Clinical trials: Older Adults With Cancer
Leukemia, Myeloid, Acute
Volasertib in Combination With Low-dose Cytarabine in Patients Aged 65 Years and Above With Previously Untreated Acute Myeloid Leukaemia, Who Are Ineligible for Intensive Remission Induction Therapy (POLO-AML-2)
To investigate the efficacy, safety, and pharmacokinetics of intravenous volasertib + subcutaneous low dose cytarabine in patients >= 65 years of age with previously untreated acute myeloid leukaemia, ineligible for intensive…
- Trial name
- NCT01721876
- Testing
- Volasertib, Cytarabine
- Where
- 122 sites in United States, Argentina and 23 more
- Volunteers
- 666 people
- Sponsor
- Boehringer Ingelheim
Myeloma
Trial of Carfilzomib Plus Melphalan and Prednisone in Elderly Untreated Patients With Multiple Myeloma (CARMYSAP)
Phase I/II trial of Carfilzomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma. Nine: University Hospital of Nantes, University Hospital of Nancy, University Hospital of Lille, University…
- Trial name
- CARMYSAP (NCT01279694)
- Testing
- Carfilzomib, Melphalan, Prednisone
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Nantes University Hospital
Acute Myeloid Leukemia
A Patient-Centered Communication Tool (UR-GOAL) Versus Usual Care for Older Patients With Acute Myeloid Leukemia, Their Caregivers, and Their Oncologists
The objective of this study is to evaluate the preliminary efficacy of the UR-GOAL tool in improving shared decision making and communication between older patients with AML and their oncologists in a pilot randomized trial.
- Trial name
- UR-GOAL 2 (NCT05335369)
- Testing
- UR-GOAL
- Where
- United States
- Volunteers
- 161 people
- Sponsor
- University of Rochester
Newly Diagnosed Multiple Myeloma
Study of SubQ Dara With Dose-Attenuated Bortezomib, Lenalidomide, Dexamethasone in Elderly NDMM
This is a single center, open-label, phase 2 study in elderly (age ≥ 70) subjects with newly diagnosed multiple myeloma who are transplant ineligible.
- Trial name
- NCT04052880
- Testing
- Daratumumab, Bortezomib, Lenalidomide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Larysa Sanchez
Esophageal Cancer, S-1
S-1 and Radiotherapy for Elderly Esophageal Cancer Patients
To investigate the efficacy and toxicity of S-1 with concurrent radiotherapy in older patients with esophageal cancer.
- Conditions
- Esophageal Cancer, S-1, Radiotherapy
- Trial name
- NCT02716688
- Testing
- S-1, radiotherapy
- Where
- China
- Sponsor
- Zhejiang Provincial People's Hospital
Breast Cancer
Capecitabine and Vinorelbine in Treating Older Women Who Have Metastatic Breast Cancer With or Without Bone Involvement
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003902
- Testing
- capecitabine, vinorelbine tartrate
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- Swiss Cancer Institute
Brain and Central Nervous System Tumors
Radiation Therapy With or Without Temozolomide in Treating Older Patients With Newly Diagnosed Glioblastoma Multiforme
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them…
- Trial name
- NCT00482677
- Testing
- temozolomide, DNA methylation analysis, quality-of-life assessment
- Where
- 22 sites in Canada, Germany and 2 more
- Volunteers
- 562 people
- Sponsor
- Canadian Cancer Trials Group
Mantle Cell Lymphoma
A Study Comparing Rituximab/Bendamustin(RB) Alternating With Rituximab/Bendamustin/Cytarabin(RBAC) With RB Therapy in Elderly Patients With Mentle Cell Lymphoma
This is a phase 2, multicenter, open-label, active-controlled randomized trial to determine efficacy and safety of rituximab/bendamustine (RB) alternating with rituximab/bendamustine/cytarabine (RBAC) compared with standard RB…
- Trial name
- NCT05245656
- Testing
- RB/RBAC alternating, RB
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Kim, Seok Jin
Hodgkin Lymphoma, Adult
Elderly Hodgkin Lymphoma Patients Treated With Chemoradiotherapy
Outcome of Hodgkin lymphoma patients over than 60 years treated by chemotherapy and/or radiotherapy: retrospective analysis.
- Trial name
- HODGSA (NCT03535948)
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Central Hospital, Nancy, France
Mantle Cell Lymphoma
Ibrutinib Combined With R-CHOP/R-DHAP in Newly Diagnosed Mantle Cell Lymphoma Patients Who Aged ≤65 Years
The purpose of the study is to better and systematically collect clinical data on the treatment of ibrutinib combined with R-CHOP/DHAP regimen for more scientific and accurate evaluation, our center has carried out the…
- Trial name
- NCT05429918
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Metastatic Renal Cell Carcinoma
Sorafenib in Elderly Patients With Metastatic Renal Cell Carcinoma
Study Design This is a multicenter, open label, first line phase II study in elderly (≥ 65 years old) metastatic Renal Cell Carcinoma (mRCC) patients not suitable for any other currently approved treatment (bevacizumab+INF…
- Trial name
- SERCC (NCT01342627)
- Testing
- Sorafenib
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Hematopoietic/Lymphoid Cancer, Unspecified Adult Solid Tumor, Protocol Specific
Quality of Life in Caregivers of Hospitalized Older Patients With Cancer
This clinical trial studies quality of life in caregivers of hospitalized older patients with cancer.
- Trial name
- NCT01866969
- Testing
- questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Diffuse Large B Cell Lymphoma
The Efficacy and Safety of ZR2 Versus R-CHOP-like Regimen for Elderly Patients With Newly Diagnosed Diffuse Large B Cell Lymphoma.
This is a prospective, single-center, open-label clinical study designed to evaluate the efficacy and safety of the Zanubrutinib, Lenalidomide and Rituximab (ZR2) versus rituximab combined with CHOP or CDOP (R-CHOP or R-CDOP) in…
- Trial name
- NCT05428670
- Testing
- Zanubrutinib+Rituximab+Lenalidomide, RCHOP/RCDOP
- Where
- China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Carcinoma, Non-small Cell Lung
Single Agent Versus Combination Chemotherapy to Treat High-risk Elderly With Non-small Cell Lung Cancer
This study will enroll elderly patients with advanced non-small cell lung cancer who are at high risk of developing chemotherapy toxicity (side effects).
- Trial name
- NCT02590003
- Testing
- Carboplatin, Nab-paclitaxel
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Yale University
Acute Myeloid Leukemia
Veneclax, Chidaniline Combined With Azacitidine Followed by Decitabine + MAG Regimen in the Treatment of Elderly Untreated AML
A multicenter, prospective, single-arm clinical study of veneclax, chidaniline combined with azacitidine (VCA) followed by decitabine + MAG regimen (D-MAG) in the treatment of elderly untreated acute myeloid leukemia (AML)
- Trial name
- NCT06827899
- Testing
- veneclax, chidaniline combined with azacitidine (VCA) followed by decitabine + MAG regimen (D-MAG)
- Where
- China
- Volunteers
- 66 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Frailty Syndrome
Frailty Trajectories and Their Association With Health Outcomes
Frailty is common in gastric cancer survivors and seriously affects their prognosis. Multiple longitudinal follow-up assessment of frailty could provide a better understanding of the frailty change of individuals.
- Trial name
- NCT05793229
- Testing
- observation
- Where
- China
- Volunteers
- 381 people
- Sponsor
- Nanjing Medical University
Leukemia, Myeloid, Acute, De Novo
Clinical Trial to Assess the Safety and Tolerability of the Combination of Low-dose Cytarabine or Azacitidine Plus Venetoclax and Quizartinib in Newly Diagnosed AML Patients Aged Equal or More Than 60 Years Old
A phase I-II trial based on the combination of three drugs regimen LDAC or Azacitidine + Venetoclax + Quizartinib that in this population could be well tolerated by a sequential type administration.
- Conditions
- Leukemia, Myeloid, Acute, De Novo, Age More 60yr
- Trial name
- NCT04687761
- Testing
- Azacitidine, Venetoclax, Quizartinib
- Where
- 15 sites in Spain
- Volunteers
- 113 people
- Sponsor
- PETHEMA Foundation
Acute Myeloid Leukemia
Venetoclax+HMA+Aclarubicin Versus Venetoclax+HMA in Treatment-Naive Elderly Patients With AML
This research is being done to assess the therapeutic efficacy and safety of a promising regimen (Venetoclax combined with Decitabine/Azacitidine and Aclarubicin) versus Venetoclax combined with Decitabine/Azacitidine in…
- Trial name
- NCT05264883
- Testing
- Venetoclax-Decitabine/Azacitidine-Aclarubicin Association, Venetoclax-Decitabine/Azacitidine Association
- Where
- China
- Volunteers
- 170 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Head & Neck Cancer, Radiotherapy
Nimotuzumab Plus Radiotherapy in Elderly Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma
This is a prospective, single-center, open-label, single-arm phase II study. The purpose of this study is to evaluate the efficacy and safety of nimotuzumab combined with concurrent intensity-modulated radiotherapy (IMRT) in…
- Trial name
- NCRHNC (NCT07821242)
- Testing
- Nimotuzumab
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ke Hu
Cancer Pain, Renal Insufficiency Chronic
Assessing Hydromorphone Sustained-Release Tablets in Elderly Cancer Pain Patients With Renal Insufficiency
This clinical study aims to understand whether domestic hydromorphinone sustained-release tablets are effective and safe in treating moderate to severe cancer pain in elderly patients with renal insufficiency.
- Conditions
- Cancer Pain, Renal Insufficiency Chronic, Hydromorphone Use
- Trial name
- NCT07421674
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Taian Cancer Hospital
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