Clinical trials: Older Women
Breast Cancer
Surgery With or Without Lymph Node Removal in Treating Older Women With Stage I or Stage IIA Breast Cancer
RATIONALE: Removing axillary lymph nodes may be effective in stopping the spread of breast cancer cells. It is not yet known if surgery to remove breast cancer is more effective with or without lymph node removal.
- Trial name
- 10-93 (NCT00002528)
- Testing
- tamoxifen citrate, conventional surgery, radiation therapy
- Where
- 21 sites in Australia, Hungary and 7 more
- Volunteers
- 473 people
- Sponsor
- ETOP IBCSG Partners Foundation
Dairy Products, Muscle Protein Synthesis
The Effect of Whole Milk to Improve Muscle Health in Older Women
Muscle and strength begin to noticeably decline around 50 years of age, increasing an individual's risk for disease and disability.
- Conditions
- Dairy Products, Muscle Protein Synthesis, Aging, Physical Activity
- Trial name
- NCT04981652
- Testing
- Whole Milk, Skim Milk, Almond Beverage
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- McMaster University
Breast Cancer
Doxorubicin or Epirubicin and Cyclophosphamide in Treating Older Women With Invasive Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as doxorubicin, epirubicin, and cyclophosphamide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00516425
- Testing
- pegfilgrastim, cyclophosphamide, doxorubicin hydrochloride
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Charing Cross Hospital
Metastatic Breast Cancer
To Compare Treatment With Doxorubicin or Capecitabine for Metastatic Breast Cancer in Women 60 Years and Older
The main purpose of this study is to compare treatment with either pegylated liposomal doxorubicin or capecitabine as first line chemotherapy for metastatic breast cancer in women 60 years and older.
- Trial name
- NCT00082095
- Testing
- Pegylated liposomal doxorubicin, Capecitabine
- Where
- 27 sites in United States
- Volunteers
- 62 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Renal Dialysis, Kidney Failure, Chronic
Safety and Pharmacokinetics of MK-2060 in Older Participants With End-Stage Renal Disease on Hemodialysis (MK-2060-004)
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of MK-2060 after intravenous (IV) administration of single and multiple doses in older adult participants with…
- Trial name
- NCT03873038
- Testing
- MK-2060
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Merck Sharp & Dohme LLC
Osteoporosis, Accidental Falls
The Effect of Digital Education for Osteoporosis Patients on Fracture Risk and Related Health Outcomes.
A digital education for osteoporosis patients (DEOP) has been developed and tested on patients in Region Vastra Gotaland, Sweden.
- Conditions
- Osteoporosis, Accidental Falls, Fractures, Bone, Patient Reported Outcome Measures
- Trial name
- NCT06603545
- Testing
- Digital education for osteoporosis patients
- Volunteers
- 2,640 people
- Sponsor
- Sahlgrenska University Hospital
Pregnancy Complications
Risk of Cesarean Section in Primiparous Women Over 35 Years of Age.
The investigators reviewed Saint Thomas Maternity Hospital's database during a 5 year period and compared two cohorts of patients (primiparous women over 35 years of age and primiparous woman between 20 and 34 years of age).
- Trial name
- NCT03771976
- Testing
- Cesarean section, No cesarean section
- Where
- Panama
- Volunteers
- 572 people
- Sponsor
- Saint Thomas Hospital, Panama
Physical Inactivity
Testing Multi-Level Remote Physical Activity Interventions in a National Sample of Older Women: The WHISH EnCore Trial
While older women are disproportionately affected by chronic diseases and conditions associated with aging, including both physical and cognitive impairments, that can be alleviated or delayed by regular physical activity, few…
- Trial name
- WHISH EnCore (NCT05566873)
- Testing
- PA Education plus human and planetary health information, PA Education plus Our Voice citizen science
- Where
- United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Stanford University
Older People, Sports
Boxing, Taekwondo and Elastic Band Training on Body Composition and Physical Performance in Older Women
The objective of this clinical trial is to compare the effect of three physical interventions (Taekwondo, Boxing, and Elastic Band Training) on body composition and physical performance in older Chilean women.
- Conditions
- Older People, Sports, Martial Arts
- Trial name
- RCT (NCT06780020)
- Testing
- Effects of different interventions using boxing, Effects of different interventions using taekwondo, Effects of different interventions using Elastic Band
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Católica del Maule
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Exercise During Chemotherapy in Older Women With Stage I-III Breast Cancer
This clinical trial evaluates the feasibility of exercise during chemotherapy in older women with stage I-III breast cancer. Previous studies have reported that exercise may reduce the chemotherapy-toxicity risk.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT05025059
- Testing
- Discussion, Exercise Intervention, Informational Intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Mammography Screening, Geriatrics
Breast Cancer Screening Decision Aid
This is a randomized survey study of 2 decision aids for breast cancer screening. Decision aids are tools that present structured information to patients about a medical test or treatment.
- Conditions
- Mammography Screening, Geriatrics, Decision Aid
- Trial name
- NCT07515846
- Testing
- Video based decision aid, Written decision aid
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy
Pharmacologic Effects of Darifenacin and Tolterodine on Cardiovascular Parameters in Healthy Subjects
This study will evaluate the pharmacologic effects of exposure to darifenacin and tolterodine on cardiovascular parameters in healthy subjects 50 years of age and older
- Trial name
- NCT00413790
- Testing
- Darifenacin, Tolterodine
- Where
- 12 sites in United States
- Volunteers
- 162 people
- Sponsor
- Novartis
Essential Hypertension
Heat Therapy in Older Hypertensive Women
The prevalence of hypertension is greater in older women than men, while the blood pressure (BP) control rate is lower in older women in US. Uncontrolled hypertension is a major risk factor for cardiovascular morbidity/mortality.
- Trial name
- NCT03857490
- Testing
- Lower leg heat therapy
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- University of Texas Southwestern Medical Center
Coronavirus Disease (COVID-19)
A Study of TAK-919 in Healthy Japanese Adults (COVID-19)
TAK-919 is a vaccine in development to protect people against Covid-19. The main aims of the study are to learn if TAK-919 can protect people from Covid-19 and to check for side effects from TAK-919.
- Trial name
- NCT04677660
- Testing
- TAK-919
- Where
- 2 sites in Japan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Takeda
Aging, Inspiratory Muscle Weakness
Effect of Inspiratory Muscle Training on Diaphragm Muscle Thickness, Fatty Liver Density and Aerobic Capacity in Elderly Men: A Randomized Controlled Trial
This randomized controlled trial aims to investigate the effects of a 4-week inspiratory muscle training (IMT) program on diaphragm muscle thickness, fatty liver density, functional capacity, and quality of life in elderly men…
- Conditions
- Aging, Inspiratory Muscle Weakness, Fatty Liver, Reduced Functional Capacity
- Trial name
- IMT AND ELDERL (NCT07193082)
- Testing
- Experimental Inspiratory Muscle Training (IMT Group), Control Group: No inspiratory muscle training.
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gümüşhane Universıty
Breast Cancer
Longitudinal Impact of Adjuvant Chemotherapy on Functional Status, Comorbidity and Quality of Life
The goal of this study is to increase our understanding of the adjuvant chemotherapy experience in older and younger adults by prospectively describing the longitudinal trajectory of functional status, comorbidity, and quality of…
- Trial name
- NCT01030250
- Where
- United States
- Volunteers
- 238 people
- Sponsor
- City of Hope Medical Center
Abdominal Obesity
Effects of Exercise Modality on Abdominal Obesity and Health Risk Factors in Older Men and Women
The prevalence of abdominal obesity in the elderly is increasing at alarming rates and thus, requires immediate attention. By comparison to younger adults, obesity reduction in the elderly presents a unique challenge and requires…
- Trial name
- NCT00520858
- Testing
- Resistance Exercise (RE), Aerobic Exercise (AE), Resistance and Aerobic Exercise (RAE)
- Where
- Canada
- Volunteers
- 145 people
- Sponsor
- Queen's University
Sialorrhea
A Retrospective Chart Abstraction to Investigate the Prevalence of Chronic Sialorrhea, and the Real-world Use of incobotulinumtoxinA Injections in Male and Female Participants Aged 18 Years and Older With Chronic Sialorrhea
A retrospective, multicenter chart abstraction to investigate the prevalence of chronic sialorrhea, and the real-world use of incobotulinumtoxinA injections in male and female participants aged 18 years and older with chronic…
- Trial name
- NCT07881497
- Where
- United States
- Volunteers
- 206 people
- Sponsor
- Medstar Health Research Institute
Cardiovascular, Comorbidity
Improving Patient-Centered Care for Underserved Older African American Patients With Cardiovascular Comorbidities
This is formative evaluation trial guided by the Values Clarification Theory25 and the Cultural Values Theory26, with specific aims to: Aim 1.
- Conditions
- Cardiovascular, Comorbidity, Diabetes, Inflammatory Joint Diseases
- Trial name
- PPC Heart (NCT07748858)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Alabama at Birmingham
Toileting Disability, Functional Urinary Incontinence
Defeating Urinary Incontinence With Exercise Training (DUET) Feasibility Study
Pilot study to determine the feasibility and possible treatment effect of a multi-component intervention combining non-drug treatments for urinary incontinence and physical activity to improve urinary incontinence, toileting…
- Trial name
- DUET (NCT02206958)
- Testing
- Defeating Urinary Incontinence with Exercise Training
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Minnesota