Clinical trials: Older Adults
Rhinitis, Allergic, Perennial
Once-Daily Investigational Nasal Spray In Adults And Adolescents With Perennial Allergic Rhinitis (PAR)
The primary objective of this study is to compare the efficacy and safety of GW685698X 100mcg once daily (QD) aqueous nasal spray with vehicle placebo nasal spray in adult and adolescent subjects (12 years of age and older) with…
- Trial name
- NCT00289198
- Testing
- FF
- Where
- 42 sites in United States, Australia and 7 more
- Volunteers
- 301 people
- Sponsor
- GlaxoSmithKline
Postoperative Delirium, Postoperative Recovery in Elderly Patients
Recovery After Upper Extrimety Surgery
The goal of this randomized clinical trial is to determine whether Bispectral Index (BIS)-guided general anesthesia improves postoperative cognitive recovery and overall quality of recovery in adults undergoing elective hand or…
- Conditions
- Postoperative Delirium, Postoperative Recovery in Elderly Patients, Postoperative Cognitive Dysfunction (POCD)
- Trial name
- Recovery (NCT07714928)
- Testing
- BIS-Guided General Anesthesia, Clinically Guided General Anesthesia
- Where
- Sweden
- Volunteers
- 112 people
- Sponsor
- Region Örebro County
Hip Fracture
Preventing Falls and Disability in Older Adults After Hip Fracture
Patients who have suffered a first hip fracture have a higher risk of falling and sustaining another hip fracture compared with age-matched adults who did not fracture.
- Trial name
- NCT00795028
- Testing
- Standard Care for people after hip fracture, Standard Care + exercise intervention
- Sponsor
- University of British Columbia
Congenital Heart Disease in Children
Impact on the Nitrogen Balance, Autonomy, Safety and Tolerance of Enteral Diets Made of With Nutrilon Without Lactose® Fortified by Concentration Versus by Maltodextrin and Oil Supplementation,After Surgery for Congenital Heart Disease, in Infants.
An adequate nutritional support after a cardiac surgery enhances the morbidity and mortality. After a cardiac surgery, the energy expenditure is estimated to be around 55 kcal/kg/d.
- Trial name
- DIETCHIRCARD (NCT03136900)
- Testing
- Nutrilon without lactose® fortified by concentration, Nutrilon without lactose® fortified by Maltodextrin and oil supplementation
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- Queen Fabiola Children's University Hospital
Risk of Falling in the Elderly
The Effect of Nurse-led Transtheoretical Model-Based Video Exercise Trainings on Fall Risk to Elderly People Living in Nursing Homes
The aim of this study is to examine the effect of video exercise trainings based on transtheoretic model given to elderly individuals living in nursing homes under the leadership of nurses on the risk of falling in elderly…
- Trial name
- NCT05655871
- Testing
- Transtheoretic Model Based Video Exercise Training, Standard Maintenance Practice
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Kastamonu University
Problematic Screen Use in Preschool Children, Anxiety Symptoms in Preschool Children
Effects of an SMS-Based Parenting Intervention on Anxiety Symptoms in Preschool Children
Excessive screen use and anxiety symptoms in preschool children have become increasingly prominent public health problems. This randomized controlled trial aims to determine whether, compared with a control group, an ecological…
- Conditions
- Problematic Screen Use in Preschool Children, Anxiety Symptoms in Preschool Children, Social-emotional Behavior Problems in Preschool Children
- Trial name
- NCT07728344
- Testing
- Ecological Momentary Parenting Intervention, General Pediatric Health Education
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- Anhui Medical University
Coronary Artery Disease, Sedentary Behavior
Sedentary Behavior Intervention for Older Adults With Coronary Heart Disease and Frailty
This study aims to evaluate the feasibility and effectiveness of a sedentary behavior intervention based on the Integrated Theory of Health Behavior Change (ITHBC) in older adults with coronary heart disease and frailty.
- Conditions
- Coronary Artery Disease, Sedentary Behavior, Prefrailty
- Trial name
- NCT07762898
- Testing
- ITHBC-Based Sedentary Behavior Intervention
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Gansu University of Chinese Medicine
Frail Elderly, Aged
Nurse Physical Activity Counseling in Primary Care
Aging veterans with functional impairments followed in primary care clinics were randomized to counseling for a walking plus strength exercise home-based exercise program or to health education by a nurse.
- Conditions
- Frail Elderly, Aged, Physical Fitness
- Trial name
- NCT00105781
- Testing
- Exercise counseling
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- US Department of Veterans Affairs
Generalized Anxiety Disorder
Antidepressant Treatment Plus Cognitive Behavioral Therapy for Generalized Anxiety Disorder in Older Adults
This study will assess whether adding cognitive behavioral therapy to the antidepressant escitalopram is effective in reducing anxiety in older adults with generalized anxiety disorder.
- Trial name
- NCT00601965
- Testing
- Escitalopram, Cognitive behavioral therapy (CBT)
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- Veterans Medical Research Foundation
Insomnia
A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia
To evaluate the long-term safety and efficacy of eszopiclone administered for 12 weeks in elderly subjects with primary chronic insomnia.Administration of eszopiclone 2 mg daily at bedtime for 12 weeks in elderly subjects with a…
- Trial name
- NCT00386334
- Testing
- Eszopiclone
- Where
- 82 sites in United States
- Volunteers
- 388 people
- Sponsor
- Sumitomo Pharma America, Inc.
Delirium, Critical Illness
Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery
"Postoperative delirium is a common and serious complication following cardiac surgery, particularly among older adults who require intensive care.
- Conditions
- Delirium, Critical Illness, Aged, Cardiopulmonary Bypass
- Trial name
- NCT07265128
- Testing
- Midazolam, Remimazolam
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Neonates, Infants Aged 0 Days to 12 Months Scheduled for Elective Surgery
Upper Airway Ultrasound to Predict Difficult Laryngoscopy in Neonates and Infants
Upper airway ultrasound (UA-US) has been utilized in adults to predict difficult laryngoscopy (Cormick-Lehane view 3 or 4) and difficult tracheal intubation (DTI) (≥3 intubation attempts) and with moderate-to-high sensitivity and…
- Trial name
- NCT07444528
- Testing
- Upper airway ultrasound
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Diabetes Mellitus, Type 2
Diabetes Resistance Training Adaptations in Elderly
This study aims to verify the effects of resistance training on neuromuscular, vascular and functional adaptations of elderly diabetics type 2.
- Trial name
- DRTAE (NCT02548000)
- Testing
- Resistance training, Stretching control
- Where
- 2 sites in Brazil
- Volunteers
- 40 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Alzheimer's Disease，Mild Cognitive Impairment
Cohort Study on Cognitive Decline in Elderly
Alzheimer's Disease (AD) prevention and control currently face severe challenges, with limited treatment options and effectiveness available. Once the disease progresses to the AD stage, it is essentially irreversible.
- Trial name
- NCT07093892
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Amyloid Cerebral Angiopathy, Alzheimer Disease
Florbetaben as an Amyloid Plaque Marker in Elderly Patients With Focal or Disseminated Superficial Hemosiderosis
The main objective of this study is to compare the distribution of Florbetaben (NEURACEQ: FBB) in the brain in amyloid cerebral angiopathy (ACA) manifested by isolated hemosiderosis in non-demented patients with that observed in…
- Trial name
- FBB ACC (NCT02664571)
- Testing
- Pet scan with FBB, MRI scan, APO E genotyping
- Where
- 2 sites in France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Delirium, Femoral Fracture
Family Caregiver Role in Decreasing Delirium in Older Patients With Fractured Femur Using HELP Principles.
The Hospital Elder Life Program (HELP) has been shown to reduce delirium in hospitalized patients. In this study a family caregiver will apply the principles of the HELP program in a structured manner following training by a…
- Trial name
- FamHelp (NCT05321771)
- Testing
- Family caregiver application of HELP principles
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rambam Health Care Campus
Pain, Acute, Child Behavior
The Effect of "Quantum-Touch" on Pain, Fear, and Anxiety of the Children
This research is a randomized controlled experimental study designed to determine the effect of the Quantum-Touch method applied during the vascular access procedure in children aged 7-12 years, on the level of pain, fear and…
- Conditions
- Pain, Acute, Child Behavior, Anxiety and Fear, Venipuncture Site Reaction
- Trial name
- NCT05828264
- Testing
- Quantum touch
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Trakya University
Aging
Trial of the Impact of the Electronic Frailty Integrated With Social Needs
Participants in Electronic Frailty Integrated with Social Needs (eFRIEND) will randomize to receive regularly scheduled in-person and telehealth contacts with a community health worker (CHW) or continue to receive standard of…
- Trial name
- NCT05293730
- Testing
- eFRIEND, Usual Care
- Where
- United States
- Volunteers
- 2,050 people
- Sponsor
- Wake Forest University Health Sciences
Sickle Cell Disease
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, flexible-adaptive, group-sequential study (Part A), followed by an open-label LTE period (Part B) to investigate the efficacy, and safety of…
- Trial name
- LIBRA (NCT06975865)
- Testing
- Rilzabrutinib
- Where
- 63 sites in United States, Belgium and 12 more
- Volunteers
- 192 people
- Sponsor
- Sanofi
Developmental Language Disorder and Language Impairment, Specific Language Impairment
Retrieval-Based Word Learning in Developmental Language Disorder During Book Reading II
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder and Language Impairment, Specific Language Impairment, Language Development
- Trial name
- NCT07048392
- Testing
- Retrieval-based word learning: Repeated Spaced Retrieval condition, Retrieval-based word learning: Repeated Study condition
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Purdue University