Clinical trials: Olfaction
Metastatic Olfactory Neuroblastoma
A Phase 2 Study Of Zanzalintinib For Patients With Recurrent Or Metastatic Olfactory Neuroblastoma
The goal of this clinical research study is to learn if zanzalintinib can help to control recurrent/metastatic ONB. The safety of zanzalintinib will also be studied.
- Trial name
- NCT07527169
- Testing
- Zanzalintinib
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Olfactory and Taste Dysfunction in SARS-CoV2 Infection
EFFECT OF COVID-19 DISEASE IN SMELL AND TASTE OF PATIENTS WITH MILD, MODERATE OR SEVERE SYMPTOMATOLOGY
This is an observational data and recording study. The aim of our study is to investigate the effect of SARS-COV2 infection on patients' sense of smell and taste, through quality control measurements using optic analogue scale…
- Trial name
- NCT04657445
- Testing
- visual analogue scale
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ioannina
Outcome
Factors Influencing the Prognosis of Olfactory Dysfunction After Upper Sensation
Objective: This study aimed to analyze the outcomes of post-infectious olfactory dysfunction treated with different doses of corticosteroids and specify factors related to the curative effect.
- Trial name
- NCT04918953
- Testing
- methylprednisolone, budesonide atomization suspension
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson´s Disease
Olfaction in Patients With Parkinson's Disease Following Treatment With Rasagiline
There is convincing evidence from numerous studies using both psychophysical and electrophysiological approaches that olfaction is markedly reduced in Parkinson´s disease (PD).
- Trial name
- NCT00902941
- Testing
- Azilect 1mg
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Technische Universität Dresden
Alzheimer Disease, Neurodegenerative Diseases
Smell, Voice and Nasal Swabs as Markers for Neuro-degenerative Disorders
Degenerative dementias including Alzheimer's Disease (AD), Parkinson's Disease with Dementia (PDD), Dementia with Lewy Bodies (DLB), Frontotemporal Dementias (FTLD), Corticobasal Degeneration (CBD) and Progressive Supranuclear…
- Trial name
- NCT03299062
- Testing
- Cytology and Immunohistochemistry
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Arkansas
COVID-19
Mindfulness-Based Stress Reduction Versus Lifestyle Intervention for Long-Haul Covid-19 Parosmia
Olfactory dysfunction (OD) is a defining symptom of COVID-19 infection. As the number of total, confirmed novel coronavirus SARS-CoV-2 (COVID-19) cases exceeds 45 million in the United States, it is estimated that up to 85% of…
- Trial name
- MBSR-LCP (NCT06789952)
- Testing
- Mindfulness-Based Stress Reduction, Lifestyle Intervention
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Washington University School of Medicine
Anosmia
Efficacy of Platelet-rich Plasma in Management of Anosmia
Olfactory dysfunction is a prevalent disorder that affects up to 20% of the general population and has significant effects on a person's quality of life as well as increased morbidity and mortality (Croy I et al., 2014;Nordin S…
- Trial name
- NCT06930248
- Testing
- Platelet rich plasma injection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Olfactory Reference Syndrome
Internet Delivered CBT for Olfactory Reference Syndrome
The primary aim of the study is to test the feasibility and efficacy of, a manual based, Internet-delivered, cognitive behaviour therapy (CBT) for patients with Olfactory Reference Syndrome (ORS) who live in Sweden.
- Trial name
- NCT03846076
- Testing
- Cognitive behavioral therapy
- Where
- Sweden
- Volunteers
- 15 people
- Sponsor
- Volen Ivanov
Parkinson Disease
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational, multi-center natural history study to assess progression of clinical features, digital outcomes, and imaging, biologic and genetic markers of…
- Trial name
- PPMI (NCT04477785)
- Where
- 50 sites in United States, Austria and 10 more
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Anosmia, Chronic Obstructive Pulmonary Disease
Firefighter's Longitudinal Airway and Respiratory Exposome/Multiome Study (FLARES)
Background: Exposure to smoke increases the risk of many diseases. People can be exposed to dangerous levels of smoke during wildfires. Also, smoke from fires that burn manmade materials may contain toxic chemicals.
- Conditions
- Anosmia, Chronic Obstructive Pulmonary Disease, Hyposmia, Chronic Rhinosinusitis
- Trial name
- NCT07867184
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 2 Diabetes Mellitus, Cognitive Function Abnormal
Efficacy Comparison of Polyethylene Glycol Loxenatide and Gliclazide on the Brain Function in T2DM Patients
This is a prospective, randomized, open label, parallel,4-month study to explore and evaluate the therapeutic effects of polyethylene glycol loxenatide on the cognitive function, olfactory function, and odor-induced brain…
- Trial name
- NCT06217887
- Testing
- loxenatide Group, Gliclazide Group
- Where
- China
- Volunteers
- 58 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Neoplasms, Malnutrition
Oral Nutritional Supplement Preferences in Patients With Cancer
Patients diagnosed with cancer have a particularly high risk of developing malnutrition due to the disease itself and due to symptoms of cancer treatments that can affect food intake such as reduced appetite, nausea, fatigue, and…
- Trial name
- NCT05816369
- Testing
- Taste session of five ONS flavors
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- University of Bergen
Head and Neck Cancer
MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer
RATIONALE: Diagnostic procedures, such as specialized types of magnetic resonance imaging (MRI), may help in planning radiation therapy that does less damage to normal tissues.
- Trial name
- NCT00984074
- Testing
- blood-oxygen-level-dependent functional magnetic resonance imaging, diffusion tensor imaging, dynamic contrast-enhanced magnetic resonance imaging
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Nasal Obstruction
Nasal Obstruction and Olfactory Losses
About 13% of US adults, some 30 million people, suffer from nasal sinus disease. Although nasal obstruction and smell loss are two of the major symptoms of the disease that are crucial to disease management, currently there is a…
- Trial name
- NCT05920330
- Testing
- Nasal Plug
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Persian Gulf Syndrome, Occupational Exposure
Investigate Olfactory Functioning as a Possible Proxy for Neurotoxic Exposure in Cohorts of Deployed and Non-Deployed Gulf War-Era Veterans.
Significant subsets of military veterans have reported such health problems as headache, joint pain, fatigue, and memory/concentration difficulties subsequent to their participation in the Gulf War.
- Trial name
- NCT00007514
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Dementia, DM
Early Detection of Cognitive Dysfunction in Diabetes
The rate of cognitive decline due to ageing is increased 1.5-fold to 2.0-fold in individuals with type 2 diabetes.There are no established specific treatment measures to prevent or ameliorate cognitive impairments in patients…
- Conditions
- Dementia, DM, MCI
- Trial name
- NCT01830998
- Where
- 3 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Wuhan General Hospital of Guangzhou Military Command
Dysosmia, Anosmia
Treatment of Pediatric Patients That Lost Sense of Smell Due to COVID-19
This research study is a randomized controlled trial in pediatric and young adult patients who have lost their sense of smell due to COVID-19 viral infection. The goals are: 1.
- Conditions
- Dysosmia, Anosmia, Covid19
- Trial name
- NCT04964414
- Testing
- Smell Retraining, Budesonide
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Amanda Stapleton
Post-viral Anosmia, Anosmia
SniffTrain: Effectiveness of Sniff Training in the Treatment of Post-Viral Anosmia
The purpose of this study is to learn whether a structured smell training program (called "sniff training") can help improve sense of smell and quality of life in people who have experienced a reduced or lost sense of smell…
- Conditions
- Post-viral Anosmia, Anosmia, Hyposmia
- Trial name
- NCT07857083
- Testing
- Sniff Training Kits
- Where
- 3 sites in United States
- Volunteers
- 204 people
- Sponsor
- University of Virginia
COVID-19
Study of Neurological Damage From Coronavirus Disease (COVID-19)
The objective of this study is to support the exploration of the NEURO-COVID-19 database and in particular to carry out the post-treatments necessary to derive quantitative information on the characterization of the lesion load…
- Trial name
- NeuroBiomarK (NCT05079373)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Strasbourg, France
Surgery, Gallbladder
Smell Memory Method for Patients Before Surgery
The research is planned as a randomized controlled experimental at Erzurum Atatürk University Health Application and Research Center.
- Conditions
- Surgery, Gallbladder, Smell
- Trial name
- NCT06414980
- Testing
- Experimental
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ataturk University