Clinical trials: Ocular Hypertension
Glaucoma
Macular Damage in Early Glaucoma and Progression
Glaucoma is the leading cause of irreversible blindness worldwide. This study aims to test a new method that may allow earlier diagnosis of glaucoma and better ways to monitor if it is getting worse.
- Trial name
- NCT02547740
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Columbia University
Primary Open-angle Glaucoma, Ocular Hypertension
Levobetaxolol Hydrochloride Eye Drops for Treatment of Primary Open-angle Glaucoma or Ocular Hypertension
To evaluate the safety and efficacy of Levobetaxolol in Chinese patients with glaucoma.
- Trial name
- NCT02617459
- Testing
- Levobetaxolol eye drops, Betaxolol eye drops
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Cataract, Ocular Hypertension
Evaluation of the Safety and Effectiveness of the Bimatoprost Implant System / IOL Combination in Patients With Ocular Hypertension or Mild to Moderate Open-angle Glaucoma
The goal of this clinical trial is to learn if the SpyGlass Pharma Bimatoprost Implant System / IOL Combination works to treat cataracts and either ocular hypertension or glaucoma.
- Conditions
- Cataract, Ocular Hypertension, Glaucoma
- Trial name
- NCT07154797
- Testing
- Bimatoprost Implant System / IOL Combination
- Where
- Honduras
- Volunteers
- 24 people
- Sponsor
- SpyGlass Pharma, Inc.
Pre-Eclampsia
Optic Nerve Sheath Measurement and Angiogenic Factors in Patients With Pre-eclampsia.
Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries.
- Trial name
- NCT06122220
- Testing
- ONSD+AF
- Where
- Panama
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Saint Thomas Hospital, Panama
Open Angle Glaucoma, Primary Open Angle Glaucoma
Safety and Effectiveness of the Hydrus Microstent
The purpose of this study is to assess the safety and effectiveness of the Hydrus Microstent for lowering intraocular pressure (IOP) in pseudophakic patients with open-angle glaucoma for whom IOP is not sufficiently controlled on…
- Conditions
- Open Angle Glaucoma, Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma, Pigmentary Glaucoma
- Trial name
- FRONTIER (NCT05198297)
- Testing
- Hydrus Microstent, Ophthalmic surgery
- Where
- 5 sites in United States
- Volunteers
- 33 people
- Sponsor
- Alcon Research
Ocular Hypertension
Safety and Efficacy Study of Bimatoprost/Timolol Fixed Combination in Patients With Glaucoma or Ocular Hypertension
The purpose of this study is to assess the safety and efficacy of Bimatoprost/Timolol Fixed Combination in patients with glaucoma or ocular hypertension
- Trial name
- NCT00332059
- Testing
- bimatoprost/timolol fixed combination
- Where
- 4 sites in United States, Austria and 2 more
- Volunteers
- 445 people
- Sponsor
- Allergan
Glaucoma
Improved Efficacy of Selective Laser Trabeculoplasty With the Addition of Rocklatan Post-treatment vs Artificial Tears Post-treatment
A randomized, single-site, parallel-group, prospective study of patients who are candidates for SLT, to study the effect of IOP change with Rocklatan vs artificial tears.
- Trial name
- NCT06819046
- Testing
- Rocklatan, Systane Ultra
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Colorado Ophthalmology Associates PC
Glaucoma, Ocular Hypertension
Safety, Tolerability and Preliminary Efficacy of Unilateral Latanoprost-loaded Punctual Plug -EXP-LP
Glaucoma is the most frequent cause of irreversible \& preventable blindness worldwide, affecting about 2% of the world's population in people over 40.
- Conditions
- Glaucoma, Ocular Hypertension, IOP
- Trial name
- EXP-LP (NCT03318146)
- Testing
- drug delivery system, XALATAN®
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shaare Zedek Medical Center
Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Increase
Assessment of Optic Sheat Diameter (ONSD) and Eyeball Transverse Diameter (ETD) Ratio Measurement From Ocular Ultrasound
The aim of this study is to evaluate the effects of different carbon dioxide gas insufflation pressures on the ultrasound-guided optic nerve sheath diameter in patients undergoing laparoscopic cholecystectomy and to determine the…
- Conditions
- Optic Nerve Sheath Diameter Measurement, Intracranial Pressure Increase, Laparoscopic Cholecystectomy Surgery
- Trial name
- ONSD ETD (NCT07784361)
- Testing
- Low Pressure Group, High Pressure Group
- Volunteers
- 68 people
- Sponsor
- Gaziantep City Hospital
Glaucoma
Fixating the Plate of Ahmed Valve to the Sclera Using a Flanged Prolene Suture
this study evaluated new technique for suturing the Ahmed valve device used to treat resistant types of glaucoma
- Trial name
- NCT06722794
- Testing
- Novel Technique for Fixating the Plate of Ahmed Valve to the Sclera Using a Single Flanged Prolene Suture
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Headache, Acute, Focal Neurologic Disease
Digital Ocular Fundus Photography in the Emergency Department: A New Application for Telemedicine?
The purpose of this study is to determine if non-dilated retinal photography in the emergency room improves the diagnosis of papilledema (optic nerve swelling) in patients with neurologic disease compared to direct ophthalmoscopy.
- Conditions
- Headache, Acute, Focal Neurologic Disease, Severely Elevated Blood Pressure, Acute Visual Loss
- Trial name
- NCT00873613
- Testing
- Use of Non-dilated retinal photography
- Where
- United States
- Volunteers
- 705 people
- Sponsor
- Emory University
Glaucoma
A Study Using Transorbital Alternating Current Stimulation for People With Glaucoma
This pilot study will test the preliminary efficacy and feasibility of an intervention protocol for one method of electric current stimulation, repetitive transorbital alternating current stimulation (rtACS), to treat visual…
- Trial name
- NCT03188042
- Testing
- rtACS Stimulation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- NYU Langone Health
Glaucoma
Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot Study
The aim of the present study is to develop a measurement protocol for optimal imaging of the anterior segment of the eye, including anterior chamber angle, Schlemm's canal, filtering bleb and pseudoexfoliation deposits on the…
- Trial name
- NCT02865473
- Testing
- Pilocarpine
- Where
- Austria
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Sjögren Syndrome, Pulmonary Hypertension
Early Detection of Pulmonary- and Pulmonary Vascular Disease in Sjögren Syndrome
According to the literature available pulmonary hypertension is present in 12 to 23% of patients suffering from Sjögren Syndrome. However epidemiological data are based on non-invasive measurements using echocardiography.
- Trial name
- NCT02752269
- Where
- Austria
- Volunteers
- 86 people
- Sponsor
- Medical University of Graz
Glaucoma
Investigation of the Glaukos® Trabecular Micro-Bypass System, Model iS3, in Subjects With Refractory Glaucoma
Prospective, multi-center, single-arm clinical trial to evaluate the safety and effectiveness of the Glaukos® Trabecular Micro-Bypass System Model iS3 (three stents per study eye) in subjects with refractory glaucoma.
- Trial name
- NCT03639870
- Testing
- Model iS3 three-stent trabecular micro-bypass system
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Glaukos Corporation
Glaucoma Eye
Changes in Eye Pressure in Glaucoma Patients Treated with Istent Inject W, Monitored by a Contact Lens Sensor
The purpose of this study is to compare the IOP-related fluctuations using the CLS (contact lens sensor) Sensimed Triggerfish in glaucoma patients before and after glaucoma surgery with iStent inject W under physiological…
- Trial name
- NCT06607705
- Testing
- Monitoring with contact lens sensor
- Where
- 2 sites in Spain
- Volunteers
- 53 people
- Sponsor
- Fundacio Privada Mon Clinic Barcelona
Glaucoma
Effect of SLT Location on Treatment Outcomes
Selective Laser Trabeculoplasty (SLT) is a glaucoma treatment that has been shown to effectively lower intraocular pressure by increasing aqueous outflow through macrophage recruitment.
- Trial name
- SLOS (NCT03164941)
- Testing
- Selective Laser Trabeculoplasty
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Glaucoma
Glaucoma Laser Assessment of Stability and Sustainability
The GLASS Study is designed to help researchers learn whether repeating a non-invasive laser treatment called DSLT (Direct Selective Laser Trabeculoplasty) can better control eye pressure in patients with early-stage glaucoma or…
- Trial name
- GLASS (NCT06963684)
- Testing
- Dual-Treatment Direct Selective Laser Trabeculoplasty (DSLT)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Twin Cities Eye Consultants
Patients With Primary Open Angle Glaucoma (POAG) or Ocular Hypertension (OHT)
Visual Outcomes of Vivity in Patients With Well Controlled Glaucoma
Glaucoma is a progressive optic neuropathy that results in a loss of contrast sensitivity and visual field if not detected and treated.
- Trial name
- NCT05075226
- Testing
- Vivity Extended Depth of Focus
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Open Angle Glaucoma
Study of ANX007 in Participants With Primary Open-angle Glaucoma
This is a double-masked, randomized, sham-controlled study evaluating two dose levels of ANX007 vs sham, administered as repeat Intravitreal (IVT) injections in patients with Primary Open-angle Glaucoma.
- Trial name
- NCT04188015
- Testing
- 2.5mg ANX007, 5.0mg ANX007
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Annexon, Inc.