Clinical trials: Older Adults With Mild Neurocognitive Disorders
Mild Cognitive Impairment
Immersive Virtual Reality for Dual-task Training in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial
Mild cognitive impairment (MCI) is a pre-dementia state marked by a higher risk of conversion to dementia. Presently, strategies to delay the progression of MCI to dementia, such as routine exercise and cognitive activities, are…
- Trial name
- NCT05730790
- Testing
- Cognitive-motor dual task training (DTT), Cognitive single task training (CSTT), Motor single task training (MSTT)
- Where
- Singapore
- Volunteers
- 54 people
- Sponsor
- Tan Tock Seng Hospital
Alzheimer Disease, Mild Dementia
Acute Effect of Low-intensity Gamma rTMS on Cognitive and EEG Parameters in Adults With Mild Dementia by Alzheimer's Disease
Neurocognitive disorders have a growing prevalence and impact on public health; their main etiology corresponds to Alzheimer's disease. To date, there is no treatment that can reverse neuronal damage in these pathologies.
- Trial name
- NCT05784298
- Testing
- low-intensity rTMS
- Where
- Mexico
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Chronic Pain, Mild Cognitive Impairment
Managing Pain and Cognitions in Older Adults With Early Cognitive Decline and Chronic Pain
The investigators aim to conduct a fully powered randomized controlled trial to compare the efficacy of two symptom management programs for older adults with early cognitive decline (either self-reported or confirmed by testing)…
- Conditions
- Chronic Pain, Mild Cognitive Impairment, Older Adults, Physical Activity
- Trial name
- NCT05373745
- Testing
- Active Brains 1, Active Brains 2
- Where
- United States
- Volunteers
- 267 people
- Sponsor
- Massachusetts General Hospital
Mild Cognitive Impairment (MCI)
Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment
Older adults with Mild Cognitive Impairment (MCI) often show less brain activity in a specific range (8-13 Hz, known as alpha power) compared to healthy older adults.
- Trial name
- NCT07097051
- Testing
- real tACS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- High Point University
Mild Cognitive Impairment, Old Age; Debility
Dual Task Perturbation Training for OAwMCI
Studies have determined that compared to cognitively intact older adults (CIOA), older adults with mild cognitive impairment (OAwMCI) exhibit more pronounced balance and gait impairments which lead to an increased risk of falls…
- Trial name
- NCT04938349
- Testing
- Dual task perturbation training
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Mild Cognitive Impairment (MCI), Depression
Brain Aging and Treatment Response in Geriatric Depression
The proposed project will evaluate the role of neuroimaging biomarkers of brain aging (i.e., neurodegenerative and vascular brain changes) and mild cognitive impairment in the patterns of treatment response to memantine combined…
- Trial name
- NCT01902004
- Testing
- Escitalopram, Memantine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of California, Los Angeles
Mild Cognitive Impairment
The Effect of Vırtual Reality Application ın Elderly People With Mild Cognitive Impairment
This study was conducted to investigate the effect of virtual reality application on visual skills, perceived occupational performance and satisfaction in elderly individuals with mild cognitive impairment.
- Trial name
- NCT06500650
- Testing
- Person-centred Occupational Therapy Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Saglik Bilimleri Universitesi
Mild Cognitive Impairment
Efficacy of Computerized Cognitive Training in the Elderly With Mild Cognitive Impairment
Mild cognitive impairment (MCI) is the prodrome of the cognitive function declining before Alzheimer's disease or other dementia showed up, the impairments of language, visuospatial relationship, attention, and memory included…
- Trial name
- NCT03577717
- Testing
- computerized cognitive training, occupational therapy
- Where
- Taiwan
- Volunteers
- 7 people
- Sponsor
- Taipei Hospital, Taiwan
Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted
Validating the On-line Creyos Cognitive Assessment Platform in Older Adults With Major Depressive Disorder or Mild Cognitive Impairment
The goal of this observational study is to validate the Creyos online cognitive assessment platform in individuals with mild cognitive impairment, or remitted major depressive disorder.
- Conditions
- Mild Cognitive Impairment (MCI), Major Depressive Disorder, Remitted, Healthy Controls Group - Age and Sex-matched
- Trial name
- Creyos-MD (NCT06780917)
- Where
- 3 sites in Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Healthy, Mild Cognitive Impairment
tES Effects on Associative Memory Performance
Previous studies showed that transcranial electric stimulation (tES) applied over the prefrontal cortex improves cognitive performance in healthy elderly adults as well as in patients suffering from mild cognitive impairment or…
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03351452
- Testing
- real anodal transcranial direct current stimulation, real transcranial alternating current stimulation
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Bern
Frailty, Mild Cognitive Impairment
Effects of Square-stepping Exercise on Frailty and Cognitive Function in Elderly With Frailty and MCI
This is a single-blinded, randomized controlled trail with pre- and post-measurements. The inclusion criteria are: (1) age between 65 to 90 years old, (2) the presence of at least one of the 5 physical characteristics defined by…
- Trial name
- NCT04463797
- Testing
- Square-stepping exercise, Stretching and strengthening
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- National Yang Ming Chiao Tung University
Mild Cognitive Impairment (MCI), Sarcopenia
Project Gnosis: the Neurophysical and Psychosocial Health Outcomes of Tai Chi for Older Adults with Cognitive Concerns or Mild Cognitive Impairment
Mild Cognitive Impairment (MCI) in older adults is linked to muscle loss (sarcopenia) and can lead to dementia, with pain further impacting cognitive and physical performance.
- Trial name
- NCT06828926
- Testing
- Tai Chi
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ohio University
Creatine, Exercise
Creatine and Resistance Training in Older Adults With Mild Cognitive Impairment
The goal of this 26-week trial is to learn if creatine supplementation and resistance training (i.e., weightlifting; exercise that increases muscle mass), alone and together, impact cognition, brain health, and physical function…
- Conditions
- Creatine, Exercise, Mild Cognitive Impairment (MCI)
- Trial name
- NCT06948149
- Testing
- Creatine monohydrate, Resistance training
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Western University, Canada
Aging, Mild Cognitive Impairment
Modulating Cortical Dynamics of Dual-task Standing in MCI
The investigators have designed a brain stimulation study to understand its effect on an individual's standing, walking, and thinking abilities in older adults with and without mild cognitive impairments (MCI).
- Trial name
- NCT05680701
- Testing
- real tACS
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Mild Cognitive Impairment
Real-time fMRI Neurofeedback in Patients With MCI
Increased activity in the hippocampus (i.e., hyperactivity) during a fMRI memory task was found in patients with Mild Cognitive Impairment due to Alzheimer's disease (MCI).
- Trial name
- NCT04020744
- Testing
- real-time fMRI based neurofeedback from the hippocampus, real-time fMRI based neurofeedback from another brain area
- Where
- 2 sites in Switzerland
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Bern
Mild Cognitive Impairment
NAD Therapy for Improving Memory and Brain Blood Flow in Older Adults With Mild Cognitive Impairment
This study will provide insight into whether a nutritional supplement, nicotinamide riboside (NR), improves memory and brain blood flow in older adults with low memory abilities.
- Trial name
- NCT03482167
- Testing
- Niagen®
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Delaware
Dementia, Neurocognitive Disorders
Effect of Individual Cognitive Stimulation on Memory and Executive Function in Older Adults With Alzheimer's Disease
This multicentre study, with a randomised controlled repeated measures experimental design, will be conducted in several Portuguese institutions, which provide care and supportive services for older adults diagnosed with mild or…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT05433493
- Testing
- Cognitive stimulation
- Where
- 14 sites in Portugal
- Volunteers
- 142 people
- Sponsor
- Rsocialform - Geriatria, Lda
Alzheimer's Disease, Healthy Non-elderly and Elderly Adults
Multiple Ascending Dose Safety, Tolerability, PK Study of AL001 in Alzheimer's Disease Patients & Healthy Adult Subjects
This is a Phase 1/2a, multi-center, placebo-controlled, double-blinded, randomized, multiple ascending dose (MAD) clinical trial to determine the safety and maximum tolerated dose of AL001.
- Trial name
- "MAD" (NCT05363293)
- Testing
- AL001
- Where
- 2 sites in United States, Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Alzamend Neuro, Inc.
Mild Cognitive Impairment, Cognitive Dysfunction
Non-randomized Clinical Trial on Cognitive Stimulation With Virtual Reality in Patients With Mild Cognitive Impairment
The purpose of this study is to find out if adding virtual reality (VR) to a cognitive training program helps improve cognitive performance in older adults with mild cognitive impairment (MCI).
- Conditions
- Mild Cognitive Impairment, Cognitive Dysfunction, Aging
- Trial name
- RVEC-DCL (NCT06977815)
- Testing
- VR-Enhanced Cognitive Rehabilitation, Standard Cognitive Rehabilitation
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Badalona Serveis Assistencials
Dysphagia, Oropharyngeal
The Efficacy of Tongue Exercises on Swallowing Function in the Elderly With Mild Cognitive Impairment
The purpose of this study is to explore the effects of tongue muscle strength and resistance exercises on dysphagia, tongue muscle strength, oral hygiene, repetitive saliva swallowing, nutrition, depression, and…
- Trial name
- NCT06490705
- Testing
- tongue resistance exercises, tongue strengthening exercises and tongue resistance exercises
- Where
- Taiwan
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Chang Gung Medical Foundation