Clinical trials: Olanzapine
Healthy
Acute Olanzapine and Lipid Response
Atypical antipsychotics are pharmaceutical drugs used to treat schizophrenia. Common side effects are weight gain, insulin resistance, and abnormal blood lipids.
- Trial name
- OLA (NCT04181385)
- Testing
- Olanzapine 10 milligram, Bromocriptine 5 milligram
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Anorexia Nervosa
Olanzapine Versus Placebo for Outpatients With Anorexia Nervosa
Anorexia Nervosa (AN) is a serious illness associated with substantial morbidity and mortality. Weight restoration is a treatment priority, and better treatments are needed.
- Trial name
- NCT01170117
- Testing
- Olanzapine
- Where
- 5 sites in United States, Canada
- Volunteers
- 152 people
- Sponsor
- New York State Psychiatric Institute
Major Depressive Disorder
The Study of Olanzapine Plus Fluoxetine in Combination for Treatment of Treatment Resistant Depression
The purposes of this study are to determine: Whether olanzapine plus fluoxetine in combination will help patients with treatment-resistant major depression.
- Trial name
- NCT00035321
- Testing
- Olanzapine, Fluoxetine
- Where
- 33 sites in United States, Canada
- Volunteers
- 600 people
- Sponsor
- Eli Lilly and Company
Bipolar Disorder, Schizoaffective Disorder
Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic Features
Aim: In a population of first episode manic patients with psychotic features, we want to compare the side effect profile, the degree of adherence and the subjective well being, as well as the efficacy of two treatments: The…
- Trial name
- NCT00202293
- Testing
- Olanzapine, Lithium, Chlorpromazine
- Where
- Australia
- Volunteers
- 83 people
- Sponsor
- Melbourne Health
Schizophrenia
A Study of Olanzapine-Samidorphan Tablets in Adults With Schizophrenia
The goal of this [clinical trial] is to [evaluate the safety and efficacy of olanzapine-samidorphan tablets] in [adults with schizophrenia].
- Trial name
- NCT06649214
- Testing
- Olanzapine-samidorphan；, Olanzapine
- Volunteers
- 654 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Senile Dementia, Alzheimer Type, Dementia, Alzheimer Type
A Comparison of Two Standard Therapies in the Management of Dementia With Agitation
The purpose of this study is to determine whether an antipsychotic medication alone or an antipsychotic medication in combination with divalproex is the most effective and safest way to treat agitation in elderly patients with…
- Conditions
- Senile Dementia, Alzheimer Type, Dementia, Alzheimer Type, Alzheimer Disease, Dementia
- Trial name
- NCT00208819
- Testing
- risperidone, quetiapine, olanzapine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Emory University
Psychosis, Substance Use Disorders
Clozapine Versus Olanzapine as Treatment for Comorbid Psychotic Disorder and Substance Use Disorder
The purpose of this trial is to determine if patients with comorbid psychotic disorder and substance use disorder will continue in treatment longer if treated with clozapine than with olanzapine, and will have greater reductions…
- Trial name
- NCT03857581
- Testing
- Clozapine, Olanzapine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Augusta University
Chemotherapy-induced Nausea and Vomiting
Olanzapine and 5-HT3 With or Without Dexamethasone to Prevent CINV
Nausea and vomiting caused by chemotherapy are considered by patients as the main side effects of cancer treatment, which affect the quality of treatment and life.At present, NCCN guidelines have recommended three or four drug…
- Trial name
- NCT05805800
- Testing
- 5HT3RA+Olanzapine, 5HT3RA+Olanzapine+Dexamethasone
- Where
- China
- Volunteers
- 275 people
- Sponsor
- Xingchen Peng
Schizophrenia
Trial Evaluating Three Fixed Doses of Paliperidone Extended-Release (ER) Tablets and Olanzapine in the Treatment of Patients With Schizophrenia
The primary objective of the double-blind phase of this study is to evaluate the efficacy and safety of 3 fixed dosages of paliperidone ER (3, 9, and 15 mg/day) compared with placebo in adult patients with schizophrenia
- Trial name
- NCT00083668
- Testing
- Paliperidone ER
- Volunteers
- 619 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acute Agitation, Behavioural Emergency
IM Olanzapine Versus Haloperidol or Midazolam
The purpose of this study is to determine whether intramuscular olanzapine is safer (fewer adverse events) and more effective (shorter time to sedation) than conventional haloperidol or midazolam when used in the management of…
- Trial name
- NCT02380118
- Testing
- Olanzapine, Haloperidol, Midazolam
- Where
- 6 sites in Hong Kong
- Volunteers
- 167 people
- Sponsor
- The University of Hong Kong
Schizophrenia
A Placebo-Controlled, Cross-Over Trial of Aripiprazole
This study is a ten-week, placebo-controlled, double-blind, cross-over, randomized trial of the novel antipsychotic agent, aripiprazole, added to 20 obese stable olanzapine-treated patients with schizophrenia or schizoaffective…
- Trial name
- NCT00351936
- Testing
- Aripiprazole
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association
Cannabinoid Hyperemesis Syndrome
Comparing Haloperidol to Olanzapine in the Treatment of Suspected Cannabinoid Hyperemesis in the Emergency Department
The aim of the study is to identify which medication (haloperidol or olanzapine) is most effective in treating nausea and abdominal pain associated with cannabinoid hyperemesis using a 10-point visual analog scale with intervals…
- Trial name
- CH2O (NCT07246187)
- Testing
- Olanzapine 10 milligram, Haloperidol
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Mercy Bon Secours Saint Vincent Medical Center
Postoperative Nausea and Vomiting
The Impact of Preoperative Olanzapine on Quality of Recovery After Discharge From Ambulatory Surgery
The primary objective of this phase 2 randomized controlled trial is to determine whether the pre-operative administration of olanzapine (5 mg PO) improves quality of recovery (assessed by the Quality of Recovery-40 (QoR-40)…
- Trial name
- NCT05676294
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 398 people
- Sponsor
- Yale University
Schizophrenia and Related Disorders, Drug Administration Schedule
"Extended" (Alternate Day) Antipsychotic Dosing
The study wishes to examine whether "extended" antipsychotic treatment, in this case, antipsychotic treatment every other day, is as effective as daily treatment.
- Conditions
- Schizophrenia and Related Disorders, Drug Administration Schedule, Drug Therapy, Antipsychotic Agents
- Trial name
- NCT04478838
- Testing
- Risperidone, Olanzapine, paliperidone
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre for Addiction and Mental Health
Schizophrenia
Efficacy of Lu 31-130 in Patients With Schizophrenia
The main purpose with the study is to explore the efficacy and safety of Lu 31-130 in patients suffering from schizophrenia compared to a standard antipsychotic drug.
- Trial name
- NCT00770744
- Testing
- Zicronapine, Olanzapine
- Where
- 21 sites in Czechia, France and 6 more
- Volunteers
- 93 people
- Sponsor
- H. Lundbeck A/S
Delirium, Agitation
Haloperidol vs Olanzapine for the Management of ICU Delirium
The purpose of this randomized clinical trial is to determine whether haloperidol is superior to olanzapine for the treatment of ICU acquired delirium.
- Trial name
- NCT00833300
- Testing
- Haloperidol, Olanzapine
- Where
- 2 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Richard Hall
Schizophrenia
Cognition, Functioning and Quality of Life
People affected by schizophrenia often experience poor concentration, lapses in memory and difficulty with completing tasks; and this set of problems are known as neuro-cognitive deficits.
- Trial name
- NCT00182442
- Testing
- Olanzapine & Quetiapine
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Hamilton Health Sciences Corporation
Schizophrenia, Schizoaffective Disorder
Olanzapine Versus Clozapine in Treatment Refractory Schizophrenia
The study involves a six-month, double-blind protocol during which eighty patients, across three sites around the country, will be randomly assigned to receive clozapine or olanzapine.
- Trial name
- NCT00179231
- Testing
- olanzapine vs. clozapine
- Volunteers
- 80 people
- Sponsor
- Vanderbilt University
Bipolar Disorder I or II
Validation of Multidimensional Assessment of THYmic States (MATHYS): A Study in a Population of Bipolar Patients Treated With Olanzapine
A non randomized study to validate the MATHYS Scale in a population of in and outpatients greater than or equal to 18 years of age, suffering from Bipolar Disorder I or II, and treated with olanzapine.
- Trial name
- NCT00259272
- Testing
- olanzapine
- Where
- 16 sites in France
- Volunteers
- 141 people
- Sponsor
- Eli Lilly and Company
Schizophrenic Disorders
Assessment of a Weight Management Program for Weight Gain in Patients With Schizophrenia
The purpose of this study is to develop the weight management program, which is combined with healthy diet, proper physical exercise, and behavior modification, related to patient's quality of life.
- Trial name
- NCT00485823
- Testing
- Olanzapine Hydrochloride, Weight Management Program
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Eli Lilly and Company