Clinical trials: Olfaction
Cystic Fibrosis in Children, Cystic Fibrosis
Sinus Disease in Young Children With Cystic Fibrosis
This is a prospective, observational study examining the impact of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators on chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) in young…
- Conditions
- Cystic Fibrosis in Children, Cystic Fibrosis, Chronic Rhinosinusitis (Diagnosis), Olfactory Disorder
- Trial name
- NCT06191640
- Testing
- Ivacaftor or elexacaftor/tezacaftor/ivacaftor
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Autism, Smell Dysfunction
Ultramicronized Palmitoylethanolamide for Smell, Taste in Children With Autism Spectrum Disorder.
Autism Spectrum Disorder (ASD) is frequently associated with atypical sensory processing across visual, auditory, olfactory, and gustatory domains, variably affecting quality of life and requiring personalized treatment.
- Conditions
- Autism, Smell Dysfunction, Taste Alterations, Sensorial Disturbance
- Trial name
- SmeTasAu (NCT07631455)
- Testing
- supplement (Paidinil® HD, Epitech Group SpA, Saccolongo, Padova, Italy) containing 12% umPEA, Lactobacillus and Omega Fatty acids
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University of Campania Luigi Vanvitelli
Olfactory Neuroblastoma, Esthesioneuroblastoma
A Natural History Study of Children and Adults With Olfactory Neuroblastoma
Background: Olfactory neuroblastoma (ONB) is a rare cancer. It grows from tissue in the upper part of the nose cavity, related to the sense of smell and can affect a person s sense of smell.
- Trial name
- NCT04755205
- Where
- United States
- Volunteers
- 525 people
- Sponsor
- National Cancer Institute (NCI)
Parkinson Disease (PD), Olfactory Dysfunction
rTMS and Olfactory Training for Parkinson's Disease
Background: Olfactory and gustatory impairments are common clinical manifestations in patients with neurodegenerative conditions like Parkinson's disease.
- Trial name
- PORT (NCT07666477)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Structured Olfactory Training
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Mustafa Baran
Patients Without an Olfactory Disorder
Standardization of a New Psychophysical Olfactory Test, TODA2
Recruitment of patients consulting the IUFC for another pathology unrelated to an olfactory disorder: Interview and clinical examination and Passing the 2 olfactory tests for 30 voluntary's patients, a second consultation of 15…
- Trial name
- TODA-STAR (NCT06386523)
- Testing
- Passage of olfactory tests
- Where
- 2 sites in France
- Volunteers
- 112 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cancer
Thalidomide and Docetaxel in Treating Patients With Advanced Cancer
RATIONALE: Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00049296
- Testing
- docetaxel, thalidomide
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Case Comprehensive Cancer Center
Breastfeeding, Odors, Body
The Effect Of Breast Milk Sniffing And Tasting On Early Feeding Tips
The study aimed to investigate the effects of breast milk sniffing and breast milk tasting and sniffing on sucking success and early feeding cues in term newborns who were started to breastfeed for the first time.
- Conditions
- Breastfeeding, Odors, Body, Newborn; Vitality
- Trial name
- NCT06341153
- Testing
- Breast Milk Odor Stimulation, Stimulation of Breast Milk Smell and Taste
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sibel Küçükoğlu
To Evaluate the Main Effects of Varying Auditory Stimuli, To Evaluate the Main Effects of Varying Olfactory Stimuli
Effects of a Multisensory VR Experience on Stress and User Experience
This study explicitly tests a multisensory virtual reality experience that combines visual, auditory, and olfactory channels to modulate the stress response in young adults.
- Trial name
- NCT07395830
- Testing
- Relaxing aroma and state of stress/calm
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad de Zaragoza
Paraosmia
Randomized Clinical Trial of Intranasal Injection of Platelet-Rich Plasma for Treatment of Parosmia
This randomized clinical trial will evaluate the benefit of platelet-rich plasma (PRP) in the treatment of qualitative olfactory dysfunction (parosmia).
- Trial name
- NCT06283745
- Testing
- Platelet-rich Plasma (PRP), Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Chronic Rhinosinusitis (CRS)
Impact of Structural and Microenvironmental Abnormalities in Olfactory Cleft on Olfaction in CRS
The purpose of this research is to investigate the impact of structural abnormalities and microenvironmental changes in the olfactory cleft on olfactory function in patients with chronic rhinosinusitis (CRS).
- Trial name
- NCT06834477
- Testing
- Computed Tomography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Sellar/Parasellar Tumor, Smell Dysfunction
Omega-3 Supplementation for Smell Dysfunction
Omega-3 supplementation has been shown to have neuroprotective and potentially anti-inflammatory properties in both central and peripheral nerve injuries.
- Trial name
- NCT02529332
- Testing
- Omega-3
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Stanford University
Very Low Birth Weight Infant
Olfactory Stimulation for Very Low Birth Weight Infants
This is a RCT study examining whether odor administration to mothers of very low birth weight infants promotes stabilization of vital signs compared with common nursing care.
- Trial name
- NCT05406804
- Testing
- Olfactory stimulation, Routine nursing care
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Brain and Central Nervous System Tumors, Childhood Langerhans Cell Histiocytosis
Indium In 111 Pentetreotide in Treating Patients With Refractory Cancer
RATIONALE: Radiation therapy uses high-energy x-rays and other sources to damage tumor cells. Giving radiation therapy in different ways may kill more tumor cells.
- Conditions
- Brain and Central Nervous System Tumors, Childhood Langerhans Cell Histiocytosis, Gastrointestinal Carcinoid Tumor, Head and Neck Cancer
- Trial name
- NCT00002947
- Testing
- indium In 111 pentetreotide
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Yale University
Anosmia, Ageusia
Efficacy of Photobiomodulation in the Rehabilitation of Olfactory Dysfunctions Induced by Long COVID-19
On January 30, 2020, the WHO (World Health Organization) declared the new coronavirus pandemic as the sixth public health emergency of international concern.
- Conditions
- Anosmia, Ageusia, COVID-19, Rehabilitation
- Trial name
- NCT06423495
- Testing
- low-intensity laser treatment
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gaffree & Guinle Universitary Hospital
SARS-CoV Infection, COVID-19
Malaysian COVID-19 Anosmia Study (Phase 1) - A Nationwide Multicentre Cross-Sectional Study
The Malaysian COVID-19 Anosmia Study is a nationwide multicentre observational study to investigate the prevalence and characteristics of olfactory and gustatory/taste disturbances in COVID-19 infection in Malaysia, and to…
- Conditions
- SARS-CoV Infection, COVID-19, Anosmia, Dysgeusia
- Trial name
- NCT04390165
- Testing
- Patient-Reported Online Questionnaire on Olfactory & Taste Disturbances
- Where
- 14 sites in Malaysia
- Volunteers
- 498 people
- Sponsor
- Hospital Sultanah Bahiyah
Spinal Cord Injury, Neurological Conditions
Olfactory Cell Transplantation and Intensive Rehabilitation to Repair Chronic Spinal Cord Injury
This is a randomised, blinded and controlled Phase I trial to measure the safety, feasibility and efficacy of a combined cell transplantation and intensive rehabilitation intervention to treat spinal cord injury.
- Conditions
- Spinal Cord Injury, Neurological Conditions, Rehabilitation Exercise
- Trial name
- NCT07596563
- Testing
- Olfactory Ensheathing Cell, biological intervention, rehabilitation
- Volunteers
- 30 people
- Sponsor
- Dr Brent McMonagle
Anosmia, Covid19
Olfactory Disfunction and Co-ultraPEALut
Olfactory dysfunction is common among patients with Corona-Virus-Infection-Disease (COVID)-19, and up to 30% of patients may report persistent disorders of smell or taste as a long-term sequelae.
- Conditions
- Anosmia, Covid19, Hyposmia, Parosmia
- Trial name
- NCT04853836
- Testing
- co-ultraPEALut, Olfactory Rehab, PEA-LUT 1 sachet
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
HIV (Human Immunodeficiency Virus)
Boosting Olfactory and Sensory Training Study (BOOST)
The goal of this study is to examine two types of olfactory interventions (conventional olfactory training vs scented marker training) in adults with HIV. The two research questions are: 1.
- Trial name
- BOOST (NCT07221123)
- Testing
- Conventional Smell Training Group, Scented Marker Group
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Head and Neck Cancer, Mucositis Oral
GM-CSF Mouthwash for Preventing and Treating Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer
GM-CSF may protect normal cells from the side effects, such as mucositis, of radiation therapy and may help damaged tissue heal faster after radiation therapy.
- Conditions
- Head and Neck Cancer, Mucositis Oral, Radiation Toxicity, Tongue Cancer
- Trial name
- NCT00293462
- Testing
- sargramostim, oral salt and soda mouthwash
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Marilyn Dodd
Alcohol Withdrawal, Anxiety
Comparison of the Effect on Anxiety of Combining Hypnosis and Aromatherapy Through Olfactory Anchoring Versus Standard Care in Patients Undergoing Alcohol Withdrawal
According to a meta-analysis published in 2019, hypnosis has demonstrated positive effects in the treatment of certain mental illnesses, particularly anxiety.
- Trial name
- ASHA (NCT07444255)
- Testing
- Usual treatment, Experimental treatment
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France