Clinical trials: Older Adults With Cancer
Rectal Cancer
External Beam Radiotherapy Combined With Endorectal High-dose-rate Brachytherapy in Elderly and Frail Patients With Rectal Cancer
ACO/ARO/AIO-22 - External beam radiotherapy combined with endorectal high-dose-ratebrachytherapy in elderly and frail patients with rectal cancer. A prospective multicentre trial of the German Rectal Cancer Study Group.
- Trial name
- ACO/ARO/AIO-22 (NCT06729645)
- Testing
- radiotherapy
- Where
- 4 sites in Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital of Cologne
Colorectal Cancer
Laparoscopic Colorectal Resection in Elderly
This is a nested cohort study of OAMBP-01. Patients over 70 years old were enrolled into the data-analysis. The purpose of this study was to examine the feasibility and safety of laparoscopic colorectal resection in elderly…
- Trial name
- NCT05563441
- Testing
- laparoscopic surgery
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Inoperable Squamous Cell Cancer of the Head and Neck
Study of a Simplified Geriatric Evaluation Performed by Oncologists Prior to Cancer Treatment by Radiotherapy or Chemotherapy in Subjects Aged 70 Years or Older With Inoperable Squamous Cell Cancer of the Head and Neck
Use by Oncologists of Validated Geriatric Assessment Tools: G8 Screening Test and Certain Tests for Thorough Geriatric Evaluation
- Trial name
- ELAN-ONCOVAL (NCT03614936)
- Testing
- Geriatric Screening Test G8, Geriatric fragility test GERICO
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
NSCLC
Mono Versus Polichemotherapy in Non Small Cell Lung Cancer (NSCLC) Elderly Patients
Between 10% and 25% of newly diagnosed stage IIIB/stage IV patients currently receive single agent chemotherapy regimens. A significant proportion of these patients will be elderly (70 years of age) and many oncologists would…
- Trial name
- NCT00754364
- Testing
- Pemetrexed/Carboplatin, Gemcitabine
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Armando Santoro, MD
Non-Small Cell Lung Cancer (NSCLC), Rehabilitation
Wireless Wearable Home Prehabilitation for Older Adults With NSCLC
This randomized controlled trial evaluates the efficacy and safety of a home-based prehabilitation program using wireless wearable monitoring devices in older patients (aged 65-85 years) with non-small cell lung cancer scheduled…
- Conditions
- Non-Small Cell Lung Cancer (NSCLC), Rehabilitation, Thoracic Surgery, Prehabilitation
- Trial name
- NCT07809763
- Testing
- Digital Home-Based Prehabilitation, Standard Perioperative Care
- Where
- China
- Volunteers
- 196 people
- Sponsor
- West China Hospital
Non-Small-Cell Lung Carcinoma
Trial to Evaluate Radiotherapy With or Without CBDCA in Elderly Patients With Non-Small Cell Lung Cancer (JCOG0301)
The purpose of this study is to evaluate whether radiotherapy with carboplatin will result in longer survival than radiotherapy alone in elderly patients with unresectable stage III NSCLC.
- Trial name
- NCT00132665
- Testing
- A: Radiotherapy alone, B: CBDCA and Radiotherapy
- Where
- 37 sites in Japan
- Volunteers
- 200 people
- Sponsor
- Japan Clinical Oncology Group
HPV Infections, Cervical Cancer Stage IIa
Immune Persistence After the Whole Vaccination Shcedule With Recombination Quadrivalent HPV Vaccine
To access the immune persistence of Chinese women aged 9-45 years after receiving quadrivalent HPV vaccine with the immunization schedule of 0, 2 and 6 months.
- Conditions
- HPV Infections, Cervical Cancer Stage IIa, Vaginal Cancer, Genital Wart
- Trial name
- NCT05371353
- Where
- 2 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Breast Cancer
Myocet Plus Endoxan for Older Patients With Breast Cancer
This study will evaluate the efficacy, safety and effect on quality of life of liposomal-encapsulated doxorubicin in combination with cyclophosphamide as first or second line treatment of older patients (≥ 70 years old) with…
- Trial name
- NCT01120171
- Testing
- Cyclophosphamide, Liposomal-encapsulated doxorubicin
- Where
- 11 sites in Greece
- Volunteers
- 64 people
- Sponsor
- Hellenic Oncology Research Group
Cervical Cancer
Concurrent Chemoradiotherapy for Cervical Cancer in Elderly Women
The purpose of this study is to evaluate the efficiency and safety of weekly Cisplatin /Liposome paclitaxel concurrent chemoradiothrapy in the treatment of locally advanced cervical cancer in elderly women.
- Trial name
- NCT01594099
- Testing
- irradiation, Cisplatin, liposome paclitaxel
- Volunteers
- 45 people
- Sponsor
- Xi'an Jiaotong University
Human Papillomavirus Infection, HPV
Human Papillomavirus in Young People Epidemiological Research 4
Anal cancer is overrepresented among gay, bisexual and other men who have sex with men (MSM), particularly those living with HIV.
- Conditions
- Human Papillomavirus Infection, HPV, HPV Infection, Anal Cancer
- Trial name
- HYPER4 (NCT05587738)
- Where
- Australia
- Volunteers
- 500 people
- Sponsor
- Monash University
Gastric Cancer
Disitamab Vedotin Combined With Sintilimab as First-line Treatment of Elderly Patients With Gastric Cancer
This study aims to explore the safety and efficacy of Disitamab vedotin combined with Sintilimab in elderly patients with HER2 overexpression Gastric Cancer. This is a single-arm exploratory clinical study.
- Trial name
- NCT05720533
- Testing
- Disitamab Vedotin Combined With Sintilimab
- Volunteers
- 20 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Pancreatic Cancer Non-resectable
Stereotactic Radiotherapy vs Best Supportive Care in Unfit Pancreatic Cancer Patients
SUMMARY Rationale: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, its incidence increases with age. Many patients with localized (non-metastatic) PC have significant comorbidities, advanced age or a…
- Trial name
- PANCOSAR (NCT05265663)
- Testing
- stereotactic ablative radiotherapy
- Where
- 2 sites in Netherlands
- Volunteers
- 98 people
- Sponsor
- Amsterdam UMC, location VUmc
Nutrition Related Cancer, Aging
Effects of Chocolate Consumption in Elderly Patients With Cancer in Palliative Care
Elderly patients with advanced cancer stage constitute an important demand for palliative care, a scenario in which metabolic and nutritional status changes may be present.
- Trial name
- NCT04367493
- Testing
- Chocolate
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Megakaryoblastic Leukemia (M7)
Reduced Intensity Donor Peripheral Blood Stem Cell Transplant in Treating Patients With De Novo or Secondary Acute Myeloid Leukemia in Remission
This phase II trial studies how well reduced intensity donor peripheral blood stem cell (PBSC) transplant works in treating patients with de novo or secondary acute myeloid leukemia (AML) in remission.
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT00045435
- Testing
- nonmyeloablative allogeneic hematopoietic stem cell transplantation, fludarabine phosphate, total-body irradiation
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Fred Hutchinson Cancer Center
ACUTE MYELOGENOUS LEUKEMIA
Investigating the Relationship Between Physical Function, Comorbidity and Cytogenetic Risk Group in Older Adults With Acute Myelogenous Leukemia (AML)
AML is a disease of older adults, with a median age at diagnosis of 67 years . An estimated 13,410 new cases of AML will be diagnosed in 2007.
- Trial name
- NCT02662933
- Testing
- Bedside assessment
- Volunteers
- 82 people
- Sponsor
- Wake Forest University Health Sciences
Cancer
Assessment of Frailty in Elderly Patients With Advanced Cancers
This study is looking at the feasibility of performing frailty assessments on elderly patients with advanced cancers
- Trial name
- FAC-C (NCT02482285)
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs
Neuromuscular Blockade on Shoulder Pain of Elderly
Insufflation pressure (IP) is the creation of a pressure barrier of air/gas within the abdomen to allow the surgeon more space to work during abdominal surgery.
- Conditions
- Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Female Genital Organs, Malignant Neoplasms of Male Genital Organs, Malignant Neoplasms of Urinary Tract
- Trial name
- NCT03210376
- Testing
- Deep Neuromuscular Blockade (NMB), Moderate Neuromuscular Blockade (NMB), Sugammadex
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Neoplasms
Low-dose Capecitabine Adjuvant Chemotherapy for Elderly Patients With Stage II/III Colorectal Cancer
Approximately half of colorectal cancer (CRC) patients were first diagnosed after 70 years old. However, compared with younger patients, elderly patients were often undertreated in chemotherapy due to their impaired tolerance.
- Trial name
- LcACEC (NCT02316535)
- Testing
- Capecitabine
- Where
- China
- Volunteers
- 710 people
- Sponsor
- West China Hospital
Stage III Non-small-cell Lung Cancer
Chemoradiation Followed by Durvalumab in Poor Risk and/or Elderly Patients With Stage III NSCLC
Elderly (age 70 years or older) or >18 years old AND poor risk (ECOG 2) newly diagnosed stage IIIA-C (AJCC 8th edition) inoperable non-small cell lung cancer (NSCLC) patients are eligible to participate in this phase II open…
- Trial name
- ESR1814205 (NCT04441138)
- Testing
- Durvalumab
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Rush University Medical Center
Gastric Cancer
XELOX With Capecitabine Maintenance or XELOX in Elderly Metastatic Adenocarcinoma of Stomach
To confirm the efficacy and safety of XELOX with capecitabine maintenance in treatment of elderly advanced gastric cancer (AGC) by comparing it with that of XELOX regimen.
- Trial name
- NCT01798251
- Testing
- Oxaliplatin, Capecitabine
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Harbin Medical University
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