Clinical trials: Ocular Surface Disease
Dry Eye, Meibomian Gland Dysfunction (Disorder)
Effect of Low-Level Light Therapy on Ocular Surface Parameters in Patients Undergoing Femto-Lasik Surgery
This study evaluates the role of perioperative low-level light therapy (LLLT) in reducing dry eye disease (DED) symptoms after femtosecond laser-assisted in situ keratomileusis (Femto-LASIK).
- Conditions
- Dry Eye, Meibomian Gland Dysfunction (Disorder), Ocular Surface Disease
- Trial name
- LLLT-Lasik (NCT07181668)
- Testing
- Low-Level Light Therapy
- Where
- Romania
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Ocular Surface Disease, Glaucoma
Hydroxypropylmethylcellulose 0.3% and Sodium Hyaluronate 0.18% for Ocular Surface Disease in Glaucoma
To study effect of hydroxypropylmethylcellulose 0.3% and sodium hyaluronate 0.18% in the treatment of ocular surface disease in glaucoma patients.
- Trial name
- NCT01284439
- Testing
- hydroxypropylmethylcellulose, sodium hyaluronate
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Glaucoma, Primary Open Angle Glaucoma
Tafluprost Preservative Free Switch Study
This study is conducted to document the effect of switching from preserved prostaglandin analogues monotherapy to preservative free tafluprost 0.0015%. The endpoints analyzed are side effect improvement in these patients.
- Conditions
- Glaucoma, Primary Open Angle Glaucoma, Ocular Hypertension
- Trial name
- NCT04654611
- Testing
- preservative free tafluprost 0.0015%
- Where
- Malaysia
- Volunteers
- 28 people
- Sponsor
- Tun Hussein Onn National Eye Hospital
Dry Eye Disease
Study on Safety and Performance of an Artificial Tear in Dry Eye Treatment in Subjects With Ocular Surface Inflammation
This is post-market study to evaluate the safety and efficacy of MDI - 101 a novel tear substitute for the treatment of dry eye (DE) in subjects with evidence of inflammation of the ocular surface.
- Trial name
- NCT04633863
- Testing
- Artificial tear MDI - 101
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- MD Italy
Dry Eye
Efficacy of 0.38% and 0.18% Sodium Hyaluronate Ocular Lubricants for Dry Eye in Adult Gazan Participants
The goal of this completed clinical trial was to determine if 0.38% and 0.18% sodium hyaluronate (SH) lubricant eye drops improve symptoms of moderate to severe dry eye disease (DED) in adult Gazan participants.
- Trial name
- NCT06851364
- Testing
- 0.38% Sodium Hyaluronate (SH) Eye Drops, 0.18% Sodium Hyaluronate Eye Drops, Normal Saline Eye Drops
- Where
- Palestinian Territories
- Volunteers
- 45 people
- Sponsor
- International Islamic University Malaysia
Dry Eye
Autologous Serum Efficacy Study in Patients With Severe Dry Eye
The purpose of this study is to compare the reduction in symptomatology of patients with severe dry eye treated with autologous serum and conventional artificial tears.
- Trial name
- NCT00779987
- Testing
- Autologous serum - Systane, Systane - Autologous serum
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- University of Chile
Dry Eye
Efficacy and Safety of Ocudox Lid Wipes Compared to Traditional Lid Cleaning
The use of povidone iodine solution for prophylaxis of endophthalmitis is well established for intraocular procedures like cataract surgery and for injections of anti-VEGF agents for retinal diseases such as age-related macular…
- Trial name
- NCT03763006
- Testing
- Eyelid cleaning
- Where
- Singapore
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Ocular Surface Disease, Neurotrophic Keratopathy Stage 1
Effect of Acoltremon Ophthalmic Solution 0.003% on Signs and Symptoms of Ocular Surface Disease in Stage I Neurotrophic Keratopathy Patients With Tear Deficiency
STUDY OBJECTIVE To assess if acoltremon 0.003% improves tear production in patients with Stage 1 Neurotrophic Keratopathy.
- Trial name
- NCT07502378
- Testing
- Patients will receive topical Acoltremon 0.003% ophthalmic solution BID in both eyes over an 8 week period., Alternative would be patient exiting the trial and starting on tears or other standard of care.
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of South Florida
Dry Eye
A Single Center, Open-Label Study to Evaluate the Ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to Detect Tear Film Stability Utilizing Miebo®
A study to investigate the ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to detect tear film stability utilizing Miebo®
- Trial name
- TFSTAB (NCT07722624)
- Testing
- Determine the ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to detect tear film stability utilizing Miebo®
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Eye Care Institute
Graft vs Host Disease, Sjogren's Disease
Cord Blood Serum in the Treatment of Ocular Surface Diseases
Human autologous serum (AS) eye drops have been successfully used in the treatment of severe ocular surface disorders and the enhancement of corneal wound healing, due to their growth factor (GF) content.
- Trial name
- NCT01234623
- Testing
- UCS eyedrops
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Tears; Excess, Eyelid Spasm
Effect of Topical Botulinum Toxin Eyedrop on Palpebral Fissure
The purpose of this research study is to test if Topical (applied to the surface of the eye) Botulinum Toxin temporarily lowers the upper eyelid and makes the eyelid appear less open and thereby affects the eye surface and…
- Trial name
- NCT06080438
- Testing
- Botulinum toxin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Miami
Dry Eye
Vevye + Flarex Combination Therapy for Dry Eye
This study evaluates the safety and efficacy of combination therapy with Vevye (cyclosporine ophthalmic solution) and Flarex (fluorometholone acetate ophthalmic suspension) in adults with moderate to severe dry eye disease.
- Trial name
- FLARE-VEV (NCT07553455)
- Testing
- Vevye(Cyclosporine 0.1% Ophthalmic Solution), Flarex
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Canyon City Eyecare
Dry Eye Disease (DED)
Telemedicine Evaluation of Dry Eye Disease Using a Portable Automatic Ocular Surface Imaging Device (PAOSID)
This study aims to evaluate the diagnostic accuracy and grading consistency of a mobile phone-attached portable automatic ocular surface imaging device (PAOSID) for assessing dry eye disease (DED).
- Trial name
- NCT06984549
- Testing
- DED diagnosis using PAOSID, DED diagnosis using slit lamp
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Chen Wei
Dry Eye Disease
Characterization of Subjective Discomfort in Patients With Tear Dysfunction
Characterization of subjective discomfort/pain in patients with ocular surface dysfunction in association with clinical and laboratory parameters, for a better understanding of the underlying pathogenic mechanisms.
- Trial name
- NCT06819631
- Where
- Italy
- Volunteers
- 12,000 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Nearsightedness, Farsightedness
Advanced Surface Ablation (ASA) vs Laser-Assisted In Situ Keratomileusis (LASIK)
The purpose of this combined retrospective and prospective chart review analysis is to investigate the safety, efficacy, and predictability obtained via Laser-Assisted In Situ Keratomileusis (LASIK) and Advanced Surface Ablation…
- Conditions
- Nearsightedness, Farsightedness, Astigmatism
- Trial name
- NCT00778570
- Where
- Canada
- Volunteers
- 4,000 people
- Sponsor
- Ottawa Hospital Research Institute
Glaucoma, Ocular Hypertension
Effects of Travatan Z and Xalatan on Ocular Surface Health
The purpose of this randomized, double-masked, parallel-group, multicenter study is to evaluate ocular surface effects after the administration of travoprost with SofZia® preservative system or Xalatan once daily for 12 weeks.
- Trial name
- NCT00708422
- Testing
- Travoprost ophthalmic solution 0.004% with SofZia® preservative system (TRAVATAN Z®), Latanoprost ophthalmic solution 0.005% (XALATAN®)
- Volunteers
- 231 people
- Sponsor
- Alcon Research
Glaucoma, Ocular Surface Disease
Treatment of Ocular Discomfort in Glaucoma Patients Using Multiple Topical Medications
To evaluate glaucoma patients' response to treatment with Xiidra, an FDA-approved drug for ocular surface discomfort, which will be prescribed as standard of care treatment.
- Trial name
- NCT04354545
- Testing
- Xiidra (Lifitegrast ophthalmic solution) 5%
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cornea
The Marker Expression of Corneal Surface From Penetrating Keratopathy After Collagenase A Assisted COMET Case Series
In order to examine the cells of the corneal epithelium in the patients who receive corneal transplantation after collagenase A assisted cultivated oral mucosa epithelium transplant (CA-COMET), we analyzed the specimens from…
- Trial name
- NCT04066439
- Testing
- specimen
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- National Taiwan University Hospital
Dry Eye Disease (DED), Glaucoma
Blinking Exercise Study
The goal of this clinical trial is to evaluate whether a structured blinking exercise can improve symptoms and signs of dry eye disease (DED) in adults with glaucoma who are using topical intraocular pressure-lowering…
- Trial name
- NCT07554937
- Testing
- Structured Blinking Exercise Training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Glaucoma, Ocular Surface Disease
Ocular Surface Disease in Glaucoma Patients on Long-Term Therapy
This cross-sectional study aims to determine the prevalence and severity of ocular surface disease among adult patients with glaucoma receiving long-term topical antiglaucoma medications.
- Conditions
- Glaucoma, Ocular Surface Disease, Dry Eye
- Trial name
- NCT07841912
- Volunteers
- 55 people
- Sponsor
- Assiut University