Clinical trials: Older Adults With Cancer
Acute Myelogenous Leukemia, Myelodysplastic Syndrome
Study of Dasatinib and All-Trans Retinoic Acid for Relapsed/Refractory and/or Elderly Patients With Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome
This is an open label, prospective, single institution dose-escalation study. The patient population includes non-induction candidate elderly patients with AML or MDS and/or patients with high-risk or relapsed/refractory AML or…
- Trial name
- NCT00892190
- Testing
- dasatinib (SPRYCEL), all trans retinoic acid (VESANOID)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Pittsburgh
Renal Cell Carcinoma (Kidney Cancer), Kidney Cancers
Targeted Abdominal CT in Conjunction With Lung Cancer Screening
Early detection through screening can improve cancer survival by identifying it when it's most treatable. The NHS now offers Lung Cancer Screening (LCS) assessments to people aged 55-74 who have ever smoked.
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Kidney Cancers, AAA - Abdominal Aortic Aneurysm, Renal Stones
- Trial name
- TACTICAL1 (NCT07171190)
- Testing
- Lung Cancer Screening Invitation Intervention, Abdominal scan intervention
- Where
- United Kingdom
- Volunteers
- 6,272 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Ovarian Cancer
Preference Study With Elderly Patients Recurrent Ovarian Cancer
Comparison of the patient compliance treosulfan oral vs. intravenous (defined as end of therapy for the patient)
- Trial name
- NCT00170690
- Testing
- Treosulfan
- Where
- Germany
- Volunteers
- 123 people
- Sponsor
- North Eastern German Society of Gynaecological Oncology
Cancer
Dyadic Life Review Intervention for Older Patients With Advanced Cancer and Alzheimer's Disease and Related Dementias and Their Caregivers
The purpose of this study is to evaluate the efficacy of Dyadic Life Review (DLR) therapy for reducing caregiver distress, measured by caregiver burden to capture the multifaceted experience of distress, among older adults with…
- Trial name
- NCT07796347
- Testing
- Dyadic Life Review
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Rochester
Common Warts
Topical 5-Fluorouracil (5FU) Plus Calcipotriol in Children With Palmoplantar Wart
Warts caused by the human papillomavirus (HPV) are one of the most common skin conditions among children. The prevalence of warts in school-aged children ranges from 10 to 20 percent.
- Trial name
- NCT06737406
- Testing
- Topical 5% fluorouracil cream, Topical 0.005% calcipotriol ointment
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Mazandaran University of Medical Sciences
Acute Myeloid Leukemia, Myelodysplastic Syndromes
DNA Hypomethylating Agents and Lenalidomide in Elderly Patients With Myeloid Malignancies in the US
The study aims to comprehensively analyze data from a large and unselected older AML population in the US, both treated and untreated.
- Trial name
- NCT02863458
- Where
- United States
- Sponsor
- The Cleveland Clinic
Acute Myeloid Leukemia
Efficacy of 5-azacytidine Added to Standard Primary Therapy in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia (AML)
The primary purpose of the study is to determine, whether the addition of 5-azacytidine to standard chemotherapy in elderly patients with newly diagnosed AML improves treatment results (event free survival).
- Trial name
- AML-AZA (NCT00915252)
- Testing
- azacitidine, standard chemotherapy (7+3 scheme): Daunorubicin, Cytarabine
- Where
- 27 sites in Germany
- Volunteers
- 214 people
- Sponsor
- University Hospital Muenster
Metastatic or Recurrent Head and Neck Squamous Cell Cancer
Phase II Trial of Carboplatin, 5-FU and Cetuximab in Elderly Fit (no Frailty) Patients With Recurrent/Metastatic HNSCC
The aim of the trial is to evaluate the clinical benefit (efficacy, safety, preservation of autonomy) of cetuximab-carboplatin-5FU combination as first line treatment of recurrent or metastatic head and neck squamous cell…
- Trial name
- ELANFIT (NCT01864772)
- Testing
- Carbo, 5FU, Cetuximab
- Where
- 2 sites in France
- Volunteers
- 85 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Advance Care Planning
Effects of Intervention on Hope, Anxiety, and Attitudes and Behavioral Intentions of Advance Care Planning in Older Adults With Cancer
The study aims to explore the impact of advance care planning on the attitudes, behavioral intentions, hopes, and anxiety of elderly people with cancer on advance care planning with the assistance of the "Advance Care…
- Trial name
- NCT06061107
- Testing
- The cartoon version of the "ACP for Seniors" brochure
- Where
- Taiwan
- Volunteers
- 82 people
- Sponsor
- National Taiwan University Hospital
Breast Cancer, Elderly
Caelyx Adjuvant in Elderly Breast Cancer
This is an open label Phase II study in elderly patients (65y or older) with early breast cancer who are candidate for adjuvant chemotherapy.
- Trial name
- NCT00284336
- Testing
- Caelyx, endoxan
- Where
- 2 sites in Belgium
- Volunteers
- 16 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Plasma Cell Myeloma
Exercise Prescription for the Improvement of Quality of Life in Elderly Patients With Multiple Myeloma
This trial studies how well exercise prescription works in improving quality of life in elderly patients with multiple myeloma. Engaging and adhering to an exercise program may improve functional status and quality of life and…
- Trial name
- NCT04100044
- Testing
- Exercise Counseling, Exercise Intervention, Questionnaire administration
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Thomas Jefferson University
Esophageal Cancer, Oesophageal Cancer
A Multicenter Open-label Phase II Trial to Evaluate Nivolumab and Ipilimumab for 2nd Line Therapy in Elderly Patients With Advanced Esophageal Squamous Cell Cancer
Cancer - including esophageal squamous cell cancer (ESCC) - is a disease of the elderly but little is known about the biology and progression of cancers in these patients.
- Conditions
- Esophageal Cancer, Oesophageal Cancer, Oesophageal Cancer Metastatic, Esophageal Cancer Metastatic
- Trial name
- RAMONA (NCT03416244)
- Testing
- Nivolumab, Ipilimumab
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- AIO-Studien-gGmbH
Mantle Cell Lymphoma
Acalabrutinib and Rituximab in Previously Untreated Mantle Cell Lymphoma
This is a phase II, single-arm, open-label, multicentre study of acalabrutinib and rituximab for elderly or frail patients with previously untreated mantle cell lymphoma.
- Trial name
- CARAMEL (NCT05004064)
- Testing
- Acalabrutinib, Rituximab
- Where
- 12 sites in United Kingdom
- Volunteers
- 48 people
- Sponsor
- University College, London
Oncologic Disorders, Tumor
The Needs and Burden of Family Caregivers of Older Adults With Cancer
Elderly cancer patients need more help from their relatives and for longer than young adults. Our hypothesis of research is that the needs and resources to help the couple " elderly patient/caregiver ", are at least in part…
- Trial name
- NCT02285296
- Testing
- personalized support program
- Where
- 2 sites in France
- Volunteers
- 78 people
- Sponsor
- University Hospital, Lille
Acute Myeloid Leukemia, Adult
Up-front Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia Patients Aged 65-75
Patients with acute myeloid leukemia aged 65-75 have a very poor prognosis, irrespective of the treatment strategy, including demethylating agents or conventional chemotherapy.
- Trial name
- NCT03902665
- Testing
- Up-front allogeneic hematopoietic stem cell transplantation (HSCT)
- Where
- Italy
- Volunteers
- 19 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Non-small Cell Lung Cancer
Study of Gleevec and Weekly Paclitaxel in Patients Aged 70 or Older With Advanced Non-small Cell Lung Cancer
This study will evaluate the clinical efficacy of combining Gleevec (imatinib mesylate), a PDGFR antagonist, with front-line, single-agent paclitaxel in a cohort of elderly patients with advanced, non-small cell lung cancer.
- Trial name
- 6137p (NCT01011075)
- Testing
- Imatinib mesylate, Paclitaxel
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- New Mexico Cancer Research Alliance
Metastatic Colorectal Cancer
Regorafenib in Metastatic Colorectal Cancer
The purpose of the study is to measure high grade (3-5) toxicity of regorafenib and to monitor the impact of treatment with regorafenib on the quality of life in older adults with metastatic colorectal cancer.
- Trial name
- NCT02466009
- Testing
- Regorafenib
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- University of Rochester
Moderate or Serious Haemophilia
Objective and Perceived Health Status of Elderly People With Moderate or Severe Haemophilia in France: an Ancillary Study of the FranceCoag Registry
Background: Elderly people with serious haemophilia (PwSH), i.e., with moderate or severe haemophilia, have major comorbidities due to consequences of haemophilia. Also, the comorbidities related to age are added.
- Trial name
- SENIORHEMO (NCT05218772)
- Testing
- Questionnaires
- Where
- 28 sites in France
- Volunteers
- 277 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Diffuse Large B Cell Lymphoma (DLBCL)
Mosunetuzumab and Polatuzumab Vedotin With Split-Dose CHP Chemotherapy for Elderly Patients With Diffuse Large B-Cell Lymphoma
This single-arm, interventional phase 2 study is designed to evaluate whether the inclusion of mosunetuzumab subcutaneous and polatuzumab vedotin (Mosun-Pola) to a split-dose CHP chemotherapy backbone will improve outcomes for…
- Trial name
- NCT06594939
- Testing
- Polatuzumab Vedotin, Mosunetuzumab, Cyclophosphamide
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Medical College of Wisconsin
Unspecified Adult Solid Tumor, Protocol Specific
Hsp90 Inhibitor AUY922 in Treating Older Patients With Advanced Solid Malignancies
This phase I trial studies the side effects and best dose of Hsp90 inhibitor AUY922 in treating older patients with advanced solid malignancies.
- Trial name
- NCT01602627
- Testing
- Hsp90 inhibitor AUY922, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Dale Shepard, MD, PhD
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