Clinical trials: Oesophageal Cancer Nos
Esophageal Cancer
Induction Immunochemotherapy Followed by Concurrent Chemoradiotherapy in Patients With ESCC.
This trial is conducted in patients with unresectable locally advanced esophageal squamous cell carcinoma. The investigators plan to enroll 60 patients with unresectable locally advanced esophageal cancer in Tianjin cancer…
- Trial name
- NCT06452602
- Testing
- Induction immunochemotherapy followed by Adebrelimab plus concurrent chemoradiotherapy, Induction immunochemotherapy followed by concurrent chemoradiotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Esophageal Cancer, Gastric Cancer
Aminocamptothecin in Treating Patients With Stomach Cancer or Cancer of the Esophagus
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of aminocamptothecin in treating patients with locally…
- Trial name
- NCT00003192
- Testing
- aminocamptothecin
- Where
- 7 sites in United States
- Volunteers
- 15 people
- Sponsor
- University of Chicago
Advanced MTAP-null Solid Tumors
A Study of Anvumetostat in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101)
The primary objective of Parts 1 and 2 of this study is to evaluate the safety, tolerability, and to determine the maximum tolerated dose (MTD) or recommended phase 2 dose (RP2D) of Anvumetostat alone and in combination with…
- Trial name
- MTAPESTRY 101 (NCT05094336)
- Testing
- Anvumetostat, Docetaxel, Comparator Anvumetostat Test Tablet
- Where
- 75 sites in United States, Australia and 12 more
- Volunteers
- 329 people
- Sponsor
- Amgen
Esophageal Cancer
AN0025 and Chemoradiotherapy Combination in Esophageal Cancer
This is an open-label, multicenter, phase Ib study to evaluate the safety, tolerability, and preliminary efficacy of AN0025 in combination with chemoradiotherapy (CRT) in patients with locally advanced/locally recurrent…
- Trial name
- NCT05191667
- Testing
- AN0025
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Adlai Nortye Biopharma Co., Ltd.
IMRT With or Without Concurrent Chemotherapy for Esophageal Cancer
Radiotherapy With or Without Concurrent Chemotherapy for Extensive Lymphatic Metastasis of Esophageal Cancer - 3JECROG P-03
The investigators aimed to compare elective nodal irradiation versus involved field irradiation with or without concurrent chemotherapy and the addition of consolidation chemotherapy for patients with extensive lymphatic…
- Trial name
- NCT03328234
- Testing
- SIB-IMRT, Paclitaxel, Platinum-Based Drug
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Chinese Academy of Medical Sciences
Esophageal Cancer, Salvage Radiotherapy
Simultaneous Integrated Boost for Mediastinal Lymph Node Recurrence After Radical Surgery of Esophageal Cancer
Esophageal cancer (EC) ranks the seventh most diagnosed malignant tumor (572,000 new cases) and the sixth cancer-related mortality (509,000 deaths) worldwide in 2018.
- Conditions
- Esophageal Cancer, Salvage Radiotherapy, Dose-escalation, Mediastinal Lymph Node Recurrence
- Trial name
- NCT03990532
- Testing
- treatment group(phase I), treatment group (phase II)
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ruijin Hospital
Esophageal Cancer (EsC)
Patient-Reported Symptom Care Versus Usual Care After Esophageal Cancer Surgery: A Single-Center Phase 3 Randomized Trial
Symptom management is fundamental to clinical care, and symptom monitoring is an effective means to detect potential adverse events early and prevent serious complications.
- Trial name
- NCT07211009
- Testing
- Patient-Reported Outcome (PRO)-Based Symptom Management, Conventional Management
- Volunteers
- 240 people
- Sponsor
- Sichuan University
Esophagus Cancer
Neoadjuvant Chemoradiotherapy Combined With PD-1 Antibody in Locally Advanced Esophageal Cancer
This study will evaluate the safety and feasibility of preoperative immune checkpoint therapy with concurrent Chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma.
- Trial name
- T+TP (NCT04177875)
- Testing
- Teripalimab
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Esophageal Cancer, Gastric Cancer
Laser Fluorescence in Cancer Surgical Treatment
The use of fluorescence for real-time evaluation of organ and tissue vascularization and lymph node anatomy is a recent technology with potential for the surgical treatment of cancer.
- Conditions
- Esophageal Cancer, Gastric Cancer, ColoRectal Cancer, Prostatic Neoplasms
- Trial name
- NCT03021200
- Testing
- Green indocianine
- Where
- Brazil
- Volunteers
- 270 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Esophageal Cancer, Radiotherapy Side Effect
IMRT With Carboplatin Versus IMRT With Carboplatin and Fluorouracil for Eldly Esophageal Cancer Patients
An open, single-center, randomized controlled phase II clinical trial to compare the efficacy and safety of conformal intensity modulated radiation therapy (IMRT) combined with carboplatin and IMRT combined with carboplatin and…
- Trial name
- NCT03910634
- Testing
- Fluorouracil, Intensity modulated radiation therapy, carboplatin
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Sun Yat-sen University
Cancer
Trial of Panitumumab/Cisplatin/Fluorouracil Combined With Radiation in Esophageal Cancer
The overall study objective is to evaluate the dose limiting toxicities and the recommended phase II dose of Panitumumab when combined with the standard of care treatment with cisplatin, fluorouracil and radiation in patients…
- Trial name
- NCT01128387
- Testing
- Panitumumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Wisconsin, Madison
Bronchial Carcinoma, Esophageal Carcinoma
Randomised Trial Evaluating the Benefit of a Fitness Tracker Based Workout During Radiotherapy
Evaluation of the impact of an activity tracker based fitness programme on the Qualitiy of Life after oncological therapy.
- Conditions
- Bronchial Carcinoma, Esophageal Carcinoma, Tumor of the Brain, Head and Neck Cancer
- Trial name
- OnkoFit II (NCT04517019)
- Testing
- Fitness tracker based activity training for Arm A and B. Booklet "physical training, exercise and cancer" and an introduction about physical activity during cancer therapy for Arm A, B, C
- Where
- Germany
- Volunteers
- 201 people
- Sponsor
- University Hospital Tuebingen
Laryngeal Cancer, Hypopharynx Cancer
A Novel Modified Tracheo-Esophageal Voice Prosthesis for Total Laryngectomy Patients
This study is being conducted at Healthcare Global Enterprises Ltd to evaluate the role of a novel Tracheo-Esophageal voice Prosthesis for total laryngectomy +/- partial pharyngectomy patients.
- Trial name
- TEP (NCT03039465)
- Testing
- Modified Trans-Esophageal Prosthesis
- Where
- India
- Volunteers
- 50 people
- Sponsor
- HealthCare Global Enterprise Ltd.
Esophageal Adenocarcinoma, Esophageal Cancer
Liquid Nitrogen Spray Cryotherapy Prior to Neoadjuvant Systemic Therapy in Esophageal Adenocarcinoma
This research study is for people who have locally advanced esophageal adenocarcinoma and are expected to receive chemotherapy. The purpose of this study is to compare the effectiveness of Liquid Nitrogen Spray Cryotherapy (LNSC)…
- Trial name
- NCT07222657
- Testing
- Standard of care chemotherapy, LNSC
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Case Comprehensive Cancer Center
Esophageal Cancer
Rehabilitative Strategies Following Oesophageal Cancer
The ReStOre trial is a multi-disciplinary intervention of exercise, diet and education for patients who have completed treatment for oesophageal cancer.
- Trial name
- ReStOre (NCT03314311)
- Testing
- Rehabilitation programme
- Where
- Ireland
- Volunteers
- 44 people
- Sponsor
- University of Dublin, Trinity College
Gastrointestinal Cancer
Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy
This is a Phase I study to evaluate the safety and tolerability of sacituzumab govitecan in combination with capecitabine for advanced gastrointestinal cancers after progression on standard therapy, and to assess correlation of…
- Trial name
- NCT06065371
- Testing
- Capecitabine, Sacituzumab govetican
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Henry Ford Health System
Advanced Solid Tumors, HER2 Mutation
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
Researchers are looking for a better way to treat people who have solid tumors with HER2-activating mutations. Before a treatment can be approved for people to take, researchers do clinical trials to better understand its safety…
- Trial name
- panSOHO (NCT06760819)
- Testing
- BAY2927088
- Where
- 54 sites in United States, Australia and 9 more
- Volunteers
- 111 people
- Sponsor
- Bayer
Survivorship
Development and Validation of a Survival Prediction Model for Esophageal Cancer Patients After Esophagectomy
In this retrospective study, we analyzed data from the Sichuan Cancer Hospital \& Institute Esophageal Cancer Case Management Database (SCH-ECCM Database) from January 2010 to December 2017.
- Trial name
- OSmodel (NCT06169930)
- Testing
- This was an observational study without any intervention
- Where
- China
- Volunteers
- 2,957 people
- Sponsor
- Yongtao Han
Oncology, Breast Cancer
The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study
The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further…
- Conditions
- Oncology, Breast Cancer, Prostate Cancer, Gynecologic Cancer
- Trial name
- MOMENTUM (NCT04075305)
- Testing
- Radiation therapy
- Where
- 18 sites in United States, Australia and 7 more
- Volunteers
- 8,000 people
- Sponsor
- UMC Utrecht
Esophageal Cancer, Malignant Neoplasm of Cardio-esophageal Junction of Stomach
Epigenetic Priming Using Azacitidine With Neoadjuvant Chemotherapy for Resectable Esophageal Cancer
The purpose of this study is to see whether giving azacitidine before each cycle of chemotherapy prior to surgery is safe.
- Trial name
- VEOX (NCT01386346)
- Testing
- Azacitidine, Oxaliplatin, Epirubicin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Weill Medical College of Cornell University
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