Clinical trials: Oesophageal Cancer Nos
Solid Tumor, Gastric Cancer
Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy Trial of BNT141 in Patients With Unresectable or Metastatic CLDN18.2-positive Gastric, Pancreatic, Ovarian and Biliary Tract Tumors
This study was planned as an open-label, multi-site, Phase I/IIa dose escalation, safety, and pharmacokinetic (PK) trial of BNT141 followed by expansion cohorts in patients with Claudin 18.2 (CLDN18.2)-positive tumors.
- Conditions
- Solid Tumor, Gastric Cancer, Gastroesophageal Junction Adenocarcinoma, Esophageal Adenocarcinoma
- Trial name
- NCT04683939
- Testing
- BNT141, Nab-paclitaxel, Gemcitabine
- Where
- 7 sites in United States, Canada
- Volunteers
- 13 people
- Sponsor
- BioNTech SE
Acute Lung Injury
A Trial to Evaluate the Impact of Lung-protective Intervention in Patients Undergoing Esophageal Cancer Surgery
The purpose of this trial is to determine whether low tidal volume during intraoperative one-lung ventilation could decrease the incidence rate of postoperative acute lung injury compared to "normal" tidal volume.
- Trial name
- NCT01194895
- Testing
- protective ventilation, conventional ventilation
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Shanghai Zhongshan Hospital
Squamous Cell Lung Cancer, Gastric Cancer
Phase Ib Study of Oral R01 Monotherapy in Advanced Solid Tumors
This is a Phase I（Ib）, open-label, single-arm clinical study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of R01 administered orally as monotherapy twice daily (BID) in patients…
- Conditions
- Squamous Cell Lung Cancer, Gastric Cancer, Esophageal Cancer
- Trial name
- NCT07806500
- Testing
- R01
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Beijing Anjianxi Bio-Medical Technology Co., Ltd.
Esophageal Cancer, Gastric Cancer
Matuzumab Treatment With Epirubicin, Cisplatin and Capecitabine (ECX) in Esophago-Gastric Cancer
The purpose of this study is to compare the effectiveness and safety of experimental treatment matuzumab and ECX chemotherapy, with ECX chemotherapy.
- Trial name
- MATRIX EG (NCT00215644)
- Testing
- Matuzumab, Epirubicin, Cisplatin
- Where
- 22 sites in Germany, Spain and 2 more
- Volunteers
- 72 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Cachexia, Oesophageal Cancer
REVOLUTION Surgery (REVOLUTION Surgery)
Some people with cancer suffer from muscle wasting, lose weight and feel tired. This process, termed cachexia, is a significant problem and can lead to a reduction in both quality and quantity of life.
- Conditions
- Cachexia, Oesophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT05642819
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Edinburgh
Esophageal Cancer
A Study of Perioperative Camrelizumab Combined With Chemotherapy in Patients With Resectable ESCC
The purpose of this study is to observe and evaluate the efficacy and safety of camrelizumab combined with albumin paclitaxel and cisplatin as perioperative treatment of advanced esophageal squamous cell.
- Trial name
- NCT05182944
- Testing
- A：non-pCR patients, B：non-pCR patients, A：pCR patients
- Where
- China
- Volunteers
- 130 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Barrett Oesophagitis With Dysplasia
Itraconazole to Prevent Recurrent Barrett's Esophagus
Recurrent Barrett's esophagus (BE) that occurs at the rate of 12.4%/year is the Achilles heel of the endoscopic treatment of high-risk BE.
- Trial name
- NCT05609253
- Testing
- Itraconazole in capsule form, Itraconazole in solution form
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Kansas Medical Center
Esophageal Cancer
Drainless Robot-assisted Minimally Invasive Esophagectomy
The aim of this study is the evaluation of two different chest drain management strategies in patients undergoing robot-assisted minimally invasive esophagectomy (RAMIE) for esophageal cancer with regard to perioperative…
- Trial name
- RESPECT (NCT05553795)
- Testing
- Early removal of chest drain, Chest drain
- Where
- Germany
- Volunteers
- 49 people
- Sponsor
- Technische Universität Dresden
Solid Tumor, Lymphoma
Study of Oral PXD101 in Patients With Advanced Solid Tumors or Lymphoma
This is a Phase I dose escalation study of PXD101 administered orally. Oral belinostat will be given once or twice daily at various dosing schedules to patients with solid tumors.
- Trial name
- NCT00413075
- Testing
- oral belinostat
- Where
- 6 sites in United States, Denmark and 1 more
- Volunteers
- 121 people
- Sponsor
- Valerio Therapeutics
Esophageal Cancer, Dysplasia
VEGF-targeted Fluorescence Near-Infrared (NIR) Endoscopy in (Pre)Malignant Esophageal Lesions
To improve detection of esophageal (pre)malignant lesions during surveillance endoscopy of patients at risk of developing malignancies, for example in Barrett's Esophagus (BE), there is a need for better endoscopic visualization…
- Trial name
- VICE (NCT02129933)
- Testing
- Bevacizumab-IRDye800CW, Near infrared fluorescence endoscopy platform
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- University Medical Center Groningen
Gastric Cancer, Esophageal Cancer
Magnetic Sentinel Lymph Node Mapping in Upper Gastro-Intestinal Cancer: A Feasibility Clinical Investigation
This is a multi-centre, partially blinded, side-by-side comparator study to assess the safety and tolerability, feasibility, and potential added diagnostic and clinical value of using the FerroTrace® and FerroMag Sentinel Lymph…
- Trial name
- MAGMAP (NCT05899985)
- Testing
- FerroTrace® and FerroMag Sentinel Lymph Node Mapping (SLNM) System
- Where
- 4 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Ferronova Pty Ltd
Esophageal Squamous Cell Carcinoma
Sequential Preoperative Penpulimab Combined With Chemoradiotherapy(CRT) for Locally Advanced Esophageal Squamous Cell Cancer
This study used an open single center study design to observe the efficacy and safety of Penpulimab combined with Chemoradiotherapy(CRT) in preoperative T2,3,4aN0-1-2M0 esophageal squamous cell carcinoma (ESCC).
- Trial name
- SPEED (NCT05561699)
- Testing
- Penpulimab Combined With CRT
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Shanghai Zhongshan Hospital
Frailty
Frailty In Thoracic Surgery for Esophageal Cancer
Background: In Demark we se an increasing life expectancy and an increasing incidence of esophageal cancer and gastroesophageal junction (c.esophagus), with an average age of 65 years at diagnosis time.
- Trial name
- NCT04145726
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Liver Cancer Stage IV, Gastric Cancer Stage IV
To Evaluate the Efficacy of NY-ESO-1-specific T Cell Receptor Affinity Enhancing Specific T Cell in Solid Tumors
The main purpose of this trial is to investigate the safety and tolerability of TAEST16001（TCR Affinity Enhancing Specific T cell Therapy）in the multi-line treatment failed advanced solid tumors except non small cell lung…
- Conditions
- Liver Cancer Stage IV, Gastric Cancer Stage IV, Esophageal Cancer, Stage IV, Bone and Soft Tissue Tumors
- Trial name
- NCT03159585
- Testing
- TAEST16001
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Zhujiang Hospital
Small Cell Lung Carcinoma, Non Small Cell Lung Carcinoma
Study of Carfilzomib With Irinotecan in Irinotecan-Sensitive Malignancies and Small Cell Lung Cancer Patients
The purpose of this study is to determine a well-tolerated dose of Carfilzomib in combination with Irinotecan (Phase 1b portion of the study) in subjects with relapsed small and non-small cell lung cancer or other…
- Conditions
- Small Cell Lung Carcinoma, Non Small Cell Lung Carcinoma, Irinotecan Sensitive Cancers
- Trial name
- NCT01941316
- Testing
- Carfilzomib, Irinotecan
- Where
- 8 sites in United States
- Volunteers
- 78 people
- Sponsor
- Cancer Research and Biostatistics Clinical Trials Consortium
Barrett's Esophagus, Esophageal Squamous Dysplasia
Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium
Assess Cryoablation (CryoBalloon Ablation cryotherapy) for treatment of Dysplastic Barrett's Esophagus, Esophageal Squamous Dysplasia and early Esophageal Cancer.
- Conditions
- Barrett's Esophagus, Esophageal Squamous Dysplasia, Esophageal Cancer
- Trial name
- ColdPlay2 (NCT02534233)
- Testing
- CryoBalloon
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Johns Hopkins University
Gastrointestinal Cancer
Artificial Intelligence and Cancer Staging in Upper Gastrointestinal Malignancies
Esophageal and stomach cancers, which constitute cancers of the upper region of the digestive system, are cancers that are frequently observed and unfortunately have a low rate of cured patients.
- Trial name
- NCT05648084
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Sebahattin Celik MD
Esophageal Cancer
Outside the Cage (OTC) Robotic Esophagectomy
The goal of this clinical trial is to evaluate the feasibility and safety of a novel non-intercostal robotic approach for minimally invasive esophagectomy (OTC MIE) in the treatment of esophageal cancer.
- Trial name
- NCT06735638
- Testing
- OTC MIE Esophagectomy
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Esophagus Cancer
Clinical Trial of Qizhu Yuling Prescription in the Prevention and Treatment of Esophagus Cancer
The purpose of this study is to evaluate the efficacy and safety of Qizhu Yuling prescription for postoperative esophagus cancer.
- Trial name
- NCT05626309
- Testing
- Qizhu Yuling Prescription
- Where
- 3 sites in China
- Volunteers
- 310 people
- Sponsor
- Jie Li
Esophagus Cancer, Stage III, Esophageal Gastric Cardia Type Metaplasia
An Exploratory Clinical Study of Apatinib for the 2nd Treatment of Esophageal Cancer or Esophageal and Gastric
The purpose of this Phase II, Open-label, single arm, exploratory study is to evaluate the efficacy and the safety of Apatinib（500mg/d）for the second - line treatment of esophageal cancer or esophageal and gastric
- Conditions
- Esophagus Cancer, Stage III, Esophageal Gastric Cardia Type Metaplasia, Esophagus Cancer, Stage IV
- Trial name
- NCT03285906
- Testing
- Apatinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
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