Clinical trials: Older Adults With Cancer
Non-small Cell Lung Cancer
A Study to Evaluate Effectiveness and Safety of Surgeries in Elderly NSCLC Patients
The trial was designed to compare effectiveness and safety of surgeries in the patients with non-small cell lung cancer
- Trial name
- NCT03429673
- Testing
- Surgeries
- Where
- 10 sites in China
- Volunteers
- 10,885 people
- Sponsor
- China-Japan Friendship Hospital
Colorectal Cancer, Neoplasm Metastasis
Study of Oxaliplatin, Capecitabine, and Bevacizumab to Treat Older Patients With Colorectal Cancer
Currently there is no one standard of care for older patients with metastatic colorectal cancer. The study will examine the tumor response to capecitabine, oxaliplatin, plus bevacizumab.
- Trial name
- NCT00120172
- Testing
- oxaliplatin, capecitabine, bevacizumab
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Geriatric Oncology Consortium
Acute Myeloid Leukemia
Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood
Quizartinib is an experimental drug. It is not approved for regular use. It can only be used in medical research. Children or young adults with a certain kind of blood cancer (FLT3-ITD AML) might be able to join this study if it…
- Trial name
- NCT03793478
- Testing
- Quizartinib, Fludarabine, Cytarabine
- Where
- 27 sites in United States, Belgium and 8 more
- Volunteers
- 65 people
- Sponsor
- Daiichi Sankyo
Cancer
Predicting Severe Toxicity of Targeted Therapies in Elderly Patients With Cancer
In order to assess the important issue of the safety of antiangiogenic TKI in geriatric population we set up this project which aims to identify, among clinical, biological, pharmacokinetic data, predictive factors for severe…
- Trial name
- PreToxE (NCT02751827)
- Testing
- Blood sample
- Where
- 2 sites in France
- Volunteers
- 312 people
- Sponsor
- Institut Bergonié
Multiple Myeloma
A Randomized Study With Oral Melphalan + Prednisone (MP) Versus Melphalan, + Prednisone + Thalidomide (MPT) for Newly Diagnosesd Elderly Patients With Multiple Myeloma
The aim of the study is to compare efficacy and toxicity of melphalan and prednisone versus meplhalan, prednisone and Thalidomide in elderly patients with multiple myeloma or patients with multiple myeloma but not eligible for…
- Trial name
- NCT01274403
- Testing
- Melphalan, Prednisone and Thalidomide
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Gruppo Italiano Studio Linfomi
Diffuse Large B Cell Lymphoma
Treatment of Elderly Patients With Diffuse Large B-cell Lymphoma
To explore the clinical features and efficacy evaluation of large b-cell lymphoma in old age.
- Trial name
- NCT03513601
- Testing
- (R)-CHOP regimen, (R)-CVP regimen
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Mingzhi Zhang
Glioma, Glioblastoma
Phase II Elderly/Frail Pts With Newly Diagnosed or Recurrent Malignant Glioma Treated With Cesium-131 GammaTile®
This is a phase 2, open-label clinical trial determining feasibility, safety, and tolerability of GammaTile® in elderly or frail subjects with newly diagnosed or recurrent malignant gliomas.
- Conditions
- Glioma, Glioblastoma, GBM, Glioma, Malignant
- Trial name
- ENDURANCE (NCT07821112)
- Testing
- GammaTile®
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Irvine
Multiple Myeloma
Daratumumab Based Response Adapted Therapy for Older Adults With Newly Diagnosed Multiple Myeloma
This is a Phase II study of daratumumab based therapies for older adults with multiple myeloma.
- Trial name
- NCT04151667
- Testing
- Daratumumab Injection, Dexamethasone Oral, Lenalidomide Pill
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Cancer
Geriatric Core Dataset (G-CODE) for Clinical Research in Elderly Cancer Patients
Older adults with cancer remain underrepresented in cancer clinical trials that establish new standards of care. Geriatric assessment (GA) is defined by geriatricians as a multidimensional interdisciplinary assessment of the…
- Trial name
- G-CODE (NCT03976531)
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Institut Bergonié
Acute Myeloid Leukemia
A Randomized Study of Gemtuzumab Ozogamicin (GO) With Daunorubicine and Cytarabine in Untreated Acute Myeloid Leukemia (AML) Aged of 50-70 Years Old
The main objective of this study is to compare conventional chemotherapy: daunorubicin and the Aracytine and this chemotherapy in combination with the monoclonal antibody used Mylotarg in divided doses.
- Trial name
- NCT00927498
- Testing
- conventional chemotherapy (AraC + Daunorubicin),, Mylotarg associated with conventional chemotherapy (AraC + Daunorubicin),
- Where
- 19 sites in France
- Volunteers
- 280 people
- Sponsor
- Acute Leukemia French Association
Colorectal Cancer
Dyadic Intervention for Psychological Distress of Patients With Colorectal Cancer and Their Spouses
The overall aim of the study is to evaluate the effects of a dyadic intervention on mutuality, psychological strengths (i.e., illness cognition and dyadic coping), illness-related communication, psychological distress, and QoL…
- Trial name
- NCT06326437
- Testing
- 6-week dyadic intervention
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sun Yat-sen University
Hematological Malignancies
Nonmyeloablative Stem Cell Transplant in Elderly
The study aimed to evaluate the efficacy of a nonmyeloablative conditioning consisting of fludarabine and total body irradiation in patients older than 60 years of age
- Trial name
- NCT00382759
- Testing
- stem cell transplant
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Advanced Non Small Cell Lung Cancer
Nivolumab and Ipilimumab Versus Chimiotherapy in First Line Treatment in PS 2 or Elderly in Advanced NSCLC Patients
Lung cancer is the most common cancer in the world and the leading cause of cancer-related deaths in Western countries. Unfortunately, at the time of diagnosis, the majority of patients already have metastatic disease and a…
- Trial name
- eNERGY (NCT03351361)
- Testing
- Nivolumab + Ipilimumab, Chemotherapy
- Where
- 30 sites in France
- Volunteers
- 217 people
- Sponsor
- Rennes University Hospital
Multiple Myeloma
Randomized Phase II Study in Elderly Patients With Newly Diagnosed Multiple Myeloma
To compare the efficacy and safety of bortezomib, lenalidomide and dexamethasone in elderly frail patients with newly diagnosed multiple myeloma.
- Trial name
- KMM1910 (NCT04277845)
- Testing
- Bortezomib, Lenalidomide, Dexamethasone
- Where
- South Korea
- Volunteers
- 49 people
- Sponsor
- Samsung Medical Center
Caregiver, Lobectomy Patient
Physical Activity Intervention Before and After Surgery in Older Adults With Lung Cancer and Their Family Caregivers
This trial studies whether a telephone-based physical activity intervention before and after lung cancer surgery can be provided to older patients and their caregivers.
- Conditions
- Caregiver, Lobectomy Patient, Lung Carcinoid Tumor, Lung Non-Small Cell Carcinoma
- Trial name
- NCT04085081
- Testing
- E-mail, Exercise Intervention, Quality-of-Life Assessment
- Volunteers
- healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Acute Myeloid Leukemia
Efficacy Study of Anti-KIR Monoclonal Antibody as Maintenance Treatment in Acute Myeloid Leukemia (EFFIKIR)
Double-Blind Placebo-Controlled Randomized Phase 2 Study evaluating the efficacy of lirilumab (IPH2102/BMS-986015) as Maintenance Treatment administered in elderly patients with Acute Myeloid Leukemia (AML) in first complete…
- Trial name
- EFFIKIR (NCT01687387)
- Testing
- IPH2102 at 0.1 mg/kg, IPH2102 at 1 mg/kg
- Where
- 43 sites in France
- Volunteers
- 152 people
- Sponsor
- Innate Pharma
Fractures, Bone, Fragility
Factors Associated With Future Fractures in Middle-aged Men and Women
From prospectively collected health and life-style data and anthropometric data in the Malmo Diet and Cancer (MDC) cohort identify factors that predicts or are associated with forthcoming fracture in middle-aged men and women.
- Conditions
- Fractures, Bone, Fragility, Life Style
- Trial name
- MDCFract (NCT04151732)
- Testing
- Physical activity, alcohol, tobacco, Hormonal factors, Cardiovascular disease
- Where
- Sweden
- Volunteers
- 30,351 people, healthy volunteers welcome
- Sponsor
- Lund University
Fragility, Cancer
Frailty Evaluation in Elderly Population With Cancer
The Comprehensive Geriatric Assessment (CGA) is, still today, barely established in the standard practice. Although the different scientific societies recommend a CGA in elderly population affected with cancer at first visit, the…
- Trial name
- ELDERLY (NCT03101631)
- Testing
- Comprehensive Geriatric Assessment (CGA)
- Volunteers
- 62 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Diabetes Mellitus, Diabetes
The Occurence of Pancreatic Cancer Studied in Association With Newly Diagnosed Diabetes in the Elderly
The aim of this study is to accomplish the early diagnosis of pancreatic cancer, in patients over 60 years of age with newly diagnosed diabetes. Only patients with type 2 diabetes are meant to be included.
- Conditions
- Diabetes Mellitus, Diabetes, Diabetes Mellitus, Type 2, Diabetes type2
- Trial name
- NODES (NCT04164602)
- Where
- Hungary
- Volunteers
- 2,522 people
- Sponsor
- University of Pecs
Acute Myeloid Leukemia, Adult
Azacytidine, Venetoclax Plus Minus Quizartinib for First Line Older/Unfit AML Patients (VENP-A-QUI)
The goal of this clinical trial is to learn if Venetoclax+Azacytidine+Quizartinib works better than standard therapy (Venetoclax+Azacytdine) to treat naïve adult patients with acute myeloid leukemia (AML) who are not suitable for…
- Trial name
- VENP-A-QUI (NCT07478991)
- Testing
- Azacitidine, Venetoclax, Quizartinib
- Where
- 52 sites in Spain
- Volunteers
- 376 people
- Sponsor
- PETHEMA Foundation
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