Clinical trials: Olfaction
Long Haul COVID-19, Post-Acute COVID-19 Syndrome
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction
The goal of this pilot study is to assess the feasibility and impact of using sodium citrate nasal spray as an adjunct to olfactory retraining in participants with long-term post-COVID-19 olfactory dysfunction.
- Conditions
- Long Haul COVID-19, Post-Acute COVID-19 Syndrome, Anosmia, Olfaction Disorders
- Trial name
- NCT06204432
- Testing
- Sodium Citrate, Normal Saline, Olfactory Training Kit - "The Olfactory Kit, by AdvancedRx"
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Chapel Hill
Mild Cognitive Impairment, Alzheimer Disease
The Brain&Senses Study
The aim of this longitudinal observational study is to evaluate the impact of sensory deficits (smell, hearing and balance on cognitive decline and quality of life in the medium term (5 years)) on a population of patients over…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Parkinson
- Trial name
- NCT06991816
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Campania Luigi Vanvitelli
Alzheimer Disease
Olfactory Neuroepithelial Tissue of Alzheimer Disease
The purpose of this study is to evaluate the olfactory neuroepithelium as a biomarker of Alzheimer disease. The early diagnosis of Alzheimer disease is of importance for obtaining better response to treatment, but recently…
- Trial name
- NCT02129452
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Loss of Smell, Olfactory Disorder
Olfactory Performance in Culinary Arts Students
The COVID-19 pandemic brought impaired smell and taste to the forefront of international public awareness and clinical importance.
- Trial name
- NCT06066307
- Testing
- Olfactory training
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Leigh Sowerby
COVID-19 by SARS-CoV-2 Infection
Frequency and Clinical Evolution of Olfactory and Taste Disorders in COVID-19 Patients
A novel coronavirus SARS-CoV-2 HAS arose in 2019 in Wuhan, China. Beside the classical semiology of this infection, numerous patients described olfactory and teste disorders.
- Trial name
- NCT04361565
- Where
- France
- Volunteers
- 81 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Healthy
Cybersickness imAgiNg Olfactory Evocation
The aim of this study is to, using fMRI, compare brain activations during olfactory imagery induced by different visual supports (words, pictures, colors and colored arrangements) in healthy subjects.
- Trial name
- CANOE (NCT05308433)
- Testing
- Functional MRI, Virtual Reality: control, Virtual Reality: experimental
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Long COVID, Long Covid19
Stellate Ganglion Block to Treat Long COVID 19 Case Series
An assessment of the effectiveness of Stellate Ganglion Block in alleviating symptoms of Long COVID-19.
- Conditions
- Long COVID, Long Covid19, Post-COVID-19 Syndrome, Post Acute COVID-19 Syndrome
- Trial name
- NCT05812209
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Metamorphosis LTD
Olfaction Disorders, Smell Disorders
Olfactory Training on Smell Dysfunction Patients in HK
Causes of olfactory dysfunction can be classified into conductive and sensorineural causes. Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery Sensorineural causes included…
- Conditions
- Olfaction Disorders, Smell Disorders, Anosmia, Hyposmia
- Trial name
- NCT05364125
- Testing
- Olfactory Training, Control
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- Pamela Youde Nethersole Eastern Hospital
Anosmia, Parosmia
Multimodal Chewing Gum Flavour Training to Aid Flavour Perception Recovery - a Pilot Study.
Olfactory training is developed for people who have partly or completely lost their sense of smell (olfactory dysfunction). Participants expose themselves to odours twice daily for usually 12 weeks or longer.
- Conditions
- Anosmia, Parosmia, Phantosmia, Dysgeusia
- Trial name
- FITS (NCT07498062)
- Testing
- Flavour impairment training using chewing gum group (FIT), Olfactory training group (OT), Waiting list control group
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Bacterial Vaginoses
Evaluate the Safety of a Single Oral Dose of Solosec™ (Secnidazole) 2g for the Treatment of Adolescent Girls With BV
A multi-center, open-label study to evaluate the treatment of one oral dose of 2g Solosec™ (Secnidazole) in adolescent girls with BV
- Trial name
- NCT03937869
- Testing
- Secnidazole
- Where
- 9 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Lupin Research Inc
Anorexia Nervosa
Impact of an Olfactory Sensory Therapeutic Group for Adolescent Patients With Restrictive Anorexia Nervosa , Pilot Study
Anorexia nervosa is a severe eating disorder of multifactorial origin and for which there is, to date, no specific, standardized and protocolized management for anorexic patients or data on the superiority of anorexia.
- Trial name
- Sens'Orality (NCT04883554)
- Testing
- Olfactory therapeutic, Body therapy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Lenval
Smell Dysfunction, Taste Dysfunction
Post-Covid-19 Patients Follow-up Study
Taste, smell, trigeminal and salivary function is impacted in post-COVID-19 patients
- Conditions
- Smell Dysfunction, Taste Dysfunction, Trigeminal Dysfunction, Salivary Dysfunction
- Trial name
- COVID-19 (NCT07571382)
- Testing
- Smell training
- Where
- Norway
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Covid19, Neurological Injury
Radiofrequency Intervention in Neurological Pathologies Post COVID-19
The sequelae that occur in post-COVID-19 patients are multiple and, at a therapeutic level, these represent a new challenge within the general context of the pandemic that the world is suffering.
- Conditions
- Covid19, Neurological Injury, Olfactory Disorder, Gustatory Agnosia
- Trial name
- NCT04920890
- Testing
- Radiofrequency therapy with manual therapy
- Where
- Spain
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Clinica Gema Leon
SARS-CoV-2 Acute Respiratory Disease
Study of the Evolution of Olfactory Disorders in Patients With Persistent Loss of Smell Following COVID-19
The COVID-19 pandemic is a novel medical challenge, particularly because of the systemic nature of this disease. Indeed, COVID-19 affects several organs and systems at once.
- Trial name
- ETOC (NCT05133596)
- Testing
- Clinical examination, Blood collection, Olfactory evoked potentials
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut Pasteur
Olfactory Disorder, Olfaction Disorders
Intranasal Injection of PRP Versus Saline for Treatment of Olfactory Dysfunction
This randomized clinical trial will evaluate the benefit of platelet-rich plasma (PrP) in the treatment of olfactory dysfunction.
- Conditions
- Olfactory Disorder, Olfaction Disorders, Olfactory Nerve Injuries, Olfactory Nerve Disorder
- Trial name
- NCT04406584
- Testing
- Injection into olfactory cleft
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Taste Alterations, Smell Disorder
Adaptation Strategies for Coping With the Impact of Sensory Alterations on Eating Behavior in Children With Cancer: A Qualitative Study From the Perspective of Children and Parents
Childhood cancer is a serious and life-changing disease that affects thousands of children every year worldwide. In addition to the disease itself, cancer treatments such as chemotherapy often cause difficult side effects.
- Conditions
- Taste Alterations, Smell Disorder, Eating Behavior Changes
- Trial name
- QUALISENS (NCT07490093)
- Testing
- No Intervention: Observational Cohort
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Leon Berard
Depression
Olfactory and Visual Perception in Depressed Patients
The study aimed to determine the emotional reactivity of depressed patients to visual and olfactory stimuli in comparison with healthy volunteers.
- Trial name
- PERODEP (NCT02857088)
- Testing
- olfactory assessment, image visualization, psychophysiological assessment
- Where
- France
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Obesity
OLFactory Odour Stimulation and FOOD Preferences
The aim of the present "OLFO-FOOD" clinical trial is to investigate, if olfactory stimulation impacts food choice, reference and calorie intake in humans with obesity assessed using a test buffet.
- Trial name
- OLFO-FOOD (NCT05869110)
- Testing
- Effects of odours on calorie intake, food choice and metabolic parameters
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- University Hospital, Basel, Switzerland
Olfactory Dysfunction
Olfactory Training in Chronic Rhinosinusitis
Persons with a loss of sense of smell, who agree to participate in this study, will be assigned to one of three groups: two groups will have smell training and the third group will not do smell training.
- Trial name
- NCT03055572
- Testing
- Olfactory Training with Essential Oils, Olfactory Training with Pure Fragrance Oils
- Sponsor
- Emory University
Hearing Loss, Deafness
Collection of Clinical Data and Specimens for Research in Hearing, Balance, Taste, Smell, Voice, Speech, and Language Disorders.
Background: People with hearing, balance, and taste, smell, voice, speech, language, and other Ear, Nose, and Throat (ENT) disorders may seek treatment at the National Institute on Deafness and Other Communication Disorders…
- Trial name
- NCT05670496
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)