Clinical trials: Older Adults With Cancer
Non-small Cell Lung Cancer
Surgical Treatment of Elderly Patients With cT1N0M0 Non-small Cell Lung Cancer Comparison Between Sublobar Resection and Lobectomy
The role of sublobar resection(Wedge resection or anatomic segmentectomy) for small(≤ 2cm) early stage non-small cell lung cancer has been studied by Lung Cancer Study Group and is being studied by several ongoing trials.
- Trial name
- STEPS (NCT02360761)
- Testing
- VATS, Thoracotomy
- Where
- 6 sites in China
- Volunteers
- 339 people
- Sponsor
- Peking University People's Hospital
Acute Lymphoblastic Leukemia
Treatment of Older Adults With Acute Lymphoblastic Leukemia
The purpose of this study is to determine the safety and effectiveness of a multi-drug regimen (which includes prednisone, vincristine, cytarabine, doxorubicin, 6 mercaptopurine, and methotrexate) which is considered standard…
- Trial name
- NCT00973752
- Testing
- Prednisone, Vincristine, Doxorubicin
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Acute Myeloid Leukemia
Everolimus (RAD001) in Elderly Patients With Acute Myeloid Leukemia
The main goal of this study is to assess the safety and tolerability of RAD001 in combination with low-dose cytarabine in acute myeloid leukemia patients unfit for intensive chemotherapy.
- Trial name
- NCT00636922
- Testing
- RAD001(Everolimus)
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Bayside Health
Acute Myeloid Leukemia, Adult
Decitabine in Combination With Low-dose Cytarabine in Elderly Patients With Acute Myeloid Leukemia
This prospective multicenter clinical study was designed to assess the efficacy and safety of decitabine in combination with low-dose cytarabine induction treatment for elderly patients with newly diagnosed acute myeloid leukemia…
- Trial name
- NCT02985372
- Testing
- Decitabine, Cytarabine
- Volunteers
- 30 people
- Sponsor
- Chunyan Ji
Glioblastoma Multiforme
Radiosurgery for Glioblastoma Multiforme
Conventional radiation for 6 weeks is not well tolerated by the elderly. Shorter courses (over 3-5 weeks) of radiation have been shown to be equivalent in outcome the elderly- particularly in patients who are generally in poor…
- Trial name
- NCT00456612
- Testing
- CyberKnife
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Beth Israel Deaconess Medical Center
Elderly Metastatic Breast Cancer Population
Elderly Metastatic Breast Cancer: Pertuzumab-Herceptin vs Pertuzumab-Herceptin-Metronomic Chemotherapy, Followed by T-DM1
Chemotherapy and HER2 targeted agents can improve survival significantly in metastatic breast cancer. Chemotherapy however is associated with significant side-effects and can impact on Quality of Life and functionality in older…
- Trial name
- NCT01597414
- Testing
- Pertuzumab + trastuzumab, Pertuzumab + trastuzumab + metronomic chemotherapy
- Where
- 30 sites in Belgium, France and 6 more
- Volunteers
- 80 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Leukemia
Physical Activity in Older Patients With Acute Myeloid Leukemia Undergoing Chemotherapy
RATIONALE: Physical activity sessions may help improve physical function, quality of life, and symptoms caused by chemotherapy in older patients with acute myelogenous leukemia.
- Trial name
- NCT00554489
- Testing
- exercise intervention
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Wake Forest University Health Sciences
Locally Advanced Esophageal Squamous Cell Carcinoma
Consolidation of Toripalimab After Chemoradiotherapy in Elderly Esophageal Cancer (EC-CRT-007)
Although definitive chemoradiotherapy (CRT) is the standard treatment option for unresectable locally advanced esophageal cancer, elderly patients tolerate intravenous concurrent CRT less well with age and comorbidities.
- Trial name
- EC-CRT-007 (NCT06187597)
- Testing
- S-1, Toripalimab, Intensity-modulated radiotherapy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Sun Yat-sen University
Breast Cancer, Physical Activity
Physical Exercise in the Quality of Life and Physical Fitness of Elderly Women With Breast Cancer
Among the possibilities of intervention to minimize the effects of cancer treatment, the exercises are efficient in improving the physical fitness and quality of life of the elderly in treatment.
- Conditions
- Breast Cancer, Physical Activity, Physical Fitness, Quality of Life
- Trial name
- NCT03226782
- Testing
- Short intervention protocol, Long intervention protocol
- Volunteers
- 68 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Gastric Cancer, Adenocarcinoma of the Esophagogastric Junction
Oxaliplatin and 5-Fluorouracil With or Without Docetaxel in Elderly Patients (>65 y) With Stomach and Esophagus Cancer
In this trial, FLOT will be evaluated as therapy option for elderly patients (>65 years) with advanced gastric cancer in comparison to the well established FLO scheme.
- Trial name
- NCT00737373
- Testing
- Docetaxel, 5-Fluorouracil, Oxaliplatin
- Where
- Germany
- Volunteers
- 143 people
- Sponsor
- Krankenhaus Nordwest
Colorectal Cancer
The Effect of IoC on Analgesia for Elderly Patients With Postoperative Effectiveness
The morbidity of colorectal cancer and the surgery number among elderly is growing. The investigators need to provide more advanced and specific monitoring technology for these patients.
- Trial name
- NCT02827682
- Testing
- Angel-6000D Multiparameter Anesthesia Monitor (IoC), BIS VISTA Monitor (BIS)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Lung Cancer, Non-small Cell Lung Cancer
Comprehensive Geriatric Assessment in Elderly Non-Small Cell Lung Cancer Patients
Lung cancer is responsible for one of the highest incidences of cancer-related mortality globally, and non-small cell lung cancer (NSCLC) accounts for the biggest subtype of lung cancer.
- Trial name
- NCT05230888
- Testing
- Questionnaires about symptoms
- Where
- United Kingdom
- Sponsor
- University of Hull
Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific
Sirolimus in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery
This clinical trial studies sirolimus in treating patients with solid tumors that are metastatic or cannot be removed by surgery. Sirolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth
- Trial name
- NCT01791088
- Testing
- sirolimus, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Chicago
Lymphoblastic Leukemia, Acute
Tyrosine Kinase Inhibitors and Low Intensity Chemotherapy in Ph+ ALL
The use of imatinib in combination with chemotherapy is now considered as the gold standard for the treatment of Ph+ ALL. The complete remission (CR) rate is 90% versus 20% to 40% with chemotherapy alone.
- Trial name
- EWALL_OBS (NCT02888977)
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Versailles Hospital
CLL, B-cell
Retrospective Study: Efficacy and Safety of Chlorambucil + Rituximab in CLL Patients
This is a non interventional study to evaluate the efficacy and safety of Chlorambucil plus Rituximab as firstline therapy in elderly and/or unfit patients affected by B-cell Chronic Lymphocytic Leukemia (B-CLL).
- Conditions
- CLL, B-cell, Small Lymphocytic Lymphoma, Untreated B-CLL
- Trial name
- NCT01862445
- Where
- 20 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Men, Life Style
Dietary Effects on Weight Loss and Lipid Profile in Sedentary Men
Negative-calorie diet is among the popular dieting guides for weight loss; however, there is still little knowledge about this method.
- Conditions
- Men, Life Style, Lipid Metabolism Disorders, Obesity
- Trial name
- NCT03082794
- Testing
- NCD, LCD
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- P.L.Shupik National Medical Academy of Post-Graduate Education
Esophageal Cancer, Chemoradiotherapy
Sintilimab After Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma
This trial is a prospective, randomized, controlled, multicenter, phase II clinical study to evaluate the efficacy and safety of sintilimab as consolidation therapy in elderly patients with esophageal cancer who did not progress…
- Conditions
- Esophageal Cancer, Chemoradiotherapy, Sintilimab, Immunotherapy
- Trial name
- NCT06413342
- Testing
- Sintilimab
- Where
- China
- Volunteers
- 191 people
- Sponsor
- Zhejiang Cancer Hospital
Esophageal Squamous Cell Carcinoma, Chemoradiotherapy
Phase III Study of Concurrent Radiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma (ESO-Shanghai 15)
So far, there is no specific clinical guideline for elderly patients (>75 yr) with esophageal squamous cell carcinoma (ESCC). Patients with locally advanced ESCC were enrolled and randomly assigned to either definitive…
- Conditions
- Esophageal Squamous Cell Carcinoma, Chemoradiotherapy, Survival
- Trial name
- NCT04519905
- Testing
- Paclitaxel plus carboplatin, radiotherapy
- Where
- 3 sites in China
- Volunteers
- 320 people
- Sponsor
- Fudan University
Non Small Cell Lung Cancer Metastatic
Atezolizumab in Elderly Patients With Advanced Non-Small-Cell Lung Cancer and Receiving Carboplatin Paclitaxel Chemotherapy
Non Small Cell Lung Cancer (NSCLC) remains the leading cause of death by cancer in the world. Because of the increase in lung cancer incidence with age and the increase of life expectancy, about half of the patients are patients…
- Trial name
- ELDERLY (NCT03977194)
- Testing
- Carboplatin, Paclitaxel, Atezolizumab
- Where
- 68 sites in France
- Volunteers
- 510 people
- Sponsor
- Intergroupe Francophone de Cancerologie Thoracique
Non-Small Cell Lung Cancer
OSI-774 (Erlotinib, Tarceva) in Elderly Patients
The purpose of this research study is to determine if OSI-774 (Tarceva) is effective in the treatment of non-small cell lung cancer and to further study its side effects.
- Trial name
- NCT00200395
- Testing
- Tarceva
- Where
- 4 sites in United States
- Volunteers
- 30 people
- Sponsor
- Montefiore Medical Center
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