Clinical trials: Oncologic
Covid19, Cancer
Serologic Response to the SARS-CoV-2 (COVID-19) MRNA-1273 Vaccine in Select Subsets of Oncology Patients
To explore the immune response to the COVID-19 vaccine in cancer patients and compare to the general population.
- Trial name
- NCT04854980
- Testing
- Blood Sample
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Rochester
Solid Cancer, Gastric (Cardia, Body) Cancer
Impact of CES1 Genotype on Capecitabine Exposure in Cancer Patients
In this study, the drug capecitabine is investigated. Capecitabine is commonly used to treat breast, colon, and stomach cancers. Capecitabine is taken in tablet form.
- Conditions
- Solid Cancer, Gastric (Cardia, Body) Cancer, Esophageal Cancer, Colorectal Cancer (CRC)
- Trial name
- ESCAPE (NCT07114627)
- Testing
- Blood sampling for pharmacokinetics
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Erasmus Medical Center
Bone Marrow Transplantation, Distress
Massage for Pediatric Oncology
Undergoing bone marrow transplantation (BMT) is associated with a high level of distress for patients and caregivers. Clinical research studies have reported benefits from massage for a) oncology patients, b) children, c) adults…
- Trial name
- NCT00843180
- Testing
- massage
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, San Francisco
Oncology
A Patient-Centric Platform Trial for Precision Oncology
XCELSIOR is a non-interventional data registry. Information about treatments, treatment decisions and rationale, and patient outcomes including safety and effectiveness of anti-cancer therapy and associated supportive care will…
- Trial name
- XCELSIOR (NCT03793088)
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- xCures
Bladder (Urothelial, Transitional Cell) Cancer
An Exploratory Clinical Study of Nimotuzumab in Bladder - Sparing Chemoradiotherapy for Muscle - Invasive Bladder Cancer
The goal of this exploratory study is to evaluate the safety and efficacy of nimotuzumab combined with chemoradiotherapy in bladder - preserving treatment for MIBC patients who are ineligible for or decline radical cystectomy.
- Trial name
- NCT07053735
- Testing
- Nimotuzumab and Radiotherapy
- Volunteers
- 30 people
- Sponsor
- Peking University First Hospital
Advanced Solid Tumors, Colorectal Cancer
Safety Study of the Drug MM-151 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment
This study is a Phase 1 and pharmacologic open-labeled dose-escalation trial using a "3+3" design, evaluating MM-151 at varying dose levels and frequencies, and subsequently in combination with irinotecan.
- Conditions
- Advanced Solid Tumors, Colorectal Cancer, Squamous Cell Head and Neck Cancer, Non Small Cell Lung Cancer
- Trial name
- NCT01520389
- Testing
- MM-151, MM-151 + irinotecan
- Where
- 4 sites in United States
- Volunteers
- 112 people
- Sponsor
- Merrimack Pharmaceuticals
Sepsis in Cancer Patients
Sepsis in Oncology Patients
The overall objective of this prospective observational study is to address the significant knowledge gap that exists around the impact of immune dysfunction on the development and survival from sepsis in patients with cancer.
- Trial name
- SEPONC (NCT06046677)
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Solid Tumor, Malignant Lymphoma
Phase 1 Dose Escalation Study of ARQ 092 in Adult Subjects With Advanced Solid Tumors and Recurrent Malignant Lymphoma
This is an open-label, Phase 1, dose escalation study of oral ARQ 092 administered to subjects with advanced solid tumors and recurrent malignant lymphoma.
- Conditions
- Solid Tumor, Malignant Lymphoma, Tumor
- Trial name
- NCT01473095
- Testing
- ARQ 092
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)
Cancer
Patient and Provider Initiated Survivorship Care Planning
Objective: to describe and compare the implementation of two cancer survivorship care tools: (1) 'My Care Plan': a patient-initiated tool and (2) 'Survivorship Care Plan Builder': a provider-initiated tool.
- Trial name
- NCT02405819
- Testing
- 'My Care Plan', 'Survivorship Care Plan Builder'
- Where
- 2 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Childhood Oncology, Mucositis Oral
Oral Mucositis Management in Pediatric Oncology Patients
This study evaluated the impact of an oral mucositis care protocol on the severity of mucositis. The main questions it aims to answer are: -What is the severity of mucositis in parents and children who receive oral mucositis…
- Trial name
- NCT06711315
- Testing
- Oral Mucosit Care Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zubeyde Ezgi Ercelik
Cancer
The Effect of Community-Provided Psychosocial Support Videos on Disease Attitudes and Symptoms
The effects of psychosocial support on the disease process have been studied with many different groups and diseases, and even the psychosocial support needed by the family of the child with a chronic disease has been the subject…
- Trial name
- NCT06011278
- Testing
- Community Supported Videos
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Koç University
Cancer, Solid Tumor
Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors
This study will evaluate safety, pharmacodynamics and biomarkers of subcutaneous (SC) DK210(EGFR) given as monotherapy and in combination with immunotherapy, chemotherapy or radiation.
- Conditions
- Cancer, Solid Tumor, Colorectal Cancer, Pancreas Cancer
- Trial name
- NCT05704985
- Testing
- DK210 (EGFR), Radiation therapy, Immune checkpoint blockers
- Where
- 7 sites in United States
- Volunteers
- 39 people
- Sponsor
- DEKA Biosciences
Pediatric Acute Myeloid Leukemia, Pediatric Acute Lymphoid Leukemia
Information Support Using an Online Learning Platform for Malaysian Pediatric Leukemia and Lymphoma Parents
This is a study protocol to determine whether it is feasible to support parents of children with blood cancers by providing information over an online learning platform. This study will be conducted in Malaysia.
- Conditions
- Pediatric Acute Myeloid Leukemia, Pediatric Acute Lymphoid Leukemia, Pediatric Non-Hodgkin Lymphoma, Pediatric Hodgkin Lymphoma
- Trial name
- eHOPE (NCT05455268)
- Testing
- eHOPE, Usual care
- Where
- 2 sites in Malaysia
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Intensive Care Units, Triage
ICU Triage Practices in a Cancer Hospital
The primary objective of this study is aimed at analyzing the ICU triage practices of clinicians at a cancer hospital with and without the use of an algorithm-based triage tool, and to assess whether or not the triage tool…
- Trial name
- NCT03401411
- Testing
- Survey, Algorithm-based Triage Tool
- Where
- 3 sites in United States, Ecuador
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Multiple Ground Glass Opacities (GGOs)
A Registry for Patients With Multifocal Ground Glass Opacities (GGOs)
The purpose of this registry study is to actively monitor people with GGOs and collect information about them, so that investigators can learn more about these lesions and about the risk of developing lung cancer in study…
- Trial name
- NCT03802981
- Where
- 32 sites in United States, Canada
- Volunteers
- 338 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer, Tumor, Solid
Performance and Safety of Biology-Guided Radiotherapy Using the RefleXion Medical Radiotherapy System (BIOGUIDE-X)
The purpose of this study is to assess the performance and safety of Biology-Guided Radiotherapy (BgRT) using the RefleXion Medical Radiotherapy System (RMRS) via optimizing F18-Fluorodeoxyglucose (FDG) dosing, assessing the…
- Conditions
- Cancer, Tumor, Solid, Cancer, Lung, Cancer, Bone
- Trial name
- BIOGUIDE-X (NCT04788147)
- Testing
- RMRS IDE Device
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- RefleXion Medical
Multiple Myeloma, Heart Disease Risk Factors
MM-CARE: Cardiovascular Risk Assessment in Adults With Multiple Myeloma
People with multiple myeloma may have health conditions or receive treatments that increase their risk of heart and blood-vessel problems.
- Trial name
- MM-CARE (NCT07783607)
- Testing
- Oncology-Embedded Cardiovascular Risk Assessment Pathway, Primary Care Provider-Directed Cardiovascular Risk Assessment Pathway
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Vermont Medical Center
Oncology
Evaluation of a New Generation of PET-CT OMNI
The overarching purpose of the study is to provide supporting evidence to the value proposition of OMNI, that offers global access to an affordable hybrid PET/CT system similar in performance to that of systems utilized by…
- Trial name
- NCT05154877
- Testing
- OMNI PET/CT Scan
- Where
- France
- Volunteers
- 45 people
- Sponsor
- GE Healthcare
Pancreas Cancer, Localized Pancreas Cancer
Neoadjuvant FOLFIRINOX Regimen in Patients With Non-metastatic Pancrease Cancer
A prospective evaluation of neoadjuvant FOLFIRINOX regimen in patients with non-metastatic pancreas cancer (Baylor University Medical Center and Texas Oncology Experience)
- Conditions
- Pancreas Cancer, Localized Pancreas Cancer, Non-metastatic Pancreas Cancer
- Trial name
- NCT01771146
- Testing
- FOLFIRINOX Regimen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor Research Institute
Hypotension, Hemodynamic Instability
Perioperative Hypotension in Gynaecologic Oncologic Surgery: HPI-ClearSight Versus Arterial Waveform Analysis
Background Intraoperative hypotension is associated with increased morbidity and mortality. The Hypotension Prediction Index (HPI) is an advancement of the arterial waveform analysis to predict intraoperative hypotension minutes…
- Conditions
- Hypotension, Hemodynamic Instability, Gynecologic Cancer
- Trial name
- NCT05354661
- Testing
- Hypotension Prediction Index
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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