Clinical trials: Older Patients
Health Risk Behaviors
Feasibility, Acceptability, and Preliminary Efficacy of an HIV Prevention Intervention for Older Black Women
The goal of this clinical trial is to learn whether a group-based HIV prevention program can improve HIV knowledge, prevention behaviors, and testing in older Black women aged 50 and older who live in subsidized housing.
- Trial name
- NCT07181616
- Testing
- Adapted W2W, Waitlist Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Laneshia Conner
Cancer, Cognitive Impairment
Cancer and Mild Cognitive Impairment Dyadic Intervention
The purpose of this study is to see whether programs that include both a patient and their spouse or a patient and family caregiver (known as a dyad) are helpful for families in which one member of the dyad has cancer and mild…
- Trial name
- NCT05144516
- Testing
- Behavioral: COPE +
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Heart Failure With Preserved Ejection Fraction
Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction
The REHAB-HFpEF trial will determine whether a novel physical rehabilitation intervention will improve the primary outcome of combined all-cause rehospitalizations and mortality and the secondary outcome of major mobility…
- Trial name
- REHAB-HFpEF (NCT05525663)
- Testing
- Rehabilitation Intervention
- Where
- United States
- Volunteers
- 880 people
- Sponsor
- Wake Forest University Health Sciences
Muscular Atrophy
A Study of LY2495655 in Older Participants Undergoing Elective Total Hip Replacement
The primary objective of this study is to test the hypothesis that appendicular lean body mass (aLBM) will increase after 12 weeks of LY2495655 treatment versus placebo in older participants undergoing elective total hip…
- Trial name
- NCT01369511
- Testing
- LY2495655
- Where
- 45 sites in United States, Austria and 9 more
- Volunteers
- 400 people
- Sponsor
- Eli Lilly and Company
Sedative Adverse Reaction, Anticholinergic Adverse Reaction
Pharmacist Led Intervention to Improve Medication Use in Older In-patients Living With Frailty: the Drug Burden Index
Older people in Canada commonly take multiple medicines for their health conditions. Certain medicines, especially when taken together can lead to serious harms, such as falls.
- Trial name
- NCT03698487
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Emily
Community-Acquired Pneumonia, Exacerbation of Chronic Heart Failure
Feasibility and Outcomes of Older Patients Hospitalization
Hospitalization is a traumatic event for the patient and his family at any age nevertheless in the older age. One of its consequences is the difficulty to resume previous activity of daily living especially in older (over 75…
- Conditions
- Community-Acquired Pneumonia, Exacerbation of Chronic Heart Failure, Exacerbation of Chronic Obstructive Pulmonary Disease, Cellulitis
- Trial name
- NCT00489021
- Testing
- sub-acute hospitalization
- Volunteers
- 300 people
- Sponsor
- Hillel Yaffe Medical Center
Breast Cancer
Combination Chemotherapy Compared With Mitoxantrone in Treating Older Patients With Advanced Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs in different combinations may kill more tumor cells.
- Trial name
- NCT00002498
- Testing
- CMF regimen, cyclophosphamide, fluorouracil
- Where
- 2 sites in Netherlands
- Sponsor
- Leiden University Medical Center
Frailty
Intrinsic Capacity and Functional Ability Monitoring With an Integrated Data Eco-System for Healthy Ageing.
In this study, 120 older adults (aged 65 years or older) either patients undergoing rehabilitation or older nursing home residents will be provided with an Eforto® device and the eco-System for Healthy Ageing (ISHA) mobile…
- Trial name
- ISHA (NCT06270979)
- Testing
- ISHA
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Prof. Ivan Bautmans
Indication for Modification of Patient Cognitive Status
Cognitive Rehabilitation in Older Adults With Neuron-up (CROAN)
Introduction. The application of new technologies for cognitive rehabilitation has increased over the last years and has enabled occupational therapists to work more efficiently, minimizing costs and time for analysis…
- Trial name
- NCT03944135
- Testing
- Web platform: Neuronup
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad de Burgos
Geriatric Assessment, Frail Elderly
Drug Reduction in Older Patients: The DROP Trial
Project Objectives: The proposed randomized, controlled trial will evaluate the effects of procedures to reduce medications among hospitalized older Veterans discharged to nursing homes using an hybrid study design to inform…
- Conditions
- Geriatric Assessment, Frail Elderly, Skilled Nursing Facilities, Patient-centered Care
- Trial name
- DROP (NCT03722017)
- Testing
- Deprescribing intervention
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- VA Office of Research and Development
Acute Myeloid Leukemia With Gene Mutations, Adult Acute Myeloid Leukemia in Remission
Midostaurin in Treating Older Patients With Mutated Acute Myeloid Leukemia Post-Transplant
This phase 2 trial studies the side effects and how well midostaurin works in treating older patients with acute myeloid leukemia with change in genetic material post-hematopoietic cell transplantation.
- Trial name
- NCT02723435
- Testing
- Midostaurin
- Sponsor
- Stanford University
Emergency Department Patient, Comfort
Enhancing the Emergency Department Experience for Older Adults: Study Protocol for the Implementation of a Comfort Menu and Cart
Introduction: The aging of the population is a global phenomenon, with projections indicating a significant increase in the proportion of individuals aged 60 years and older by 2050.
- Trial name
- NCT06681376
- Testing
- Comfort menu and cart
- Where
- Brazil
- Volunteers
- 264 people
- Sponsor
- Hospital Sirio-Libanes
Vaccination
Evaluation of a Tdap-IPV (Tetanus, Diphteria, Pertussis and Inactivated Polio) Vaccination Remedial Strategy on Vaccination Coverage in Patients 65 Years of Age or Older
In France, vaccination coverage is insufficient (in 2002, 71.2% coverage for tetanus, 41.9% for poliomyelitis and 33.7% for diphteria).
- Trial name
- HOSPIVAC (NCT03587610)
- Testing
- Remedial vaccination
- Where
- France
- Volunteers
- 218 people
- Sponsor
- Centre Hospitalier le Mans
Arteriosclerosis
Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA)
RATIONALE: Atherothrombosis is a progressive and generalized vascular disease resulting in events leading to myocardial infarction (heart attack), stroke, and vascular death.
- Trial name
- NCT00050817
- Testing
- clopidogrel (SR25990)
- Where
- 32 sites in United States, Argentina and 30 more
- Volunteers
- 15,603 people
- Sponsor
- Sanofi
Surgery, Geriatric Assessment
Implementation Pilot of Preoperative CGA Before Major Surgery
The goal of this clinical trial is to test whether a new implementation package can help older adults prepare for major surgery.
- Conditions
- Surgery, Geriatric Assessment, Health Services Research, Implementation Science
- Trial name
- NCT06184724
- Testing
- Implementation Package for CGA, Routine Clinical Care
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Neuroblastoma, Ganglioneuroblastoma
Induction Chemoimmunotherapy for Patients With High-risk Neuroblastoma
The modern strategy of therapy of high-risk neuroblastoma, stage 4, consists of three phases - induction, consolidation and post- consolidation.
- Trial name
- NCT06071897
- Testing
- monoclonal antibodies GD2
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Stem Cell Transplant
Assessment of Elderly Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Patients older than 60 years are more and more transplanted. Comprehensive geriatric assessment (CGA) have been developed and are currently used in patients with cancer, it has been correlated with the prognosis.
- Trial name
- ELDERGRAF (NCT04375579)
- Testing
- Comprehensive geriatric assessment (CGA)
- Where
- 18 sites in France
- Volunteers
- 205 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aging
Continuous Connected Patient Care (CCPC), a Pilot Testing a Novel Device for Continuous Vitals Monitoring - Older Adults Department PHC
To confirm feasibility and accessibility of the CCPC Platform (Oxymotion, Bridge Health Solutions medication adherence software, CloudDX home kit) in two different environments - 1) hospital (Acute Care for Elderly Unit) and 2)…
- Trial name
- NCT06638060
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Type2Diabetes
Evaluation of SGLT2-i Effectivness and Safety in Elderly Type 2 Diabetes Patients
The aim of the study is to evaluate the benefits, documented in experimental settings, of treatment with SGLT2-i in subjects with type 2 diabetes and older than 70 years in normal clinical practice.
- Trial name
- SOLDMiDiab02 (NCT05477017)
- Testing
- SGLT2 inhibitor
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- University of Milan
Subjective Cognitive Decline, Subjective Cognitive Complaint
The Efficacy and Mechanism of Acupuncture Treatment in Patients With Subjective Cognitive Decline
This study evaluates the efficacy and mechanism of acupuncture treatment in patients with subjective cognitive decline. Half of patients will receive acupuncture treatment for 12 weeks, while the other half will receive sham…
- Trial name
- NCT03444896
- Testing
- Acupuncture group
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Hospital of Traditional Chinese Medicine