Clinical trials: Oncologic
MTAP-null Non-Small-Cell Lung Cancer, MTAP-null Solid Tumors
A Phase 1/2 Study of Anvumetostat in Combination With IDE397 in Participants With Advanced Methylthioadenosine Phosphorylase (MTAP)-Null Solid Tumors
The main aims of this study are to evaluate the safety and tolerability, and to determine the maximum tolerated dose (MTD) or the recommended combination dose of Anvumetostat in combination with IDE397 in adult participants with…
- Trial name
- NCT05975073
- Testing
- Anvumetostat, IDE397
- Where
- 27 sites in United States, Australia and 5 more
- Volunteers
- 53 people
- Sponsor
- Amgen
Metastatic Breast Cancer
A Clinical Trial to Compare Efficacy and Tolerability of Faslodex With Arimidex in Patients With Advanced Breast Cancer
The purpose of this study is to compare the efficacy and tolerability of Faslodex (fulvestrant) with Arimidex (anastrozole) in postmenopausal women with hormone receptor positive advanced breast cancer.
- Trial name
- FIRST (NCT00274469)
- Testing
- fulvestrant, anastrozole
- Where
- 41 sites in United States, Brazil and 7 more
- Volunteers
- 205 people
- Sponsor
- AstraZeneca
Oncologic Disorders, Neurologic Disorder
Advanced Imaging Holistic Omics Biobank
Imaging methods today represent the pillar of prevention, diagnosis, patients monitoring and treatment. Improvement in technology led the development of increasingly high-performance scanners whose potential has not yet been…
- Conditions
- Oncologic Disorders, Neurologic Disorder, Pulmonary Disease, Cardiovascular Diseases
- Trial name
- NCT06523270
- Testing
- Computed Tomography (CT) using Photon Counting CT scanner (Neaotom Alpha, Siemens) and Magnetic Resonance (MRI)
- Where
- Italy
- Volunteers
- 50,000 people
- Sponsor
- IRCCS San Raffaele
Leukemia, Lymphocytic, Acute, Leukemia, Myeloid, Acute
High- Fiber/ Low-fat Diet for Prevention of Recurrent Clostridioides Difficile Infection in Oncology
The primary objective of the study is to determine whether dietary intervention to increase fiber and decrease fat reduces C. difficile infection recurrence in a cohort of oncology patients.
- Conditions
- Leukemia, Lymphocytic, Acute, Leukemia, Myeloid, Acute, Lymphoma, Clostridium Difficile Infection
- Trial name
- NCT04940468
- Testing
- Diet Intervention
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Colorado, Denver
Cancer Pain, Oncology
Randomized Controlled Trial of Virtual Reality Assisted Guided Imagery (VRAGI) for Pain in Advanced Cancer Patients.
Introduction Patients with advanced cancer often experience high levels of debilitating pain and pain-related psychological distress.
- Conditions
- Cancer Pain, Oncology, Virtual Reality, Depression, Anxiety
- Trial name
- NCT05348174
- Testing
- Virtual Reality Assisted Guided Imagery (VRAGI)
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Prisma Health-Upstate
Head and Neck Cancer
Impact in Head and Neck Oncology of Support by a Nurse in the Patient's Care Pathway
Head and neck cancers (HNC) constitute a significant global health burden, ranking fourth in terms of cancer incidence and fifth in terms of cancer-related mortality.
- Trial name
- COACH-ORL (NCT06203808)
- Testing
- COMPLETION OF QUESTIONNAIRES
- Where
- France
- Volunteers
- 320 people
- Sponsor
- University Hospital, Toulouse
Neurosurgery, Neuro-Oncology
Intraoperative Hyperspectral Imaging for Fluorescence Guided Surgery in Low Grade Gliomas
The purpose of this study is to obtain images of brain tumours during surgery using a new type of surgical camera. The study will assess how the information obtained from the images during surgery matches the removed tissue.
- Conditions
- Neurosurgery, Neuro-Oncology, Brain Tumor
- Trial name
- Neuro-qFHSI (NCT05397574)
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Cancer
Digital Symptom Tracking, Patient Engagement and Quality of Life in GI Oncology Clinic Patients
A pilot study of an ePRO system in cancer patients receiving systemic therapies.
- Trial name
- NCT03459352
- Testing
- ePRO
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Oncology, Adapted Physical Activity
Feasibility of Adapted Physical Activity Based on a Walking Platform in Hospitalized Old Patients for Cancer
The investigator propose to evaluate the interest of the provision of a suitable treadmill offering fall protection and verticalization assistance.
- Trial name
- APPAHOCA (NCT03473652)
- Testing
- Adapted walking platform
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Centre Francois Baclesse
Lung Cancer, Esophageal
Photodynamic Therapy (PDT) Oncology Registry
The data elements for the PDT Registry project include virtually all the elements in the standard hospital-based cancer registry record, although in some cases at a finer level of detail.
- Trial name
- PDT Registry (NCT01842555)
- Testing
- Registry
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Main Line Health
Gastric Cancer
Gastric Cancer Risk Factors Knowledge in European and Latinamerican Population
This study is divided into two parts: Part 1: An interventional study, with a pre-post study design to determinate the grade of knowledge of established GC risk factors.
- Trial name
- LEGACY-3 (NCT04019808)
- Where
- 8 sites in Argentina, Chile and 5 more
- Volunteers
- 800 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Locally Advanced (Unresectable) or Metastatic Solid Tumors
A Study of NEOK001, a B7-H3 and ROR1 Targeting Bispecific ADC in Participants With Select Solid Tumors
This is a first in human (FIH), Phase 1, dose escalation and expansion study in select solid tumors. This study includes 2 parts: a Dose Escalation and Backfill portion (Part A) and a Dose Expansion portion (Part B).
- Trial name
- NCT07612176
- Testing
- NEOK001, NEOK001 RDE
- Where
- 9 sites in United States
- Volunteers
- 155 people
- Sponsor
- NEOK Bio, Inc.
Cirrhosis
Use of the French Healthcare Insurance Database
Hepatocellular carcinoma (HCC) has become the second most common cause of cancer death in the world, estimated responsible for nearly 745,000 deaths in 2012 (9.1% of all cancer deaths).
- Trial name
- SAMHEPAT (NCT02983968)
- Testing
- Description of the cirrhosis management
- Where
- France
- Volunteers
- 75,868 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Geriatric Oncology, Supportive Care
The GOS-Frail (Geriatric Oncology Supportive Care for Frail Older Adults With Cancer) Study
Background Cancer is more prevalent in older adults, but most cancer treatment trials have mainly involved young and healthy subjects.
- Conditions
- Geriatric Oncology, Supportive Care, Quality of Life
- Trial name
- GOS-Frail (NCT06553378)
- Testing
- Geriatric Oncology Supportive Clinic
- Where
- Singapore
- Volunteers
- 154 people
- Sponsor
- Tan Tock Seng Hospital
Cancer, With Caregiver Support Time
French Validation of an Interview Guide to Cancer Announcement : the Psycho Oncology Basic Documentation
Validation of the PO-BADO in its short and long versions that need a standardized validation process with the inclusion of 450 Patients
- Conditions
- Cancer, With Caregiver Support Time, 18 Years and Over
- Trial name
- PO-BADO (NCT02874001)
- Volunteers
- 252 people
- Sponsor
- Institut Bergonié
Cancer
Oncology-patient-reported Anxiety, Mood, and QoL During the COVID-19 Pandemic
ONCOVID is a prospective cohort study investigating oncology-patient-reported anxiety, mood, and quality of life during the COVID-19 pandemic.
- Trial name
- ONCOVID (NCT04340219)
- Testing
- Survey administration
- Where
- Belgium
- Volunteers
- 394 people
- Sponsor
- University Hospital, Ghent
Colorectal Cancer, Psycho-Oncology
The Effects of Nurse Navigation Program on Symptom Management and Psychosocial Adjustment in Colorectal Cancer Patients
This study was conducted to examine the effect of the nurse navigation program (NNP) applied to patients with colorectal cancer on symptom management and psychosocial adjustment to the disease.
- Conditions
- Colorectal Cancer, Psycho-Oncology, Nursing
- Trial name
- NCT05571098
- Testing
- individualized colorectal cancer education, psycho-oncological counseling, telephone support hotline service
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi
Leukemia
Interleukin-2 in Treating Children Who Have Undergone Bone Marrow Transplantation for Acute Myeloid Leukemia
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill more cancer cells. PURPOSE: Phase I trial to study the effectiveness of interleukin-2 in treating children who have undergone bone marrow transplantation…
- Trial name
- NCT00009698
- Testing
- aldesleukin
- Where
- 119 sites in United States, Australia and 4 more
- Volunteers
- 1 people
- Sponsor
- Children's Oncology Group
Leukemia, Childhood, Solid Tumor, Childhood
Observational MyPal-Child Study on the ePRO-based Early Palliative Care Digital System in Paediatric Oncology Patients
The main aim of the study is the evaluation of the feasibility of comprehensive service which has been developed while considering patient-orientated needs.
- Trial name
- MyPal4Kids (NCT04381221)
- Where
- 3 sites in Czechia, Germany
- Volunteers
- 100 people
- Sponsor
- Centre for Research and Technology Hellas
Neoplasms, Children
Hospital-based Home Care for Children With Cancer
The purpose of this non-randomized controlled intervention study was to evaluate the effects of a hospital-based home care program for children with cancer at a university hospital in Denmark.
- Trial name
- NCT01538706
- Testing
- Hospital-based home care
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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