Clinical trials: Older Adults With Cancer
Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma
Toripalimab Plus Rituximab Followed by R-CHOP for Elderly Patients With Untreated Diffused B Cell Lymphoma
1. Phase I portion of this study will evaluate the efficacy and saftey of toripalimab plus rituximab in treating untreated elderly diffuse large B cell lymphoma patients. 2.
- Conditions
- Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma Grade IIIb, Transformed Lymphoma
- Trial name
- NCT04058470
- Testing
- Toripalimab, Rituximab, R-CHOP Protocol
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Huiqiang Huang
Malignant Haemopathies, Acute Leukemia
Unicentric Retrospective Analysis of a Cohort of 602 Young Adult and Adolescent Patients (AJA), Aged 15 to 30 Years, With Haematological Malignancies, and Managed Between 2000 and 2016
Unicentric retrospective analysis of a cohort of 602 young adult and adolescent patients, aged 15 to 30 years, with haematological malignancies, and managed between 2000 and 2016
- Conditions
- Malignant Haemopathies, Acute Leukemia, Non-hodgkin Lymphoma, Hodgkin Lymphoma
- Trial name
- HEMAJA (NCT03469921)
- Testing
- administered therapeutic regimens
- Where
- France
- Volunteers
- 602 people
- Sponsor
- Institut Paoli-Calmettes
Acute Myeloid Leukemia
Venetoclax + Cytarabine Versus Idarubicin + Cytarabine : Efficacity Assessment as Post-remission Therapy to Elderly Patients With Acute Myeloid Leukemia in First Remission
For the FILO group, the standard of care for induction chemotherapy of elderly fit patients with AML is represented by the combination of Cytarabine, Idarubicin and Lomustine.
- Trial name
- LAMSA2020 (NCT04968015)
- Testing
- Cytarabine-Venetoclax Association, Cytarabine-Idarubicin Association
- Where
- 26 sites in France
- Volunteers
- 134 people
- Sponsor
- French Innovative Leukemia Organisation
Cancer-related Problem/Condition, Cognitive Impairment
Memory and Attention Adaptation Training-Geriatrics (MAAT-G) Phase II
Cancer-related cognitive dysfunction (CRCD) affects up to 75% of patients receiving chemotherapy and older adults are at greater risk of developing CRCD, which can negatively affect their functional independence and quality of…
- Trial name
- NCT04669301
- Testing
- MAAT-G, Supportive therapy (time and attention control)
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Rochester
NSCLC Stage IV, KRAS P.G12C
Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance Status
ADEPPT is an international, multicentre, single-arm phase II trial. The protocol treatment consists of adagrasib, which is administered at a dose of 600 mg orally, twice daily until progression or unacceptable toxicity.The…
- Trial name
- ADEPPT (NCT05673187)
- Testing
- Adagrasib
- Where
- 18 sites in Belgium, France and 4 more
- Volunteers
- 68 people
- Sponsor
- ETOP IBCSG Partners Foundation
Colorectal Neoplasms, Colorectal Carcinoma
FOLFIRI + Panitumumab First-line Treatment in Elderly Patients With Unresectable Metastatic Colorectal Cancer, RAS/BRAF Wild-type and Good Performance Status
To estimate progression-free survival at one year in elderly patients with RAS/BRAF wild-type unresectable mCRC and good performance status treated with FOLFIRI + panitumumab as first-line therapy.
- Conditions
- Colorectal Neoplasms, Colorectal Carcinoma, Colorectal Cancer Metastatic, Neoplasm Metastasis
- Trial name
- OPALO (NCT03142516)
- Testing
- Panitumumab, Irinotecan, Folinic acid
- Where
- 12 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Grupo Espanol Multidisciplinario del Cancer Digestivo
Non-small Cell Lung Cancer
Cetuximab and Vinorelbine in Elderly Subjects With Lung Cancer
The purpose of this study is it to determine how well patients with non-small cell lung cancer respond to cetuximab plus vinorelbine.
- Trial name
- NCT00165334
- Testing
- Cetuximab, Vinorelbine (Navelbine)
- Where
- 3 sites in United States
- Volunteers
- 53 people
- Sponsor
- Dana-Farber Cancer Institute
Acute Myeloid Leukemia
Venetoclax and Decitabine Assessment in Patients (≥60 - <75 Years) with Newly Diagnosed AML Eligible for Allo-SCT
This trial is a no profit, prospective, phase II, multicentre, non-randomised, uncontrolled, single group assignment, open label study to evaluate the safety and efficacy of the "chemo-free" combination Venetoclax plus Decitabine…
- Trial name
- NCT04476199
- Testing
- Venetoclax and Decitabine
- Where
- 25 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Gruppo Italiano Trapianto di Midollo Osseo
Esophageal Squamous Cell Carcinoma
Radiotherapy Plus Durvalumab in Elderly Esophageal Squamous Cell Carcinoma
The incidence and mortality of esophageal cancer are at the forefront in China, among which the elderly patients account for a large proportion.
- Trial name
- NCT04851132
- Testing
- Radiotherapy, Durvalumab
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Chinese Academy of Medical Sciences
AML, Adult
Comparison of VA and D/IA Induction Regimens in Elderly Fit Acute Myeloid Leukemia Patients
This study is a multicenter, randomized, controlled phase III clinical trial aimed at comparing the efficacy of two induction chemotherapy regimens-VA (Venetoclax + Azacitidine) and D/IA (Daunorubicin/Idarubicin + Cytarabine)-in…
- Trial name
- NCT07132684
- Testing
- Daunorubicin/Idarubicin, Cytarabine, Azacitidine
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
AML (Acute Myelogenous Leukemia
Fitness in Elderly AML Patients
The study aims to evaluate the outcome of patients (overall survival) who received treatments commensurate with the proposed "Fitness" parameters compared to that of patients whose treatment differed either in the direction of…
- Trial name
- AML-FITNESS (NCT07598838)
- Testing
- Fitness Categories: FIT, UNFIT and FRAIL
- Where
- Italy
- Volunteers
- 725 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Diffuse Large B-Cell Lymphoma
The Efficacy and Safety of ZR2 Versus R-miniCHOP in the Treatment of Unfit or Frail de Novo Diffuse Large B-cell Lymphoma Patients Aged Older Than or Equal to 70 Years
A multicenter, prospective, randomized, open-label, controlled trial to evaluate the efficacy and safety of zanubrutinib, rituximab and lenalidomide (ZR2) versus rituximab combined with low-dose CHOP (R-miniCHOP) in the treatment…
- Trial name
- NCT05179733
- Testing
- six courses of zanubrutinib, rituximab and lenalidomide, six courses of rituximab combined with low-dose CHOP
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Ruijin Hospital
Colorectal Cancer
S-1/Leucovorin (SL) Versus sLV5FU2 as the First-line Treatment for Elderly Patients With Colorectal Cancer
This phase II trial on the assumption that S-1 combined with Leucovorin may have better efficacy and safety than simplified 5-FU/LV infusion therapy in elderly patients with advanced colorectal cancer.
- Trial name
- NCT01193452
- Testing
- S-1, Leucovorin, leucovorin, 5-fluorouracil
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Cancer
A Study of a Telemedicine Program for Older Adults With Cancer
The purpose of this study is to find out if a telemedicine program for older adults in cancer treatment is a practical way to understand and meet these participants' unique needs.
- Trial name
- NCT04917848
- Testing
- Tele-Geriatric Oncology program
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer
Bevacizumab and Capecitabine as First-Line Therapy in Treating Older Patients With Metastatic Colorectal Cancer
RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT00107315
- Testing
- bevacizumab, capecitabine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Roswell Park Cancer Institute
Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS)
Phase 2 Study of Azacitidine (Vidaza) vs MGCD0103 vs Combination in Elderly Subjects With Newly Diagnosed Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)
The purpose of the study is to determine how effective azacitidine, MGCD0103, and the combination of azacitidine and MGCD0103 are in treating AML or MDS in people over 60 years of age.
- Trial name
- NCT00666497
- Testing
- Azacitidine, MGCD0103
- Where
- 8 sites in United States, Canada and 1 more
- Volunteers
- 6 people
- Sponsor
- Mirati Therapeutics Inc.
Lung Cancer (NSCLC), Geriatric Assessment
Practical Geriatric Assessment in Older Adults With Non-Small Cell Lung Cancer Undergoing Stereotactic Body Radiation Therapy
National guidelines recommend that older adults with cancer undergo a special health assessment before starting cancer treatment.
- Conditions
- Lung Cancer (NSCLC), Geriatric Assessment, Stereotactic Body Radiation Therapy (SBRT)
- Trial name
- Lung-GAP (NCT06987890)
- Testing
- Practical Geriatric Assessment
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Brigham and Women's Hospital
Colorectal Cancer, Fragility
MPI Predicts Outcome of CRC Elderly Patients (MPI=MULTIDIMENSIONAL PROGNOSTIC INDEX; CRC=COLORECTAL CANCER)
Patients aged ≥75 year scheduled for CRC surgery were studied (104 cases) and variables associated with major postoperative complications / mortality were evaluated.
- Conditions
- Colorectal Cancer, Fragility, Elderly
- Trial name
- MPI;CRC (NCT04594655)
- Testing
- surgery
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Lymphoma, Large B-Cell, Diffuse
R-CHOP + GM-CSF for Previously Untreated LCL in Elderly
Patients will receive 6 to 8 cycles of R-CHOP (Rituximab, Cyclophosphamide, doxorubicin, vincristine, and prednisone), with GM-CSF.
- Trial name
- NCT00582725
- Testing
- R-CHOP+GM-CSF
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Wisconsin, Madison
Leukemia
S9031-S9333-S0112-S0301-A Biomarkers Associated With Response to Cytarabine in Samples From Older Patients With Acute Myeloid Leukemia
RATIONALE: Studying samples of blood and tissue from patients with cancer treated with cytarabine in the laboratory may help doctors learn more about the effects of cytarabine on cells.
- Trial name
- NCT01338974
- Testing
- gene expression analysis, proteomic profiling, flow cytometry
- Volunteers
- 290 people
- Sponsor
- SWOG Cancer Research Network
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.