Clinical trials: Oesophageal Motility Disorder
Anesthesia
Risk of Gastric Reflux During Tulip vs GMA(Glottis Mask Airway) Airway
Glottis mask airway (GMA) is supraglottic airway device and is frequently used in patients undergoing general anesthesia. However, gastroesophageal reflux remains a risk during ventilation through supraglottic airway devices.
- Trial name
- TUGGER (NCT06527352)
- Testing
- glottis mask airway, tulip shaped, classical shaped
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Air Force Military Medical University, China
Gastroesophageal Reflux Disease
A Study to Compare PK, PD and Safety of the AD-214 and AD-2141
A study to compare safety, pharmacokinetics and pharmacodynamics of AD-214 to AD-2141 in healthy volunteers.
- Trial name
- NCT05062876
- Testing
- AD-214, AD-2141
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Addpharma Inc.
Gastroesophageal Reflux Disease
Double-dose Rabeprazole Accelerates and Sustains the Control of Symptoms in Patients With NERD
To the best of our knowledge, there has been no randomized controlled trial to compare double dose PPI therapy with standard one dose PPI therapy for NERD patients.
- Trial name
- DRNERD (NCT01391715)
- Testing
- rabeprazole, standard dose rabeprazole
- Where
- South Korea
- Sponsor
- Inje University
GERD, Acid Reflux, Treatment
Potassium Competitive Acid Blocker (PCAB) Test-Guided vs Physiologic Test-Guided Treatment in Patients With Typical Reflux Symptoms
The goal of this clinical trial is to learn if a short course of a potassium-competitive acid blocker (PCAB) test can guide treatment of adults with typical reflux symptoms as effectively as standard physiologic testing with…
- Trial name
- NCT07707011
- Testing
- PCAB-test guided
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Obesity, Morbid, Obesity, Abdominal
Long-term Follow-up After OAGB
This study follows patients who have undergone one-anastomosis gastric bypass (OAGB), a type of weight-loss surgery, to check for changes in the stomach and esophagus over time.
- Conditions
- Obesity, Morbid, Obesity, Abdominal, Ona Anastomosis Gastric Bypass, GERD
- Trial name
- NCT07125638
- Where
- Italy
- Volunteers
- 2,368 people
- Sponsor
- Azienda Sanitaria Locale Napoli 2 Nord
Asthma, Gastroesophageal Reflux Disease
Evaluate the Effects on Asthma Control of Rabeprazole Given Twice Daily in Subjects With Asthma.
The hypothesis for this study is that potent anti-secretory therapy with high dose PPI improves asthma control regardless of either asthma severity or the presence of GERD symptoms.
- Trial name
- NCT00214552
- Testing
- rabeprazole
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Associated Scientists to Help Minimize Allergies
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
Obesity, Obesity, Morbid
Biological Sample Repository for Gastrointestinal Disorders
The goal of this observational study has the purpose of collecting biological samples from obese patients undergoing evaluation for weight loss by means of medical or endoscopic therapies; and of post bariatric surgery patients…
- Conditions
- Obesity, Obesity, Morbid, Obesity, Primary, Gastro-Intestinal Disorder
- Trial name
- NCT05874726
- Testing
- Blood Collection, Urine Collection, Tissue Sample Collection
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
Barrett's Esophagus, Gastroesophageal Reflux Disease (GERD)
Epidemiology of Barrett's Esophagus: A Population Based Study
To assess attitudes toward screening for esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE) in the community. To develop a population based clinical risk factor prediction model for the diagnosis of BE and identify…
- Conditions
- Barrett's Esophagus, Gastroesophageal Reflux Disease (GERD), Olmsted County Resident
- Trial name
- NCT01286155
- Where
- United States
- Volunteers
- 534 people
- Sponsor
- Mayo Clinic
Asthma, Gastroesophageal Reflux Disease
Reflux Disease Therapy in the Management of Childhood Asthma-data Entry and Analysis Only
There have been a number of studies which attribute causality between reflux disease and asthma. In addition, clinicians typically treat chronic asthmatics with high dose acid suppressing medications (e.g. lansoprazole).
- Trial name
- NCT01536457
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Children's Center for Digestive Health Care
GERD
An Open, Randomized, Two Way Crossover Study Comparing the Effect of 20mg Esomeprazole Administered Orally and Intravenously as a 15 Minute Infusion on Basal and Pentagastrin-Stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD)
This study looks at the effect on basal and pentagastrin-stimulated acid output of 40 mg Esomeprazole (Nexium) administered orally and intravenously as a 15-minute infusion to people with symptoms of Gastroesophageal Reflux…
- Trial name
- NCT00629564
- Testing
- Esomeprazole
- Volunteers
- 60 people
- Sponsor
- AstraZeneca
Refractory Chronic Cough
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory chronic cough (RCC)
- Trial name
- MACS-1 (NCT05110144)
- Testing
- Duloxetine 30 MG, Duloxetine 60 MG, Amitriptyline 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Achalasia
Comprehensive Esophageal Diagnostics Study
The prospective clinical trial will study muscle fibrosis in relation to lower esophageal sphincter (LES) measurements on Functional Lumen Imaging Probe (FLIP) Topography (the novel technology that utilizes impedance planimetry)…
- Trial name
- NCT04641702
- Testing
- Atropine challenge, Esophageal muscle biopsy
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Gastroesophageal Reflux
A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of Vonoprazan in Adolescents With Symptomatic Gastroesophageal Reflux Disease
The primary objective of this study is to evaluate the pharmacokinetic profile of vonoprazan in adolescent participants with symptomatic gastroesophageal reflux disease (GERD).
- Trial name
- NCT05343364
- Testing
- Vonoprazan
- Where
- 10 sites in United States
- Volunteers
- 24 people
- Sponsor
- Phathom Pharmaceuticals, Inc.
Obese Adults
Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity
This study will assess whether a single subcutaneous dose of tirzepatide 7.5 mg , compared with saline placebo, increases total esophageal acid exposure time during a 96-hour wireless pH recording beginning about 48 hours after…
- Trial name
- NCT07893457
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastro -Oesophagal Reflux, Laryngo-pharyngeal Reflux
European TIF2.0 Registry
This is a European, multi-centre, prospective registry that aims to determine the safety and efficacy of transoral incisionless fundoplication, with or without concomitant hiatal hernia repair, for the treatment of patients with…
- Trial name
- EURO-TIF (NCT07395219)
- Testing
- Transoral incisionless fundoplication with or without concomitant hiatal hernia repair with the EsophyX device
- Where
- 7 sites in Austria, Italy and 5 more
- Volunteers
- 500 people
- Sponsor
- Cleveland Clinic London
Mitral Valve (MV) Regurgitation
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (FR)
A pilot study to evaluate the safety and performance of the MRace System to treat severe mitral regurgitation and to gather data on its performance thereby providing guidance for future clinical development.
- Trial name
- ACCESS-MR (FR) (NCT07757607)
- Testing
- Transcatheter mitral valve repair (MRace Implant and Delivery System)
- Volunteers
- 20 people
- Sponsor
- Polares Medical SA
Chest Pain, Gastrointestinal Reflux Disease
Dexilant Treatment in Gastrointestinal Reflux Disease (GERD Related Non Cardiac Chest Pain
The purpose of this study is to investigate a new treatment for non-cardiac chest pain (NCCP) related to gastrointestinal reflux disease (GERD), called Dexilant.
- Trial name
- Dexilant (NCT01637571)
- Testing
- Dexilant
- Where
- United States
- Sponsor
- University of Iowa
Gastroesophageal Reflux
The Influence of Hypnotic Medications on Sleep Arousal and Its Effect on Gastroesophageal Reflux
This is a continuation of a study that has already been completed in the division of gastroenterology (GI) looking at the effects of sleep medication zolpidem (Ambien) on subjects with Gastroesophageal reflux disease (GERD).
- Trial name
- NCT00462137
- Testing
- Sleep Studies
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Thomas Jefferson University
Achalasia, EGJ Outflow Obstruction
Safety and Efficacy of a Novel SpydrBlade Flexible Bipolar in POEM
Achalasia is an idiopathic motility disorder, primarily identified by the absence of esophageal peristalsis and the inability of the lower esophageal sphincter (LES) to relax properly.
- Trial name
- NCT07406945
- Testing
- SpydrBlade Flex
- Where
- 2 sites in Ecuador, Hong Kong
- Volunteers
- 73 people
- Sponsor
- Chinese University of Hong Kong