Clinical trials: Ocular Diseases
Mobility, Depressive Symptoms
Effectiveness of AMICOPE Intervention to Maintain Self-Perceived Health and Intrinsic Capacity in Older People
In their day to day, persons do from simple to more or less complicated tasks and activities (ie: stand from a chair, open a door, shopping, read, drive, play chess, remind an appointment...).
- Conditions
- Mobility, Depressive Symptoms, Nutrition, Healthy, Cognitive Decline
- Trial name
- EFICIS (NCT05249504)
- Testing
- VIVIFRAIL, Nutrition, Psychology
- Volunteers
- 212 people
- Sponsor
- Fundacio Salut i Envelliment UAB
GLAUCOMA 1, OPEN ANGLE, D (Disorder)
Spectral Domain Optical Coherence Tomography Analysis for Glaucoma
The aim of this study is to examine whether there is a difference in macular ganglion cell complex thickness and retinal nerve fiber layer thickness in early-stage Primary open angle glaucoma and normal tension glaucoma with…
- Trial name
- NCT01612416
- Testing
- RS-3000 OCT measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Inonu University
Cataract
Symfony vs Vivity in Dim Light
The purpose of this study is to evaluate the visual outcomes of the Symfony lens and the Vivity lens under mesopic lighting conditions in adult patients undergoing routine cataract surgery.
- Trial name
- NCT06229106
- Testing
- Symfony IOL, Vivity IOL
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Carolina Eyecare Physicians, LLC
Cataract
Physiologic Phacofluidics: Ghost Protocol
The goal of this clinical trial is to investigate the early post-operative benefits of performing phacoemulsification at physiologic intraocular pressures.
- Trial name
- NCT06904404
- Testing
- Cataract surgery at high IOP, Cataract surgery at low IOP
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Wolfe Eye Clinic
Glaucoma
Evaluation of the Xen Implant in Glaucoma Surgery
Glaucoma is a blinding optic neuropathy that affects 60 million people around the world. Primary open-angle glaucoma is the most common etiology.
- Trial name
- Xen (NCT03733600)
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Allergic Conjunctivitis
Olopatadine 0.2% for the Treatment of Allergic Conjunctivitis
The purpose of this study is to demonstrate that Olopatadine 0.2% is superior to vehicle in the treatment of the signs and symptoms associated with allergic conjunctivitis or rhinoconjunctivitis.
- Trial name
- NCT00331500
- Testing
- Olopatadine Hydrochloride Ophthalmic Solution, 0.2%, Olopatadine Hydrochloride Ophthalmic Solution Vehicle
- Volunteers
- 287 people
- Sponsor
- Alcon Research
Retinitis Pigmentosa
Development of Visual Function Evaluation Method (2)
The objective of this study is to develop the comprehensive visual function evaluation method in severe visually impaired patient.
- Trial name
- NCT03626207
- Where
- Japan
- Volunteers
- 8 people
- Sponsor
- Astellas Pharma Inc
Macular Degeneration, Retinal Drusen
Non-Damaging Photothermal Therapy of Non-exudative Age Related Macular Degeneration
This is a randomized controlled study of non-damaging photothermal macular grid laser versus sham laser therapy in patients with dry age-related macular degeneration (AMD) and large high-risk drusen.
- Trial name
- NCT02569892
- Testing
- Pascal Retinal Laser Photocoagulator
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Stanford University
Dry Eye Disease (DED)
Anti-inflammatory Effects and Clinical Efficacy of Topical Thealoz Total Eye Drops in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation
Dry eye disease (DED) is a highly prevalent ocular condition and induces a significant burden to the affected patients. Regardless of the underlying etiology, DED is associated with increased inflammation of the entire ocular…
- Trial name
- NCT07245836
- Testing
- Thealoz Total® Eye Drops, Laboratoires Thea, Clermont Ferrand, France
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Cornea, Anesthesia; Reaction
The Effects of Nitrogen Protoxide and Oxygen on Corneal Endothelial in Pediatric Patients
To evaluate the mean changes in Endothelial Cell and Corneal pachymetry in eyes that operated under N2O + sevoflurane and O2 + sevoflurane general anesthesia.
- Trial name
- NCT03006211
- Testing
- Nitrogen protoxide, Oxygen
- Volunteers
- 40 people
- Sponsor
- Inonu University
Light Sensitivity
"Eye Protection After Mydriatic Use for ROP Screening: Impact on Vitals Signs and Pain Scores"
Pupillary dilation induced by mydriatic agents during Retinopathy of Prematurity exams can persist for hours. Despite regular use of eye protection for mydriatic-induced light sensitivity for infants, children and adults, eye…
- Trial name
- NCT01860534
- Testing
- eye covers
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Neuromyelitis Optica Spectrum Disorders
The Safety and Efficacy of NouvSoma001 in Neuromyelitis Optica Spectrum Disorders
This is a single-center, randomized, open-label, placebo-controlled, dose-escalation trial. The objective of this research is to evaluate the safety, tolerability, and efficacy of intrathecal administration of human-induced…
- Trial name
- NCT06620809
- Testing
- Extracellular vesicles derived from human-induced neural stem cells for intrathecal injection
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Tongji Hospital
Non-24-Hour Sleep-Wake Disorder
Tasimelteon for the Treatment of Non-24-hour Sleep-Wake Disorder (N24HSWD) in Blind Individuals With no Light Perception
The purpose of this study is to evaluate the safety of tasimelteon in male and female patients who suffer from Non-24-Hour Sleep-Wake Disorder.
- Trial name
- NCT01429116
- Testing
- tasimelteon
- Where
- 22 sites in United States
- Volunteers
- 200 people
- Sponsor
- Vanda Pharmaceuticals
Asthenopia
Accommodative Relief for Uncomfortable Non-Presbyopes
This study will determine how multifocal contact lens correction affects symptoms of discomfort and asthenopia in a group of myopic contact lens wearers in the non-presbyopic age range (ages 30-40 years).
- Trial name
- NCT03544216
- Testing
- Multifocal Contact Lens, Single Vision Contact Lens
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Dry Eye Disease (DED)
Clinical Efficacy and Molecular Dynamics of Quantum Molecular Resonance (QMR) Electrotherapy in Dry Eye Management
This project aims to investigate the clinical efficacy and molecular mechanisms of Quantum Molecular Resonance (QMR) electrotherapy in the management of dry eye disease (DED).
- Trial name
- NCT06955806
- Testing
- The Rexon-Eye, an electrotherapy device utilizing Quantum Molecular Resonance (QMR) technology
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Myopia
Contact Lens in Pediatrics (CLIP) in an Asian Population Study
To evaluate the safety, efficacy and physiological performance of daily disposable spherical and toric soft contact lenses in a vision-corrected population of children ages 8-11 years of age.
- Trial name
- CLIP (NCT00473304)
- Testing
- Johnson&Johnson Acuevue daily disposable lenses
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Primary Open Angle Glaucoma
How Does Your Genetic Make-up (Profile) Influence Your Glaucoma?
Glaucoma is a group of diseases in which visual loss occurs because of damage to the optic nerve. Research has shown that certain genes may cause glaucoma in some cases.
- Trial name
- NCT00626847
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Proliferative Vitreoretinopathy
Imaging and Predictive Modelling of Proliferative Vitreoretinopathy.
Patients with retinal detachment are at risk of recurrence and failure of surgery requiring multiple surgeries due to a condition called proliferative vitreoretinopathy (PVR).
- Trial name
- NCT07682025
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Retinitis Pigmentosa
Safety and Efficacy of the Alpha AMS Subretinal Implant
The aim of this single-centre study is to assess the safety and efficacy of the Retina Implant Alpha AMS (Retina Implant AG, Reutlingen, Germany) in participants with severe visual impairment secondary to outer retinal…
- Trial name
- OX-RI (NCT02720640)
- Testing
- Implant 'on' vs implant 'off'
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Macular Degeneration
VEGF Gene Association With Response to Neovascular Age-related Macular Degeneration With Anti-VEGF Agents
The main purpose of this study is to investigate the association between VEGF gene polymorphism and the response to intravitreal drugs in neovascular age-related macular degeneration.
- Trial name
- NCT01655589
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Institute of Vision, Brasil
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