Clinical trials: Olfaction Disorders
COVID - 19
Efficacy of Olfactive Training on Loss of Smell and Taste Caused by SARS CoV2 COVID-19 (Covid-Smell)
The purpose of this study is to evaluate efficiency of two months of olfactive training on olfactory and taste loss secondary to covid-19. We will compare 2 groups : olfactive training group versus no olfactive training group.
- Trial name
- COVID-SMELL (NCT07190911)
- Testing
- Olfactory rehabilitation consists of smelling a series of spices every day for 2 months
- Where
- Guadeloupe
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Depressive Symptoms, Depressive Disorder, Major
Olfactory Training and Emotional State
During the past three decades, researchers have paid particular attention to the study of olfactory disorders in depression. Recent studies have shown that depression is characterized by a change in olfactory and emotional…
- Trial name
- ENOLFEA (NCT03605524)
- Testing
- Sensory training
- Where
- 3 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Gingivitis, Periodontitis
The Impact of Non-surgical Periodontal Therapy on Patients' Halitosis, Taste Perception, and Smell Sensation
The goal of this observational study is to evaluate the effect of non-surgical periodontal treatment on patient halitosis, smell, and taste perception in gingivitis and periodontitis patients.
- Trial name
- NCT06063460
- Testing
- Periodontal examination, baseline questionnaire about sociodemographic characteristics, smoking habits, oral hygiene habits, halitosis, smell and taste perception, phase I periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people
- Sponsor
- Necmettin Erbakan University
Apnea of Prematurity, Prematurity
Nasal Olfactory Stimulation and Its Effect on Respiratory Drive in Preterm Infants
This trial analyzes the effect of an olfactory stimulation with vanilla or strawberry aroma compared to placebo on desaturations and bradycardia in preterm infants with apnea of prematurity.
- Conditions
- Apnea of Prematurity, Prematurity, Infant, Premature, Diseases
- Trial name
- NOSE (NCT05878925)
- Testing
- Aroma
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Alzheimer Disease, Mild Cognitive Impairment
Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Elderly
Olfactory identification deficits occur in patients with Alzheimer's disease (AD), are associated with disease severity, predict conversion from mild cognitive impairment (MCI) to AD and are associated with healthy elderly…
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment, Delirium, Dementia, Amnestic, Cognitive Disorders
- Trial name
- NCT01951118
- Testing
- Donepezil
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- New York State Psychiatric Institute
Idiopathic Anosmia, Idiopathic Hyposmia
Alpha-synuclein Rt-quic and Neurologic Symptoms in Persons With idiOpathic anosMiA
Test of early warning signs and RT-QuIC in patients with idiopathic olfactory dysfunction
- Conditions
- Idiopathic Anosmia, Idiopathic Hyposmia, Idiopathic Olfactory Dysfunction
- Trial name
- AROMA (NCT05740683)
- Testing
- RT-QuiC
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Danish Dementia Research Centre
Olfactory Neuroblastoma, Esthesioneuroblastoma
Phase 2 Study of Bintrafusp Alfa in Recurrent/Metastatic Olfactory Neuroblastoma (BARON).
Background: Olfactory neuroblastoma (ONB) is a rare cancer of the nasal cavity. At diagnosis, it is usually locally advanced. It tends to spread to the neck. Sometimes it spreads to the lungs and bones.
- Conditions
- Olfactory Neuroblastoma, Esthesioneuroblastoma, Neoplasm of the Nasal Cavity
- Trial name
- NCT05012098
- Testing
- Bintrafusp alfa/M7824, Ibuprofen, PET scan
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Frailty, Perioperative/Postoperative Complications
Correlation of Preoperative Global Olfactory Function With Frailty, Perioperative Neurocognitive Disorders and Mortality
The aims of this research project are to evaluate whether global olfactory impairment is a reliable indicator of preoperative frailty and cognitive impairment, and whether it may predict postoperative neurocognitive disorders…
- Conditions
- Frailty, Perioperative/Postoperative Complications, Olfactory Disorder, Neurocognitive Disorders
- Trial name
- NCT04761458
- Testing
- Olfactory function testing, Edmonton Frail Scale, Clinical Frailty Scale
- Where
- Belgium
- Volunteers
- 215 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Meningioma, Pituitary Disease
The Impact of Endoscopic Endonasal Skull Base Surgery on Olfaction
In this study, the research team will investigate the incidence and etiology of olfactory dysfunction following endoscopic endonasal skull base surgery, by combining clinical assessments with histomolecular analysis.
- Conditions
- Meningioma, Pituitary Disease, Pituitary Adenoma, Craniopharyngioma
- Trial name
- Endo-Olfact (NCT06874426)
- Testing
- Endoscopic endonasal skull base surgery
- Where
- 3 sites in Belgium, Germany and 1 more
- Volunteers
- 154 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Olfactory Disorder
cAMP (Cyclic Adenosine Monophosphate) Levels in the Nose
The purpose of this study is to determine the normal distribution of nasal tissue cathelicidin antimicrobial peptides (cAMP) levels in subjects with normal smell and subjects with smell dysfunction.
- Trial name
- NCT01332825
- Testing
- saline nasal irrigation
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Washington
Overweight and Obesity
ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study
The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof.
- Trial name
- OLFO-Brain (NCT06370845)
- Testing
- Inhalation - Natural Odour
- Where
- 2 sites in Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Seasonal Allergic Rhinitis
Treatment of Olfactory Dysfunction in Seasonal Allergic Rhinitis
People with allergies frequently complain of a loss or reduction in the sense of smell. In this study, the investigators propose to perform a randomized, double blind, placebo controlled parallel study of subjects with nasal…
- Trial name
- NCT00361439
- Testing
- Mometasone
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Chicago
End Stage Renal Disease, Olfactory Disorders
Helping Olfaction and Nutrition On Renal Replacement
This clinical trial examines whether nasal theophylline administration can improve olfaction and nutrition in hemodialysis patients.
- Trial name
- HONORR (NCT02479451)
- Testing
- Theophylline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Spinal Cord Injury at C5-Th10 Level With Complete Lesion, Spinal Cord Transection
Autologous Bulbar Olfactory Ensheathing Cells and Nerve Grafts for Treatment of Patients With Spinal Cord Transection
The purpose of this experimental therapy is to evaluate the safety and efficacy of transplantation of autologous olfactory ensheathing cells (OECs) and olfactory nerve fibroblasts (ONFs) obtained from the olfactory bulb with…
- Trial name
- NCT03933072
- Testing
- obtaining of autologous human olfactory bulb, autologous sural nerve preparation, production of Glial Neuropatch, microsurgical reconstruction of the transected spinal cord with autologous Glial Neuropatch-nerve bridges
- Where
- Poland
- Volunteers
- 2 people
- Sponsor
- Nicholls Spinal Injury Foundation
SARS-CoV-2 Infection, Cognitive Disorder
Investigation of the Persistence of SARS-CoV-2 in the Olfactory Mucosa of Patients With Prolonged Symptoms of COVID-19
NEUROCOVID is a prospective multicenter study comparing the proportion of patients with SARS-CoV-2 viral RNA at the level of the olfactory clefts in a group of cases compared to a group of controls as well as the correlations…
- Trial name
- NEUROCOVID (NCT05220241)
- Testing
- Nasopharyngeal swab for RT-PCR SARS-CoV-2
- Where
- 2 sites in France
- Volunteers
- 51 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP), Smell Loss
Olfactory Cleft Obstruction and Electrophysiological Field Potentials Predict Olfactory Restoration by Dupilumab in CRSwNP Patients.
The goal of this observational study is to learn what can predict the return of the sense of smell in patients with chronic rhinosinusitis with nasal polyps being treated with dupilumab.
- Trial name
- NCT06892704
- Testing
- Dupilumab - Standard Dose
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Perioperative Neurocognitive Disorder
Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment
Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear.
- Trial name
- NCT06488807
- Testing
- Olfactory Enrichment
- Where
- China
- Volunteers
- 686 people
- Sponsor
- Shanghai 10th People's Hospital
Telomere Disease, Telomere Shortening
Nasal Brushing for the Diagnosis and Understanding of Telomeropathies
To date, the diagnosis of telomeropathies is based on telomere length measured in blood cells. However, this type of analysis is not always sufficient because some mutations underlying the development of telomeropathies are not…
- Trial name
- TELOSTIC (NCT05508321)
- Testing
- Nasal brushing, Sniffin' Sticks
- Where
- Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Tracheal Stenosis, Laryngeal Stenosis
Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells
The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis
- Conditions
- Tracheal Stenosis, Laryngeal Stenosis, Mesenchymal Stem Cells
- Trial name
- NCT03130374
- Testing
- Olfactory mucosa-derived mesenchymal stem cells
- Where
- 2 sites in Belarus
- Volunteers
- 12 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
ESRD
Smell, Taste, Salivary Flow, and Oral Health in Patient Receiving Dialysis: A Before and After Study.
Studies show that the change of smell and taste, also dry mouth are the most common symptoms in end stage renal disease patients, the accumulation of uremic toxins would damage the intrinsinc antioxidant systems of the olfactory…
- Trial name
- NCT04401358
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- National Taiwan University Hospital