Clinical trials: Oesophagectomy
Surgical Procedures, Minimally Invasive
Comparison of Ivor Lewis and Tri-incision Approaches for Patients With Esophageal Cancer
Esophagectomy for esophageal cancer is a technically complex procedure which is associated with high perioperative mortality, even in high volume centers[1].
- Conditions
- Surgical Procedures, Minimally Invasive, Operative, Esophageal Neoplasms
- Trial name
- NCT02017002
- Testing
- Ivor Lewis, Tri-incision
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Anemia
Pilot Study of Epoetin Alfa for Patients Having Abdominal or Pelvic Surgery for Cancer
This pilot study is looking at how well epoetin alfa, given in the immediate post-operative period, works in reducing anemia and the need for transfusions.
- Trial name
- NCT00294203
- Testing
- Epoetin Alfa group
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Florida
Esophageal Adenocarcinoma
RAMIE Versus MIE for Resectable Esophageal Cancer, a Randomized Controlled Trial (ROBOT-2 Trial).
BACKGROUND: For patients with esophageal cancer, radical esophagectomy with 2-field lymphadenectomy is the cornerstone of the multimodality treatment with curative intent.
- Trial name
- ROBOT-2 (NCT04306458)
- Testing
- Minimally invasive esophagectomy, daVinci Xi system
- Where
- Germany
- Volunteers
- 218 people
- Sponsor
- University Medical Center Mainz
Anastomotic Leak, Esophageal Cancer
Assessment of Graft Perfusion and Oxygenation for Improved Outcome in Esophageal Cancer Surgery
After the esophagectomy, the stomach is most commonly used to restore continuity of the upper gastro-intestinal tract. The esophagogastric anastomosis is prone to serious complications such as anastomotic leakage (AL) The…
- Trial name
- EDOBS (NCT03587532)
- Testing
- Indocyanine green angiography, Hemodynamic evaluation, Biological and pathological markers of ischemia
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- University Hospital, Ghent
Esophageal Cancer
Preoperative Arterial Embolization Before Oncologic Esophagectomy as a Technique for Ischemic Gastric Conditioning
This retrospective monocentric comparative study aims to assess the efficacy of preoperative ischemic conditioning, in preventing anastomotic leakage in esophageal cancer surgery.
- Trial name
- NCT06312839
- Testing
- Collecting data from the medical record
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Esophageal Cancer, Adenocarcinoma, Esophageal
Preoperative Chemotherapy vs. Chemoradiation in Esophageal / GEJ Adenocarcinoma
The best treatment for resectable esophageal or gastroesophageal adenocarcinoma is unknown. Although an operation to remove the esophagus is the most common treatment, previous studies have shown that patients live longer when…
- Conditions
- Esophageal Cancer, Adenocarcinoma, Esophageal, Adenocarcinoma, Gastroesophageal Junction
- Trial name
- POWERRANGER (NCT01404156)
- Testing
- (Epirubicin Cisplatin 5-Fluorouracil / Xeloda) OR 5-Fluorouracil Leucovorin Oxaliplatin Docetaxel, Carboplatin paclitaxel plus concurrent radiotherapy
- Where
- 3 sites in Canada
- Volunteers
- 29 people
- Sponsor
- Dr. Gordon Buduhan
Anastomotic Leak Esophagus
Anastomotic Leaks in Esophageal Squamous Cell Carcinoma Patients After Trimodal Therapy
To investigate the clinical factors and preoperative treatment to the future anastomotic location of cervical esophagus that were correlated with anastomotic leaks in esophageal squamous cell carcinoma patients undergoing…
- Trial name
- NCT06556355
- Testing
- neoadjuvant chemoradiation and McKeown esophagectomy
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Qiaoqiao Li
Esophageal Cancer
Trial of Enteral Nutrition Enriched With Eicosapentaenoic Acid (EPA) in Upper Gastrointestinal Cancer Surgery
This study aims to examine whether providing tube feeding with a formula enriched with omega-3 fats is better than traditional standard tube feeding in terms of preserving nutritional status, improving immune function and…
- Trial name
- NCT00790140
- Testing
- Prosure, Ensure Plus
- Where
- Ireland
- Volunteers
- 120 people
- Sponsor
- University of Dublin, Trinity College
Esophageal Neoplasms
Esophagectomy: Sweet Versus Ivor-Lewis (ESVIL) (ECTOP-2001)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-2001. Esophageal carcinoma is an aggressive disease with a poor prognosis.
- Trial name
- NCT01047111
- Testing
- Esophagectomy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fudan University
Lung Neoplasms, Esophageal Neoplasms
The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery
The purpose of this study is to determine whether the use of different dose of LMWH compared with fondaparinux for thromboprophylaxis is efficacious and safety after thoracic surgery.
- Conditions
- Lung Neoplasms, Esophageal Neoplasms, Venous Thromboembolism
- Trial name
- NCT01267305
- Testing
- Fondaparinux, Nadroparin Calcium
- Where
- China
- Volunteers
- 362 people
- Sponsor
- Shanghai Zhongshan Hospital
Esophageal Cancer, Esophagus Cancer
Endoluminal Vacuum Therapy to Prevent Anastomotic Leakage After Esophagectomy Due to Esophageal Cancer
A prospective, multi-centre, exploratory and observational one-arm study to evaluate preventive Endoluminal Vacuum Therapy(pEVT) to prevent anastomotic leakage after esophagectomy due to esophageal cancer.
- Conditions
- Esophageal Cancer, Esophagus Cancer, Anastomotic Leak
- Trial name
- ESPY (NCT06097078)
- Testing
- Eso-SPONGE®
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Aesculap AG
Esophageal Cancer, Surgery
Conventional Oral Intake vs Delayed Oral Intake With Jejunostomy Feeding After Esophagectomy (JNS Study)
Comparison of nutritional and early surgical outcome between early and delayed oral feeding after esophagectomy for esophageal cancer
- Conditions
- Esophageal Cancer, Surgery, Jejunostomy; Complications, Nutrition Related Cancer
- Trial name
- JNS (NCT05318404)
- Testing
- Jejunostomy feeding
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Esophageal Cancer (EsC)
Non-intubated Versus Intubated Anesthesia in Thoracoscopic Esophagectomy for Esophageal Cancer
This is a prospective, single-center, non-inferiority randomized controlled trial designed to evaluate the perioperative safety and feasibility of non-intubated spontaneous ventilation anesthesia (NIV) compared to conventional…
- Trial name
- NCT07104838
- Testing
- Non-intubated spontaneous ventilation anesthesia
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Esophageal Cancer
Trial Comparing Side-to-Side Stapled and Hand-sewn Esophagogastric Anastomosis in Neck
Carcinoma esophagus is a common cause of dysphagia. Once dysphagia occurs, a majority of the tumours are advanced. Most of them would require some form of treatments for control of dysphagia and to improve the quality of life.
- Trial name
- NCT00497549
- Testing
- side-to-side stapled, hand sewn
- Where
- India
- Volunteers
- 174 people
- Sponsor
- All India Institute of Medical Sciences
Esophagus Cancer, Carcinoma Esophagus
Supercharged TRAM Evaluation in Cervical Esophagogastroplasty After Esophagectomy
Esophagectomy has high rates of morbidity and mortality, in many cases due to esophagus reconstruction. Anastomotic leakage and fistula are the main esophagectomy complications.
- Trial name
- Supercharged (NCT05954702)
- Testing
- Supercharged TRAM esophagectomy, Conventional Esophagectomy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Instituto do Cancer do Estado de São Paulo
Esophageal Squamous Cell Carcinoma, Surgery
PPIO-007 Correlation Analysis of Type II Diabetes Mellitus on Short-term and Long-term Outcomes of Patients With Esophageal Squamous Cell Cancer Undergoing Minimally Invasive Esophagectomy
To date, there is controversy as to whether type II diabetes mellitus is associated with adverse short- and long-term outcomes in patients with esophageal squamous cell carcinoma undergoing minimally invasive esophagectomy.
- Trial name
- NCT06333665
- Testing
- Whether there is type 2 diabetes mellitus before surgery
- Where
- China
- Volunteers
- 605 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Oesophageal Cancer, Gastric Cancer
Google Location History Following Oesophagectomy and/or Gastrectomy
Surgery is the mainstay of treatment for patients with early-disease esophageal and gastric cancer. Open surgery for oesophageal cancer commonly involves large incisions in the chest, which is associated with a high rate of…
- Conditions
- Oesophageal Cancer, Gastric Cancer, Survivorship, Quality of Life
- Trial name
- NCT05035602
- Testing
- Physical activity assessment
- Where
- United Kingdom
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Esophageal and/or Cardia Cancer, Esophagectomy
Paracetamol Absorption Technique as a Method for Measuring Gastric Tube Outlet
Retention of the gastric tube after esophagectomy is a clinically important problem, and there is a need of a simple method to evaluate emptying rate from the gastric tube after esophagectomy.
- Conditions
- Esophageal and/or Cardia Cancer, Esophagectomy, Gastric Pull-up Reconstruction
- Trial name
- NCT02158286
- Testing
- Measuring emptying rate from the gastric tube
- Where
- Sweden
- Volunteers
- 13 people
- Sponsor
- Region Skane
Esophageal Neoplasm, Laryngeal Neoplasms
Feasibility Study CORPPS
The incidence of cancer in France has increased by +135% to reach nearly 400,000 new cases in 2018. The ten-year cancer control strategy 2021-2030 and the health innovation plan have defined strategic axes.
- Trial name
- FAISA-CORPPS (NCT05406024)
- Testing
- Digital platform
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Lille
Esophageal Cancer
Assessment of a Modified Minimally Invasive Esophagectomy
This is a retrospective case series of a novel fully minimally invasive esophagectomy procedure for patients with primary esophageal cancer.
- Trial name
- NCT04219410
- Testing
- Fully minimally invasive esophagectomy
- Volunteers
- 142 people
- Sponsor
- Kaiser Permanente