Clinical trials: Older People
Major Depressive Episode (MDE), Beliefs
Belief Update: The Effects of Depression and Antidepressants in Older People
People in good health do not perceive the future in the same way as those suffering from depression. This difference in perception affects behaviour and emotions and warrants further investigation, both before and after treatment…
- Conditions
- Major Depressive Episode (MDE), Beliefs, Beliefs About Future, Depression
- Trial name
- OLDBELIEFS (NCT07681492)
- Testing
- Response to questionnaire
- Where
- 2 sites in France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Center Guillaume Régnier
Chronic Pain
Nature as a Buffer Among People With Chronic Pain
This randomized controlled trial examines the effect of nature exposure on pain intensity levels among older adults who experience chronic pain.
- Trial name
- NCT03153891
- Testing
- Natural Environment, Built Environment
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Cornell University
Older Adults, Balance, Older People
AquaReBal - Aquatic Reactive Balance Training for Older Adults
Falls are the second leading cause of accidental injury deaths worldwide, mostly in older adults. Injuries resulting from a fall are a leading cause of hospitalizations among older adults in Canada with a higher total injury cost…
- Conditions
- Older Adults, Balance, Older People, Aquatic Physical Exercise
- Trial name
- AquaReBal (NCT06720974)
- Testing
- AquaReBal
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Józef Piłsudski University of Physical Education
Cardiovascular Diseases
Tackling Disruptions to Frailty Interventions: Developing Personalized Interventions Targeted for Older Persons With Cardiac Frailty
Background: Muscle mass loss and metabolic dysfunction, exacerbated by inactivity and nutritional inadequacies, underpin both cardiovascular disease and frailty in ageing.
- Trial name
- INDEPENDENCY (NCT05946174)
- Testing
- Intervention Set A, Intervention Set B, Intervention Set C
- Where
- 6 sites in Singapore
- Volunteers
- 500 people
- Sponsor
- National Heart Centre Singapore
Diabetes Mellitus, Type 2
Self-Care for Older People With Diabetes Mellitus
In Singapore, the prevalence of diabetes was approximately 12.8% in 2014 and was projected to rise to 22.7% in 2035. In 2015, the International Diabetes Federation (IDF) reported that Singapore has the second highest proportion…
- Trial name
- SCOPE-DM (NCT03890991)
- Testing
- SCOPE-DM, SCOPE-DM with 3 months' supply of glucometer, SCOPE-DM with 6 months' supply of glucometer
- Where
- Singapore
- Volunteers
- 320 people
- Sponsor
- National University of Singapore
Cognitive Impairment
Nurse-Led Active Music Program in Older Adults With Cognitive Impairment
This pilot study evaluated the feasibility and acceptability of a structured, nurse-led active music program for older adults with cognitive impairment living in a long-term care facility.
- Trial name
- NCT07831850
- Testing
- Nurse-Led Active Music Program
- Where
- Spain
- Volunteers
- 11 people
- Sponsor
- Universidad de Almeria
COVID-19
A Clinical Trial on Booster Immunization of Two COVID-19 Vaccines Constructed From Different Technical Routes
This is an open-label, randomized, parallel-controlled clinical trial conducted in people aged 18 years and older to evaluate the immunogenicity and safety of two SARS-CoV-2 bivalent vaccines constructed by adenovirus type…
- Trial name
- NCT05886790
- Testing
- Prototype and Omicron BA.4/5 Bivalent Recombinant COVID-19 Vaccine(Adenovirus Type 5 Vector) For Inhalation, Bivalent COVID-19 mRNA Vaccine, Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) For Inhalation
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Physical Activity
Supervised Group-based Walking Intervention Among Inactive Older Adults in Saudi Arabia
The purpose of the proposed study is to compare the effects of supervised group-based walking and non-supervised individual-based walking interventions on frailty, cognitive function and quality of life among inactive older…
- Trial name
- NCT05151575
- Testing
- supervised group-based walking and non-supervised individual-based walking interventions
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
HIV, Cardiovascular Disease
Ugandan Non-Communicable Diseases and Aging Cohort
Longitudinal cohort study of older-aged people living with HIV infection in southwestern Uganda and age and gender-matched HIV uninfected controls with the primary aim of measuring the epidemiology of cardiovascular and pulmonary…
- Conditions
- HIV, Cardiovascular Disease, Chronic Obstructive Pulmonary Disease, Atherosclerosis
- Trial name
- UGANDAC (NCT02445079)
- Testing
- This is an observational study only
- Where
- Uganda
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Frailty, Frailty Syndrome
Maintaining and imPrOving the intrinSIc capaciTy Involving Primary Care and caregiVErs
The POSITIVE platform offers the possibility of unsupervised monitoring of pre-frailty and frailty status in a community setting, to detect the onset of frailty and to assess its evolution.
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome
- Trial name
- POSITIVE (NCT04592146)
- Testing
- Frailty multicomponent intervention supported by POSITIVE, Frailty multicomponent intervention
- Where
- 3 sites in Poland, Spain and 1 more
- Volunteers
- 150 people
- Sponsor
- Hospital Universitario Getafe
Falls
VISIBLE Study (Visual Intervention Strategy Incorporating Bifocal & Long-distance Eyewear)
The purpose of this study is to determine whether the provision of supplementary plain distance glasses for outdoor use to older users multifocal glasses will reduce falls rates over a 12 month period.
- Trial name
- VISIBLE (NCT00350389)
- Testing
- Outdoor use of plain distance glasses with counselling
- Where
- Australia
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- The University of New South Wales
Type 2 Diabetes Mellitus, Aging
Heat Shock Response is Blunted in Elderly Diabetic People But Recovered by Strength Training
The aim of this study was to compare the heat shock response (HSR) between healthy middle-aged adults, healthy elderly adults and type 2 diabetic elderly people.
- Trial name
- NCT03489083
- Testing
- Strength training, No Training
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Toileting-Related Falls, Fall Risk
Integrated Prevention, Treatment, and Rehabilitation for Toileting-Related Falls
Toileting-related falls may result from a combination of urinary symptoms, impaired gait and balance, reduced muscle strength, cognitive or emotional problems, and unsafe environmental conditions.
- Trial name
- NCT07738354
- Testing
- Individualized Multidimensional Management Program for Toileting-Related Fall Prevention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Qing Yuan
Dementia, Mild Cognitive Impairment
Dual-Task Training for People With Mild Cognitive Impairment and Mild Dementia
Evidence shows that people with dementia have a higher prevalence of sleep disturbance, cognitive decline, behavioral disturbance, and experience motor dysfunction. These symptoms are interrelated.
- Conditions
- Dementia, Mild Cognitive Impairment, Older Adult
- Trial name
- DTT (NCT06348810)
- Testing
- Dual-task training, Cognitive training, Motor training
- Where
- Indonesia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Diffuse Large B Cell Lymphoma (DLBCL), High Grade B Cell Lymphoma
A Study of Glofitamab-based Treatment in People With Diffuse Large B-cell Lymphoma
The researchers are doing this study to find out if the study treatment is an effective treatment that causes few or mild side effects in people with diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma (HGBCL), or…
- Trial name
- NCT06765317
- Testing
- Glofitamab, Polatuzumab, Rituximab
- Where
- 8 sites in United States
- Volunteers
- 42 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Age-Related Memory Disorders
Nintendo Wii Virtual Reality Application In Dementia
•This study was planned to investigate the effects of the Nintendo Wii virtual reality application on muscle strength and fall risk in individuals with AD.
- Trial name
- NCT04819126
- Testing
- Nintendo Wii Virtual Reality Application
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Kırıkkale University
Immunogenicity, Vaccine
Immunogenicity of the BNT162b2 Covid-19 Vaccine in Elderly People Aged 85 and Older in Greece
Real-world evidence confirming the effectiveness and safety of the new COVID-19 vaccines among the elderly is currently lacking.
- Trial name
- GREVAXIMO (NCT04756817)
- Where
- Greece
- Volunteers
- 297 people
- Sponsor
- G.Gennimatas General Hospital
Aging Well
Telematic Dance Intervention on Quality of Life of Older
The aim of this study is to analyse the effectiveness of a telematic dance intervention on the quality of life of older people. This project is a controlled, randomized clinical trial.
- Trial name
- NCT04681976
- Testing
- Telematic dance program
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Hiv, Atherosclerosis
Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
The goal of this clinical trial is to conduct a dietary intervention targeting HIV specific gut microbiota alterations for primary atherosclerotic cardiovascular disease (ASCVD) prevention and evaluate its effectiveness in…
- Conditions
- Hiv, Atherosclerosis, Diet, Healthy
- Trial name
- NCT06560840
- Testing
- dietary intervention
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Fudan University
Older People, Exercise
Effect Of Functional Balance Exercise İn Elderly
The elderly population is increasing in Turkey and in the world. Many health problems, such as a decrease in physical and psychological abilities and an increase in chronic problems, occur with aging.
- Trial name
- NCT06383676
- Testing
- Functional reaction balance training, Functional balance training
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Tarsus University