Clinical trials: Olfaction
Smell Disorder, Taste Disorders
Taste and Smell Impairment in Critically Ill COVID-19 Patients
Evaluating the smell and taste perceptions of patients hospitalized in the intensive care unit with suspicion of Coronavirus disease-19 diagnosis with a survey study
- Conditions
- Smell Disorder, Taste Disorders, Coronavirus Infection
- Trial name
- NCT04532632
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Pinar Ay Sayin
Head and Neck Cancer
Gemcitabine and Doxorubicin in Treating Patients With Recurrent or Progressive Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy, such as gemcitabine and doxorubicin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00509665
- Testing
- doxorubicin hydrochloride, gemcitabine hydrochloride
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medical University of South Carolina
Head and Neck Cancer
Collecting and Storing Tissue Samples From Patients With Head and Neck Cancer
RATIONALE: Collecting and storing samples of tissue, blood, and saliva from patients with cancer to study in the laboratory may help the study of cancer in the future.
- Trial name
- NCT00898300
- Testing
- biologic sample preservation procedure, biopsy
- Where
- 98 sites in United States, Canada
- Volunteers
- 351 people
- Sponsor
- Radiation Therapy Oncology Group
Amyloidosis, Cardiac Amyloidosis
Study of Olfactory Disorders in Patients With Cardiac Amyloidosis
Amyloidosis is a disease caused by the continuous accumulation of fibrillary proteins in the extracellular matrix causing the architecture of different organs to be disrupted. The prevalence of the disease increases with age.
- Conditions
- Amyloidosis, Cardiac Amyloidosis, Olfactory Loss, Hyposmia
- Trial name
- AMYLODOR (NCT04661800)
- Testing
- Sniffin's stick test
- Where
- France
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19, Anosmia
Finding Out if COVID-19 Infection Can be pREdicted by ChAnges in Smell and/or Taste
The FORECAST Study is an observational cohort study looking at two cohorts of patients presenting with COVID-19: a general public cohort, aiming to investigate if new loss or reduced sense of smell and/or taste are early signs of…
- Trial name
- FORECAST (NCT04377815)
- Testing
- General Public cohort
- Where
- 2 sites in United Kingdom
- Volunteers
- 569 people, healthy volunteers welcome
- Sponsor
- University College, London
Kidney Failure, Chronic, Olfaction Disorders
Taste And Smell TEsting in End Stage Renal Disease
Malnutrition is an important complication of advanced kidney disease and impairment in smell and taste may affect nutritional status.
- Conditions
- Kidney Failure, Chronic, Olfaction Disorders, Taste Disorders, Malnutrition
- Trial name
- TASTE ESRD (NCT03043144)
- Testing
- Worsening of olfaction from enrollment visit to 6 months, Worsening of taste from enrollment visit to 6 months, Serum Zinc
- Where
- United States
- Sponsor
- Beth Israel Deaconess Medical Center
Cholecystectomy, Laparoscopic
Effect of Coffee Smelling on Pain, Physiological Parameters and Time to Discharge From Post Anesthesia Care Unit in Patients Undergoing Laparoscopic Cholecystectomy
This research was designed as a randomized controlled trial to determine the effects of coffee sniffing on pain and physiological parameters in patients undergoing cholecystectomy surgery.
- Trial name
- NCT07437599
- Testing
- Coffee Smell
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Istanbul University - Cerrahpasa
Post-traumatic Olfactory Dysfunction, Traumatic Brain Injury
Acupuncture for Post-traumatic Olfactory Dysfunction: A Randomized Controlled Trial
The goal of this clinical trial is to learn if acupuncture based on the "Form-Qi-Spirit" theory works to treat post-traumatic olfactory dysfunction in adults. It will also learn about the safety of this acupuncture treatment.
- Conditions
- Post-traumatic Olfactory Dysfunction, Traumatic Brain Injury, Olfactory Dysfunction
- Trial name
- NCT07834047
- Testing
- Acupuncture, Corticosteroid therapy
- Where
- 2 sites in China
- Volunteers
- 84 people
- Sponsor
- Beijing Tiantan Hospital
Alzheimer Disease (AD), Dementia Alzheimer Type
Effects on the Olfactory Epithelium and the Olfactory Nerve From Exposure to Diesel Exhaust
The goal of this study is to study the effect exposure to air pollution and its effect on development of dementia. Does the diesel exhaust change the function of the olfactory system? Have the exposures measurable effects on the…
- Conditions
- Alzheimer Disease (AD), Dementia Alzheimer Type, Air Pollution Exposure
- Trial name
- DINOSE (NCT07237958)
- Testing
- Diesel Exhaust Particles, Filtered air
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Umeå University
Digestive Cancers
Sensory Evaluation of Taste and Smell in Oncology
Nutritional status is a major issue in the management of cancer patients. Forty to 60% of patients are undernourished at diagnosis.
- Trial name
- SENSEO (NCT06643026)
- Testing
- Food preference
- Where
- 3 sites in France
- Volunteers
- 69 people
- Sponsor
- Hospices Civils de Lyon
Infarction, Middle Cerebral Artery, Ischemic Stroke,
Implantation of Olfactory Ensheathing Cells (OECs)
Recruited patients should receive the endoscopic surgery for picking the olfactory mucosa 1 to 2 months before transplantation. The Olfactory Ensheathing Cells (OECs) will be cultured and expanded under the rule of GTP.
- Conditions
- Infarction, Middle Cerebral Artery, Ischemic Stroke,, Stroke With Hemiparesis,, Thromboembolic Stroke.
- Trial name
- OECs (NCT01327768)
- Testing
- Olfactory ensheathing cells
- Where
- Taiwan
- Volunteers
- 6 people
- Sponsor
- China Medical University Hospital
Melanoma, Non-small Cell Lung Cancer (NSCLC)
Taste and Smell Dysfunction in Patients More Than Two Years After Start of Immune Checkpoint Inhibitor Therapy
Background of the study: Immune checkpoint inhibitors (ICIs) are widely used as treatment for multiple cancer types and the number of patients with longterm disease control after ICIs is increasing.
- Conditions
- Melanoma, Non-small Cell Lung Cancer (NSCLC), Urogenital Cancers
- Trial name
- TasteSPICIER (NCT06495008)
- Testing
- no intervention, only questionnaires, saliva collection and taste/smell tests
- Where
- Netherlands
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Anosmia, COVID-19
Effectiveness and Safety of Platelet Rich Plasma (PRP) on Persistent Olfactory Dysfunction Related to COVID-19
Olfactory dysfunction (OD) is a well know symptom of coronavirus disease 2019 (COVID-19), accounting for 48 to 85% of patients. In 1 to 10% of cases, patients develop a chronic olfactory dysfunction (COD,) lasting more than 6…
- Trial name
- NCT05226546
- Testing
- Platelet rich plasma (PRP), olfactory training
- Where
- Belgium
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Spinal Cord Injury
Collection and Characterisation of Human Olfactory Ensheathing Cells
We aim to retrieve olfactory bulbs (OBs) from suitable human donors. We have defined two groups who will qualify: Group 1 - Deceased Donors: 1A: Donors after brainstem death (DBDs) undergoing solid organ donation 1B: Donors after…
- Trial name
- NCT02870426
- Testing
- Frontal Craniotomy and retrieval of OBs, OB Retrieval During Anterior Cranial Surgery
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's, University of London
COVID-19, Olfactory Disorder
Fluvoxamine to Augment Olfactory Recovery For Long COVID-19 Parosmia
This study will investigate the efficacy of oral fluvoxamine in olfactory improvement following Covid-19- associated parosmia. This is a randomized, double-blinded, placebo-controlled trial.
- Conditions
- COVID-19, Olfactory Disorder, Parosmia
- Trial name
- FluCOP (NCT05216614)
- Testing
- Fluvoxamine
- Where
- United States
- Sponsor
- Washington University School of Medicine
Olfactory Dysfunction, Wellbeing
Impact of Smell Testing on Health Outcomes
Smell dysfunction is frequent yet neglected. The sense of smell plays a crucial role in signaling disease, safety, and overall quality of life.
- Trial name
- NCT07222891
- Testing
- Patient-centered information and education
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Monell Chemical Senses Center
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers
To establish the diagnostic and prognostic models that could help the preclinical identification of subjects at higher risk of clinical progression to mild cognitive impairment and dementia based on combined features of baseline…
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT06561906
- Testing
- Multimodal magnetic resonance imaging scanning, behavioral, genetic and plasma biomarker testing
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Lung Neoplasms
Identifying Unique Scent Signature of Lung Cancer Through Body Odor
The purpose of this study is to show that dogs are able to detect cancer in sweat samples. This potentially would be the base for developing a new efficient, non invasive and inexpensive diagnosis tool of lung cancer.
- Trial name
- NCT01527461
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Treatment-resistant Depression
Olfactory and Brain Stimulations in Treatment-resistant Depression
This is a prospective, randomized, double-blind, parallel-group controlled trial. The aim of this research project is to compare the clinical benefits achieved in patients with major depressive disorder (MDD) following two types…
- Trial name
- COBRA (NCT05661383)
- Testing
- Non-invasive brain stimulation protocol (intermittent theta burst protocol (iTBS)) combined with pleasant odors delivered during the iTBS procol., Non-invasive brain stimulation protocol (intermittent theta burst protocol (iTBS)) delivered alone.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hôpital le Vinatier
Bladder Cancer, Breast Cancer
Combination Chemotherapy Plus Filgrastim in Treating Patients With Advanced Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Colony-stimulating factors such as filgrastim may increase the number of immune cells found in bone marrow or…
- Conditions
- Bladder Cancer, Breast Cancer, Carcinoma of Unknown Primary, Esophageal Cancer
- Trial name
- NCT00014456
- Testing
- filgrastim, docetaxel, gemcitabine hydrochloride
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Dartmouth-Hitchcock Medical Center