Clinical trials: Older Women
Frail Elderly Syndrome
Exercise Mediation on Hormonal, Immune and Psychological Well-being in Institutionalized Frail Older Women.
Frailty syndrome is a complex aging expression determined by ontogenetic and phylogenetic factors. Chronic stress has been shown to have immunosuppressive effects, to accelerate immunosenescence and to cause cumulative disorders…
- Trial name
- UC (NCT04435899)
- Testing
- Physical exercise
- Where
- Portugal
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Resilience, Psychological
Resilience Intervention for Older, HIV-Infected Women
The goal of this study is to refine and pilot the Relaxation Response Resiliency (3RP) intervention for women age 50 and over who are living with HIV, a group especially burdened by stressors related both to aging and living with…
- Trial name
- BRIgHT (NCT03071887)
- Testing
- Relaxation Response Resiliency Program (3RP)
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Massachusetts General Hospital
Stress Urinary Incontinence, Menopause
The Anabolic Effect of Testosterone on Pelvic Floor Muscles
Stress urinary incontinence is the most common female pelvic floor disorder encountered in clinical practice with significant negative impact on quality of life.
- Trial name
- NCT06111209
- Testing
- Testosterone cypionate
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
Protein-energy; Imbalance
Assessment of Dietary Protein Needs of Older Women
The purpose of this study is to evaluate dietary protein requirements in elderly women aged 80 years and older using the indicator amino acid oxidation technique.
- Trial name
- NCT01193946
- Testing
- dietary control
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Purdue University
Dementia, Cognition
Cognitive and Functional Status and Dialysis Outcomes in Older Hemodialysis Patients
The purpose of this study is to estimate how quickly cognitive status and functional status in older patients on hemodialysis declines.
- Conditions
- Dementia, Cognition, End-stage Renal Disease
- Trial name
- NCT00739843
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Chicago
Older Adult
High-intensity Interval Training Combined with Muscle-strength Training in Older Women
Women generally live longer than men but often experience a faster muscle mass loss due to inactivity, which can lead to weakness and disability. Despite these risks, women, particularly older women, are less active than men.
- Trial name
- NCT06825130
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter
S0028, Gemcitabine and Paclitaxel in Treating Patients With Advanced or Recurrent Cancer of the Urinary Tract
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving more than one drug may kill more tumor cells.
- Conditions
- Bladder Cancer, Transitional Cell Cancer of the Renal Pelvis and Ureter, Urethral Cancer
- Trial name
- NCT00022633
- Testing
- gemcitabine hydrochloride, paclitaxel
- Where
- 92 sites in United States
- Volunteers
- 65 people
- Sponsor
- SWOG Cancer Research Network
Physical Activity
Smart Walk 50+: Feasibility of a Smartphone-delivered Physical Activity Program for African American Women 50 Years and Older
The purpose of this study is to establish the acceptability and feasibility of a culturally relevant, theory-based smartphone-delivered physical activity intervention among African American women aged 50-65 years.
- Trial name
- NCT04073355
- Testing
- Physical Activity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Alopecia Areata
Investigate the Efficacy and Safety of Farudodstat Compared With Its Placebo in Adult Alopecia Areata Participants
The main purpose of this study is to measure the efficacy of farudodstat compared to placebo at Week 12 from the treatment start, in adult participants with Alopecia Areata (AA) with 30% or greater scalp hair loss.
- Trial name
- FAST-AA (NCT05865041)
- Testing
- Farudodstat
- Where
- 19 sites in United States
- Volunteers
- 60 people
- Sponsor
- ASLAN Pharmaceuticals
Breast Cancer, Cancer Survivor
Aerobic Exercise, Resistance Exercise, or Flexibility and Relaxation Training in Inactive Older Female Breast Cancer Survivors
RATIONALE: Aerobic exercise, resistance exercise, and flexibility and relaxation training may reduce fatigue and improve the health and quality of life of breast cancer survivors.
- Conditions
- Breast Cancer, Cancer Survivor, Fatigue, Long-term Effects Secondary to Cancer Therapy in Adults
- Trial name
- NCT00662103
- Testing
- exercise intervention, laboratory biomarker analysis, questionnaire administration
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- OHSU Knight Cancer Institute
Breast Cancer
Capecitabine and Vinorelbine in Treating Older Women Who Have Metastatic Breast Cancer With or Without Bone Involvement
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003902
- Testing
- capecitabine, vinorelbine tartrate
- Where
- Switzerland
- Volunteers
- 110 people
- Sponsor
- Swiss Cancer Institute
Ovarian Cancer, Frailty
FRAGINOC Study: Screening and Geriatric Assessment and Intervention in Older Patients With Epithelial Ovarian Cancer
Ovarian cancer (OC) is the fifth most common cause of cancer death. More than 40% are older than 70 years. The standard treatment is radical surgery combined with chemotherapy.
- Trial name
- FRAGINOC (NCT05810701)
- Testing
- Comprehensive geriatric assessment and individualised physical training
- Where
- 5 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Odense University Hospital
Acute Kidney Injury
Frailty and Outcomes in Critically Ill Patients Receiving CRRT
This nationwide observational cohort study will investigate the association between frailty, chronological age, and clinical outcomes in critically ill patients receiving continuous renal replacement therapy (CRRT) in Sweden.
- Trial name
- CRRT-AF (NCT07837219)
- Volunteers
- 22,000 people
- Sponsor
- Karolinska Institutet
Human Papillomavirus Infection
Clinical Evaluation of the APTIMA® HPV Assay Using the TIGRIS® System
The purpose of this study is to provide data on the performance of the APTIMA HPV Assay using the TIGRIS System in detecting HPV types that may cause cervical cancer.
- Trial name
- NCT00973362
- Testing
- APTIMA HPV Assay, FDA-Approved HPV DNA Test
- Where
- 17 sites in United States
- Volunteers
- 12,896 people, healthy volunteers welcome
- Sponsor
- Gen-Probe, Incorporated
Breast Cancer, Estrogen Receptor Positive Breast Cancer
A Breast Cancer Treatment Decision Aid for Women Aged 70 and Older
The purpose of this research study is to evaluate a decision aid to help women aged 70 and older decide on treatment for their breast cancer.
- Conditions
- Breast Cancer, Estrogen Receptor Positive Breast Cancer, Node-negative Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
- Trial name
- NCT02823262
- Testing
- Breast Cancer Treatment Decision Aid for women 70+, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pelvic Organ Prolapse
Predictors of Post Operative Morbidity in Older Women With Pelvic Organ Prolapse
The Investigators hypothesize that functional status scores in elderly women undergoing surgery for pelvic organ prolapse will be lower at 6 weeks post-operatively but will have returned to baseline at 12 weeks post-operatively.
- Trial name
- NCT01967446
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Type 2 Diabetes Mellitus (T2DM)
Effect of Tai Chi Versus Moderate-intensity Combined Exercise Training on Cardiovascular Health and Physical Functional Performance in Older Men and Women With T2DM: the Tai Chi Intervention for Diabetes Management During Aging (TIDA) Study
This randomized, single-blind, controlled clinical trial compares the effects of a 12-week Tai Chi program versus moderate-intensity combined exercise (MICE) training on cardiovascular health, glycemic control, and physical…
- Trial name
- TIDA (NCT07131761)
- Testing
- Tai chi, Moderate-Intensity Combined Exercise (MICE), Control ( No Exercise )
- Volunteers
- 66 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Older Men and Women With High Fall Risk
A Balanced Assessment and Training Protocol (BATP) to Address Balance Disorders in Older and Neurologically Disabled Veterans
Falls are by far the leading cause of accidental injury and death in older adults. The Veteran population is more severely affected by falls since it is significantly older than the overall population (45% over 65 years of age…
- Trial name
- BATP (NCT04359888)
- Testing
- Multi-Modality Balance Intervention, Balanced Reach Training (BRT)
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Aged, Exercise Therapy
Comparative Effects of Multicomponent Training Concerning Elastic Band Training on Physical Fitness, Postural Balance, and Health-related Quality of Life in Older Women
Objective: To compare the effects of MCT versus EBT on functional fitness, postural balance, and HRQoL in older women. Methods: Single-blind, parallel-group randomized controlled trial lasting 16 weeks (2 sessions/week, 60 min).
- Conditions
- Aged, Exercise Therapy, Physical Performance
- Trial name
- RCT (NCT07561879)
- Testing
- Multicomponent training program, Elastic band training program
- Volunteers
- 40 people
- Sponsor
- Universidad Católica del Maule
Elderly; Renal Insufficiency
Using Informatics to Enhance Care of Older Emergency Department Patients
The subjects in this study are physicians working in the Wishard Emergency Department. The purpose of this study is to measure the extent to which information technology (i.e.-computers) improves emergency department care.
- Trial name
- NCT00297869
- Testing
- Computer-Assisted Decision Support
- Where
- United States
- Volunteers
- 1,350 people
- Sponsor
- Indiana University