Clinical trials: Ocular Surface
Ocular Discomfort
Evaluation of the VisuXL® Performance on Ocular Surface Discomfort
VisuXL® is a medical device that is effective in various ocular surface disorders (ocular dryness, changes in the continuity of the corneal and conjunctival surface, environmental stress, exposure to UV and ionizing radiation…
- Trial name
- NCT03844737
- Testing
- VisuXL®
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- VISUfarma SpA
Human Amniotic Membrane(AM)
Using Amniotic Membrane as the Carrier for ex Vivo Cell Culture for Cell Therapy in Ocular Surface Reconstruction
The use of amniotic membrane in ophthalmic surgery has been shown to provide an alternative for corneal and conjunctival reconstruction in many clinically challenging situations.
- Trial name
- NCT01341223
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Ptosis, Eyelid
Effect of Eyelid Patching After Ptosis Surgery
The goal of this randomized, controlled, observer-blinded study is to compare the effect of compression dressing after ptosis surgery.
- Trial name
- NCT05770973
- Testing
- Compression dressing (build by Kompressen, gauze swabs, Nobamed Paul Danz AG, Wetter, Germany and NOBALUMENAL® - steril, eye pad, Nobamed Paul Danz AG, Wetter, Germany
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Augenklinik LMU
Dry Eye, Acupuncture
Medical vs Acupuncture for Dry Eye
This randomized clinical trial was designed to evaluate the effectiveness of acupuncture combined with artificial tears compared to artificial tears alone in patients with moderate dry eye disease.
- Trial name
- ADET (NCT07185854)
- Testing
- Artificial tears, Traditional Chinese Medicine Acupuncture
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Nadide Koca
We Investigated the Effect of Sleep Deprivation on the Tear Film and Ocular Surface.
Sleep Deprivation Reduces Tear Secretion and Impairs the Tear Film
Tear film consists of three layers including outer lipid layer, aqueous layer and inner mucin layer.1,2 Lipid layer protects the aqueous layer of tear film from evaporation and mucin layer adhere the tear film to ocular surface.
- Trial name
- NCT02026986
- Testing
- sleep deprivation
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hallym University Medical Center
Cornea
The Marker Expression of Corneal Surface From Penetrating Keratopathy After Collagenase A Assisted COMET Case Series
In order to examine the cells of the corneal epithelium in the patients who receive corneal transplantation after collagenase A assisted cultivated oral mucosa epithelium transplant (CA-COMET), we analyzed the specimens from…
- Trial name
- NCT04066439
- Testing
- specimen
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- National Taiwan University Hospital
Presbyopia
A Prospective Study to Evaluate the Raindrop Near Vision Inlay in Presbyopic Patients With Treatments to Optimize the Ocular Surface Before Implantation
The objective of this study is to evaluate the Raindrop® Near Vision Inlay for the improvement of near vision in presbyopic patients with treatments to optimize the ocular surface before corneal inlay surgery.
- Trial name
- NCT03126877
- Testing
- Mitomycin C, Raindrop Near Vision Inlay
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Whitten Laser Eye
Ocular Surface Disease, Dry Eye Syndromes
Platelet Rich Plasma Eye Drops for Treatment of Ocular Surface Disease
The purpose of this study is to evaluate prospectively the efficacy of topical administration of autologous platelet rich plasma as monotherapy for the treatment of symptoms and clinical signs in cases affected by moderate to…
- Trial name
- NCT04608084
- Testing
- Autologous platelet rich plasma eye drops
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Limbus Corneae Insufficiency Syndrome
Safety Study of Stem Cell Transplant to Treat Limbus Insufficiency Syndrome
The purpose of the study is to determine whether allogenic bone marrow stem cell transplant is safe and effective in the treatment of limbus insufficiency syndrome versus allogenic limbus stem cell transplant.
- Trial name
- NCT01562002
- Testing
- Stem Cell with Amniotic Membrane Transplant
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Persistent Corneal Epithelial Defects, Dry Eye
Platelet Rich Plasma in Corneal Surface Diseases
The Aim of the study is to evaluate the efficacy of platelet rich plasma eye drops in the management of different corneal surface disorders.
- Trial name
- NCT05320172
- Testing
- Autologous platelet rich plasma eye drops
- Volunteers
- 70 people
- Sponsor
- Assiut University
Pterygium, Ocular Surface Cicatrizing Diseases
Assessment of Fibrin Glue in Pterygium Surgery and Other Forms of External Eye Surgery
Tisseel fibrin adhesive has been used extensively in many forms of surgery. Its use in eye surgery has been relatively recent. A few studies recently showed it was effective in securing conjunctival grafts in pterygium surgery…
- Trial name
- NCT00344201
- Testing
- Tisseel fibrin adhesive
- Where
- Singapore
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Sjogren's Syndrome, Dry Eye
AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Patients With SS Dry Eye
The objective of the present study was to evaluate the efficacy of autologous serum tears combined with 0.05% cyclosporin eye drop in treating Sjögren's syndrome dry eye and their effect on corneal nerves.
- Conditions
- Sjogren's Syndrome, Dry Eye, Ocular Surface Disease
- Trial name
- AST/SS (NCT06013436)
- Testing
- Autologous serum tears combined with 0.05% cyclosporin eye drop
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Keratoconus
Variability of Pentacam-derived Back Elevation Measurements in Keratoconus and Cross-linked Corneas
Primary objective of this study was to assess the intrasession, intersession and interobserver variability of the Pentacam-derived posterior corneal elevation measurements in keratoconus eyes and eyes that underwent Corneal…
- Trial name
- NCT01471873
- Testing
- Corneal Collagen Cross-linking (CXL)
- Where
- Greece
- Volunteers
- 67 people
- Sponsor
- Democritus University of Thrace
Dry Eye
OSIG-eye Drops Treatment for Dry Eye Disease
The main objective of this study is to assess the clinical and mechanistic effect of using Ocular surface immunoglobulin (OSIG) eye drops for treating Dry Eye Disease.
- Trial name
- NCT04510428
- Testing
- Ocular Surface Immune Globulin (OSIG)
- Where
- United States
- Sponsor
- University of Illinois at Chicago
Glaucoma
Switching From Preserved to Preserved-free Treatments for Glaucoma.
A 1-year prospective, randomized, investigator-masked trial comparing the confocal and clinical effects of treatment with unpreserved prostaglandins (tafluprost) versus preserved prostaglandins (latanoprost) in newly-diagnosed…
- Trial name
- NCT01433900
- Testing
- Tafluprost, Latanoprost
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Paolo Fogagnolo
Glaucoma
Safety and Tolerability of the Preservative-free Ophthalmic Solution PRO-122 Compared With Krytantek Ofteno®
Therapeutic indication: Ocular hypotensive Use: Primary open-angle glaucoma and ocular hypertension. Objectives: To evaluate the safety and tolerability of the preservative-free formulation PRO-122 manufactured by Sophia…
- Trial name
- PRO-122/I (NCT03966365)
- Testing
- PRO-122, Krytantek Ofteno®
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Tears; Excess, Eyelid Spasm
Effect of Topical Botulinum Toxin Eyedrop on Palpebral Fissure
The purpose of this research study is to test if Topical (applied to the surface of the eye) Botulinum Toxin temporarily lowers the upper eyelid and makes the eyelid appear less open and thereby affects the eye surface and…
- Trial name
- NCT06080438
- Testing
- Botulinum toxin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Miami
Dry Eye, Neuropathic Pain
Neurosensory Abnormalities in SymptomAtic Ocular Surface Patients (NASA)
This study is designed to measure how common nerve abnormalities are within a group of patients who feel discomfort within their eyes.
- Trial name
- NASA (NCT04838223)
- Testing
- Hyperosmolar Response, Proparacaine Challenge Test, Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) Optional; only for Contact Lens Wearers
- Where
- 16 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Tufts Medical Center
Dry Eye Disease (DED) , Diabetic Macular Edema
Association Between Dry Eye Disease and Diabetic Macular Edema
This study evaluates the association between dry eye disease (DED) and diabetic macular edema (DME) in adult patients at the Ophthalmology Department, Faculty of Medicine, Sohag University.
- Trial name
- DED-DME (NCT07392307)
- Testing
- Dry Eye Disease Assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Keratoconus, Pellucid Marginal Degeneration
Corneal Cross Linking and Topography Guided Excimer Laser Treatment
Topography guided laser treatment enables the surgeon to correct higher order aberrations in corneas with irregular astigmatism.
- Trial name
- NCT01682993
- Testing
- Topography guided Excimer Laser treatment and Corneal Cross Linking, Corneal Cross Linking
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna