Clinical trials: Oncologic
Oncology, Quality of Life
Long-term Follow-up and Quality of Life of Patients Treated With Anticancer Drugs
Currently, aspects related to the effects of anticancer treatments and the quality of life of patients and their needs are still poorly documented at the Rafael Institute.
- Conditions
- Oncology, Quality of Life, Symptoms and Signs
- Trial name
- THERAPINNOV (NCT06317714)
- Testing
- questionnaires
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Institut Rafael
Pediatric Residents Rotating in Pediatric Oncology
Narrative Medicine and Pediatric Oncology
The investigators' objective is to implement an innovative curriculum in narrative medicine for pediatric residents rotating at Memorial Sloan Kettering Cancer Center (MSKCC), and to evaluate whether this curriculum is protective…
- Trial name
- NCT04489316
- Testing
- Narrative medicine curriculum
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Weill Medical College of Cornell University
Colon Cancer
Colon Cancer Prognosis After Radical Surgery
1. Radical surgery. It is supposed to improve prognosis of colon cancer. A surrogate measure of achievement of radical surgery is the number of lymph nodes removed with the specimen. 2. Markers.
- Trial name
- NCT00963352
- Where
- 2 sites in Norway
- Volunteers
- 300 people
- Sponsor
- Haraldsplass Deaconess Hospital
Stage II Breast Cancer, Stage III Breast Cancer
Ask Questions (ASQ):Implementation of a Communication Intervention
This clinical trial implements a communication intervention to improve patient-oncologist communication in the outpatient medical oncology setting.
- Conditions
- Stage II Breast Cancer, Stage III Breast Cancer, Stage IV Breast Cancer, Stage II Colorectal Cancer
- Trial name
- NCT05025748
- Testing
- Behavioral Intervention
- Where
- 8 sites in United States
- Volunteers
- 81 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Cardiotoxicity
Effect of Remote Ischaemic Conditioning in Oncology Patients
Cancer survival has improved steadily due to earlier detection and treatment. Despite the established efficacy of anthracycline chemotherapy, its damaging effects on the heart (cardiotoxicity) limits treatment and confers acute…
- Trial name
- ERIC-ONC (NCT02471885)
- Testing
- Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 128 people
- Sponsor
- University College, London
Melanoma
Adjuvant Nivolumab & Low Dose Ipilimumab for Stage III & Resected Stage IV Melanoma
Effective adjuvant treatment can increase cure in patients with high-risk resected melanoma. High dose interferon is a standard of care in the adjuvant setting but is highly toxic and marginally effective.
- Trial name
- NCT02656706
- Testing
- Ipilumumab, Nivolumab
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Brown University
Physical Activity, Mobile Application
HopeMove App in Pediatric Cancer Patients
This pilot feasibility study aims to assess the acceptability, usability, safety, and initial effects of the HopeMove mobile health app on fatigue in adolescents aged 13 to 18 years undergoing hematology-oncology treatment.
- Trial name
- NCT07274358
- Testing
- HopeMove Mobile Application
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Koç University
Non-Small Cell Lung Cancer
GEMINI-NSCLC: NSCLC Biomarker Study
GEMINI NSCLC Study is a non-interventional study that will be collecting clinical and molecular health information from patients with NSCLC who will receive longitudinal blood collection in addition to their standard of care…
- Trial name
- NCT05236114
- Testing
- Observation
- Where
- 58 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- Tempus AI
Cancer
Textual Analysis of Narratives Produced by Adolescent Oncology Patients: A Research Project
This research project builds on a long-standing tradition within our Institute of documenting "free thoughts" and personal reflections shared by adolescent oncology patients and their families.
- Trial name
- Testi AYA (NCT07527416)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
I Cell Disease, Fucosidosis
Study of Pulmonary Complications in Pediatric Patients With Storage Disorders Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
OBJECTIVES: I. Evaluate bronchoalveolar lavage fluid and serum obtained from pediatric patients with storage disorders prior to allogeneic hematopoietic stem cell transplantation (HSCT) for the presence of proinflammatory…
- Conditions
- I Cell Disease, Fucosidosis, Globoid Cell Leukodystrophy, Adrenoleukodystrophy
- Trial name
- NCT00005900
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Fairview University Medical Center
Neuroblastoma
High-Dose 131I-MIBG Therapy Combined With Vincristine and Five Days of Irinotecan for Resistant/Relapsed Neuroblastoma
This is a pilot study to determine whether doses of 15 mCi/kg and 18 mCi/kg of 131I-MIBG are tolerable when given with irinotecan/vincristine on a one week schedule to children and young adults with high-risk refractory/relapsed…
- Trial name
- NCT01313936
- Testing
- Metaiodobenzylguanidine (MIBG)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of California, San Francisco
Malignancy, Immune System Diseases
Immuno-Oncology Database and Bioregistry
Immunotherapy, especially immune checkpoint inhibitors (ICIs), are effective in treating many different types of cancers. ICIs fight cancer by driving the immune system into an "activated state" that makes it harder for tumor…
- Conditions
- Malignancy, Immune System Diseases, Autoimmune Diseases
- Trial name
- IOG (NCT04656873)
- Testing
- Biospecimen Collection, Medical Chart Review, Questionnaires/Surveys
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Cancer
Cardio-Oncology Rehabilitation Exercise
Women with breast cancer who are referred to the cardiac rehabilitation program at the Toronto Rehabilitation Institute will be invited to enrol in this observational study.
- Trial name
- CORE (NCT05522959)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of Toronto
Colorectal Cancer
Phase II Trial of Abraxane and Capecitabine in Metastatic Colon Cancer (COL 01)
This is an open-label, phase II study to evaluate the efficacy and safety of Abraxane in combination with Capecitabine in patients with metastatic colorectal cancer in the second or third line
- Trial name
- ABX067 (NCT00625573)
- Testing
- Abraxane
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mt. Sinai Medical Center, Miami
Deprescribing, Palliative Care
DEprescribing: Perceptions of PAtients Living With Advanced Cancer
Polymedication in palliative oncology care is a real public health problem. This phenomenon has been shown to increase the risk of iatrogenesis, reduce patients' quality of life and increase healthcare costs.
- Conditions
- Deprescribing, Palliative Care, Oncology
- Trial name
- DEPAL (NCT06193083)
- Testing
- Semi-directed individual interviews, The self-administered questionnaires, rPATD and BMQ, The self-administered FCCHL (Functional, Communicative and Critical Health Literacy) / HLS14 (14-item health literacy scale)
- Where
- 8 sites in France
- Volunteers
- 325 people
- Sponsor
- Nantes University Hospital
Respiration Disorders
Randomized Study of Propofol Versus Fentanyl and Midazolam in Pediatric Patients Requiring Mechanical Ventilation and Sedation Therapy
OBJECTIVES: I. Assess the degree of amnesia afforded by study sedatives relative to the patient's intensive care unit experiences. II.
- Trial name
- NCT00004424
- Testing
- fentanyl, Midazolam, propofol
- Volunteers
- 120 people
- Sponsor
- FDA Office of Orphan Products Development
Myelofibrosis
Myelofibrosis Treated With Pacritinib Before aSCT. (HOVON134MF)
The only curative treatment for patients with myelofibrosis (MF) is allogeneic stem cell transplantation (SCT). Treatment with JAK2 inhibitors like pacritinib improves condition of MF patients, decreases spleen size and might…
- Trial name
- HOVON134MF (NCT03645824)
- Testing
- Pacritinib
- Where
- 12 sites in Belgium, Netherlands
- Volunteers
- 61 people
- Sponsor
- Stichting Hemato-Oncologie voor Volwassenen Nederland
Integrative Oncology
Survey of Sexual Health in Cancer Patients
Sexual health, a vital aspect of the overall human health and a critical component of quality of life, can be negatively affected by cancer and cancer treatments.
- Trial name
- S&C (NCT06428279)
- Testing
- Survey
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Institut Rafael
Cancer
Affinity: Hospital Trial
Method comparison study to compare the Affinity prototype device using a capillary blood sample against routine venous laboratory results, in patients undergoing systemic anti-cancer therapy (SACT).
- Trial name
- NCT04211727
- Testing
- Capillary finger prick blood sample
- Where
- United Kingdom
- Volunteers
- 247 people
- Sponsor
- Entia Ltd
Breast Cancer
A Real-World Study of Early Breast Cancer Patients Eligible for Treatment With CDK4/6 Inhibitors
The aim of this study was to describe treatment patterns, patient characteristics and clinical outcomes among hormone receptor positive/human epidermal growth factor receptor 2 negative (HR+/HER2-) early breast cancer (eBC)…
- Trial name
- LEEWARD (NCT07647042)
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- Novartis Pharmaceuticals
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