Clinical trials: Older Adults With Cancer
Multiple Myeloma
Study of Teclistamab in Combination in Elderly Patients With Multiple Myeloma
The primary hypothesis of this study is that teclistamab SC in combination with daratumumab SC or lenalidomide will be safe and induce a high rate of VGPR or better in newly diagnosed multiple myeloma patients This is an…
- Trial name
- IFM2021-01 (NCT05572229)
- Testing
- Teclistamab, Daratumumab, Lenalidomide
- Where
- 22 sites in France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Lille
Mantle Cell Lymphoma (MCL)
Ibrutinib Combined With Bendamustine and Rituximab in Newly Diagnosed Mantle Cell Lymphoma Patients Who Aged > 65 Years
This study is a prospective observational clinical trial. A total of 19 research centers were involved in this study. Each site plans to enroll 2-3 patients, and a total of 60 patients will be enrolled.
- Trial name
- NCT05406154
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
Diffuse Large B-Cell Lymphoma
Glofitamab, Polatuzumab Vedotin and Zanubrutinib in First-line Elderly DLBCL
This study aims to assess the efficacy and safety of the chemotherapy-light combination of glofitamab, polatuzumab vedotin and zanubrutinib (GPZ) in elderly patients with previously untreated diffuse large B-cell lymphoma.
- Trial name
- NCT07012980
- Testing
- Glofitamab, Polatuzumab Vedotin, Zanubrutinib
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Shanghai Zhongshan Hospital
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
Vorinostat, Azacitidine, and Gemtuzumab Ozogamicin for Older Patients With Relapsed or Refractory AML
The purpose of this study is to test the safety of vorinostat (Zolinza) and azacitidine (Vidaza) when combined with gemtuzumab ozogamicin (GO) at different dose levels.
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
- Trial name
- NCT00895934
- Testing
- vorinostat, gemtuzumab ozogamicin, azacitidine
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Leukemia, Nonlymphocytic, Acute
Therapy of Acute Myeloid Leukemia in Patients Over the Age of 60 : DA Versus Mitoxantrone With Intermittent AraC
Single Arm-Studies suggest improved remission and survival rates for a Protocol with Mitoxantron 10mg/m2 for 3 days combined with AraC 1g/m2 bid on days 1+3+5+7 compared to a conventional DA 7+3 protocol (45mg/m2 Daunorubicin).
- Trial name
- NCT00180167
- Testing
- randomization between two established Chemotherapies
- Where
- Germany
- Volunteers
- 492 people
- Sponsor
- Technische Universität Dresden
Head and Neck Cancer, Head and Neck Neoplasms
Radiotherapy, Cetuximab, and Injections of TNFerade™ Biologic for Elderly or Frail Patients With Head and Neck Cancer
This study is looking at the safety and tolerability of TNFeradeä Biologic combined with conventional once daily radiation therapy in elderly or frail patients with new onset locally advanced head and neck tumors.
- Trial name
- NCT00496236
- Testing
- TNFerade biologic
- Where
- United States
- Sponsor
- GenVec
Elderly Patients With a Solid Tumor
Are the Fried Criteria Predictive of a Functional Decline in Older People With Solid Malignant Tumors?
Identifying the frail elderly patients or those at risk of becoming frail has become a cornerstone of modern geriatric medicine. Many instruments have been developed to identify fragility at the individual level.
- Trial name
- NCT02662179
- Testing
- Quality of life evaluation, Functional decline assessment, Physical decline assessment
- Where
- 2 sites in Belgium
- Volunteers
- 62 people
- Sponsor
- Brugmann University Hospital
Leukemia
Everolimus MICE-regimen in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
RATIONALE: Drugs used in chemotherapy, such as mitoxantrone hydrochloride, cytarabine, etoposide, and idarubicin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from…
- Trial name
- AML1208 (NCT01154439)
- Testing
- cytarabine, etoposide, everolimus
- Where
- 5 sites in Italy
- Volunteers
- 11 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Colorectal Cancer, Fatigue
Physical Activity Intervention for Older Patients During Chemotherapy for Colorectal Cancer
This study will see if patient who undergo a physical activity intervention called Walk With Ease report experiencing less fatigue and a higher quality of life during chemotherapy for colorectal cancer than those who do not…
- Trial name
- NCT02191969
- Testing
- Walk With Ease
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cancer
Decreasing Polypharmacy in Older Adults With Curable Cancers Trial
This is a single-site cluster-randomized trial to assess efficacy and implementation outcomes of deprescribing interventions in 72 older adults with polypharmacy (PP) and curable cancers initiating chemotherapy.
- Trial name
- NCT05046171
- Testing
- Pharmacist-led deprescribing, Patient education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Rochester
Pancreatic Cancer, Pancreatitis
Pancreatic Disease Burden in Older Adults (1990-2040)
Using data from the Global Burden of Disease Study 2021, the investigators analyzed age-standardized incidence, mortality, and disability-adjusted life-years (DALYs) for pancreatic cancer and pancreatitis in adults aged ≥70 years…
- Trial name
- NCT07177599
- Testing
- Natural history
- Volunteers
- 723,415 people
- Sponsor
- Changhai Hospital
Esophageal Cancer, Radiotherapy Side Effect
IMRT With Carboplatin Versus IMRT With Carboplatin and Fluorouracil for Eldly Esophageal Cancer Patients
An open, single-center, randomized controlled phase II clinical trial to compare the efficacy and safety of conformal intensity modulated radiation therapy (IMRT) combined with carboplatin and IMRT combined with carboplatin and…
- Trial name
- NCT03910634
- Testing
- Fluorouracil, Intensity modulated radiation therapy, carboplatin
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Sun Yat-sen University
Hematologic Malignancies
Post-Transplant Cyclophosphamide in Patients Aged >/= 65 Years Undergoing Haploidentical Transplant
The purpose of this phase 1 study is to determine the optimal dose of the immune suppressive drug, cyclophosphamide, following standard allogeneic stem cell transplant in patients aged >/= 65 years with hematologic malignancies.
- Trial name
- GeriBMT (NCT05849207)
- Testing
- Cyclophosphamide
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Ronald Paquette
Fractures, Bone, Fragility
Factors Associated With Future Fractures in Middle-aged Men and Women
From prospectively collected health and life-style data and anthropometric data in the Malmo Diet and Cancer (MDC) cohort identify factors that predicts or are associated with forthcoming fracture in middle-aged men and women.
- Conditions
- Fractures, Bone, Fragility, Life Style
- Trial name
- MDCFract (NCT04151732)
- Testing
- Physical activity, alcohol, tobacco, Hormonal factors, Cardiovascular disease
- Where
- Sweden
- Volunteers
- 30,351 people, healthy volunteers welcome
- Sponsor
- Lund University
Breast Cancer, Frailty
Multicomponent Prehabilitation in Older Adults With Breast Cancer
Older adults with breast cancer frequently present with frailty, decreased functional reserve, and increased risk of postoperative complications.
- Conditions
- Breast Cancer, Frailty, Sarcopenia, Aging
- Trial name
- PREHAB-BC65 (NCT07531836)
- Testing
- Home-based Multicomponent Prehabilitation (Vivifrail), Supervised Multicomponent Prehabilitation, Comprehensive Geriatric Assessment and Optimization
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Fundacion Miguel Servet
Acute Myeloid Leukemia
Azacitidine Compared to Conventional Chemotherapy as Consolidation of Elderly Patients With AML
The purpose of this study is to determine whether Azacitidine consolidation is superior to standard DA consolidation treatment of acute myeloid leukemia in first complete remission in elderly patients.
- Trial name
- NCT01794169
- Testing
- Azacitidine, DA
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Karolinska University Hospital
AML, Adult, Acute Myeloid Leukemia
Quality of Life Model for Older Patients With AML
The purpose of this study is to describe the differences in quality of life (QOL) among newly diagnosed patients diagnosed with acute myeloid leukemia (AML) to help design a patient decision-making QOL model for aligning…
- Trial name
- NCT04380441
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Peripheral T Cell Lymphoma, Unspecified, Angioimmunoblastic Lymphadenopathy
Immunotherapy in Peripheral T Cell Lymphoma - the Role of Alemtuzumab in Addition to Dose Dense CHOP
Peripheral T cell lymphomas comprise 10-15% of all malignant lymphomas. The prognosis is significantly worse than that of aggressive B cell lymphomas.
- Conditions
- Peripheral T Cell Lymphoma, Unspecified, Angioimmunoblastic Lymphadenopathy, Extranodal NK/T-cell Lymphoma
- Trial name
- A-CHOP-14 (NCT00725231)
- Testing
- alemtuzumab, chemotherapy
- Where
- Germany
- Volunteers
- 274 people
- Sponsor
- University of Göttingen
COVID-19
The Standard of Care Combined With Glucocorticoid in Elderly People With Mild or Moderate COVID-19
This study is aimed to explore the dual-dimensional early intervention strategy of standard of care combined with host immunomodulation in elderly patients with mild and moderate COVID-19.
- Trial name
- NCT05855395
- Testing
- Glucocorticoid
- Where
- 15 sites in China
- Volunteers
- 5,815 people
- Sponsor
- Huashan Hospital
Cancer, Aging
Virtual Peer-support Exercise Intervention for Older Adults with Cancer
Background: By 2030, 23% of Canadians will be over 65 years of age. Two in five of these individuals will be diagnosed with cancer.
- Trial name
- NCT05549479
- Testing
- Peer Matching, Qualified Exercise Professional Support Sessions
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
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