Clinical trials: Olfaction
Olfactory Disorder, COVID19
Assessment of Olfactory Dysfunction in SARS CoV-2 (COVID-19) Infection
This study is designed to investigate the acuity of olfactory dysfunction in COVID-19 positive patients in the United Kingdom. In particular defining severity with objective testing and determining if this has any predictive…
- Conditions
- Olfactory Disorder, COVID19, SARS-CoV-2, Anosmia
- Trial name
- ODYSSI (NCT04466982)
- Where
- 3 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Hearing Loss, Head and Neck Neoplasms
NIDCD Otolaryngology Clinical Protocol Biospecimen Bank
Background: Many disorders of the head and neck can affect a person s hearing; balance; smell; taste; swallowing; voice; or speech. These disorders include cancers and genetic and inflammatory diseases.
- Conditions
- Hearing Loss, Head and Neck Neoplasms, Hearing Disorders, Laryngeal Disease
- Trial name
- NCT06303180
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
COVID-19
Diagnostic Performance of Dogs for the Olfactory Detection of COVID-19
Considering the favorable preliminary data of few european diagnostic studies on dog detection, we develop in 2021 a pilot study in response to the plan of CHU Bordeaux and Nouvelle Aquitaine French region for an expanded…
- Trial name
- CYNOCOV (NCT05846074)
- Testing
- sweat samples and used face mask will be collected
- Where
- 6 sites in France
- Volunteers
- 1,548 people
- Sponsor
- University Hospital, Bordeaux
Adult With Stroke and Olfaction's Complaint
REEDUCATION OF OLFACTORY DISORDERS AFTER A CEREBRAL VASCULAR ACCIDENT IN ADULTS
Study context: The literature identifies more and more research revealing olfactory disorders, with a high frequency after an acquired brain injury.
- Trial name
- RE-OLF (NCT04703218)
- Testing
- olfactory rehabilitation
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Caen
Hyposmia, COVID-19
Olfactory Training as a Treatment for Olfactory Dysfunction Post COVID-19
Olfactory dysfunction is a defining symptom of COVID-19 infection. Studies have demonstrated improved olfaction in patients with post infectious olfactory dysfunction after an olfactory training (OT).
- Conditions
- Hyposmia, COVID-19, Parosmia, Anosmia
- Trial name
- OTTODC19 (NCT05384561)
- Testing
- Smell training
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Université du Québec à Trois-Rivières
COVID-19
α-synuclein Seeding Activity in the Olfactory Mucosa in COVID-19
Loss of the sense of smell is a characteristic feature of COVID-19 and likely related to viral invasion of the olfactory mucosa but is also a prodromal feature of PD.
- Trial name
- NCT05401773
- Testing
- Real-time Quaking-Induced Conversion (RT-QuIC)
- Where
- Austria
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Heavy Drinking
Targeted Extinction of Drug Cues During Sleep - Olfactory Cue Reactivity Task
The study aims to utilise olfactory stimulation in addition to the visual stimulation in cue reactivity tasks to enhance precision in measuring alcohol based cues in individuals diagnosed with heavy drinking.
- Trial name
- TEDDS_OCRT (NCT05189379)
- Testing
- Non-Alcoholic Odour, Alcoholic Odour, Non-Alcoholic Images
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- Central Institute of Mental Health, Mannheim
SARS-CoV-2
ANalyzing Olfactory Dysfunction Mechanisms In COVID-19
We aim to understand the mechanism of olfactory dysfunction in COVID-19.
- Trial name
- ANOSMIC-19 (NCT04445597)
- Testing
- Sampling of tissue
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Anxiety State
The Effect of Lavender Smell on Anxiety
Esophagogastroduodenoscopy and colonoscopy are invasive procedures that enable the diagnosis, diagnosis, treatment, biopsy, photo and video recording of the gastrointestinal tract.
- Trial name
- NCT04596904
- Testing
- Lavender oil application group, Distilled water application group
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Olfactory Disorder
Steroid Nasal Irrigation for Flavor Evaluation and Detection Study
The purpose of this research study is to examine the efficacy of a 12-week smell training intervention for participants with olfactory dysfunction following an infection of the upper respiratory tract.
- Trial name
- SNIFFED (NCT02985515)
- Testing
- Smell training
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Fatigue, Head and Neck Cancer
Insomnia in Patients Undergoing Chemotherapy and Radiation Therapy for Head and Neck Cancer
RATIONALE: Learning about insomnia and quality of life in patients undergoing chemotherapy and radiation therapy for cancer may help doctors learn about the effects of treatment and plan the best treatment.
- Conditions
- Fatigue, Head and Neck Cancer, Psychosocial Effects of Cancer and Its Treatment, Sleep Disorders
- Trial name
- NCT00616590
- Testing
- medical chart review, questionnaire administration, fatigue assessment and management
- Where
- 3 sites in United States
- Sponsor
- Vanderbilt University
COVID-19-Induced Parosmia
Stellate Ganglion Block for COVID-induced Parosmia
Chronic olfactory dysfunction, both hyposmia and parosmia, from the COVID-19 pandemic is a growing public health crisis with up to 1.2 million people in the United States affected.
- Trial name
- SGB (NCT06253806)
- Testing
- Stellate Ganglion Block
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Washington University School of Medicine
Psychiatric Disorder, Benzodiazepine Withdrawal
Influence of Olfaction Essential Oils on the Consumption of Benzodiazepine Receptor Agonists & Z-Drugs (BZRAs) Prescribed as " if Needed " in Psychiatric Outpatients (HECBA-PSY).
The goal of this interventional study is to test the use of olfactory Essential Oils through a nasal stick as one of the non-medicinal strategies to propose to the patient to reduce the consumption of medication in a population…
- Trial name
- HECBA-PSY (NCT05583240)
- Testing
- Essences and Essential Oils
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
SARS-CoV Infection, COVID-19
Malaysian COVID-19 Anosmia Study (Phase 2) - A Nationwide Multicentre Case-Control Study
The Malaysian COVID-19 Anosmia Study is a nationwide multicentre observational study to investigate the prevalence and characteristics of olfactory and gustatory/taste disturbances in COVID-19 infection in Malaysia, and to…
- Conditions
- SARS-CoV Infection, COVID-19, Anosmia, Dysgeusia
- Trial name
- NCT04384042
- Testing
- Patient-Reported Online Questionnaire on Olfactory & Taste Disturbances
- Where
- 14 sites in Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Sultanah Bahiyah
Glaucoma
Assessment of the Ability to Distinguish Odors in Glaucoma Patients
Glaucoma is one of the leading causes of blindness worldwide. The key feature of glaucoma is damage to the optic nerve head with loss of retinal ganglion cells and local tissue remodeling.
- Trial name
- NCT00304824
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Sinusitis
Olfactory Dysfunction of Rhinosinusitis - Cyclic Adenosine Monophosphate (cAMP)/Calcium Signaling Study
The study examines the biochemistry underlying human olfaction in both normal and diseased states. The study aims are: 1. to determine the levels of cAMP in olfactory tissue from people with chronic rhinosinusitis and other nasal…
- Trial name
- cAMP (NCT00970190)
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Greg Davis
Brain and Central Nervous System Tumors, Head and Neck Cancer
Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous System Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplant may allow the doctor to give higher doses of…
- Conditions
- Brain and Central Nervous System Tumors, Head and Neck Cancer, Lymphoma
- Trial name
- NCT00007982
- Testing
- filgrastim, carmustine, cisplatin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Herbert Irving Comprehensive Cancer Center
Idiopathic Anosmia, Idiopathic Hyposmia
Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
Test of early warning signs and RT-QuIC in patients with idiopathic olfactory dysfunction
- Conditions
- Idiopathic Anosmia, Idiopathic Hyposmia, Idiopathic Olfactory Dysfunction
- Trial name
- AROMA (NCT05740683)
- Testing
- RT-QuiC
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Dementia Research Centre
Central Compartment Atopic Disease (CCAD)
Development of A Multi-section Olfactory Cleft Opacity Staging System in Patients With CCAD
This study aims to develop a modified CT scoring system to evaluate the association between olfactory cleft obstruction patterns and olfactory dysfunction in patients with central region atopic disease (CCAD).
- Trial name
- NCT07380945
- Testing
- Computer Tomography
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Hematologic Cancer, Undernutrition
CAncer, NUtrition and Taste - Validation of the CANUT-QVA Questionnaire on Eating Habits in Cancer Patients
Cancer patients are at high risk of undernutrition, which is generally more pronounced for solid tumours (upper digestive tract, Ear Nose and Throat (ENT), bronchial tubes).
- Conditions
- Hematologic Cancer, Undernutrition, Chemotherapy Effect, Taste Disorders
- Trial name
- CANUT-QVA (NCT04235153)
- Testing
- Evaluation of the 9 dimensions of the CANUT-QVA questionnaire
- Where
- France
- Volunteers
- 127 people
- Sponsor
- Hospices Civils de Lyon