Clinical trials: Older Adults With Cancer
Stage I Multiple Myeloma, Stage II Multiple Myeloma
Bortezomib, Dexamethasone, and Cyclophosphamide in Treating Older Patients With Multiple Myeloma
This phase II trial studies the side effects and how well lower doses of bortezomib, dexamethasone, and cyclophosphamide work in treating older patients with multiple myeloma.
- Conditions
- Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
- Trial name
- NCT02082405
- Testing
- bortezomib, cyclophosphamide, dexamethasone
- Sponsor
- Case Comprehensive Cancer Center
Acute Myeloid Leukemia
Sulfasalazine in AML Treated by Intensive Chemotherapy: Elderly Patients-first Line Treatment
Acute myeloid leukemia (AML) is a heterogeneous clonal myeloid neoplasm where abnormal proliferation and impaired differentiation of hematopoietic stem and myeloid progenitor cells impedes normal hematopoiesis.
- Trial name
- SALMA (NCT05580861)
- Testing
- Sulfasalazine
- Where
- 13 sites in France
- Volunteers
- 64 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lymphoma
Combination Chemotherapy, Rituximab, and Yttrium Y 90 Ibritumomab Tiuxetan in Treating Patients With Newly Diagnosed Large B-Cell Lymphoma
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, vincristine, and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00690560
- Testing
- rituximab, cyclophosphamide, doxorubicin hydrochloride
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Antoine Lacassagne
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Safety and Anti-Disease Activity of CHR-2797 (Tosedostat) in Elderly and/or Treatment Refractory Patients With Acute Myeloid Leukemia (AML) and Multiple Myeloma (MM)
This is an open-label, non-randomised, multi-centre phase I-II study of CHR-2797 administered orally once a day. The study involves two distinct phases: Phase I: an open-label, dose-escalating phase of the study to explore the…
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndrome, Multiple Myeloma
- Trial name
- NCT00689000
- Testing
- CHR-2797 (tosedostat): Aminopeptidase inhibitor
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Chroma Therapeutics
Acute Myeloid Leukemia
The Role of Maintenance Oral Clofarabine in Older Adults With Acute Myeloid Leukemia
The purpose of this study is to determine the side effects of the study drug, clofarabine, when given by mouth to patients with acute myeloid leukemia (AML), in remission.
- Trial name
- NCT01065545
- Testing
- Clofarabine
- Sponsor
- Northwestern University
Acute Myeloid Leukemia
A Pivotal Study of APG-2575 (Lisaftoclax) Combined With Azacitidine in the Treatment of Acute Myeloid Leukemia
A global, multicenter, randomized, double-blind, placebo-controlled, phase III pivotal registration study, to evaluate the efficacy of APG-2575 (Lisaftoclax) combined with azacitidine (AZA) versus placebo combined with…
- Trial name
- NCT06389292
- Testing
- APG-2575(Lisaftoclax ), Azacitidine Injection
- Where
- 6 sites in China, Russia
- Volunteers
- 486 people
- Sponsor
- Ascentage Pharma Group Inc.
Cognitive Decline, Urinary Bladder Cancer
Association of POCD With Circulating Biomarkers in Patients Undergoing TUR of Bladder Tumor
Bladder tumor is one of the most widespread tumors in the world, with increasing prevalence at the global level. One of the procedures in patients with bladder tumors is transurethral resection of the bladder (TURM) most often…
- Conditions
- Cognitive Decline, Urinary Bladder Cancer, Frail, Biomarker
- Trial name
- NCT07165236
- Where
- Croatia
- Volunteers
- 42 people
- Sponsor
- Osijek University Hospital
Solid Tumor Regardless of Localization and Stage
Combination Chemotherapy in Treating Older Patients With Solid Tumour,
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- OLD (NCT00664911)
- Testing
- chemotherapy
- Where
- 29 sites in France
- Volunteers
- 516 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Melanoma, Immune-related Adverse Event
Thymosin Alpha 1 Combined With Anti-PD-1 Monoclonal Antibody in Elderly Patients With Advanced Melanoma
Primary Objective: To evaluate the effectiveness of Thymosin Alpha-1 combined with PD-1 monoclonal antibody in elderly patients with advanced melanoma .
- Conditions
- Melanoma, Immune-related Adverse Event, Immune Checkpoint Inhibitor
- Trial name
- NCT07644897
- Testing
- Thymosin Alpha 1 and Anti-PD-1 monoclonal antibody
- Where
- 2 sites in China
- Volunteers
- 55 people
- Sponsor
- Sun Yat-sen University
Hodgkin Lymphoma
Adriamycin, Vinblastine, DTIC and Revlimid in Elderly Hodgkin Lymphoma Patients
The purpose of this study is to determine within the scope of the trial what the maximum tolerated dose (MTD) of lenalidomide in combination with AVD should be.
- Trial name
- AVD-Rev (NCT01056679)
- Testing
- Doxorubicine, DTIC, Lenalidomide
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University of Cologne
Acute Myeloid Leukemia
Rapamycin in Combination With Low-dose Aracytin in Elderly Acute Myeloid Leukemia Patients
These study is designed to evaluate the tolerability and efficacy of sirolimus (rapamycin) in combination with low-dose aracytin in elderly AML.
- Trial name
- LAM-RAPA (NCT00235560)
- Testing
- rapamycin
- Where
- 3 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Geriatric Assessment, Geriatric Oncology
Geriatric Oncology Care in Brazil: Remote Geriatric Assessment-Driven Interventions With Supportive Care
The goal of this clinical trial is to determine whether a telehealth-delivered, geriatric assessment-guided supportive care program (GAIN-S) can improve health outcomes in older adults (age 65 and above) with solid tumors who are…
- Conditions
- Geriatric Assessment, Geriatric Oncology, Quality of Life, Functional Decline
- Trial name
- GAIN-S (NCT07084454)
- Testing
- GAIN-S Multidisciplinary Telehealth Intervention, Standard Oncology Care
- Where
- Brazil
- Volunteers
- 350 people
- Sponsor
- Cristiane Decat Bergerot, PhD
Adult Liver Carcinoma, Caregiver
Walking for Recovery From Surgery in Improving Quality of Life in Older Adults With Lung or Gastrointestinal Cancer and Their Family Caregivers
This pilot clinical trial studies how well Walking for Recovery from Surgery works in improving quality of life in older adults with lung or gastrointestinal cancer and their family caregivers.
- Conditions
- Adult Liver Carcinoma, Caregiver, Colorectal Carcinoma, Lung Carcinoma
- Trial name
- NCT03267524
- Testing
- Exercise Intervention, Quality-of-Life Assessment, Survey Administration
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Lung Cancer
Carboplatin and Paclitaxel in Treating Older Patients With Metastatic or Recurrent Unresectable Non-small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00005059
- Testing
- carboplatin, paclitaxel
- Where
- 18 sites in United States
- Volunteers
- 51 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Breast Neoplasms, HER2/Neu Positive
Tolerability of the Combination of Lapatinib and Trastuzumab in Adults Age 60 or Older With HER2 Positive Locally Advanced or Metastatic Breast Cancer
This phase II trial studies the side effects and how well lapatinib ditosylate and trastuzumab work in treating older patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer that has spread from where…
- Conditions
- Breast Neoplasms, HER2/Neu Positive, Geriatric Health Services
- Trial name
- NCT01273610
- Testing
- Lapatinib, Trastuzumab, laboratory biomarker analysis
- Where
- 8 sites in United States
- Volunteers
- 40 people
- Sponsor
- City of Hope Medical Center
Lymphoma
Combination Chemotherapy Plus Filgrastim With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies such as rituximab can locate tumor cells and either kill them or deliver tumor-killing…
- Trial name
- NCT00028717
- Testing
- filgrastim, rituximab, cyclophosphamide
- Where
- 13 sites in Netherlands
- Volunteers
- 400 people
- Sponsor
- Commissie Voor Klinisch Toegepast Onderzoek
Infections, Papillomavirus
Human Papilloma Virus (HPV) Vaccine Immunogenicity and Safety Trial in Young and Adult Women With GSK Biologicals' HPV-16/18
Infection with human papillomavirus (HPV) has been clearly established as the central cause of cervical cancer. Indeed, certain oncogenic types of HPV can infect the cervix (part of the uterus or womb).
- Trial name
- NCT00196937
- Testing
- Cervarix
- Where
- 6 sites in Germany, Poland
- Volunteers
- 667 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Brain and Central Nervous System Tumors, Neuroblastoma
Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00281905
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Where
- 21 sites in Ireland, United Kingdom
- Volunteers
- 50 people
- Sponsor
- Children's Cancer and Leukaemia Group
Breast Cancer
'ADVANCE' (A Pilot Trial)
This study is being conducted to carefully study how chemotherapy is tolerated in group of patients age 70.
- Trial name
- NCT03858322
- Testing
- Paclitaxel, Cyclophosphamide, Carboplatin
- Where
- 5 sites in United States
- Volunteers
- 41 people
- Sponsor
- Dana-Farber Cancer Institute
Esophageal Squamous Cell Carcinoma (ESCC)
An Observational Study on the Safety and Efficacy of Immunotherapy Combined With Concurrent Chemoradiotherapy in Elderly Patients With Esophageal Squamous Cell Carcinoma
Title: Observational Study on the Safety and Efficacy of Immunotherapy Combined with Concurrent Chemoradiotherapy in Elderly Patients with Esophageal Squamous Cell Carcinoma Study Purpose: This single-center, open-label…
- Trial name
- NCT07080437
- Testing
- Immunotherapy Therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Three Gorges Hospital of Chongqing University
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