Clinical trials: Older Adults With Cancer
Cancer of Head and Neck
Study Comparing Pembrolizumab With Methotrexate in Elderly, Frail or Cisplatin-ineligible Patients With Head and Neck Cancers
The study is designed as an open-label, randomized, prospective, multicenter, phase II study comparing pembrolizumab with methotrexate in elderly, frail or cisplatin-ineligible patients with squamous carcinoma of the head and…
- Trial name
- ELDORANDO (NCT03193931)
- Testing
- Pembrolizumab Injection, Methotrexate Injectable Solution
- Where
- Germany
- Volunteers
- 47 people
- Sponsor
- AIO-Studien-gGmbH
Lymphoma
Rituximab and Combination Chemotherapy in Treating Older Patients With Diffuse Large B-Cell Lymphoma
RATIONALE: Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread.
- Trial name
- NCT00101010
- Testing
- Filgrastim, Pegfilgrastim, Rituximab
- Where
- 7 sites in United States
- Volunteers
- 80 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Myelogenous Leukemia, Myelodysplastic Syndromes
Clofarabine and Ara-C for the Treatment of Relapsed AML and Untreated MDS
The purpose of this trial is to to determine the safety and effectiveness of therapeutic combination - Clofarabine and Cytarabine for the treatment of AML and MDS.
- Conditions
- Acute Myelogenous Leukemia, Myelodysplastic Syndromes, Chronic Myelogenous Leukemia
- Trial name
- NCT00334074
- Testing
- Clofarabine and Cytarabine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Confort, Older Adults With Cancer
Enhancing Patient Experience in Geriatric Oncology
Approximately 60% of new cancer diagnoses and 70% of cancer-related deaths occur in adults aged 65 years and older, a population frequently affected by multimorbidity, frailty, sensory impairment, and treatment-related symptom…
- Trial name
- NCT07671586
- Testing
- Comfort menu and cart implemented
- Where
- Brazil
- Volunteers
- 264 people
- Sponsor
- Hospital Sirio-Libanes
Acute Myeloid Leukemia
A Study Comparing Allogeneic Hematopoietic Cell Transplantation Versus Best Available Standard of Care Therapy in Elderly Patients With Acute Myeloid Leukemia
A subject of major interest for researchers, clinicians, patients, and payers, is the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in the treatment of these older patients with AML.
- Trial name
- ALLO-BEST (NCT04822766)
- Testing
- Hematopoietic stem cell transplantation, Best chemotherapy treatment
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Leukemia
CMA-676 in Treating Older Patients With Acute Myeloid Leukemia in First Relapse
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of CMA-676 in treating older patients who have acute…
- Trial name
- NCT00003673
- Testing
- chemotherapy, gemtuzumab ozogamicin
- Where
- 10 sites in United States
- Volunteers
- 55 people
- Sponsor
- Pfizer
Old Injury
Prehabilitation & Rehabilitation in Oncogeriatrics: Adaptation to Deconditioning Risk and Accompaniment of Patients' With Cancer
With the conjunction of increased life expectancy and the increasing incidence of cancer with aging, older patient represent an increasing proportion of cancer patients.
- Trial name
- PROADAPT (NCT03659123)
- Testing
- standardized geriatric intervention
- Where
- 10 sites in France
- Volunteers
- 148 people
- Sponsor
- Hospices Civils de Lyon
Graft vs Host Disease, Myelodysplastic Syndromes
Selective T-Cell Depletion to Reduce GVHD (Patients) Receiving Stem Cell Tx to Treat Leukemia, Lymphoma or MDS
This study will evaluate the safety and effectiveness of stem cell transplantation in which the donors T lymphocytes have undergone "selective depletion." Certain patients with cancers of the blood undergo transplantation of…
- Conditions
- Graft vs Host Disease, Myelodysplastic Syndromes, Leukemia, Leukemia, Myeloid
- Trial name
- NCT00025662
- Testing
- RFT5-SMPT-dgA, Isolex system
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Leukemia, Myeloid, Acute
Oral Clofarabine for Acute Myeloid Leukemia
This is a phase I study designed to test the safety of oral clofarabine when given as consolidation therapy to older patients with AML in remission.
- Trial name
- NCT00727766
- Testing
- Clofarabine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Colorectal Cancer
An Observational Study of Avastin in First Line in Elderly Patients With Metastatic Colorectal Cancer (CASSIOPEE)
This multicenter, prospective, observational study will evaluate the efficacy and safety of Avastin (bevacizumab) in first-line therapy in elderly patients with metastatic colorectal cancer.
- Trial name
- NCT01555762
- Where
- 166 sites in France
- Volunteers
- 402 people
- Sponsor
- Hoffmann-La Roche
Head & Neck Cancer, Radiotherapy
Nimotuzumab Plus Radiotherapy in Elderly Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma
This is a prospective, single-center, open-label, single-arm phase II study. The purpose of this study is to evaluate the efficacy and safety of nimotuzumab combined with concurrent intensity-modulated radiotherapy (IMRT) in…
- Trial name
- NCRHNC (NCT07821242)
- Testing
- Nimotuzumab
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Ke Hu
Small-cell Lung Cancer
Amrubicin Study for Elderly Patients With Extensive-disease Small-cell Lung Cancer (ED-SCLC)
The purpose of this study is to compare the efficacy and toxicity of amrubicin with carboplatin plus etoposide in elderly patients with extensive-disease small-cell lung cancer.
- Trial name
- NCT00286169
- Testing
- Amrubicin Hydrochloride
- Where
- 8 sites in Japan
- Volunteers
- 130 people
- Sponsor
- Sumitomo Pharma Co., Ltd.
Cancer
Study of Elderly Patients With Cancer and Seen in Consultation of Geriatric Oncology in the Nord Pas-de-Calais (CONSOG).
The aim of this study is to establish a common geriatric oncology medical database. The patients concerned are the patients having benefited from a geriatric oncology consultation in one of the participating centres.
- Trial name
- CONSOG (NCT02501174)
- Where
- 15 sites in France
- Volunteers
- 2,914 people
- Sponsor
- Centre Oscar Lambret
Leukemia, Myeloid, Myelodysplastic Syndromes
Gleevec/Low-Dose Ara-C Study for Elderly Patients With AML and Myelodysplastic Syndromes
The goal of this clinical research study is to learn if the combination of Gleevec (imatinib mesylate) and low doses of Cytarabine (ara-C) may help to control leukemia while causing fewer side effects than standard high dose…
- Trial name
- NCT00451997
- Testing
- Gleevec, Ara-C
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center
Glioblastoma, Glioblastoma, IDH-Wildtype
ERAS-801 for the Treatment of Resectable and Progressive or Recurrent or Elderly Newly Diagnosed IDH Wildtype Grade IV Glioblastoma or Gliosarcoma With an EGFR Amplification or Mutation, ERAS801-SARG Trial
This phase Ib trial tests the safety and side effects of ERAS-801 in treating patients with isocitrate dehydrogenase (IDH) wildtype, epidermal growth factor receptor (EGFR) amplified or mutated grade IV glioblastoma or…
- Conditions
- Glioblastoma, Glioblastoma, IDH-Wildtype, Gliosarcoma, Recurrent Glioblastoma, IDH-Wildtype
- Trial name
- NCT07089641
- Testing
- Biospecimen Collection, Echocardiography Test, EGFR Inhibitor ERAS-801
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Lung Neoplasm Malignant, Mesothelioma; Lung
Feasibility Trial of a Personalised Nutrition and Activity Programme for People With Lung Cancer Over 65 Years
People with cancer affecting the lungs tend to be older and frailer compared to people with other cancers. As a result, they may have poorer quality of life and are less able to tolerate treatments for their cancer, such as…
- Trial name
- CanBenefitII (NCT05404022)
- Testing
- Tailored nutrition and physical activity programme
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people
- Sponsor
- University of Hull
Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia
5-azacytidine Treatment Versus 5-azacytidine Followed by Allogeneic Stem Cell Transplantation in Elderly Patients With Myelodysplastic Syndrome (MDS)
5-azacytidine treatment prolongs survival in patients with myelodysplastic syndrome (MDS), but does not cure the disease. Allogeneic stem cell transplantation is a curative treatment option but is associated with a high risk…
- Trial name
- NCT01404741
- Testing
- allogeneic stem cell transplantation, 5-azacytidine until progress
- Where
- 17 sites in Germany
- Volunteers
- 191 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cancer-related Problem/Condition, Cognitive Impairment
Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase II
Cancer-related cognitive dysfunction (CRCD) affects up to 75% of patients receiving chemotherapy and older adults are at greater risk of developing CRCD, which can negatively affect their functional independence and quality of…
- Trial name
- NCT04669301
- Testing
- MAAT-G, Supportive therapy (time and attention control)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Rochester
Colorectal Neoplasms
Risk-adapted Screening in First-degree Relatives of Patients With Colorectal Cancer
BACKGROUND: First-degree relatives of patients with colorectal cancer are at increased risk for colorectal cancer as well. Nevertheless, participation in the German national screening program stagnates at 2-3 percent per year…
- Trial name
- FAMKOL (NCT01903395)
- Testing
- Nurse-led counselling
- Where
- 33 sites in Germany
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Lung Cancer
Ph II Gemcitabine, Erlotinib, and Gemcitabine With Erlotinib/Elderly Patients W/ IIIB/IV NSCLC
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00283244
- Testing
- erlotinib hydrochloride, gemcitabine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 147 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
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