Clinical trials: Olfactory Dysfunction, open to volunteers
Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction
PANDORA: Evaluation of Platelet-rich Plasma in Non-tumoural Odour Disorders: a Descriptive Pilot Study.
This is a prospective, single-center, single-arm, non-comparative descriptive pilot study evaluating autologous platelet-rich plasma (PRP) injections in adults with persistent (>6 months) non-tumoural olfactory dysfunction…
- Conditions
- Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction, Age-related Degenerative Olfactory Dysfunction
- Trial name
- PANDORA (NCT07473830)
- Testing
- Autologous Platelet-Rich Plasma (PRP) Injection
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Mild Cognitive Impairment
Observation of Inhalation of CXMCI-01 Essential Oil on Patients With Mild Cognitive Impairment
Memory declined and cognitive impairment are common complaints in neurology clinics. Before diagnosing as dementia, individuals will undergo a transition period, including mild cognitive impairment (MCI).
- Trial name
- CXMCI-01-MCI (NCT06902181)
- Testing
- Experimental Group - 100% CXMCI-01 Essential Oil
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital
Olfactory Dysfunction, Post Viral Olfactory Dysfunction (PVOD)
The Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is the modified olfactory training device effective in treating patients with…
- Trial name
- NCT06829706
- Testing
- Conventional olfactory training device, Modified olfactory training device
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
Olfactory Dysfunction, Anosmia
Topical Versus Injection PRP for Olfactory Dysfunction
The goal of this clinical trial is to determine whether two different delivery methods of autologous platelet-rich plasma (PRP) can improve olfactory function in adults with persistent olfactory dysfunction lasting more than…
- Conditions
- Olfactory Dysfunction, Anosmia, Hyposmia
- Trial name
- TOP-IN (NCT07151703)
- Testing
- Intranasal Injection of Autologous PRP, Carrier-Assisted Topical Application of Autologous PRP, platelet-rich plasma
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hyposmia, Olfactory Dysfunction
Slow-SPEED UK: A Double-Blind Randomised Feasibility Trial
Slow-SPEED UK is an 18-month randomised, double-blind feasibility trial evaluating the delivery, adherence, and acceptability of a digitally supported physical activity programme in community-dwelling adults aged 40 and over with…
- Conditions
- Hyposmia, Olfactory Dysfunction, Anosmia
- Trial name
- Slow-SPEED (NCT06600438)
- Testing
- Slow-SPEED app
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Queen Mary University of London
Olfactory Dysfunction
Olfactory Dysfunction in Aging Adults
This prospective longitudinal cohort study will enroll adults aged 50 years and older to characterize olfactory dysfunction in aging.
- Trial name
- NCT07660887
- Testing
- Clinical and Biomarker Assessments
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Olfactory Impairment
Study of Chemosensory Enhancement Through Neuromodulation Training (SCENT): Open Label
Smell dysfunction significantly impacts quality of life and safety, with limited effective treatments. This open-label study evaluates the preliminary efficacy of combining non-invasive trigeminal nerve stimulation (TNS) with…
- Trial name
- SCENT-OL (NCT07689773)
- Testing
- Trigeminal Nerve Stimulation-enhanced Smell Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Medical University of South Carolina
Covid19, Olfactory Dysfunction
Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation
Investigation of the mechanisms of persistent SARS-CoV-2 associated olfactory dysfunction (OD) in patients with well-documented olfactory function.
- Trial name
- DysOSMIC (NCT06482138)
- Testing
- Biopsy and Cytobrush
- Where
- 7 sites in Belgium, Germany and 1 more
- Volunteers
- 240 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Glioblastoma Multiforme, Adult, Glioblastoma or Gliosarcoma
Prognostic Potential of Olfactory Function in Glioblastoma: a Prospective Observational Study
The study aims to investigate the prognostic significance of olfactory function in patients with glioblastoma. We are examining olfactory function at various points during therapy and correlating the results with survival data.
- Conditions
- Glioblastoma Multiforme, Adult, Glioblastoma or Gliosarcoma, Glioblastoma, Adult
- Trial name
- OLFGBM (NCT06954636)
- Testing
- olfactory testing (threshold and identification test)
- Where
- 2 sites in Germany
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Sied Kebir
Olfactory Dysfunction, Chronic Rhinosinusitis
The Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With CRS
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can treat postoperative olfactory dysfunction in…
- Trial name
- NCT06837051
- Testing
- Conventional olfactory training device, Modified olfactory training device, Budesonide irrigation
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Peking University Third Hospital
Chronic Rhinosinusitis (CRS)
Impact of Structural and Microenvironmental Abnormalities in Olfactory Cleft on Olfaction in CRS
The purpose of this research is to investigate the impact of structural abnormalities and microenvironmental changes in the olfactory cleft on olfactory function in patients with chronic rhinosinusitis (CRS).
- Trial name
- NCT06834477
- Testing
- Computed Tomography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Alzheimer Disease, Late Onset, Mild Cognitive Impairment
Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers
To establish the diagnostic and prognostic models that could help the preclinical identification of subjects at higher risk of clinical progression to mild cognitive impairment and dementia based on combined features of baseline…
- Conditions
- Alzheimer Disease, Late Onset, Mild Cognitive Impairment, Subjective Cognitive Decline
- Trial name
- NCT06561906
- Testing
- Multimodal magnetic resonance imaging scanning, behavioral, genetic and plasma biomarker testing
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cystic Fibrosis in Children, Cystic Fibrosis
Sinus Disease in Young Children With Cystic Fibrosis
This is a prospective, observational study examining the impact of highly effective cystic fibrosis transmembrane conductance regulator (CFTR) modulators on chronic rhinosinusitis (CRS) and olfactory dysfunction (OD) in young…
- Conditions
- Cystic Fibrosis in Children, Cystic Fibrosis, Chronic Rhinosinusitis (Diagnosis), Olfactory Disorder
- Trial name
- NCT06191640
- Testing
- Ivacaftor or elexacaftor/tezacaftor/ivacaftor
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, Los Angeles
Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Neural Dissimilarity in Patients With Chronic Rhinosinusitis With Nasal Polyps Treated With Biologics
This project will focus on rehabilitation of olfactory dysfunction in patients with chronic rhinosinusitis with polyps given biological treatment based on functional magnetic resonance imaging.
- Conditions
- Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Functional Magnetic Resonance Imaging (fMRI)
- Trial name
- NCT07819162
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet