Clinical trials: Ocular Hypertension
Glaucoma Open-Angle
A Prospective Interventional Cohort Study to Evaluate the Efficacy and Safety of the AquaLumen, a Novel Filtration Procedure for the Treatment of Open Angle Glaucoma
The study will follow a group of patients with glaucoma disease that undergo a surgical procedure intended to reduce the intra-ocular pressure (IOP) for a period of one year.
- Trial name
- NCT06809647
- Testing
- Glaucoma surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- PLU Ophthalmic
Glaucoma
Examining The Efficacy, Safety And Improved Tolerability Of Travoprost BAK Free Ophthalmic Solution (Travatan-Z) Compared To Prior Prostaglandin Therapy
Examine the safety, tolerability and efficacy of travoprost benzalkonium chloride (BAK) free ophthalmic solution compared to either latanoprost or bimatoprost monotherapy.
- Trial name
- NCT00444665
- Testing
- Travatan-Z
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Alcon Research
Ocular Hypertension
Safety and Efficacy Study of Brimonidine/Timolol Fixed Combination in Patients With Glaucoma or Ocular Hypertension
The purpose of this study is to assess the safety and efficacy of Brimonidine/Timolol Fixed Combination in patients with glaucoma or ocular hypertension
- Trial name
- NCT00332384
- Testing
- brimonidine/timolol fixed combination
- Where
- United States
- Volunteers
- 573 people
- Sponsor
- Allergan
Glaucoma, Ocular Hypertension
1 Year Study Trav/Brinz QD Fixed Combination Versus COSOPT
Parallel, Multi-Center, Double-masked, Active controlled, three arm study comparing the IOP lowering efficacy and safety over 12 months of morning or evening instillations of Travoprost/Brinzolamide vs.
- Trial name
- NCT00767481
- Testing
- Travoprost/Brinzolamide, Cosopt
- Where
- Mexico
- Volunteers
- 6 people
- Sponsor
- Alcon Research
Open-Angle Glaucoma
A Study of the iStent in Combo With Cataract Surgery in Newly Diagnosed Open Angle Glaucoma or OH Patients.
The purpose of this study is to evaluate the safety and efficacy of the iStent trabecular micro-bypass stent in reducing intraocular pressure (IOP) in subjects with newly diagnosed open-angle glaucoma and subjects diagnosed with…
- Trial name
- NCT00326066
- Testing
- Glaucoma Surgery, cataract surgery only
- Where
- 9 sites in Austria, Germany and 3 more
- Volunteers
- 47 people
- Sponsor
- Glaukos Corporation
Glaucoma, Primary Open Angle
Prospective, Single Center Switching Study of 0.0015% Tafluprost Ophthalmic Solution in Primary Open-angle Glaucoma and Ocular Hypertension Patients With Corneal Disorders (Switching From 0.005% Latanoprost Ophthalmic Solution)
The objective of this study was to investigate the improving effect of corneal disorder in primary open-angle glaucoma and ocular hypertension patients, when switched from the 0.005% latanoprost ophthalmic solution (one drop at a…
- Trial name
- NCT04737928
- Testing
- Latanoprost, tafluprost
- Where
- Taiwan
- Volunteers
- 1 people
- Sponsor
- Santen Pharmaceutical (Taiwan) Co., LTD
Glaucoma, Ocular Hypertension
Real World Data Study Assessing The Persistency Of Xalacom And The Other Fixed Dose Combination Products, Duotrav And Ganfort, In The United Kingdom
The hypothesis is that there is no difference in persistency between Xalacom and the alternative fixed dose combination products (Duotrav and Ganfort) over a 12 month period.
- Trial name
- NCT01206361
- Testing
- XALACOM, Duotrav, Ganfort
- Volunteers
- 2,015 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Open-angle Glaucoma
A Multicenter Study of the Pigmentation in the Trabecular Meshwork After Two Years of Treatment With TRAVATAN 0.004% Ophthalmic Solution
The purpose of this study was to assess the pigmentation in the trabecular meshwork of patients who had been treated for at least 2 years with TRAVATAN compared with patients without exposure (or less than 1 month) to a…
- Trial name
- NCT01485822
- Testing
- Trabecular Meshwork Tissue Collection, Travoprost 0.004% ophthalmic solution
- Volunteers
- 88 people
- Sponsor
- Alcon Research
Open Angle Glaucoma (OAG)
Safety and Performance Study of the CyPass System Applier Model 241
This is a retrospective chart review of cases in which the CyPass Micro-Stent was implanted using the Model 241 Applier. The objective of this study is to characterize and evaluate the safety of the Model 241 Applier when used…
- Trial name
- RePASS (NCT02228577)
- Where
- Germany
- Volunteers
- 172 people
- Sponsor
- Transcend Medical, Inc.
Systemic Lupus Erythematosus
WEUKBRE5716: Steroid-related Damage in Systemic Lupus Erythematosus (Hopkins)
The study is designed to assess the association between steroid exposure and five potentially steroid-related adverse events within a cohort of individuals with systemic lupus erythematosus (SLE).
- Trial name
- NCT01616472
- Testing
- Cumulative corticosteroid exposure
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Glaucoma
Glaucoma Evaluation With the P200TE
Images captured on the P200TE device on glaucoma patients
- Trial name
- NCT06305481
- Testing
- P200TE
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Optos, PLC
Glaucoma
Brimonidine Purite 0.15% Versus Dorzolamide 2% Used as Adjunctive Therapy to Latanoprost
Evaluate the relative efficacy and tolerability of Alphagan P compared to Trusopt as adjunctive therapy
- Trial name
- NCT00348400
- Testing
- Brimonidine Purite 0.15%, Dorzolamide 2%, Latanoprost
- Where
- United States
- Sponsor
- Innovative Medical
Primary Open Angle Glaucoma, Ocular Hypertension
Safety and Efficacy Assessment of Monoprost® in Comparison With Lumigan® 0.01 % and Lumigan® 0.03% Unit Dose
Primary objective: The primary objective is to demonstrate the superiority of Monoprost® versus Lumigan® 0.01% and Lumigan® 0.03% Unit Dose in term of safety with respect to the assessment of conjunctival hyperaemia in the worse…
- Trial name
- NCT02017327
- Testing
- Monoprost, Lumigan 0.01%, Lumigan 0.03% Unit Dose
- Where
- France
- Volunteers
- 379 people
- Sponsor
- Laboratoires Thea
Open-Angle Glaucoma, Ocular Hypertension
Phase 3 Study to Evaluate IOP Lowering Therapy in Open Angle Glaucoma and Ocular Hypertension C-01-70
To compare intraocular pressure lowering effectiveness of a combination drug vs. two individual drugs dosed alone.
- Trial name
- NCT00047541
- Testing
- Alcon Investigational Agent
- Where
- United States
- Sponsor
- Alcon Research
Open-Angle Glaucoma, Ocular Hypertension
A Phase III Study of Brimonidine Tartrate Ophthalmic Solution, 0.15% in Patients With Open-Angle Glaucoma or Ocular Hypertension
The primary objective of this study is to compare the safety and efficacy of Brimonidine Tartrate Ophthalmic Solution, 0.15% in patients with open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00061529
- Testing
- Brimonidine Tartrate Ophthalmic Solution
- Where
- United States
- Sponsor
- Alcon Research
Glaucoma, Open-Angle, Cataract Senile
A Clinical Feasibility Study of the Aquea Intracanalicular Glaucoma Micro-coil Stent
The purpose of this research study is to evaluate the safety and effectiveness of the Aquea Intracanalicular Glaucoma Stent in lowering intraocular pressure (IOP) in patients with cataract and open angle glaucoma.
- Trial name
- NCT07698353
- Testing
- Aquea Zealix™
- Where
- Panama
- Volunteers
- 29 people
- Sponsor
- Aquea Health, Inc.
Ocular Hypertension, Primary Open Angle Glaucoma
Glaucoma Adherence Study, Spain
The purpose of this study is to evaluate adherence to DuoTrav® when reinforced by the use of the Travalert™ Dosing Aid.
- Trial name
- GAS (NCT00680329)
- Testing
- Travoprost 0.004%/timolol 0.05% fixed combination eye drops (DuoTrav), Travalert Dosing Aid
- Where
- Spain
- Volunteers
- 55 people
- Sponsor
- Alcon Research
Open-Angle Glaucoma, Ocular Hypertension
Safety and Efficacy Study of DE-104 Ophthalmic Solution to Treat Open-angle Glaucoma or Ocular Hypertension
To investigate safety, efficacy, and the dose-response relationship of DE-104 in lowering intraocular pressure in Japanese and Non-Japanese subjects with primary open-angle glaucoma or ocular hypertension.
- Trial name
- NCT00868894
- Testing
- DE-104 medium concentration, DE-104 high concentration, 0.005% latanoprost
- Where
- 6 sites in United States
- Volunteers
- 49 people
- Sponsor
- Santen Inc.
Glaucoma, Angle-Closure
Safety and Effectiveness of the XEN45 Glaucoma Treatment System in Patients With Angle Closure Glaucoma
This study will evaluate the safety and IOP-lowering effectiveness of XEN in patients with Angle Closure Glaucoma.
- Trial name
- NCT03362931
- Testing
- XEN45
- Where
- 16 sites in Australia, Canada and 4 more
- Volunteers
- 65 people
- Sponsor
- Allergan
Open Angle Glaucoma or Ocular Hypertension
A Long-term Study of DE-117 Ophthalmic Solution Monotherapy and Concomitant Use of DE-117 Ophthalmic Solution With Timolol Ophthalmic Solution in Patients With OAG or OH: RENGE Study
The purposes of this study are to evaluate the long-term safety and intraocular pressure-lowering efficacy of DE-117 ophthalmic solution monotherapy and concomitant use of DE-117 ophthalmic solution with timolol ophthalmic…
- Trial name
- NCT02822729
- Testing
- DE-117 ophthalmic solution, Timolol ophthalmic solution
- Where
- Japan
- Volunteers
- 125 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.