Clinical trials: Oesophageal Cancer Nos
Esophageal Cancer, Gastric Cancer
Irinotecan and Paclitaxel in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus or Stomach
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00020761
- Testing
- irinotecan hydrochloride, paclitaxel
- Where
- 4 sites in United States
- Volunteers
- 51 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Esophageal Cancer, Chemoradiation
Organ Motion and Early Tumor Response Measurement
To quantify motion based variation of the target volume of the primary tumor over the course of chemoradiotherapy in esophageal cancer patients, and to use this information to calculate appropriate PTV (planning target volume)…
- Trial name
- NCT02139488
- Testing
- Fiducial markers, Fiducial markers, Pet and MRI
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- The Netherlands Cancer Institute
Esophagus Cancer
Radiochemotherapy in Elderly Patients With Oesophagus Cancer
Phase II study of radiochemotherapy for elderly patients with oesophagus cancer.
- Trial name
- Chronos (NCT02879227)
- Testing
- Cisplatin, Oxaliplatin
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Immunotherapy, Chemotherapy
Clinical Study of Chemotherapy and Immunotherapy Combined With Lactobacillus Johnsonii in Patients With Multiple Irresectable Solid Tumors
This study plans to enroll 156 patients aged 18-75, who will be randomly divided into two groups to evaluate the clinical efficacy and safety of chemotherapy and immune therapy combined with Lactobacillus johnsonii in patients…
- Trial name
- NCT07191405
- Testing
- oral Lactobacillus johnsonii (1×10¹¹ CFU, twice daily)
- Volunteers
- 156 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lung Cancer, Esophageal Cancer
A Multi Tumor, Open Phase I Clinical Study on the Progression of First-line Anti-tumor Therapy Using Cardonizumab Combined With Pulsed Low-dose Rate External Irradiation (PLDR)
At present, the treatment methods for recurrent cancers are very limited. The immune checkpoint inhibitors (ICBs) is a promising new directions for recurrent lung cancer/ esophageal cancer / cervical cancer, but the clinical…
- Conditions
- Lung Cancer, Esophageal Cancer, Cervical Cancer
- Trial name
- NCT06232083
- Testing
- PLDR+Cardunizumab
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Anhui Provincial Hospital
HER-2 Positive Gastric Cancer, Gastrooesophageal Cancer
Trial of Afatinib in Combination With Weekly Paclitaxel in the Second Line Treatment
The investigators are doing this research program to find out if the investigational drug, afatinib which is a medication known to block the function of the ErbB2 protein might help standard chemotherapy, in particular…
- Conditions
- HER-2 Positive Gastric Cancer, Gastrooesophageal Cancer, Esophageal Cancer
- Trial name
- NCT02274012
- Testing
- Afatinib, Paclitaxel
- Sponsor
- Columbia University
Advanced Solid Tumor, Unresectable Solid Tumor
A Beta-only IL-2 ImmunoTherapY Study
This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a…
- Conditions
- Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer
- Trial name
- ABILITY-1 (NCT05086692)
- Testing
- MDNA11, Pembrolizumab (KEYTRUDA®)
- Where
- 25 sites in United States, Australia and 6 more
- Volunteers
- 160 people
- Sponsor
- Medicenna Therapeutics, Inc.
Esophageal Cancer, Gastro-esophageal Junction Cancer
Quality of Life With Esophageal Stent Trial
The aim of this study is to compare, specialist nurse home visits in patients with inoperable cancer in the esophagus or cardia, who are palliated with Self Expanding Metal Stent, to standard patient contact with regards to…
- Trial name
- QUEST (NCT01044511)
- Testing
- Home visits, standard
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Michael Bau Mortensen
Esophagojejunal Anastomotic Leak
Impact of Endo-vac Therapy for Esophago-jejunal Anastomotic Leak
The goal of this observational study is to assess the impact of endoscopic vacuum therapy in patients who underwent total gastrectomy due to gastric cancer and developed esophago-jejunal anastomotic leakage.
- Trial name
- ENDO-VAL (NCT07295236)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Clinical Oncology
Oesophageal Cancer, Esophageal Stent Stenosis
Esophageal Multisegmented FCSEMS for Malignant Strictures
Objective: To assess the safety and feasibility of the implementation of the esophageal multisegmented fully covered self-expandable metal stent (SEMS) for the palliation of patients with malignant dysphagia.
- Trial name
- EATERS (NCT04415463)
- Testing
- Multisegmented fully covered self-expandable metal stent
- Where
- Netherlands
- Volunteers
- 23 people
- Sponsor
- Radboud University Medical Center
Esophageal Cancer
Testing TH-302, in Combination With Preoperative Chemoradiotherapy, in Esophageal Cancer.
Open-label, single-center phase 1 study of an investigational agent TH-302 and standard chemoradiotherapy with a 3+3 dose escalation design through 3 dose levels.
- Trial name
- NCT02598687
- Testing
- TH-302, HX4 scan, Carboplatin
- Sponsor
- Maastricht Radiation Oncology
Carcinomas, Squamous Cell, Dysphagia
A Pilot Study of Acupuncture Treatment for Dysphagia
The current standard of care for advanced HNC is concurrent chemoradiation therapy (CRT), which has led to increased survival rates, but with significant acute and long-term toxicities.
- Trial name
- NCT00797732
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Dana-Farber Cancer Institute
Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial
This phase II/III trial compares the addition of nivolumab to the usual treatment of paclitaxel and ramucirumab to paclitaxel and ramucirumab alone in treating patients with gastric or esophageal adenocarcinoma that may have…
- Conditions
- Advanced Esophageal Adenocarcinoma, Advanced Gastric Adenocarcinoma, Advanced Gastroesophageal Junction Adenocarcinoma, Clinical Stage II Esophageal Adenocarcinoma AJCC v8
- Trial name
- NCT06203600
- Testing
- Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging
- Where
- 378 sites in United States
- Volunteers
- 224 people
- Sponsor
- National Cancer Institute (NCI)
Gastric Adenocarcinoma, Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma
Efficacy of Tirellizumab Combined With Oral, Intravenous and Abdominal Chemotherapy in Peritoneal Metastatic Gastric/Gastroesophageal Junction Adenocarcinoma
For peritoneal metastatic gastric/gastroesophageal junction adenocarcinoma (cT3-4NanyM1), PD-1 antibody combined with chemotherapy and hyperthermic intraperitoneal chemotherapy (HIPEC) can downstage tumor stage, increase the…
- Conditions
- Gastric Adenocarcinoma, Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma, Peritoneal Metastasis
- Trial name
- NCT06914687
- Testing
- Tislelizumab, S-1, Oxaliplatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fudan University
Esophageal Squamous Cell Cancer, Elderly Patients
Sequential Paclitaxel Chemotherapy and Radiotherapy as 1st Line Treatment for Elderly Esophageal Squamous Cell Cancer
Elderly patients with metastatic esophageal squamous cell carcinomas have poor prognosis and majority of them were intolerable to combined chemotherapy in China.
- Trial name
- NCT02016287
- Testing
- Sequential chemotherapy （paclitaxel 80mg/m2 d1,d8) and radiotherapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shen Lin
Prostate Cancer, Head and Neck Cancer
Online Adaptive Radiotherapy Using a Novel Linear Accelerator (ETHOS)
The study focuses on the scientific and clinical evaluation of online adaptive radiotherapy (ART) using the Varian/SHS ETHOS treatment system.
- Conditions
- Prostate Cancer, Head and Neck Cancer, NSCLC, SCLC
- Trial name
- ART-02 (NCT06116019)
- Testing
- Online adaptive radiation therapy
- Where
- Germany
- Volunteers
- 649 people
- Sponsor
- Charite University, Berlin, Germany
Barrett Esophagus, Esophageal Cancer
Raman Probe for In-vivo Diagnostics (During Oesophageal) Endoscopy
To develop and endoscopic Raman spectroscopy probe for delivery down and channel in an endoscope to make near instant assessments of the condition of the oesophagus without the need for expensive and distressing tissue removal…
- Trial name
- RaPIDE (NCT03468634)
- Testing
- endoscopy
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Subjects With Resectable and Localized Gastric Cancer, Subjects With Resectable Esophageal Cancer or Liver Cancer
Phase II Study of Neoadjuvant Immune Checkpoint Inhibitor in Patients With Resectable Gastrointestinal Cancers
This is a phase II, open-label, prospective single-centered study. Subjects who meet the inclusion/exclusion criteria will be allocated to appropriate cohorts: 1) gastric cancer, 2) esophageal cancer and 3) hepatocellular…
- Conditions
- Subjects With Resectable and Localized Gastric Cancer, Subjects With Resectable Esophageal Cancer or Liver Cancer, Subjects With Resectable Liver Cancer
- Trial name
- NeoChance (NCT04196465)
- Testing
- IMC-001
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Asan Medical Center
Cancer of the Head and Neck, Cancer of Lung
Real-time Activity Monitoring to Prevent Admissions During RadioTherapy
This study will aim to demonstrate that implementation of a rapid, multidisciplinary supportive care program for patients receiving chemoradiotherapy who are deemed to be at high risk for hospitalization based on real-time…
- Conditions
- Cancer of the Head and Neck, Cancer of Lung, Cancer of Esophagus, Cancer of Stomach
- Trial name
- RAMPART (NCT03102229)
- Testing
- Enhanced Supportive Care - Status Checks, Enhanced Supportive Care - Referrals
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Montefiore Medical Center
Esophageal Cancer, Patient-reported Outcomes
Dynamic Follow-up of Symptoms Based on Patient-reported Outcomes in Immunotherapy for Esophageal Cancer: a Prospective Multicentre Cohort Study (SPRING)
Immunotherapy shows satisfactory effectiveness and safety in patients with esophageal cancer. Immunotherapy-based regimens have a better survival benefit compared to previous chemotherapy and radiotherapy.
- Conditions
- Esophageal Cancer, Patient-reported Outcomes, Immunotherapy
- Trial name
- NCT06012318
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Guangdong Provincial People's Hospital
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