Vitreous Hemorrhage
Use of Intravitreal Ranibizumab in the Treatment of Vitreous Hemorrhage
Primary Objective: To investigate the effectiveness of intravitreal applications of 0.5 mg Lucentis (ranibizumab) in patients with vitreous hemorrhage due to proliferative diabetic retinopathy.
- Trial name
- NCT01824043
- Testing
- intravitreal ranibizumab injections
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital Regional de São José - Dr. Homero de Miranda Gomes
Anterior Ischemic Optic Neuropathy
PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
The primary objective of this study is to determine whether the use of PDE5 inhibitors (vardenafil, sildenafil, or tadalafil) increases the risk for the development of NAION.
- Trial name
- NCT00867815
- Testing
- Diagnostic procedures
- Where
- 13 sites in United States, Australia and 1 more
- Volunteers
- 10 people
- Sponsor
- Bayer
Dry Eye
The Prophylactic Use of Topical Cyclosporine A 0.05% to Prevent Graft Versus Host Disease Related Dry Eye
The purpose of this study is to determine whether Restasis is an effective treatment for preventing the occurrence and progression of dry eye syndrome in patients who have recently received a bone marrow transplant and are at…
- Trial name
- NCT00553735
- Testing
- Cyclosporine A 0.05%, Arificial Tear
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Glaucoma, Glaucoma, Open-Angle
The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma Patients
Glaucoma represents a group of conditions that cause damage to the optic nerve and can lead to irreversible vision loss. Current treatments are aimed at lowering intraocular pressure while minimizing medication side effects.
- Conditions
- Glaucoma, Glaucoma, Open-Angle, Glaucoma; Drugs, Droopy Eyelid
- Trial name
- NCT04007276
- Testing
- brimonidine tartrate ophthalmic solution 0.025%, sterile balanced saline solution
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tulane University
Progressive Supranuclear Palsy, Parkinson's Disease
Postural Instability in Progressive Supranuclear Palsy
The purpose of this study is to better understand why individuals with Progressive Supranuclear Palsy (PSP) fall. Understanding the mechanism of gait and balance dysfunction in individuals with PSP may provide us with important…
- Trial name
- NCT01563276
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cognition Disorders
Impact of Glasses for Vision Problems on Cognitive Function in Rural Older Adults
The aim of this project is to explore whether vision correction can effectively slow cognitive decline in older adults. The primary question it seeks to answer is: Can providing free near and/or distance vision correction glasses…
- Trial name
- CLEVER (NCT06836440)
- Testing
- Free Prescription Glasses
- Where
- China
- Volunteers
- 964 people, healthy volunteers welcome
- Sponsor
- Yuju Wu
AMD
the Blood-Aqeous Barrier During Anti-Angiogenic Therapy in Exudative Age-Related Macular Degeneration
To evaluate the status of the blood-aqueous barrier by objectively measuring protein concentration in the aqueous humor using laser flare photometry (LFP) in patients with exudative age-related macular degeneration (AMD)…
- Trial name
- BABAMD (NCT07375901)
- Testing
- laser flare photometry before intravitreal injection
- Where
- Ukraine
- Volunteers
- 30 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Strabismus, Nystagmus, Congenital
Genetic Studies of Strabismus, Nystagmus, and Associated Disorders
Strabismus (misalignment of the eyes) often runs in families. In this study, the investigators are looking for genetic variants associated with strabismus and nystagmus.
- Trial name
- NCT04770519
- Testing
- whole genome sequencing or whole exome sequencing
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Boston Children's Hospital
Acanthamoeba Keratitis
Parasitic Ulcer Treatment Trial Pilot
This is a study of optimal treatments for acanthamoeba keratitis. In the first part of the study, participants will be randomized to chlorhexidine monotherapy or chlorhexidine plus povidone iodine.
- Trial name
- NCT03484507
- Testing
- Chlorhexidine, Povidone-Iodine, Prednisolone Sodium Phosphate
- Where
- 2 sites in India
- Volunteers
- 49 people
- Sponsor
- University of California, San Francisco
Glaucoma, Open-Angle
A Study of the Rate of Progression of Glaucoma During a Follow-up Period of Two Years
This is an epidemiological, non-interventional, prospective study to collect data on glaucoma progression in a routine setting. Patients may receive treatment at the discretion of their physician per local standard of care.
- Trial name
- NCT01629407
- Testing
- Standard of Care
- Where
- Spain
- Volunteers
- 315 people
- Sponsor
- Allergan
Cataract, Presbyopia
Clinical Trial With PRECIZON Presbyopic
The purpose of this clinical trial is to evaluate the effectiveness of the PRECIZON Presbyopic.
- Trial name
- NCT02409771
- Testing
- PRECIZON Presbyopic
- Where
- 6 sites in Belgium, Germany and 3 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ophtec BV
Retinopathy of Prematurity
Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening
Retinopathy of Prematurity (ROP) screening is one of many potentially painful diagnostic and therapeutic procedures performed routinely on preterm infants in the Neonatal Intensive Care Unit.
- Trial name
- NCT00921544
- Testing
- Sucrose, Sterile water
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Coombe Women and Infants University Hospital
Alzheimer Disease, Alzheimer Dementia
Multimodal Ocular Imaging in Neurodegeneration
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are two of the most common types of age-related neurodegenerative disorders.
- Conditions
- Alzheimer Disease, Alzheimer Dementia, Frontotemporal Dementia
- Trial name
- NCT03699644
- Testing
- Spectral-Domain Optical Coherence Tomography (SD-OCT), Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Diabetic Retinopathy, Depression
Diabetic Retinopathy as a Marker of Cognitive Dysfunction and Depression
In recent years damage to the nerve fibers in the retina has been experienced as an early sign of complications resulting from type 2 diabetes.
- Conditions
- Diabetic Retinopathy, Depression, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- DIRMA (NCT04610749)
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- Region of Southern Denmark
HIV/AIDS, Psychological Trauma
Efficacy of EMDR Therapy, as Compared to Treatment as Usual, in Reducing Clinical Symptoms in People With HIV
People living with HIV may suffer HIV-related psychological trauma. Studies also show that this group is vulnerable to non-HIV-related trauma. Trauma can increase vulnerability to stress and reducing the ability to cope.
- Conditions
- HIV/AIDS, Psychological Trauma, PTSD
- Trial name
- NCT03848858
- Testing
- EMDR plus TAU
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Parc de Salut Mar
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